ACUTE LYMPHOBLASTIC LEUKEMIA

This study tests a vaccine called Triplex to prevent cytomegalovirus (CMV) infection in adults who have received a stem cell transplant. CMV can cause serious illness in people with weakened immune systems. The vaccine uses harmless pieces of CMV DNA to help the body build immuni…

This early-stage trial tests a new approach for adults with B-cell acute lymphoblastic leukemia (B-ALL) that has returned or not responded to standard treatment. Doctors take a patient's own T cells (a type of immune cell), add a gene that helps them recognize and attack leukemia…

This early-phase study tests a new drug called GNC-038, a quad-specific antibody designed to attack cancer cells in people with relapsed or refractory non-Hodgkin's lymphoma or acute lymphoblastic leukemia. The main goals are to check the drug's safety, find the right dose, and s…

This study gives venetoclax to people with certain blood cancers who already benefited from it in earlier studies. The goal is to track long-term safety and side effects. About 165 adults are taking part, and they must continue to tolerate the drug well.

This study tests whether a stronger chemotherapy regimen (using total body irradiation and cyclophosphamide) before a stem cell transplant can lower the chance of leukemia returning in adults aged 40-70 with acute lymphoblastic leukemia in remission. About 242 participants will b…

This study tests a stem cell transplant using donors who are not a perfect match for people with blood cancers like leukemia or lymphoma. The goal is to see if adding certain drugs after the transplant can prevent complications and improve survival. About 300 adults and children …

This study looks at how to best give a chemotherapy drug called pegaspargase to children and teens with acute lymphoblastic leukemia (ALL). About 2,000 participants will receive either one or two doses during early treatment to see which approach works better and causes fewer sid…

This study tests a personalized treatment where a child's own immune cells are modified in a lab to recognize and attack cancer cells that have a protein called CD19. It is for children and young adults with certain types of leukemia or lymphoma that have come back or not respond…

This study tests a new drug called ziftomenib for people with acute myeloid leukemia (AML) that has come back or not responded to treatment. The trial includes about 263 participants and aims to find the safest dose and see if the drug can control the disease. It also looks at ho…

This study tests whether adding two adult cancer drugs, bortezomib and vorinostat, to standard chemotherapy is safe and effective for infants under 1 year old with acute lymphoblastic leukemia (ALL). About 50 babies will receive the combination therapy. The goal is to see if it r…

This study tests a new form of chemotherapy called calaspargase pegol (SC-PEG) in 240 children and teens with acute lymphoblastic leukemia or lymphoblastic lymphoma. The goal is to see if giving it every 3 weeks is as safe and effective as the standard drug Oncaspar given every 2…

This study tests a personalized treatment approach for children aged 1-18 with newly diagnosed acute lymphoblastic leukemia or lymphoma. Using genetic information from each child's cancer, doctors add targeted drugs or immunotherapy to standard chemotherapy to improve cure rates …

This study tests FDA-approved CAR-T cell therapy in 150 children and adults with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia or large B-cell lymphoma. Participants receive immune cells that are modified to recognize and attack cancer cells. The main goals are to…

This study is testing a modified chemotherapy plan for children with Down syndrome who have newly diagnosed acute lymphoblastic leukemia (ALL). The treatment uses lower doses of certain drugs to reduce side effects while still fighting the cancer. About 60 children across Asia ar…

This early-stage study tests a new way to prepare the body for a donor stem cell transplant in people with high-risk leukemia or myelodysplastic syndrome (MDS). It combines targeted radiation (TMLI) with two chemotherapy drugs to kill cancer cells and make room for healthy donor …

This trial was designed to test the safety and best dose of the drug revumenib in children with certain types of leukemia after they had a stem cell transplant. The goal was to see if revumenib could help keep the cancer from coming back. However, the study was withdrawn before a…

This study tests adding the drug inotuzumab ozogamicin (InO) to standard treatment for adults newly diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The goal is to see if this chemotherapy-free approach leads to faster and deeper remission, …

This study tests two drug combinations for adults aged 65 and older with acute lymphoblastic leukemia (ALL). One group gets blinatumomab plus standard chemotherapy; the other gets blinatumomab, dasatinib, and prednisone. The goal is to see if these combos help control the cancer …

This study tests a new treatment for people with a type of leukemia that has come back or not responded to standard therapy. The treatment uses the patient's own immune cells (T cells) that are modified in a lab to better find and kill leukemia cells. A special safety switch is a…

This study tests a new treatment called rapcabtagene autoleucel (YTB323) for several types of blood cancer, including chronic lymphocytic leukemia, small lymphocytic lymphoma, diffuse large B-cell lymphoma, and acute lymphoblastic leukemia. About 217 adults will receive this ther…

This study tests whether adding the immunotherapy drug blinatumomab to standard chemotherapy helps adults with a certain type of leukemia live longer. About 488 people with newly diagnosed BCR-ABL-negative B-cell acute lymphoblastic leukemia will take part. The goal is to see if …

This early-phase study tests whether adding specially treated immune cells (called veto cells) from a donor can help stem cell transplants work better in people with blood cancers like leukemia or lymphoma. The goal is to help the donor cells grow without causing severe graft-ver…

This study tests whether adding blinatumomab to standard targeted therapy (TKI) can better treat adults with a specific type of leukemia (Ph+ ALL). About 17 participants will receive the drug combination after initial treatment. The goal is to see if more patients achieve a deep …

This study tested a powerful chemotherapy regimen (Hyper-CVAD) combined with the targeted drug ponatinib in 88 adults with a specific, aggressive leukemia (Philadelphia chromosome-positive ALL). The goal was to see if this combination could improve how long patients stayed cancer…

This study looks at a powerful mix of chemotherapy drugs (Hyper-CVAD and dasatinib) for people with a specific genetic type of acute lymphoblastic leukemia (Ph+ ALL). Some participants also receive a donor stem cell transplant. The goal is to see how well this approach controls t…

This early-phase trial tests whether giving healthy donor NK cells along with two drugs (vactosertib and IL-2) is safe and helps the cells survive longer in people with advanced colorectal, stomach/esophageal, or blood cancers. About 12 participants will receive the combination t…

This study looks at children, teens, and young adults with acute leukemia or myelodysplastic syndrome who need a stem cell transplant. It compares two donor types: a partially matched family donor versus a fully matched unrelated donor. The goal is to see which option leads to fe…

This study tests a combination of low-intensity chemotherapy, a targeted drug called ponatinib, and an immunotherapy called blinatumomab in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL), a fast-growing blood cancer. The goal is to see if this app…

This study tests a new way to deliver radiation before a stem cell transplant for people with leukemia or myelodysplastic syndrome (MDS). Instead of radiating the whole body, the new method (TMLI) targets only the bone marrow and lymph nodes, which may reduce damage to healthy or…

This study looks at children and teens with a specific type of leukemia called Philadelphia chromosome-positive ALL. It tests whether a targeted drug called imatinib works as well with a milder chemotherapy regimen as it does with a stronger one, but with fewer side effects. The …

This study tests whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant from a partially matched donor, can reduce serious infections while still preventing graft-versus-host disease (a condition where donor cells attack the patient's body). About 3…

This study tests a drug called inotuzumab ozogamicin in 40 adults with B-cell acute lymphoblastic leukemia who still have tiny amounts of cancer cells after treatment. The drug works like a smart bomb, attaching to a protein on cancer cells and killing them. The goal is to see if…

This large phase 3 study is testing different combinations and doses of chemotherapy drugs in over 9,000 children and young adults newly diagnosed with standard-risk B-cell acute lymphoblastic leukemia or localized B-cell lymphoblastic lymphoma. The goal is to find which treatmen…

This early-phase trial tests a new treatment called huCART19-IL18 for people with certain blood cancers (leukemia and lymphoma) that have come back or not responded to standard therapy. The treatment uses a patient's own immune cells, modified to better find and attack cancer cel…

This study looks at whether training parents in specific skills can improve learning and school functioning for Latino children with acute leukemia or lymphoma. About 214 families will take part, with some parents receiving a high-intensity program and others getting standard sup…

This study tests whether siltuximab can lessen the severity of cytokine release syndrome (CRS) and nerve-related side effects (ICANS) that often occur after CAR-T cell therapy for blood cancers like lymphoma, multiple myeloma, and leukemia. About 30 participants will receive silt…

This study follows 350 stem cell transplant survivors to see how their heart, lungs, and muscles work together over two years. Researchers measure exercise capacity and other health markers to learn why transplant survivors have a higher risk of heart disease. Participants includ…

This study is testing a new blood test called AlloHeme that can detect tiny amounts of a patient's own cells returning after a bone marrow transplant. The goal is to see if this test can predict a cancer relapse earlier than standard methods. The study involves 307 adults with le…

This study collects blood and bone marrow samples from 550 people with blood cancers like leukemia and lymphoma. Researchers will study the samples in the lab to learn more about how these cancers work and find new ways to treat them. Participants only give samples when already n…

This study tests whether a special website and video coaching for parents can help children aged 6-12 who were treated for leukemia or lymphoma improve their learning and school performance. Many children survive these cancers but may struggle with memory, attention, and thinking…

This study collects white blood cells from people aged 3 to 65 with leukemia or lymphoma that hasn't been cured by standard treatments. The cells are used to create a personalized therapy called CAR T-cells, which may be given later. The procedure, called leukapheresis, takes 4-6…

This study looks at how the bacteria in the gut (microbiome) are connected to cancer-related symptoms in children aged 5-18 with acute lymphoblastic leukemia. Researchers will collect stool samples and symptom reports at several points during chemotherapy. The goal is to understa…

This study follows over 1,500 young adult survivors of childhood cancers like leukemia, brain tumors, and Hodgkin lymphoma to see how frailty—a measure of physical weakness and vulnerability—changes over five years. Researchers want to find out if frailty can predict future chron…

This study looks at how worried or anxious parents feel about money while their child is being treated for acute lymphoblastic leukemia. Researchers will track these feelings over time and see what factors, like income or hospital policies, affect them. About 100 parents will tak…

This study looks at whether an iPad-based thinking exercise program is practical for children and teens who had a stem cell transplant for leukemia. Researchers want to see if kids can stick with the program and if it helps their memory and problem-solving skills. Only 17 partici…