New hope for kids with blood cancer: tailored treatments aim to boost cure rates and cut side effects

NCT ID NCT03117751

Ongoing Disease control Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether using each child's unique genetic information to guide treatment can improve outcomes for acute lymphoblastic leukemia and lymphoma. About 790 children aged 1-18 will receive a combination of chemotherapy and newer targeted therapies, such as CAR T cells or blinatumomab, based on their cancer's genetic features. The trial also aims to reduce nerve damage by adjusting vincristine doses for those at higher risk.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: combination chemotherapy with targeted drugs (e.g., tyrosine kinase inhibitors, CAR T cells, blinatumomab, bortezomib, ruxolitinib, nelarabine) and reduced-dose vincristine
What this could lead to: If successful, this could improve survival and reduce nerve damage from chemotherapy for children with these blood cancers.
What could go wrong: This is an early-to-mid stage trial combining many new approaches, so results may not confirm benefit. Side effects from the intensive therapy could be serious.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia leukemia lymphoblastic lymphoma lymphoma mixed phenotype acute leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LYMPHOBLASTIC LEUKEMIA ACUTE LYMPHOBLASTIC LYMPHOMA

Contacts and locations

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Locations

Children's Hospital of Illinois at OSF-Saint Francis Medical Center (St. Jude Midwest Affiliate - Peoria)

Peoria, Illinois, 61637, United States
Children's Hospital of Michigan

Detroit, Michigan, 48201, United States
Cook Children's Medical Center

Fort Worth, Texas, 76104, United States
Lucile Packard Children's Hospital Stanford University

Palo Alto, California, 94305, United States
Rady Children's Hospital San Diego

San Diego, California, 92123, United States
St. Jude Affiliate Clinic - Novant Health Hemby Children's Hospital

Charlotte, North Carolina, 28204, United States
St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
The Royal Children's Hospital Melbourne

Parkville, Victoria, 3052, Australia

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