Can a simple timing change make leukemia therapy safer?
NCT ID NCT05519579
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving a chemotherapy drug (methotrexate) into the spinal fluid before and during blinatumomab treatment can prevent nerve-related side effects in adults with acute lymphoblastic leukemia. The trial enrolls 20 people receiving their first cycle of blinatumomab. Researchers will track how many participants experience neurotoxicity and whether the leukemia responds to treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
methotrexate and blinatumomab
What this could lead to
If it works, this could make a key leukemia treatment safer by reducing nerve-related side effects.
What could go wrong
This is a small, early-phase trial with only 20 participants, so results may not apply broadly. The approach may not reduce neurotoxicity as hoped.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Northside Hospital
RECRUITINGAtlanta, Georgia, 30342, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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