Silver vs. chlorhexidine: a kinder mouthwash for Kids' teeth?
NCT ID NCT07728409
First seen Jul 27, 2026 · Last updated Jul 29, 2026 · Updated 2 times
Summary
This trial tests whether a silver nanoparticle mouthwash can reduce cavity-causing bacteria in children as effectively as chlorhexidine, but without the staining and taste issues. About 96 children aged 6–12 at high risk for cavities will rinse twice daily for 14 days. The study measures changes in salivary Streptococcus mutans levels and saliva pH.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- silver nanoparticle mouthwash (10 ppm) and chlorhexidine mouthwash (0.2%)
- What this could lead to
- If effective, silver nanoparticle mouthwash could offer a gentler, kid-friendly alternative to chlorhexidine for preventing cavities in children.
- What could go wrong
- This is a small, short-term trial in 96 children. Silver nanoparticles are still experimental, and long-term safety or effectiveness is not yet known.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 96 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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6 to 12 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 6-12 years with mixed dentition. * American Society of Anesthesiologists (ASA) physical status I or II * High caries risk, defined as DMFT/dmft score ≥ 3, Dentocult SM Strip mutans score ≥ 2, or salivary S. mutans ≥ 10⁵ CFU/mL at screening * Presence of at least 20 natural teeth. * No antibiotic therapy in the preceding 3 months. * Parent/guardian willing to provide written informed consent. * Child assent obtained using age-appropriate methods. Exclusion Criteria: * Systemic diseases affecting salivary flow (e.g., Sjögren's syndrome, uncontrolled diabetes, cystic fibrosis). * Special healthcare needs or developmental disabilities affecting. compliance * Active fixed or removable orthodontic appliances. * History of allergy to silver compounds, chlorhexidine, or mint flavoring. * Use of any antimicrobial mouthwash in the preceding 3 months. * Active oral mucosal lesions or periodontal disease. * Professional fluoride treatment within the past month. * Participation in another clinical trial within the past 6 months.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
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