New hope for babies with aggressive leukemia: international trial launches

NCT ID NCT05327894

Recruiting now Disease control Sponsor: Princess Maxima Center for Pediatric Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tests a drug called blinatumomab in infants under 1 year old who have a specific, hard-to-treat type of leukemia (KMT2A-rearranged). The goal is to improve how long these babies stay cancer-free and to help them live longer. About 160 infants from around the world will take part, and the treatment is given alongside standard chemotherapy.

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Conditions

The condition(s) this trial relates to.

acute biphenotypic leukemia acute lymphoblastic leukemia B-lymphoblastic leukemia/lymphoma with t(v;11q23.3) mixed phenotype acute leukemia mixed phenotype acute leukemia with t(v;11q23.3) Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LYMPHOBLASTIC LEUKEMIA MIXED PHENOTYPE ACUTE LEUKEMIA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Email: •••••@•••••

Locations

AUH Skejby
RECRUITING

Aarhus, Denmark
Aghia Sophia' Children's Hospital
ACTIVE_NOT_RECRUITING

Athens, Greece
Antwerp University Hospital
RECRUITING

Antwerp, Belgium
Australian and New Zealand Children's Haematology/Oncology Group
RECRUITING

Clayton, Victoria, Australia
Azienda Ospedaliera Universitaria Citta' Della Salute E Della Scienza Di Torino
RECRUITING

Torino, Italy
Azienda Ospedaliera Universitaria Meyer IRCCS
RECRUITING

Florence, Italy
CHC MontLegia
RECRUITING

Liège, Belgium
CHI Montpellier
ACTIVE_NOT_RECRUITING

Montpellier, France
CHRU Strasbourg Hautepierre
RECRUITING

Strasbourg, France
CHRU de Lille
ACTIVE_NOT_RECRUITING

Lille, France
CHU Amiens
RECRUITING

Amiens, France
CHU Besancon
ACTIVE_NOT_RECRUITING

Besançon, France
CHU Charles Nicolle
RECRUITING

Rouen, France
CHU Nancy
RECRUITING

Nancy, France
CHU Nantes
RECRUITING

Nantes, France
CHU Reims
RECRUITING

Reims, France
CHU Rennes
RECRUITING

Rennes, France
CHU Timone
ACTIVE_NOT_RECRUITING

Marseille, France
CHU de Bordeaux
RECRUITING

Bordeaux, France
CHU de Nice
ACTIVE_NOT_RECRUITING

Nice, France
Centre Hospitalier Regional De La Citadelle
ACTIVE_NOT_RECRUITING

Liège, Belgium
Centre Hospitalier Universitaire de Toulouse
RECRUITING

Toulouse, France
Charite Universitaetsmedizin Berlin KöR
RECRUITING

Berlin, Germany
Chiba University Hospital
RECRUITING

Chiba, Japan
Children's UH
RECRUITING

Uppsala, Sweden
Childrens Cancer Center Queen Silvia Children´s Hospital, Sahlgrenska University Hospital
RECRUITING

Gothenburg, Sweden
Christchurch Children's Hospital
RECRUITING

Christchurch, New Zealand
Cliniques Universitaires Saint-Luc
ACTIVE_NOT_RECRUITING

Brussels, Belgium
Copenhagen-Rigshospitalet
RECRUITING

Copenhagen, Denmark
Ehime University Hospital
RECRUITING

Ehime, Japan
Gemeinnutzige Salzburger Landes kliniken Betriebsgesellschaft mbH
RECRUITING

Salzburg, Austria
HCE
ACTIVE_NOT_RECRUITING

Grenoble, France
HELIOS Klinikum Krefeld GmbH
ACTIVE_NOT_RECRUITING

Krefeld, Germany
Haukeland University Hospital
ACTIVE_NOT_RECRUITING

Bergen, Norway
HeSPHO
ACTIVE_NOT_RECRUITING

Athens, Greece
Hiroshima University Hospital
RECRUITING

Hiroshima, Japan
Hokkaido University Hospital
ACTIVE_NOT_RECRUITING

Hokkaido, Japan
Hospital Infantil Universitario Nino Jesus
RECRUITING

Madrid, Spain
Hospital Motol V Uvalu 841
RECRUITING

Prague, Czechia
Hospital Universitario Y Politecnico La Fe
RECRUITING

Valencia, Spain
Hospital de Pediatría S.A.M.I.C. "Juan P. Garrahan"
SUSPENDED

Buenos Aires, Argentina
Hyogo Prefectural Kobe Childrens Hospital
ACTIVE_NOT_RECRUITING

Hyōgo, Japan
Hôpital Robert Debré, APHP
RECRUITING

Paris, France
Hôpital Universitaire des Enfants Reine Fabiola
RECRUITING

Brussels, Belgium
IRCCS Ospedale Pediatrico Bambino Gesù
RECRUITING

Roma, Italy
Institute of Hematology and Pediatric Oncology
RECRUITING

Lyon, France
Instituto Portugues de Oncologica Lisboa
RECRUITING

Lisbon, Portugal
Istituto Di Ricovero E Cura A Carattere Scientifico Materno Infantile Burlo Garofolo
RECRUITING

Trieste, Italy
Jeddah-King Abdulaziz Medical City
ACTIVE_NOT_RECRUITING

Jeddah, Saudi Arabia
Johannes Gutenberg University Mainz
RECRUITING

Mainz, Germany
Justus-Liebig-Universitaet Giessen
RECRUITING

Giessen, Germany
Kagoshima University Hospital
RECRUITING

Kagoshima, Japan
Kanagawa Childrens Medical Center
RECRUITING

Kanagawa, Japan
Karolinska University Hospital
ACTIVE_NOT_RECRUITING

Stockholm, Sweden
King Abdulaziz Medical City, King Abdullah International Medical Research Center
ACTIVE_NOT_RECRUITING

Riyadh, Saudi Arabia
Klinikum Der Landeshauptstadt Stuttgart gKAöR
RECRUITING

Stuttgart, Germany
Klinikum Dortmund gGmbH
RECRUITING

Dortmund, Germany
Klinikum rechts der Isar der TU Muenchen AöR
RECRUITING

München, Germany
Kuopio University Hospital
RECRUITING

Kuopio, Finland
Kyoto Prefectural University of Medicine
RECRUITING

Kyoto, Japan
Kyoto University Hospital
RECRUITING

Kyoto, Japan
L'Azienda Ospedaliera Di Rilievo Nazionale Santobono-Pausilipon
RECRUITING

Naples, Italy
Linkoping University Hospital
RECRUITING

Linköping, Sweden
Medical University Of Graz
RECRUITING

Graz, Austria
Medical University Of Innsbruck
RECRUITING

Innsbruck, Austria
Medizinische Hochschule Hannover
RECRUITING

Hanover, Germany
Mie University Hospital
ACTIVE_NOT_RECRUITING

Mie, Japan
Mitera
ACTIVE_NOT_RECRUITING

Marousi, Greece
Monash Children's Hosptial
ACTIVE_NOT_RECRUITING

Clayton, Australia
Nagoya University Graduate School of Medicine
RECRUITING

Nagoya, Japan
National Center for Child Health and Development
RECRUITING

Tokyo, Japan
National Children's Cancer Service
RECRUITING

Dublin, Ireland
National Institute of Children's Diseases
ACTIVE_NOT_RECRUITING

Bratislava, Slovakia
New Children's Hospital
RECRUITING

Helsinki, Finland
New Lambton Heights- John Hunter Children's Hospital
RECRUITING

New Lambton Heights, Australia
Nippon Medical School Hospital
RECRUITING

Tokyo, Japan
North Adelaide- Womens and Childrens Hospital
RECRUITING

Adelaide, Australia
Odense University Hospital
RECRUITING

Odense, Denmark
Osaka City General Hospital
RECRUITING

Osaka, Japan
Osaka University Graduate School of Medicine 2-2
RECRUITING

Osaka, Japan
Oulu University Hospital
ACTIVE_NOT_RECRUITING

Oulu, Finland
Perth Children's Hospital
RECRUITING

Perth, Australia
Princess Máxima Center for pediatric oncology
RECRUITING

Utrecht, Utrecht, 3584 CS, Netherlands

Contact Email: •••••@•••••
Queensland Children's Hospital
ACTIVE_NOT_RECRUITING

South Brisbane, Australia
Royal Children's Hospital (Children's Cancer Centre)
ACTIVE_NOT_RECRUITING

Parkville, Australia
Saitama Prefectural Childrens Medical Center
RECRUITING

Saitama, Japan
Schneider Childrens Medical Center
RECRUITING

Petah Tikva, Israel
Shizuoka Childrens Hospital
RECRUITING

Shizuoka, Japan
Skane University Hospital
ACTIVE_NOT_RECRUITING

Lund, Sweden
St. Anna Children's Hospital
RECRUITING

Vienna, Austria
St. Olavs Hospital
RECRUITING

Trondheim, Norway
Starship Children's Hospital
RECRUITING

Auckland, New Zealand
Sydney Childrens Hospital
RECRUITING

Sydney, Australia
TRS
RECRUITING

Paris, France
Tampere University Hospital
RECRUITING

Tampere, Finland
The Childrens Hospital at Westmead
RECRUITING

Westmead, Australia
The University of Tokyo Hospital
RECRUITING

Tokyo, Japan
Tohoku University Hospital
ACTIVE_NOT_RECRUITING

Tōhoku, Japan
Tokyo Metropolitan Childre's Medical Center
ACTIVE_NOT_RECRUITING

Tokyo, Japan
Turku University Hospital
RECRUITING

Turku, Finland
UZ Leuven
RECRUITING

Leuven, Belgium
Umea University Hospital
RECRUITING

Umeå, Sweden
Universitaetsklinikum Bonn AöR
RECRUITING

Bonn, Germany
Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR
RECRUITING

Dresden, Germany
Universitaetsklinikum Erlangen AöR
RECRUITING

Erlangen, Germany
Universitaetsklinikum Halle (Saale) AöR
RECRUITING

Halle, Germany
Universitaetsklinikum Muenster AöR
ACTIVE_NOT_RECRUITING

Münster, Germany
Universitaetsklinikum Schleswig-Holstein AöR
RECRUITING

Kiel, Germany
Universitaetsklinikum Tuebingen AöR
RECRUITING

Tübingen, Germany
Universitair Ziekenhuis Gent
RECRUITING

Ghent, Belgium
University General Hospital Of Heraklion
RECRUITING

Heraklion, Greece
University Hospital Brno
RECRUITING

Brno, Czechia
University Hospital Olomouc
ACTIVE_NOT_RECRUITING

Olomouc, Czechia
University Hospital Virgen Del Rocio S.L.
RECRUITING

Seville, Spain
University Medical Center Hamburg-Eppendorf
RECRUITING

Hamburg, Germany
University Of Verona Medical School
RECRUITING

Verona, Italy
University Semmelweis
RECRUITING

Budapest, Hungary
University of Pécs
RECRUITING

Pécs, Hungary
Universitätsklinikum Augsburg
RECRUITING

Augsburg, Germany
Universitätsklinikum Heidelberg AöR
RECRUITING

Heidelberg, Germany
Universitätsklinikum Ulm
RECRUITING

Ulm, Germany
Universtitätsklinikum Eppendorf
ACTIVE_NOT_RECRUITING

Hamburg, Germany
Vall D'hebron Institut De Recerca
RECRUITING

Barcelona, Spain
Vilnius University Hospital Santaros Klinikos
ACTIVE_NOT_RECRUITING

Vilnius, Lithuania

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