ACUTE LYMPHOBLASTIC LEUKEMIA

This study is testing a stem cell transplant from a partially matched family donor for patients with hard-to-treat blood cancers like leukemia and lymphoma. Before the transplant, patients receive chemotherapy and radiation to wipe out their own bone marrow and cancer cells. The …

This study is testing a treatment called CAR T-cell therapy for children and young adults (up to age 21) whose CD19-positive leukemia has come back or hasn't responded to other treatments. Doctors collect a patient's own immune cells, modify them in a lab to better target cancer,…

This early-stage trial is testing the safety of a modified donor stem cell transplant, called Orca-Q, for people with certain blood cancers like leukemia. The goal is to see if this engineered transplant can help patients recover their blood counts while reducing serious complica…

This study is testing whether KTE-X19, a type of CAR T-cell therapy, can help adults with B-cell acute lymphoblastic leukemia who are in remission but still have tiny amounts of cancer cells detectable in their bone marrow. The treatment involves collecting and genetically modify…

This early-stage study is testing a new type of stem cell transplant for adults aged 60-75 with acute leukemias or myelodysplastic syndrome (MDS). The approach combines a precise form of radiation targeting bone marrow and lymph nodes with chemotherapy, followed by an infusion of…

This early-stage study is testing a personalized cell therapy called CAR-T for adults with certain blood cancers that have returned or not responded to at least two prior treatments. Doctors will collect a patient's own immune cells, genetically modify them to better target cance…

This large study aims to improve treatment for adults with acute lymphoblastic leukemia (ALL), a fast-growing blood cancer. It will test whether adding new, targeted immunotherapy drugs to standard treatment can better control the disease and reduce the need for stem cell transpl…

This study is testing a refined procedure for umbilical cord blood transplants in adults and children with high-risk blood cancers like leukemia and lymphoma. The goal is to see if this optimized approach improves survival and reduces complications compared to standard transplant…

This study is testing whether combining two drugs, blinatumomab and asciminib, can help control a fast-growing blood cancer called Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). It will involve about 40 adults and teenagers, including those newly diagnosed and thos…

This study is testing whether a new type of CAR-T cell therapy can be successfully made at the hospital for patients with a specific type of leukemia that has come back or hasn't responded to other treatments. The main goal is to see if the process of creating this personalized c…

This early-stage study is testing the safety of a new type of CAR T-cell therapy for children and young adults (up to age 21) whose acute lymphoblastic leukemia has come back or hasn't responded to other treatments. The therapy uses the patient's own modified immune cells designe…

This early-phase study is testing the safety of giving two different types of genetically modified immune cell therapies, one after the other, to children and young adults whose B-cell leukemia has come back or hasn't responded to treatment. The goal is to see if a second, experi…

This study aims to find better treatments for children and young adults whose leukemia has returned or is hard to treat. It screens patients' blood and bone marrow to understand their specific cancer and match them to new, targeted therapy trials. The goal is to control the disea…

This early-stage study aims to find out if adding a drug called ruxolitinib to standard chemotherapy is safe and tolerable for adolescents and young adults (ages 18-40) newly diagnosed with a specific, hard-to-treat form of acute lymphoblastic leukemia (ALL). The main goal is to …

This trial is testing whether adding two targeted immunotherapies, inotuzumab and blinatumomab, to standard chemotherapy can better control leukemia in children and young adults. It aims to see if this combination helps more patients achieve deep remission with minimal detectable…

This study is testing a new drug called MK-1045 for people with a type of blood cancer called B-cell acute lymphoblastic leukemia (B-ALL) that has returned or is not responding to current treatments. The first part of the study aims to find a safe and effective dose. The second p…

This study is testing a personalized cell therapy for adults with advanced B-cell leukemias that have not responded to standard drugs. Doctors take a patient's own immune cells, modify them in a lab to target a protein (CD19) found on their cancer cells, and then infuse them back…

This study tests whether adding the drug ruxolitinib to two standard medications helps prevent graft-versus-host disease (GVHD) in children and young adults receiving bone marrow transplants for blood cancers. GVHD is a serious complication where donor immune cells attack the pat…

This early-stage study is testing a new drug called bleximenib in people with acute leukemia that has come back or not responded to other treatments. The first goal is to find a safe and effective dose. The second goal is to see if this dose can help patients achieve remission, w…

This early-stage trial is testing the safety of a new CAR T-cell therapy for adults with B-cell acute lymphoblastic leukemia (B-ALL). It is for patients who are in their first remission but still have tiny, hard-to-detect amounts of cancer cells. The main goal is to find a safe d…

This study is testing whether removing a specific type of immune cell (called naive T cells) from a donor's stem cells before transplant can prevent chronic graft-versus-host disease in children and young adults with blood cancers. Chronic graft-versus-host disease is a serious c…

This early-stage study is testing whether combining two oral drugs, revumenib and mezigdomide, is safe and effective for people with specific types of acute leukemia that have returned or not responded to prior treatments. The trial will enroll about 52 participants aged 12 and o…

This study is testing a new oral drug called revumenib to see if it can safely help prevent certain aggressive types of leukemia from coming back after a patient has received a stem cell transplant. The trial will enroll about 27 patients, including children as young as 2, who ha…

This study is testing a modified, two-step stem cell transplant procedure designed to be safer. It aims to reduce deaths caused by the transplant treatment itself in patients with various blood cancers and disorders. The trial compares two gentler preparation methods using lower …

This early-stage study is testing a new cell therapy for adults with certain blood cancers who have received a bone marrow transplant from a partially matched family donor. Researchers take a special type of the patient's own immune cells, grow and activate them in a lab, and the…

This study is testing a new combination of three drugs (venetoclax, cladribine, and cytarabine) for adults with a specific type of acute lymphoblastic leukemia (ALL) that has returned or not responded to previous treatments. The goal is to see if this drug combo can effectively c…

This study is testing a new experimental drug that delivers radiation directly to cancer cells in patients with high-risk blood cancers like acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The goal is to find the safest and most effective dose of this targete…

This early-stage study is testing the safety and feasibility of using bone marrow from deceased donors for patients with various blood cancers like leukemia and lymphoma. The goal is to see if this type of transplant can help patients when a living donor isn't available. Research…

This study is testing a new method to help patients recover their immune systems faster after a stem cell transplant for leukemia. It involves giving patients a special, filtered portion of their donor's immune cells, aiming to reduce the risk of life-threatening viral and fungal…

This study aims to find out if a drug called Inotuzumab Ozogamicin works better than standard therapy for children with high-risk relapsed B-cell ALL. About 100 children aged 1 to 18 will receive one cycle of either treatment, then be followed for up to 5 years. The main goal is …

This early study is testing a two-part immune therapy for adults with high-risk acute lymphoblastic leukemia (ALL) who have just received a stem cell transplant from a matched relative. The goal is to see if giving specially engineered immune cells (CAR T-cells) followed by a vac…

This study is testing whether a personalized immune cell therapy called obecabtagene autoleucel (obe-cel) can help prevent relapse in adults with B-cell acute lymphoblastic leukemia who are currently in their first complete remission with no detectable cancer cells. The therapy i…

This study is testing a new support program called MedSupport, designed to help families of children with acute lymphoblastic leukemia (ALL) give their child's oral chemotherapy medication consistently at home. Researchers want to see if this program, which includes screening for…

This is the first time a new drug called ziftomenib is being tested in people. The study aims to find a safe and effective dose for adults with advanced acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) that has returned or not responded to other treatments. It w…

This study is testing a new oral medication called revumenib for people with acute leukemias that have come back or not responded to standard treatments. The first part of the study aims to find the safest and most effective dose. The second part will test how well the drug works…

This trial is testing a new combination of targeted drugs for children and young adults whose acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LBL) has come back or not responded to standard treatments. It aims to see if matching drugs to specific genetic changes in …

This study is testing the safety of a new type of stem cell transplant for children whose cancers have come back or are very hard to treat. Doctors use a half-matched family donor and a special process to remove certain immune cells from the transplant, aiming to reduce complicat…

This study tests a personalized immune cell therapy for patients with blood cancers like leukemia, lymphoma, and myeloma. After receiving chemotherapy and a cord blood transplant, patients get infusions of natural killer (NK) cells—immune cells that may kill remaining cancer cell…

This study is testing a new, experimental CAR-T cell therapy designed to fight two targets (CD19 and CD22) on cancer cells at once. It is for children and young adults (ages 3-39) whose B-cell leukemia or lymphoma has come back or hasn't responded to standard treatments. Doctors …

This study is testing a drug called ponatinib in children and teenagers (ages 1 to 18) whose cancers have come back or have not responded to standard treatments. The main goals are to find a safe dose and see if the drug can help control various advanced cancers, including leukem…

This early-phase study is testing the safety of an experimental cell therapy called LV009 injection. It is for adults whose CD19-positive blood cancers, like non-Hodgkin lymphoma or acute lymphoblastic leukemia, have returned or not responded to other treatments. The main goal is…

This study is testing whether a series of advanced blood and bone marrow tests can help doctors better monitor children and young adults with a type of leukemia (B-ALL) who have recently received CAR-T cell therapy. The goal is to see if these tests can identify who is at high ri…

This study is testing if giving a protective chemotherapy directly into the spinal fluid before and during a powerful leukemia drug (blinatumomab) can prevent brain-related side effects. The goal is to keep the drug's cancer-fighting power while shielding the nervous system. It i…

This study is for people with acute leukemia or myelodysplastic syndrome (MDS) who need a stem cell transplant from a donor. The main goal is to find the best way to reduce a serious complication called graft-versus-host disease (GVHD), where the donor's immune cells attack the p…

This early-stage study is testing whether collecting a patient's own blood-forming stem cells and giving them back alongside CAR-T therapy is safe and feasible for people with aggressive blood cancers that have come back or not responded to other treatments. The main goals are to…

This international study is testing a drug called blinatumomab for infants under one year old who have a specific, hard-to-treat type of leukemia. The goal is to see if adding this drug to standard chemotherapy can better control the cancer, prevent it from coming back, and impro…

This study is testing which of two drug regimens works better to prepare high-risk or relapsed acute leukemia patients for a stem cell transplant. Researchers will compare a new combination called TmBU against a standard modified Bu/Cy regimen. The main goal is to see which appro…

This early-stage trial is testing the safety and proper dosing of an experimental oral medication called MRX-2843. It is for adolescents and adults whose acute leukemia has come back or has not responded to previous treatments. The main goal is to find the highest dose that can b…

This study is testing a new smartphone app designed to help teenagers and young adults with leukemia remember to take their daily oral chemotherapy pills. For two months, 60 participants will use the app, which sends personalized reminder messages based on their daily mood and sc…

This study is testing a new combination of drugs for adults with a specific, aggressive type of leukemia (Philadelphia chromosome-positive ALL) that has come back or hasn't responded to other treatments. The treatment combines an immunotherapy drug that helps the immune system fi…

This study is testing whether adding new targeted drugs to standard chemotherapy works better than chemotherapy alone for adults newly diagnosed with a fast-growing blood cancer called acute T-lymphocytic leukemia. About 154 patients will be randomly assigned to receive either th…

This early-stage study is testing whether adding a new drug called calaspargase pegol to standard chemotherapy is safe for young adults newly diagnosed with acute lymphoblastic leukemia. Researchers will monitor 7 participants closely for side effects and early signs of how well …

This early-stage trial is testing a new cell therapy for children and adults whose leukemia has come back or persists after a donor stem cell transplant. Doctors take immune cells (T cells) from the original donor, genetically modify them to better recognize and attack the patien…

This study aims to collect blood and tissue samples to help develop a single blood test that can detect many different cancers early. Researchers will enroll 2,000 people, including those with cancer and those without, to create a reference set for testing. The goal is to validat…

This early-stage trial is testing a new vaccine designed to prevent serious cytomegalovirus (CMV) infections. The study involves patients with blood cancers who are receiving a stem cell transplant from a partially matched donor, a procedure that carries a high risk of CMV. Resea…

This study is testing a new vaccine approach to prevent a common and serious viral infection called CMV in patients receiving a stem cell transplant for blood cancers. Researchers are giving the vaccine to the healthy stem cell donors, hoping the donor's boosted immunity will be …

This study is testing a 6-month virtual diet education program called PEDALL. It aims to prevent unhealthy weight gain in children and teens (ages 5-21) who are receiving maintenance chemotherapy for acute lymphoblastic leukemia (ALL). Participants will be randomly assigned to re…

This study is testing whether online brain training and mindfulness exercises can help children and teenagers recover their thinking skills and emotional well-being after intensive leukemia treatments like CAR-T therapy or chemotherapy. Researchers will compare children who recei…

This is a small, early-stage study to see if a special exercise program can help children with acute lymphoblastic leukemia (ALL) who are showing early signs of muscle weakness and frailty from their treatment. Researchers will enroll 60 children aged 5-17 and randomly assign tho…

This study is testing if a simple mandala coloring activity can help reduce anxiety and fear in children with leukemia before they receive a specific type of spinal chemotherapy. Researchers will work with 60 children aged 4 to 12. They will compare anxiety and fear levels betwee…

This study is testing a new laboratory method to detect very small numbers of leftover leukemia cells in the blood and bone marrow of children. The goal is to better predict which children are at high risk of their cancer coming back after initial treatment. If successful, this c…

This study aims to understand how young adult survivors of childhood leukemia feel about exercise. Researchers will test 125 inactive survivors using computer tasks and questionnaires before and after physical activity. The goal is to learn about emotional barriers to exercise an…

This study aims to understand why some patients with acute lymphoblastic leukemia (ALL) develop serious liver damage from a key chemotherapy drug called asparaginase. Researchers will collect saliva samples from up to 500 patients to look for specific genetic markers. The goal is…

This study aims to understand how a steroid drug called dexamethasone moves through the body and brain in children being treated for leukemia. Researchers will measure drug levels in the blood and spinal fluid and see if they are linked to side effects like bone weakening or nerv…

This study aims to understand why young survivors of leukemia, chronic lung disease from prematurity, and heart transplants often struggle with exercise. Researchers will measure heart and lung function during bike workouts in 90 participants aged 8-25. The goal is to gather data…

This early-stage study aims to understand how the body absorbs, breaks down, and eliminates the experimental drug bleximenib in people with acute leukemia. Researchers will give a small, traceable radioactive version of the drug to 10 participants with specific types of advanced …

This study aims to understand why children with cancer in low- and middle-income countries often have worse outcomes than those in wealthier nations. Researchers will look back at the medical records of up to 18,000 young patients (ages 0-21) to measure how often treatment fails …

This study aims to learn how radiation and chemotherapy affect the bone marrow of people with acute leukemia. Researchers will use special scans and collect blood and bone marrow samples from about 74 adult participants at different times during their treatment. The goal is to ga…

This study aims to understand if CAR-T cell therapy, a powerful new cancer treatment, might affect heart function in the first few days after patients receive it. Researchers will follow 60 patients with blood cancers, performing heart ultrasounds before and shortly after their C…

This study aims to collect the detailed information doctors need to choose the most appropriate treatment plan for children newly diagnosed with certain types of acute leukemia. Children aged 1-18 will receive 7 days of initial chemotherapy while their cancer cells are tested. Th…

This study is a large registry that collects information on how adult patients with acute lymphoblastic leukemia (ALL) and related blood cancers are diagnosed and treated in real-world clinics. It aims to track patient outcomes, survival, and quality of life over time to help res…