ACUTE LYMPHOBLASTIC LEUKEMIA

This study aims to cure children with acute lymphoblastic leukemia and lymphoma by personalizing their treatment. Doctors use genetic tests on each child's cancer to choose targeted drugs or advanced immunotherapies. The goal is to improve survival rates and quality of life by ma…

This study is testing a new, longer-lasting version of a standard chemotherapy drug (asparaginase) for children and teens with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma. Researchers want to see if giving this new drug, called SC-PEG, every 3 weeks into a vein w…

This study is testing whether adding a targeted drug called inotuzumab ozogamicin to standard treatment can help adults with a specific, newly diagnosed type of acute lymphoblastic leukemia (Ph+ ALL) achieve a deep remission faster. The goal is to see if this approach leads to be…

This trial is testing a stem cell transplant method for people with blood cancers who don't have a perfectly matched donor. It uses stem cells from a partially matched, unrelated donor along with specific medications to prevent complications. The main goal is to see if this appro…

This study tested a multi-part treatment for adults with a specific, aggressive type of acute lymphoblastic leukemia (ALL). The goal was to see if combining intensive chemotherapy, a targeted drug called dasatinib, and for some patients, a stem cell transplant from a donor, could…

This study tests a personalized treatment called CAR-T cell therapy for children and young adults whose B-cell blood cancers have returned or resisted standard treatments. Doctors collect a patient's own immune cells, modify them in a lab to better target cancer cells, and then i…

This study is testing a multi-step treatment plan for adults with a specific, aggressive form of leukemia (ALL) that has come back or hasn't responded to prior therapy. The plan combines lower-intensity chemotherapy with two targeted drugs, ponatinib and blinatumomab, to attack t…

This early-stage trial is testing a new version of CAR-T cell therapy called huCART19-IL18 for adults with certain blood cancers that have returned or not responded to standard treatments. The study aims to find a safe dose and see if the therapy can be reliably manufactured. It …

This study is testing if using a lower dose of a standard drug (cyclophosphamide) given after a stem cell transplant can reduce serious infections in the first 100 days. The trial aims to see if this lower dose is just as good at preventing graft-versus-host disease, a common and…

This study is testing a targeted drug called inotuzumab ozogamicin for adults with B-cell acute lymphoblastic leukemia (ALL) who are in remission but still have tiny amounts of cancer cells detectable by sensitive tests. The drug is designed to seek out and destroy these remainin…

This study is testing a new type of treatment for people whose acute lymphoblastic leukemia (ALL) has come back or hasn't responded to other therapies. Doctors take a patient's own immune cells (T cells), genetically modify them to better find and attack leukemia cells, and add a…

This large, late-stage trial is testing if adding a targeted immunotherapy drug called blinatumomab to standard chemotherapy helps adults with a specific type of acute lymphoblastic leukemia (ALL) live longer. The study involves nearly 500 adults aged 30-70 with newly diagnosed, …

This study is testing whether adding two drugs, bortezomib and vorinostat, to standard chemotherapy is safe and effective for treating infants under one year old with a severe blood cancer called acute lymphoblastic leukemia (ALL). The goal is to better control the disease, impro…

This early-stage study aims to find the safest and most effective dose of a targeted radiation treatment, given with chemotherapy, to prepare patients for a donor stem cell transplant. It is for people with high-risk forms of acute leukemia or myelodysplastic syndrome who are not…

This study is testing two different treatment plans for adults aged 65 and older with a type of blood cancer called acute lymphoblastic leukemia (ALL). One plan combines an immunotherapy drug (blinatumomab) with standard chemotherapy. The other plan combines a targeted drug (dasa…

This study collects a person's own white blood cells to potentially make a future cancer treatment called CAR-T cell therapy. It is for children and adults (ages 3-65) with certain types of leukemia or lymphoma that have not been cured by standard treatments. The collected cells …

This study allows patients already receiving venetoclax in other trials to continue treatment if they are benefiting and tolerating it well. The main goal is to collect long-term safety information by tracking any side effects. It includes about 165 patients with various blood ca…

This study is testing a new type of personalized immune cell therapy called rapcabtagene autoleucel (a CAR-T cell therapy) for adults with several aggressive or returning blood cancers. The main goals are to find a safe and effective dose and to see if the therapy can shrink or e…

This study aims to find out which type of donor leads to better outcomes for children and young adults receiving a stem cell transplant for serious blood cancers like leukemia. It directly compares transplants from a partially matched family member to those from a fully matched u…

This study is testing whether adding the drug ponatinib to a specific chemotherapy regimen and another drug called venetoclax can help patients whose T-cell acute lymphoblastic leukemia has returned or not responded to prior treatment. It aims to see if this combination can put t…

This study is testing a new, more targeted form of radiation as a preparatory step before a stem cell transplant. It is for patients with certain types of leukemia or myelodysplastic syndrome who need a transplant but do not have a fully matched donor. The goal is to see if this …

This trial is for children and young adults with a specific, aggressive type of leukemia (Ph+ ALL). It tests whether a standard chemotherapy regimen works as well as a stronger one when both are given with the targeted drug imatinib, aiming to maintain high cure rates while reduc…

This study is testing a combination of intensive chemotherapy (called Hyper-CVAD) and a targeted drug called ponatinib for adults with a specific type of acute lymphoblastic leukemia (ALL) that involves a genetic change called Philadelphia chromosome or BCR-ABL. The main goal is …

This study tested a comprehensive support program to help children with acute lymphoblastic leukemia (ALL) take their daily oral chemotherapy medication more consistently. It compared a high-tech program with smart pill bottles and text reminders against standard education alone.…

This early-stage study is testing whether immune cells from healthy donors, given along with two other drugs, are safe for people with advanced colorectal, stomach, or hard-to-treat blood cancers. The goal is to see if this combination helps the donor immune cells last longer in …

This study is testing a new type of cell therapy for patients with blood cancers or bone marrow diseases who need a stem cell transplant from a partially matched family donor. The goal is to see if adding specially treated immune cells, called 'veto cells,' can help the donor's c…

This large French study aims to find the best way to give a key drug called pegaspargase to children and teenagers with acute lymphoblastic leukemia (ALL). The drug works by starving the leukemia cells. Researchers are comparing two different dosing schedules to see which one is …

This study is testing several FDA-approved CAR-T cell therapies for patients whose blood cancers have returned or not responded to standard treatments. It involves about 150 participants with conditions like acute lymphoblastic leukemia and various lymphomas. The main goals are t…

This is an early-stage study testing the safety and dosing of a new experimental drug called GNC-038 in adults with aggressive blood cancers that have returned or not responded to standard treatments. The drug is a 'quad-specific antibody' designed to attack cancer cells by bindi…

This study is testing a new blood test called AlloHeme to see if it can predict when leukemia or a related blood cancer might return after a patient receives a bone marrow transplant. Researchers will track over 300 patients for two years, collecting regular blood and bone marrow…

This study is testing a vaccine designed to prevent cytomegalovirus (CMV) infection in adults with blood cancers who are receiving a half-matched stem cell transplant. CMV is a common virus that can become life-threatening when the immune system is weakened after transplant. The …

This study is testing whether an online coaching program for parents can help children who have survived leukemia or lymphoma do better in school. Many kids face learning and memory challenges after cancer treatment. Researchers are comparing this special website and video coachi…

This study tests whether a special parenting skills program helps Latino children who have survived leukemia or lymphoma do better in school. Researchers are comparing an intensive 8-session training for parents against a standard single-session meeting to see which improves chil…

This study is testing whether a drug called siltuximab can help control two serious side effects that sometimes occur after CAR-T cell therapy for blood cancers. CAR-T therapy can cause dangerous immune overreactions called cytokine release syndrome (CRS) and neurological problem…

This small pilot study is testing whether an iPad-based brain training program is practical and helpful for children and young adults (ages 6-21) who have had a stem cell transplant for leukemia. The main goal is to see if participants can stick with the program. Researchers will…

This study aims to measure and understand the financial stress and worry parents experience while their child is being treated for acute lymphoblastic leukemia (ALL). Researchers will survey 100 parents at different points during their child's treatment to see how money worries c…

This study aims to understand why people who survive a blood cancer transplant have a higher risk of heart disease. Researchers will closely monitor 350 adult patients' heart, lung, and muscle function before their transplant and for two years after. The goal is to learn how thes…

This study aims to understand why many young adults who survived childhood cancer experience early signs of aging and frailty, which can lead to serious health problems later in life. Researchers will follow over 1,500 survivors for five years, measuring their physical fitness an…

This study collects blood and bone marrow samples from people with blood cancers like leukemia and lymphoma. Researchers will study these samples in the lab to better understand how these cancers work. The goal is to find new targets for future treatments and improve detection me…