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Could a single radiation dose ease bone pain as well as five?

NCT ID NCT07772206

Symptom relief Sponsor: Oman Ministry of Health Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time

Summary

This trial is testing whether a single, higher dose of radiation (8 Gy) can relieve pain from bone metastases as effectively as a standard course of five smaller doses (20 Gy total). The study includes adults with cancer that has spread to the bones and who have significant pain. The main goal is to see if this approach is practical and acceptable to patients, while also checking pain relief, side effects, and the need for repeat treatment. The results will help design a larger study to confirm the best way to deliver palliative radiotherapy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Radiotherapy (single-fraction 8 Gy vs multifraction 20 Gy in 5 fractions)
What this could lead to
If successful, this could show that a single radiation session is as effective as multiple sessions for easing bone pain, making treatment faster and more convenient for patients.
What could go wrong
This is a small feasibility study, not a large definitive trial, so results may not be conclusive. There are risks of pain flare or side effects from radiation, and the single dose may not control pain as well as multiple doses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * Histologically proven malignancy * Radiological evidence of bone or spine metastases * Pain score ≥4 on Numeric Rating Scale (NRS-11) * ECOG Performance Status 0-3 * Life expectancy ≥3 months. * Ability to provide written informed consent Exclusion Criteria: * Spinal cord compression requiring emergency therapy * Previous radiotherapy to same site * Unstable pathological fracture requiring surgery * Pregnancy * Inability to provide consent * Oligometastatic bone metastases requiring Stereotactic Body Radiotherapy (SBRT)

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Conditions

The condition(s) this trial relates to.

Cancer Pain metastatic carcinoma in the bone

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bone metastases of A malignant tumor Cancer pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Royal Hospital

    Muscat, Muḩāfaz̧at Masqaţ, 100, Oman

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