ACUTE LYMPHOBLASTIC LEUKEMIA
Clinical trials for ACUTE LYMPHOBLASTIC LEUKEMIA explained in plain language.
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Scientists test Two-Pronged attack on tough blood cancers
Disease control CompletedThis early-stage study tested a combination of two drugs, veliparib and temozolomide, in adults with acute leukemias that had returned or were hard to treat. The main goal was to find the highest dose patients could safely tolerate. Researchers also wanted to see if the drug comb…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 01, 2026 14:43 UTC
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New engineered cell therapy tested in kids with Tough-to-Treat cancers
Disease control CompletedThis study tested a new type of personalized cell therapy for children and young adults whose leukemia or lymphoma had come back or did not respond to standard treatments. Researchers collected a patient's own immune cells, genetically modified them in a lab to recognize a protei…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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Precision radiation aims to make leukemia transplants safer
Disease control CompletedThis study tested a new, more targeted form of radiation (TMLI) used to prepare patients for a stem cell transplant for acute lymphoblastic leukemia (ALL). The goal was to see if this method was safe and feasible, aiming to keep the cancer-fighting benefits of radiation while red…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: NA • Sponsor: Hospital Universitario Dr. Jose E. Gonzalez • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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First human test of new engineered immune cell therapy for tough cancers
Disease control CompletedThis early-stage study tested the safety and highest tolerable dose of a new, genetically modified immune cell therapy called PRGN-3007 UltraCAR-T in adults with advanced blood cancers and triple-negative breast cancer. The main goal was to see how much of the treatment patients …
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Mar 30, 2026 14:27 UTC
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New hope for leukemia patients as drug seeks to control relapsed cancer
Disease control CompletedThis study tested a targeted drug called inotuzumab ozogamicin in 44 Chinese adults whose acute lymphoblastic leukemia had returned or did not respond to prior treatment. The goal was to confirm how well the drug works and how safe it is for this specific patient group. Researche…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE4 • Sponsor: Pfizer • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Race against time: study tests best way to find Life-Saving transplant donors
Disease control CompletedThis study aimed to find the best strategy for finding bone marrow transplant donors for patients with blood cancers and disorders. It compared whether patients should first search for a perfectly matched unrelated donor or go directly to alternative donors like family members or…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: NA • Sponsor: Center for International Blood and Marrow Transplant Research • Aim: Disease control
Last updated Mar 23, 2026 15:16 UTC
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Scientists test new drug combo to make risky cancer transplants safer
Disease control CompletedThis study tested the safety of swapping out one drug (cyclophosphamide) for another (bendamustine) in the days following a bone marrow transplant. It involved 50 patients with various blood cancers who needed a transplant but lacked a perfectly matched donor. The goal was to see…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE1 • Sponsor: University of Arizona • Aim: Disease control
Last updated Mar 23, 2026 15:14 UTC
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New hope for blood cancer patients: gentler transplants from family donors
Disease control CompletedThis study tested a less intense bone marrow transplant procedure for adults with various blood cancers who needed a transplant but did not have a fully matched donor. It used stem cells from a half-matched family member (like a parent, child, or sibling) after a milder pre-trans…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Mar 20, 2026 14:48 UTC
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Personalized dosing breakthrough tested for adult leukemia treatment
Disease control CompletedThis study tested whether adjusting the dose of a key chemotherapy drug (L-asparaginase) based on individual patient measurements could help adults with acute lymphoblastic leukemia complete their full treatment course. It involved 100 adults aged 18-50 who received multi-phase c…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE2 • Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated Mar 20, 2026 14:48 UTC
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Major trial tests tailored, intensive therapies to fight aggressive blood cancers
Disease control CompletedThis large study aimed to find the best treatment plans for adults newly diagnosed with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma. It tested personalized, intensive chemotherapy approaches, including a specific drug (nelarabine) for a certain type of ALL, and e…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: PHASE3 • Sponsor: Goethe University • Aim: Disease control
Last updated Mar 16, 2026 15:23 UTC
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Researchers look back at leukemia treatment results
Knowledge-focused CompletedThis study collected information from 84 patients who had already received a targeted leukemia drug called anti-CD22 between 2014 and 2019. The goal was to learn more about how safe and effective the treatment was in everyday medical practice, outside of formal clinical trials. R…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Sponsor: Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:12 UTC
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Scanning for hidden cancer: can a simple test predict who will beat leukemia?
Knowledge-focused CompletedThis small study tested whether PET-CT scans, a type of imaging, can help predict how well patients with hard-to-treat leukemia will respond to CAR T-cell therapy. Researchers scanned 10 patients before and after their cell therapy to see if cancer hiding outside the bone marrow …
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:35 UTC
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Scientists hunt hidden cause of deadly clots in kids with leukemia
Knowledge-focused CompletedThis study aimed to understand why children with acute lymphoblastic leukemia sometimes develop dangerous blood clots during treatment. Researchers followed 24 children to measure tiny cell particles in their blood that might trigger clotting. The goal was to learn more about the…
Matched conditions: ACUTE LYMPHOBLASTIC LEUKEMIA
Phase: NA • Sponsor: CHU de Reims • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:29 UTC