New cocktail of drugs hopes to beat childhood leukemia that Won't quit
NCT ID NCT05751044
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This trial tests a combination of dasatinib, venetoclax, and chemotherapy in children and young adults with relapsed or refractory acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LBL). The study has two phases: first to find the safest dose, then to see how well it shrinks tumors or clears leukemia cells from the bone marrow. Only 26 participants will be enrolled, and all have tumors with specific genetic changes in the MAPK/SRC pathway.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
dasatinib, venetoclax, dexamethasone, cyclophosphamide, cytarabine
What this could lead to
If successful, this could offer a new treatment option for children with hard-to-treat blood cancers that have returned or not responded to standard therapy.
What could go wrong
This is an early-phase trial with only 26 participants, so results may not apply broadly. The drug combination can cause serious side effects, and it is not yet known if it will improve survival.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Bristol Royal Hospital for Children
NOT_YET_RECRUITINGBristol, B52 8BJ, United Kingdom
Contact Email: •••••@•••••
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CHRU Lille - Hôpital Jeanne de Flandre
NOT_YET_RECRUITINGLille, 59037, France
Contact Email: •••••@•••••
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CHU Nantes Hôpital Mère-Enfant
NOT_YET_RECRUITINGNantes, 44093, France
Contact Email: •••••@•••••
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Centre Léon Bérard
NOT_YET_RECRUITINGLyon, 69 373, France
Contact Email: •••••@•••••
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Charité Universitätsmedizin Berlin
NOT_YET_RECRUITINGBerlin, 13353, Germany
Contact Email: •••••@•••••
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Fondazione MBBM c/o Centro ML Verga
NOT_YET_RECRUITINGMonza, 20900, Italy
Contact Email: •••••@•••••
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Great North Children's Hospital
NOT_YET_RECRUITINGNewcastle, NE1 4LP, United Kingdom
Contact Email: •••••@•••••
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Great Ormond Street Hospital for Children NHS Trust
NOT_YET_RECRUITINGLondon, WC1N 2BH, United Kingdom
Contact Email: •••••@•••••
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Helsinki University Hospital, New Children's Hospital
NOT_YET_RECRUITINGHelsinki, FI00029, Finland
Contact Email: •••••@•••••
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Hopital La Timone - Enfants
NOT_YET_RECRUITINGMarseille, 13005, France
Contact Email: •••••@•••••
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Hospital Infantil Universitario Niño Jesús
NOT_YET_RECRUITINGMadrid, 28009, Spain
Contact Email: •••••@•••••
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Hospital Sant Joan de Déu de Barcelona
NOT_YET_RECRUITINGBarcelona, 08950, Spain
Contact Email: •••••@•••••
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Hôpital Robert Debré
NOT_YET_RECRUITINGParis, 75019, France
Contact Email: •••••@•••••
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Hôpital des Enfants GH Pellegrin - CHU de Bordeaux
NOT_YET_RECRUITINGBordeaux, 33076, France
Contact Email: •••••@•••••
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IRCCS Istituto Giannina Gaslini
NOT_YET_RECRUITINGGenova, 16147, Italy
Contact Email: •••••@•••••
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Karolinska university hospital
RECRUITINGStockholm, 171 76, Sweden
Contact Email: •••••@•••••
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La Fe
NOT_YET_RECRUITINGValencia, 46026, Spain
Contact Email: •••••@•••••
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Oslo University Hospital
NOT_YET_RECRUITINGOslo, 0373, Norway
Contact Email: •••••@•••••
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Ospedale Infantile Regina Margherita
NOT_YET_RECRUITINGTurin, 10126, Italy
Contact Email: •••••@•••••
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Ospedale Pediatrico Bambino Gesù, IRCCS
NOT_YET_RECRUITINGRoma, 0165, Italy
Contact Email: •••••@•••••
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Our Lady's Hospital for Sick Children
NOT_YET_RECRUITINGDublin, D12N512, Ireland
Contact Email: •••••@•••••
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Padova Azienda Ospedaliera
NOT_YET_RECRUITINGPadova, 35128, Italy
Contact Email: •••••@•••••
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Princess Máxima Center for Pediatric Oncology
NOT_YET_RECRUITINGUtrecht, Utrecht, 3584CS, Netherlands
Contact Email: •••••@•••••
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Rigshospitalet Copenhagen
RECRUITINGCopenhagen, DK-2100, Denmark
Contact Email: •••••@•••••
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Royal Marsden NHS Trust
NOT_YET_RECRUITINGSutton, SM2 5PT, United Kingdom
Contact Email: •••••@•••••
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Schneider's Children's Medical Center
NOT_YET_RECRUITINGPetah Tikva, 4920235, Israel
Contact Email: •••••@•••••
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Sheba Medical Center Hospital
NOT_YET_RECRUITINGRamat Gan, 52621, Israel
Contact Email: •••••@•••••
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St. Anna Kinderspital
NOT_YET_RECRUITINGVienna, 1090, Austria
Contact Email: •••••@•••••
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Universitair Ziekenhuis Gent
NOT_YET_RECRUITINGGhent, 9000, Belgium
Contact Email: •••••@•••••
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Universitätsklinikum Augsburg
NOT_YET_RECRUITINGAugsburg, 86156, Germany
Contact Email: •••••@•••••
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Universitätsklinikum Essen
NOT_YET_RECRUITINGEssen, 45147, Germany
Contact Email: •••••@•••••
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Universitätsklinikum Frankfurt
NOT_YET_RECRUITINGFrankfurt, 60590, Germany
Contact Email: •••••@•••••
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Universitätsklinikum Münster
NOT_YET_RECRUITINGMünster, 48149, Germany
Contact Email: •••••@•••••