ACUTE LYMPHOBLASTIC LEUKEMIA
Clinical trials for ACUTE LYMPHOBLASTIC LEUKEMIA explained in plain language.
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Half-Matched donor transplants offer hope for blood cancer patients
Disease control CompletedThis study tested a stem cell transplant from half-matched (haploidentical) family donors for people with various blood cancers. The treatment used a reduced-intensity chemotherapy and radiation regimen to prepare the body for the transplant. The goal was to see how many patients…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated May 17, 2026 00:32 UTC
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New approach boosts medication adherence in young leukemia patients
Disease control CompletedThis study tested a program to help children with acute lymphoblastic leukemia (ALL) take their daily chemotherapy pills more consistently. About 570 children in remission were assigned to either an educational program or an intensive support program. The goal was to see if extra…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE3 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated May 17, 2026 00:29 UTC
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Tailored chemo dosing shows promise for adult leukemia patients
Disease control CompletedThis study tested whether giving personalized doses of the chemotherapy drug L-asparaginase could be safe and effective for adults aged 18 to 50 with newly diagnosed acute lymphoblastic leukemia (ALL). Researchers aimed to find the best dose for each patient to complete all 30 pl…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated May 17, 2026 00:28 UTC
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Experimental combo targets tough leukemias
Disease control CompletedThis early-phase study tested a combination of two drugs—veliparib and temozolomide—in 66 adults with acute leukemias that had come back or not responded to standard treatment. The goal was to find the safest dose and see how well the combination worked. Veliparib blocks a repair…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 15, 2026 11:54 UTC
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Engineered immune cells show promise against tough childhood cancers
Disease control CompletedThis study tested a new treatment for children and young adults (ages 1-39) with B-cell leukemia or lymphoma that did not respond to standard therapy. The treatment involved taking a patient's own white blood cells, modifying them in a lab to target the CD22 protein on cancer cel…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 14, 2026 12:03 UTC
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New hope for chinese adults with Tough-to-Treat leukemia: targeted drug shows promise
Disease control CompletedThis study tested a drug called inotuzumab ozogamicin in 44 adults from China whose acute lymphoblastic leukemia (ALL) had come back or stopped responding to other treatments. The goal was to see if the drug could make the cancer disappear or reduce it significantly. The drug wor…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE4 • Sponsor: Pfizer • Aim: Disease control
Last updated May 08, 2026 12:02 UTC
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New radiation technique aims to cut side effects in leukemia transplants
Disease control CompletedThis study tested a new way to give radiation before a stem cell transplant for people with acute lymphoblastic leukemia (ALL). The new method, called total marrow and lymphoid irradiation (TMLI), targets the bone marrow and lymph nodes while sparing healthy tissues. Fourteen pat…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: NA • Sponsor: Hospital Universitario Dr. Jose E. Gonzalez • Aim: Disease control
Last updated May 06, 2026 16:14 UTC
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Tailored chemo and transplants show promise for adult blood cancer
Disease control CompletedThis study tested a more intensive, personalized treatment plan for over 1,000 adults newly diagnosed with acute lymphoblastic leukemia or lymphoblastic lymphoma. The approach used pediatric-style chemotherapy, targeted drugs, and stem cell transplants based on each patient's ris…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE3 • Sponsor: Goethe University • Aim: Disease control
Last updated May 06, 2026 16:14 UTC
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New drug combo may reduce transplant complications in blood cancer patients
Disease control CompletedThis study tested different combinations of immune-suppressing drugs to prevent graft-versus-host disease (GVHD) in 174 patients with blood cancers who received a stem cell transplant from an unrelated donor. The goal was to find the most effective approach to reduce severe GVHD,…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE3 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated May 06, 2026 16:02 UTC
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New drug combo may make Half-Matched transplants safer for blood cancer patients
Disease control CompletedThis study tested whether replacing a standard transplant drug (cyclophosphamide) with a different drug (bendamustine) could make half-matched bone marrow transplants safer for people with blood cancers like leukemia and lymphoma. About 50 patients took part. The goal was to redu…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE1 • Sponsor: University of Arizona • Aim: Disease control
Last updated May 01, 2026 15:57 UTC
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First human test of new engineered immune cell therapy for tough cancers
Disease control CompletedThis early-stage study tested the safety and highest tolerable dose of a new, genetically modified immune cell therapy called PRGN-3007 UltraCAR-T in adults with advanced blood cancers and triple-negative breast cancer. The main goal was to see how much of the treatment patients …
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Mar 30, 2026 14:27 UTC
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PET scans reveal hidden leukemia spots that could impact CAR t success
Knowledge-focused CompletedThis study tested whether a special PET scan (FDG PET-CT) can find leukemia that has spread outside the bone marrow in people with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia. Ten participants, ages 5 to 39, received a PET scan before and after CAR T-cell therap…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated May 17, 2026 00:29 UTC
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Which donor search strategy saves more lives?
Knowledge-focused CompletedThis study looked at 1,753 patients needing a bone marrow transplant for blood cancers or other serious blood disorders. It compared two approaches: first searching for a matched unrelated donor, or going straight to an alternative donor (like a half-matched family member). The g…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: NA • Sponsor: Center for International Blood and Marrow Transplant Research • Aim: Knowledge-focused
Last updated May 17, 2026 00:25 UTC
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Tiny cell fragments may explain clot danger in Kids' leukemia treatment
Knowledge-focused CompletedThis study looked at 24 children with acute lymphoblastic leukemia to understand why blood clots form during early treatment. Researchers measured tiny cell fragments called microparticles, which can trigger clotting. The goal was to see if these fragments contribute to the incre…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: NA • Sponsor: CHU de Reims • Aim: Knowledge-focused
Last updated May 14, 2026 12:05 UTC
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Italian study reviews Real-World use of targeted leukemia drug
Knowledge-focused CompletedThis study reviewed the medical records of 84 people with acute lymphoblastic leukemia (ALL) who received a drug called anti-CD22 outside of clinical trials in Italy. The goal was to better understand the drug's side effects, how well it works, and its costs in everyday practice.…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Sponsor: Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS • Aim: Knowledge-focused
Last updated May 13, 2026 16:01 UTC
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Personalized plans may boost transplant survival in seniors
Knowledge-focused CompletedThis study tested a personalized geriatric optimization plan (GO!) in 30 patients aged 60 and older who were getting a stem cell transplant for blood cancers or bone marrow failure. The plan included tailored changes to diet, sleep, activity, and medications. The goal was to see …
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: NA • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated May 12, 2026 13:42 UTC