Promising combo therapy for infant leukemia enters human trials

NCT ID NCT02553460

Ongoing Disease control Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether adding two adult cancer drugs, bortezomib and vorinostat, to standard chemotherapy is safe and effective for infants with acute lymphoblastic leukemia (ALL). About 50 newly diagnosed infants will receive the combination. The goal is to see if it reduces leukemia cells without causing too many side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bortezomib and vorinostat (cancer drugs) added to standard chemotherapy
What this could lead to: If it works, this could lead to a more effective treatment for infant leukemia, potentially improving survival rates.
What could go wrong: This is an early-phase trial with only 50 infants, so results may not apply broadly. The added drugs could cause serious side effects, and the combination may not work better than standard therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute leukemia of ambiguous lineage acute lymphoblastic leukemia acute undifferentiated leukemia bilineal acute myeloid leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LYMPHOBLASTIC LEUKEMIA

Contacts and locations

Locations

Alberta Children's Hospital

Calgary, Alberta, T3A 6A8, Canada
Centre Hospitalier Universitaire Sainte-Justine

Montreal, Quebec, H3T 1C5 CAN, Canada
Centre Hospitalier Universitaire de Quebec

Québec, Quebec, G1V 4G2, Canada
Children's & Women's Health Centre of British Columbia

Vancouver, British Columbia, V6H 3V4, Canada
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital and Clinics of Minnesota

Minneapolis, Minnesota, 55404, United States
Children's Hospital of Orange County

Orange, California, 92868, United States
Children's Hospital of the King's Daughters (CHKD)

Norfolk, Virginia, 23507, United States
Cincinnati Children's Hospital

Cincinnati, Ohio, 45229, United States
Lucile Packard Children's Hospital Stanford University

Palo Alto, California, 94304, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
St. Jude Affiliate-Charlotte

Charlotte, North Carolina, 28204, United States
St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
Stollery Children's Hospital

Edmonton, Alberta, T6G 2B7, Canada
The Montreal Children's Hospital (MUHC-McGill)

Montreal, Quebec, H4A 3J1, Canada

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