Engineered immune cells take on childhood leukemia and lymphoma
NCT ID NCT04787263
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing a therapy where a child's own immune cells are modified in a lab to recognize and attack cancer cells. The treatment is for children with B-cell acute lymphoblastic leukemia or certain types of lymphoma that have come back or not responded to standard treatments. The goal is to find a safe dose and see if the therapy can shrink or eliminate the cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CAR T-cells (a type of immune cell modified to target cancer cells)
- What this could lead to
- If successful, this could offer a new treatment option for children with hard-to-treat B-cell cancers, potentially leading to remission.
- What could go wrong
- This is an early-phase trial with only 32 participants, so results may not apply to everyone. CAR T-cell therapy can cause serious side effects like cytokine release syndrome.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
IRCCS Ospedale Pediatrico Bambino Gesù
Roma, 00165, Italy
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Other studies related to the condition(s) this trial covers.
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