New drug combo shows promise in preventing deadly transplant complication

NCT ID NCT01743131

Completed Disease control Sponsor: Boston Children's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding the drug abatacept to standard medications (calcineurin inhibitor and methotrexate) could better prevent severe acute graft-versus-host disease (aGVHD) after a stem cell transplant from an unrelated donor. A total of 186 participants aged 6 and older took part. The goal was to reduce severe aGVHD without increasing infections, but lifelong immune suppression is still needed, so this is about disease control, not a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ACUTE LYMPHOBLASTIC LEUKEMIA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acute biphenotypic leukemia acute lymphoblastic leukemia acute myeloid leukemia acute undifferentiated leukemia bilineal acute myeloid leukemia cancer graft versus host disease myelodysplastic syndrome neoplasm acute graft versus host disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GRAFT VS HOST DISEASE MALIGNANCY

Contacts and locations

Locations

Children's Healthcare of Atlanta at Egleston

Atlanta, Georgia, 30322, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Children's and Women's Health Center of BC

Vancouver, British Columbia, V6H 3V4, Canada
Dana-Farber Cancer Institute

Boston, Massachusetts, 02115, United States
Emory University/Winship Cancer Center

Atlanta, Georgia, 30322, United States
Michael Grimley

Cincinnati, Ohio, 45229, United States
Seattle Cancer Care Alliance

Seattle, Washington, 98101, United States
UCSF Benioff Children's Hospital Oakland

Oakland, California, 94609, United States
University of Florida

Gainesville, Florida, 32610, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Utah

Salt Lake City, Utah, 84113, United States
Washington University

St Louis, Missouri, 63141, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.