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Talking therapy may offer a path away from opioids for cancer survivors

NCT ID NCT05067556

Symptom relief Sponsor: Virginia Commonwealth University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused This study
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 18, 2026 · Last updated Aug 19, 2026 · Updated 1 time

Summary

This pilot trial tests whether Acceptance and Commitment Therapy (ACT), a type of talking therapy, can help disease-free cancer survivors manage chronic pain and reduce long-term opioid use. Participants attend six weekly virtual sessions with a psychologist. The study focuses on whether the approach is feasible and acceptable, while also looking at changes in pain intensity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Acceptance and Commitment Therapy for chronic pain (ACT-CP), a behavioral intervention delivered via virtual sessions
What this could lead to
If successful, this could offer a non-drug way to help cancer survivors manage chronic pain and reduce reliance on opioids.
What could go wrong
This is a small pilot study focused on feasibility, so it may not show clear pain relief or opioid reduction. Results may not apply to all survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 18 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2021

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of cancer of any type, currently in remission, having completed active primary therapy. Patients on oral adjuvant hormone therapy will still be eligible. * Completed active therapy must have been curative in intent (for example stage IV cancer patients such as head and neck cancer patients treated with curative intent are eligible). * Self-reported cancer pain for \>= 3 months * Opioid use \>= 5MME/day (morphine milligram equivalents) as prescribed by physician for cancer-related pain for at least 6 months beyond completion of their cancer treatment * VCUHealth system patient Exclusion Criteria: * History of opioid use prior to cancer diagnosis * Anyone with prior history of substance use disorder or currently enrolled in a methadone program * Anyone with schizophrenia or bipolar disorder * Current utilization of psychotherapy services for pain, depression, anxiety, and/or PTSD * Cognitive concerns that would prevent meaningful engagement in treatment * Inability to converse in English * Lack of working telephone and Internet connection (must have at least one or the other) * Anyone found to have progression of cancer * Anyone diagnosed with cancer recurrence or new cancer during their study period * Documented diagnosis of or positive screen for current substance use disorder (score \>5 on the Drug Abuse Screening Test-10 \[DAST-10\]) * Anyone scoring \>=8 on ORT indicating very high risk for opioid abuse

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Conditions

The condition(s) this trial relates to.

cancer Cancer Pain Chronic Pain chronic pain syndrome Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer pain Chronic pain Pain Survivorship

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Virginia Commonwealth University

    Richmond, Virginia, 23219, United States

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