New model aims to Fine-Tune leukemia drug dosing, reduce side effects
NCT ID NCT07499349
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study aims to create a computer model that predicts how the drug Erwinase behaves in the body of children and young adults with acute lymphoblastic leukemia (ALL). By analyzing data from about 475 patients, researchers hope to find the best doses to kill cancer cells while avoiding harmful side effects like high ammonia levels. The model will help doctors personalize treatment, but it is an early research step and not a new therapy itself.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Erwinase (asparaginase enzyme)
- What this could lead to
- If successful, this could lead to more precise dosing of Erwinase, improving treatment outcomes and reducing side effects like hyperammonemia in children and young adults with ALL.
- What could go wrong
- This is an observational modeling study, not a treatment trial. The model may not fully capture individual patient variability, and its benefits depend on future validation and implementation in clinical practice.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Aarhus University Hospital
RECRUITINGAarhus, Denmark
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