New immune cell therapy aims to prevent leukemia return after transplant

NCT ID NCT06704152

Recruiting now Disease control Sponsor: BlueSphere Bio, Inc Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This early-phase trial tests a new cell therapy called BSB-1001 in 38 adults with high-risk blood cancers (AML, ALL, or MDS) who are getting a stem cell transplant. BSB-1001 is made from donor immune cells that are modified to attack a specific marker on cancer cells. The goal is to see if it is safe and can prevent the cancer from coming back.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BSB-1001 (a type of immune cell therapy that targets a specific protein on cancer cells)
What this could lead to: If it works, this could help prevent blood cancers from coming back after a stem cell transplant, offering a new option for patients with hard-to-treat leukemia or MDS.
What could go wrong: This is an early-phase trial with only 38 participants, so it may not work as hoped. Risks include serious side effects like graft-versus-host disease (GVHD) or other immune reactions.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia acute myeloid leukemia adult acute lymphoblastic leukemia myelodysplastic syndrome Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALL, RECURRENT, ADULT AML, ADULT RECURRENT MDS

Contacts and locations

Locations

City of Hope National Medical Center
RECRUITING

Duarte, California, 91010, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
Washington University at St Louis
RECRUITING

St Louis, Missouri, 63110, United States

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