Leukemia Survivors' immunity under the microscope

NCT ID NCT05622682

Completed Knowledge-focused Sponsor: Children's Hospital of Philadelphia Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study followed 89 children who finished chemotherapy for acute lymphoblastic leukemia (ALL) to see how their immune systems bounced back. Researchers measured antibody levels for vaccine-preventable diseases and tracked infections during the first year off treatment. The goal is to learn whether kids need extra vaccine doses after leukemia therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors know when to give extra vaccines to children after leukemia treatment, reducing infection risk.
What could go wrong: This is an observational study, not a treatment trial. It gathers information but does not test a new therapy, so it won't directly change care yet.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia childhood acute lymphoblastic leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LYMPHOBLASTIC LEUKEMIA, PEDIATRIC

Contacts and locations

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States
CHRISTUS Children's (Affiliate of Baylor College of Medicine)

San Antonio, Texas, 78207, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Helen DeVos Children's Hospital

Grand Rapids, Michigan, 49503, United States
Monroe Carell Jr. Children's Hospital at Vanderbilt

Nashville, Tennessee, 37232, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States

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