Massive new study aims to outsmart childhood leukemia

NCT ID NCT04307576

Recruiting now Disease control Sponsor: Mats Heyman Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This study is testing a new, comprehensive treatment plan for children and young adults (ages 0-45) newly diagnosed with acute lymphoblastic leukemia (ALL). It combines the best approaches from previous successful treatments to improve survival and reduce side effects. The study will enroll over 6,400 participants across many hospitals. The goal is to see if this new plan works better than current standard treatments.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia leukemia lymphoblastic leukemia, acute, with lymphomatous features Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEUKEMIA, ACUTE LYMPHOBLASTIC

Contacts and locations

Locations

Aalborg University Hospital, Dept of Paediatrics
RECRUITING

Aalborg, 9000, Denmark
Aarhus University Hospital
RECRUITING

Aarhus, 8000, Denmark
Aarhus University Hospital, Child and Adolescent Health
RECRUITING

Aarhus, 8200, Denmark
Aberdeen Royal Infirmary, Aberdeen
NOT_YET_RECRUITING

Aberdeen, AB25 2ZN, United Kingdom
Addenbrooke's Hospital, Cambridge
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Alder Hey Children's Hospital, Liverpool
RECRUITING

Liverpool, L12 2AP, United Kingdom
Beatson West of Scotland Cancer Centre, Glasgow
NOT_YET_RECRUITING

Glasgow, G12 0YN, United Kingdom
Belfast City Hospital, Belfast
NOT_YET_RECRUITING

Belfast, BT9 7AB, United Kingdom
Birmingham Children's Hospital, Birmingham
RECRUITING

Birmingham, B4 6NH, United Kingdom
Bristol Royal Hospital for Children / Bristol Haematology and Oncology Centre
RECRUITING

Bristol, BS2 8BJ, United Kingdom
CHC MontLégia, Boulevard Patience et Beaujonc 2
RECRUITING

Liège, 4000, Belgium
CHR de la Citadelle
RECRUITING

Liège, 4000, Belgium
CHRU Besançon
RECRUITING

Besançon, 25030, France
CHRU Brest - Morvan
RECRUITING

Brest, 29609, France
CHRU Tours- Hôpital Clocheville
RECRUITING

Tours, 37000, France
CHRU de Lille - Hôpital Jeanne de Flandre
RECRUITING

Lille, 59037, France
CHU Amiens Groupe Hospitalier Sud
RECRUITING

Amiens, 80054, France
CHU Angers
RECRUITING

Angers, 49033, France
CHU Bordeaux - Groupe Hospitalier Pellegrin
RECRUITING

Bordeaux, 33076, France
CHU Clermont-Ferrand
RECRUITING

Clermont-Ferrand, 63000, France
CHU De La Réunion - Site Nord (Hôpital Félix GUYON)
RECRUITING

Saint-Denis, 97400, France
CHU Dijon Hôpital François Mitterrand
RECRUITING

Dijon, 21000, France
CHU Nantes-Hôpital enfant-adolescent
RECRUITING

Nantes, 44093, France
CHU Nice - Hôpital l'Archet 2
RECRUITING

Nice, 6200, France
CHU Paris - Hôpital Robert Debré
RECRUITING

Paris, 75019, France
CHU Paris Armand Trousseau
RECRUITING

Paris, 75012, France
CHU Paris Saint Louis
RECRUITING

Paris, 75010, France
CHU Poitiers
RECRUITING

Poitiers, 86021, France
CHU Reims-American Hospital
RECRUITING

Reims, 51100, France
CHU Rennes - Hôpital sud
RECRUITING

Rennes, 35203, France
CHU Rouen
RECRUITING

Rouen, 76031, France
CHU Saint Etienne Hôpital Nord
RECRUITING

Saint-Etienne, 42055, France
CHU Strasbourg -Hôpital de Hautepierre
RECRUITING

Strasbourg, 67098, France
CHU Toulouse
RECRUITING

Toulouse, 31059, France
CHU de Grenoble site Nord - Hôpital Albert Michallon
RECRUITING

Grenoble, 38043, France
CHU de Lyon HCL - GH Est-Institut d'hématologie et d'oncologie pédiatrique IHOP
RECRUITING

Lyon, 69373, France
CHU de Marseille - Hôpital de la Timone
RECRUITING

Marseille, 13385, France
CHU de Montpellier - Hôpital Arnaud de Villeneuve
RECRUITING

Montpellier, 34295, France
CHU de Nancy - Hôpital de Brabois Enfant
RECRUITING

Vandœuvre-lès-Nancy, 54511, France
Centre Hospitalier Universitaire Caen
RECRUITING

Caen, 14033, France
Centro Hospitalar e Universitário de Coimbra, EPE - Hospital Pediátrico de Coimbra
NOT_YET_RECRUITING

Coimbra, 3000-602, Portugal
Children's Hospital, Affiliate of Vilnius University Hospital Santaros Klinikos
RECRUITING

Vilnius, 08661, Lithuania
Churchill Hospital, Oxford
NOT_YET_RECRUITING

Oxford, OX3 7LE, United Kingdom
Cliniques Universitaires Saint-Luc (UCL)
RECRUITING

Brussels, 1200, Belgium
Derriford Hospital
RECRUITING

Plymouth, United Kingdom
Evangelisches Klinikum Bethel
RECRUITING

Bielefeld, 33617, Germany
Freeman Hospital, Newcastle
NOT_YET_RECRUITING

Newcastle, NE7 7DN, United Kingdom
Great Ormond Street Hospital for Children, London
RECRUITING

London, WC1N 3JH, United Kingdom
HELIOS Klinikum Krefeld
RECRUITING

Krefeld, 47805, Germany
Haukeland University Hospital, Dept of Haematology
RECRUITING

Bergen, 5021, Norway
Haukeland University Hospital, Dept of Paediatrics
RECRUITING

Bergen, 5021, Norway
Helsinki University Hospital, Dept of Haematology
RECRUITING

Helsinki, 00029, Finland
Helsinki University Hospital, Dept of Paediatrics
RECRUITING

Helsinki, 00029, Finland
Hospital Infantil Universitario Nino Jesus
NOT_YET_RECRUITING

Madrid, Spain
Hospital Sant Joan De Deu Barcelona
RECRUITING

Esplugues de Llobregat, Spain
Hospital Universitari Vall D Hebron
RECRUITING

Barcelona, Spain
Hospital Universitario De Cruces
NOT_YET_RECRUITING

Barakaldo, Spain
Hospital Universitario La Paz
NOT_YET_RECRUITING

Madrid, Spain
Hospital Universitario Miguel Servet
NOT_YET_RECRUITING

Zaragoza, Spain
Hospital Universitario Y Politecnico La Fe
NOT_YET_RECRUITING

Valencia, Spain
Hôpital de la mère et de l'enfant
RECRUITING

Limoges, 87042, France
Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE
RECRUITING

Lisbon, 1099-023, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil, EPE
RECRUITING

Porto, 4200-072, Portugal
John Radcliffe Hospital, Oxford
RECRUITING

Oxford, OX3 9DU, United Kingdom
Karolinska University Hospital, Dept of Paediatric Oncology and Haematology
RECRUITING

Stockholm, 17176, Sweden
Karolinska University Hospital, Patient area Haematology
RECRUITING

Stockholm, 17176, Sweden
King's College Hospital
RECRUITING

London, United Kingdom
Klinikum Bremen Mitte
RECRUITING

Bremen, 28177, Germany
Kuopio University Hospital, Dept of Haematology
RECRUITING

Kuopio, 70029, Finland
Kuopio University Hospital, Dept of Paediatrics
RECRUITING

Kuopio, 70029, Finland
L'hôpital Universitaire des enfants Reine Fabiola (Huderf)
RECRUITING

Brussels, 1020, Belgium
Landspitali University Hospital, Children's Hospital
RECRUITING

Reykjavik, 101, Iceland
Leeds General Infirmary, Leeds
RECRUITING

Leeds, LS1 3EX, United Kingdom
Leeds St James University Hospital
RECRUITING

Leeds, LS9 7TF, United Kingdom
Leicester Royal Infirmary, Leicester
RECRUITING

Leicester, LE1 5WW, United Kingdom
Linköping University Hospital, Dept of Haematology
RECRUITING

Linköping, 58185, Sweden
Linköping University Hospital, Dept of Paediatrics
RECRUITING

Linköping, 58185, Sweden
Noah's Ark Children's Hospital for Wales, Cardiff
NOT_YET_RECRUITING

Cardiff, CF14 4XW, United Kingdom
Norrland University Hospital, Dept of Haematology
RECRUITING

Umeå, 90185, Sweden
Norrland University Hospital, Dept of Paediatrics
RECRUITING

Umeå, 90185, Sweden
North Estonia Medical Centre, Dept of Haematology
RECRUITING

Tallinn, 13419, Estonia
Nottingham City Hospital
NOT_YET_RECRUITING

Nottingham, NG5 1PB, United Kingdom
Nottingham Queen's Medical Centre
RECRUITING

Nottingham, NG7 2UH, United Kingdom
Odense University Hospital, Dept of Paediatrics
RECRUITING

Odense, 5000, Denmark
Oslo University Hospital, Dept of Haematology
RECRUITING

Oslo, 0372, Norway
Oslo University Hospital, Dept of paediatric haemato- and oncology
RECRUITING

Oslo, 0424, Norway
Oulu University Hospital, Dept of Haematology, Dept of Medicine
RECRUITING

Oulu, 90029, Finland
Oulu University Hospital, Dept of Paediatrics
RECRUITING

Oulu, 90029, Finland
Our Lady's Children's Hospital
RECRUITING

Dublin, Ireland
Princess Máxima Center for Pediatric Oncology
RECRUITING

Utrecht, 3584, Netherlands
Rigshospitalet, Dept of Haematology
RECRUITING

Copenhagen, 2100, Denmark
Rigshospitalet, Dept of Paediatrics
RECRUITING

Copenhagen, 2100, Denmark
Royal Aberdeen Children's Hospital, Aberdeen
RECRUITING

Aberdeen, United Kingdom
Royal Belfast Hospital for Sick Children, Belfast
RECRUITING

Belfast, BT12 6BA, United Kingdom
Royal Hallamshire Hospital, Sheffield
RECRUITING

Sheffield, S10 2JF, United Kingdom
Royal Hospital for Children and Young People, Edinburgh
RECRUITING

Edinburgh, EH9 1LF, United Kingdom
Royal Hospital for Children, Glasgow
RECRUITING

Glasgow, G51 4TF, United Kingdom
Royal Manchester Children's Hospital, Manchester
RECRUITING

Manchester, M13 9WL, United Kingdom
Royal Marsden Hospital, Sutton
RECRUITING

Sutton, SM2 5PT, United Kingdom
Royal Stoke University Hospital, Stoke
NOT_YET_RECRUITING

Stoke, ST4 6QG, United Kingdom
Royal Victoria Infirmary, Newcastle
RECRUITING

Newcastle upon Tyne, NE1 4LP, United Kingdom
Sahlgrenska University Hospital, Dept of Paediatric Haematology and Oncology
RECRUITING

Gothenburg, 41685, Sweden
Sahlgrenska University Hospital, Section for Haematology and coagulation
RECRUITING

Gothenburg, 41345, Sweden
Sheffield Children's Hospital, Sheffield
RECRUITING

Sheffield, S10 2TH, United Kingdom
Skåne University Hospital, Dept of Haematology
RECRUITING

Lund, 22185, Sweden
Skåne University Hospital, Dept of Paediatrics
RECRUITING

Lund, 22185, Sweden
Southampton General Hospital, Southampton
RECRUITING

Southampton, SO16 6YD, United Kingdom
St. Bartholomews Hospital
RECRUITING

London, United Kingdom
St. Olavs University Hospital, Dept of Haematology
RECRUITING

Trondheim, 7030, Norway
St. Olavs University Hospital, Dept of Paediatrics
RECRUITING

Trondheim, 7006, Norway
Stavanger University Hospital, Dept of Haematology
RECRUITING

Stavanger, 4011, Norway
Tallinn Children´s Hospital, Dept of Paediatrics
RECRUITING

Tallinn, 13419, Estonia
Tampere University Hospital, Dept of Haematology
RECRUITING

Tampere, 33521, Finland
Tampere University Hospital, Dept of Paediatrics
RECRUITING

Tampere, 33521, Finland
Tartu University Hospital
RECRUITING

Tartu, 50406, Estonia
The Christie NHS Foundation Trust (PTC)
RECRUITING

Manchester, M20 4BX, United Kingdom
The Clatterbridge Cancer Centre NHS Foundation Trust
RECRUITING

Liverpool, United Kingdom
The Queen Elizabeth Hospital, Birmingham
RECRUITING

Birmingham, B15 2TH, United Kingdom
Turku University Hospital, Clinical Haematology and Stem Cell Transplantation Unit
RECRUITING

Turku, 20520, Finland
Turku University Hospital, Dept of Paediatrics
RECRUITING

Turku, 20520, Finland
University College London Hospital, London
RECRUITING

London, NW1 2BU, United Kingdom
University Hospital Antwerp
RECRUITING

Edegem, 2650, Belgium
University Hospital Ghent
RECRUITING

Ghent, 9000, Belgium
University Hospital Leuven, Dept of Paediatrics
RECRUITING

Leuven, 3000, Belgium
University Hospital North Norway, Dept of Haematology
RECRUITING

Tromsø, 9019, Norway
University Hospital Son Espases
NOT_YET_RECRUITING

Palma de Mallorca, Spain
University Hospital Virgen Del Rocio S.L.
NOT_YET_RECRUITING

Seville, Spain
University Hospital of North Norway, Dept of Paediatrics
RECRUITING

Tromsø, 9038, Norway
University Hospital of Wales, Cardiff
NOT_YET_RECRUITING

Cardiff, United Kingdom
University Medical Center Utrecht
RECRUITING

Utrecht, Netherlands
Universitätsklinikum Bonn
RECRUITING

Bonn, 53113, Germany
Universitätsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, 20246, Germany
Universitätsmedizin Mainz
RECRUITING

Mainz, 55131, Germany
Uppsala University Hospital, Dept of Haematology
RECRUITING

Uppsala, 75185, Sweden
Uppsala University Hospital, Dept of Paediatric Haematology and Oncology
RECRUITING

Uppsala, 75185, Sweden
Western General Hospital, Edinburgh
RECRUITING

Edinburgh, EH2 2XU, United Kingdom
Örebro University Hospital, Section for Haematology
RECRUITING

Örebro, 70185, Sweden

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