Myocardial disorder

This trial is testing the best timing for opening additional blocked arteries in people who have had a severe type of heart attack (STEMI) with multiple blocked vessels. After the main blocked artery is opened, participants are randomly assigned to have the other blockages treate…

This trial investigates whether using a temporary heart pump (microaxial flow pump) right after opening a blocked artery improves survival in people with cardiogenic shock—a life-threatening condition where the heart can't pump enough blood. It also tests whether advanced monitor…

This trial tests whether starting a temporary balloon pump in the aorta before the standard artery-opening procedure (angioplasty) can improve outcomes for people who arrive at the hospital 4 to 12 hours after a major heart attack. Half of the participants will receive the balloo…

This trial tests whether giving empagliflozin before or after a procedure to open a blocked heart artery (primary PCI) reduces heart muscle injury during a heart attack. Adults aged 18-75 of South Asian origin having their first heart attack will be randomly assigned to receive e…

This study tests whether pacing the heart from a specific spot (posterosuperior bundle) can lower the chance of atrial fibrillation (AF) in people with sinus node dysfunction (a slow or irregular heartbeat). About 300 adults who need a pacemaker will be randomly assigned to get p…

This trial tests whether a virtual world-based cardiac rehabilitation program can improve heart health and participation compared to standard in-person rehab. The program, called Destination Cardiac Rehab, is a 3D interactive telehealth option that patients can use from home. Res…

This study tests whether adding mobile health tools—like smartphone apps, connected scales, blood pressure monitors, and activity trackers—to standard cardiac rehab helps heart patients monitor their health and stick to healthy habits at home. The trial enrolls adults who have ha…

This study tests a new device (Sphere-9 catheter and Affera system) to treat ventricular tachycardia, a fast, dangerous heart rhythm, in 260 adults who have had a heart attack. Participants must have had repeated episodes despite medication or a defibrillator. The goal is to see …

This trial tests whether heart attack patients who have had complete artery-opening procedures can safely stop aspirin after 3-6 months and continue with only a P2Y12 inhibitor. The goal is to see if this approach reduces bleeding problems without increasing the risk of another h…

This study tests whether a medicine given as a nose spray before a heart stent procedure can reduce heart muscle injury or heart attack. About 1800 adults scheduled for elective stent placement will receive either the medicine or a placebo spray. Researchers will measure heart da…

This trial investigates whether adding a PCSK9 inhibitor to a high-intensity statin can reduce liver fat—measured by a non-invasive FibroScan—in diabetic patients who have recently had a heart attack or unstable angina. Half the participants will receive the combination therapy, …

This trial tests whether a hybrid cardiac telerehabilitation program — combining in-person sessions, live video workouts, and remote monitoring — can improve adherence to exercise rehab in people with coronary artery disease or stable heart failure. Participants are randomly assi…

This study tests whether a 6-month program delivered through the Telegram messaging app can help people stop smoking after a heart attack. 142 adult smokers who use Telegram will either get the chatbot support or standard advice. The goal is to see if more people quit with the ch…

This trial tests whether adding eccentric cycling—a type of exercise where muscles lengthen under tension—to standard cardiac rehabilitation can improve recovery in people who have had a heart attack. Eccentric exercise may allow higher muscle loads with less cardiovascular deman…

This study tests whether giving high-risk heart attack patients personalized education before they leave the hospital can reduce their chances of being readmitted. The education covers disease management, medication adherence, lifestyle changes, and recognizing warning signs. Res…

This study tests a newer, more natural pacing method for people with heart failure and electrical problems in the heart. The approach uses the heart's own conduction system to improve coordination between chambers. Researchers will track patients for two years to see if this meth…

This trial tests whether filtering a specific inflammatory protein (C-reactive protein, or CRP) from the blood can improve outcomes in people with cardiogenic shock—a life-threatening condition where the heart cannot pump enough blood—after a heart attack. About 50 participants w…

This trial investigates whether patients with acute coronary syndrome can safely stop taking aspirin soon after a heart stent procedure and continue with only a potent antiplatelet drug (ticagrelor or prasugrel). The standard approach is to take both aspirin and a P2Y12 inhibitor…

This study tests whether a proactive, pharmacist-led telephone program can help people who have had a heart attack reach safer cholesterol levels. Participants receive pharmacist calls, repeat blood tests, and medication adjustments based on national guidelines. The goal is to se…

This study tests whether adding a drug called inclisiran to standard cholesterol-lowering therapy (statins) helps people who recently had a heart attack or unstable angina lower their LDL ('bad') cholesterol more than statins alone. About 300 adults in Saudi Arabia will receive e…

This trial tests whether a less intensive antiplatelet therapy is safer and as effective as standard dual therapy for people with spontaneous coronary artery dissection (SCAD), a rare cause of heart attack in women aged 30–55. Unlike typical heart attacks, SCAD involves a tear in…

This study tests a simple balloon inflation technique to modify blood clots during emergency heart artery opening. 100 heart attack patients will either get the balloon procedure or standard care. The goal is to see if this reduces damage to the heart muscle and improves recovery…

This study tests whether the diabetes drug ertugliflozin, started within 72 hours of a first heart attack, can improve heart function in people with type 2 diabetes. About 476 adults will be randomly assigned to take the drug or receive standard care. Researchers will measure cha…

This study compares two approaches to blood thinning after a heart attack in patients with atrial fibrillation. One group gets two blood thinners (a DOAC plus clopidogrel), while the other gets only one (a DOAC alone). The goal is to see if using just one drug reduces bleeding ri…

This study compares two ways to guide stent placement during emergency treatment for a severe type of heart attack (STEMI). About 2,500 patients will be randomly assigned to receive either standard X-ray guidance or ultrasound guidance (IVUS) during the procedure. The goal is to …

This study looks at whether icosapent ethyl, a purified fish oil medication, can reduce inflammation and improve heart structure in people with coronary artery disease. Researchers will follow 420 patients for one year, comparing those who receive standard care plus icosapent eth…

This study looks at 240 adults having a major heart attack (STEMI) when the standard emergency procedure to open the blocked artery is expected to be delayed by over an hour. Half will get a clot-busting drug (tenecteplase) right away, followed by the procedure within 2-24 hours.…

This study compares a moderate statin (pitavastatin) combined with ezetimibe against high-intensity statins (atorvastatin or rosuvastatin) in patients aged 75+ with coronary artery disease who need a stent. The goal is to see if the combo is just as good at preventing heart attac…

This study looks at a special stent (a small mesh tube) coated with a drug called sirolimus, used to open blocked heart arteries. Researchers will follow 300 adults who received this stent during a standard heart procedure to see how safe and effective it is over 5 years. The mai…

This study tests a drug called pelacarsen in people who recently had a heart attack and have high levels of Lp(a), a type of fat in the blood that raises heart risk. The goal is to see if the drug can safely lower Lp(a) levels and improve heart health. About 240 adults in the US …

This study tests whether a wearable monitoring system (ECG patch, temperature patch, and pulse oximeter) can reduce major heart complications in hospitalized patients with heart disease. About 1500 adults will be monitored either with standard care (vital signs every 4-8 hours) o…

This study compares two approaches for people with heart failure and narrowed heart arteries: a stent procedure plus guideline-directed medications versus medications alone. About 1,150 participants will be followed for at least two years to see which group has fewer major heart …

This study tests whether using a patient's genetic information to choose anti-platelet drugs can lower bleeding risks compared to standard care. About 1,760 high-risk patients receiving a heart stent will be assigned to either a personalized drug plan or usual therapy. The goal i…

This study tests whether a new wire-free imaging method called μFR can help doctors decide which blocked heart arteries need stents after a heart attack. About 350 patients with multiple blocked arteries will be randomly assigned to standard care or μFR-guided treatment. The goal…

This study tests a new use of low-intensity focused ultrasound (LIFU) to calm nerve signals that can trigger dangerous heart rhythms after a heart attack. About 100 adults who recently had a severe heart attack will receive either real or fake ultrasound sessions during and for a…

This study tests a drug called NL005 in people who have had a severe type of heart attack (STEMI) and undergone emergency artery-opening treatment. The goal is to see if NL005 can reduce permanent heart muscle damage. Participants will receive either NL005 or a placebo daily for …

This study looks at whether setting a pacemaker to a personalized rate of 75 beats per minute, instead of the usual 50-60, can improve heart function and blood flow to the brain in people with high blood pressure and a slow heart rate. About 70 patients aged 65 and older will be …

This study tests whether drinking a specially designed milk every day for a year can reduce the chance of stents narrowing again and prevent further heart problems in people who have had a first heart attack. About 140 adults who recently had a stent placed will be randomly assig…

This study compares a new stent that releases sirolimus and ascorbic acid (vitamin C) to a standard everolimus-releasing stent in over 2,000 people with coronary artery disease. The goal is to see if the new stent is as good at preventing heart-related complications like death, h…

This study tests whether removing blood clots from heart arteries during emergency treatment can improve long-term heart health. About 6,760 adults having a severe heart attack will be randomly assigned to get standard care or standard care plus clot removal. Researchers will tra…

This study tests a new radiation treatment for people with a life-threatening fast heart rhythm called ventricular tachycardia that hasn't been helped by medication or prior procedures. About 24 adults with an implanted defibrillator will receive a single, targeted dose of radiat…

This trial tests a hybrid exercise program (HyBEST) for people with coronary artery disease. It combines supervised sessions at a center with home workouts using a wearable tracker. The goal is to see if this approach improves exercise capacity, body composition, and quality of l…

This study compares a three-drug combination (atorvastatin, ezetimibe, and bempedoic acid) against the usual two-drug therapy for lowering LDL cholesterol in people who have had a heart attack or unstable angina. About 120 adults will take either the triple or dual therapy for 3 …

This study compares two types of drug-coated balloons used to open blocked heart arteries in people with acute coronary syndrome (a serious heart condition). About 60 adults will receive either a sirolimus-coated or paclitaxel-coated balloon. The main goal is to see which balloon…

This study involves 8,100 adults who had a heart attack and received a stent. It compares different approved blood-thinning strategies to see which one best prevents another heart attack, stroke, or death while also reducing serious bleeding. Participants will either receive a sh…

This study tests whether routinely placing a small tube in the leg artery (distal perfusion catheter) is better than waiting until a problem arises in patients on mechanical heart pumps. About 500 adults with severe heart failure or shock will be randomly assigned to one of the t…

This study tests a new, small pacemaker that doesn't need wires (leads) to help people with a slow heartbeat. About 15 adults with certain heart rhythm problems will get the device to see if it's safe and works well. The pacemaker is placed directly in the heart to keep the beat …

This study tests whether inserting a heart pump (IABP) early, before severe shock develops, can reduce deaths in patients who develop a hole in the heart after a heart attack. The trial will enroll 100 patients across 5 centers, randomly assigning half to receive the pump within …

This study tracks 1,200 people with coronary artery disease who receive a drug-coated balloon instead of a metal stent during angioplasty. The goal is to see if this approach reduces heart-related deaths, heart attacks, and the need for repeat procedures. Researchers hope to conf…

This study tests a new treatment called MiSaver, made from umbilical cord blood cells, for people who recently had a heart attack. The goal is to see if it safely helps the heart pump better and reduces future heart problems. About 102 participants will either receive the cell tr…

This early-stage trial tests whether a patch loaded with lab-grown heart muscle cells can help repair damaged heart tissue. Sixteen people with severe heart failure who are already scheduled for bypass surgery will receive either the stem cell patch or a blank patch during their …

This study tests whether the drug nicorandil can improve blood flow in the heart's tiny vessels after a heart attack. About 170 patients having emergency angioplasty will receive either nicorandil or a placebo directly into their heart artery. The goal is to see if nicorandil red…

This early study tests a new, wire-free pacemaker (ALPS) in 10 people with bradycardia (slow heart rate). The goal is to see if it is safe and works well. Participants will be monitored for device-related problems and how well the pacemaker controls their heart rhythm.

This study tests whether Tanhuo decoction, a traditional herbal mixture, can reduce inflammation and prevent future heart or brain events in elderly patients who have had both a heart attack and hardened brain arteries. About 480 participants will take either the herbal drink or …

This study tests whether giving a triple combination of cholesterol-lowering drugs (a high-intensity statin, ezetimibe, and bempedoic acid) right after a heart attack works better than usual care. About 600 adults hospitalized for a heart attack will be randomly assigned to the t…

This study looks at 4,400 people who had a heart attack and got a stent. It tests two drug strategies: one to lower bleeding risk by adjusting blood thinners, and another to lower cholesterol using a milder statin plus ezetimibe. The goal is to find the safest and most effective …

This pilot study tests whether taking a synbiotic supplement (a mix of probiotics and prebiotics) for 10 weeks can lower TMAO levels and improve other heart health markers in 80 adults who recently had a heart attack. The goal is to see if changing gut bacteria can help prevent f…

This study tests whether a smartwatch, combined with artificial intelligence, can help monitor heart attack patients during their recovery at home. About 1,050 participants will either use the smartwatch with AI, a smartwatch without AI, or receive standard care. The goal is to s…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This trial tests two different heart pacing leads—one without a hollow core (lumenless) and one with a stylet—to see which works better for left bundle branch pacing. About 288 people with slow heart rhythms will take part. Doctors will use continuous monitoring to guide the lead…

This study compares two blood thinners, bivalirudin and heparin, used during a heart procedure called PCI in people with acute coronary syndrome who are at high risk of bleeding. About 5,270 participants will be randomly assigned to receive one of the two drugs. The goal is to se…

This early-phase trial tests a new treatment for people in shock after a severe heart attack. The therapy uses specially engineered immune cells (CAR-DC) to target a protein found in heart scar tissue, aiming to calm the immune response. The study will enroll 18 patients and prim…

This study looks at two ways to treat people with a type of heart attack (NSTE-ACS) who have multiple blocked arteries. One group gets all blockages fixed during the same emergency procedure, while the other group fixes the main blockage first and the others later. The goal is to…

This study tests whether heart attack patients with high bleeding risk can safely take blood thinners for only one month after a special drug-coated stent, instead of the usual 12 months. About 468 participants will be randomly assigned to the shorter or standard therapy. The goa…

This Phase 3 trial tests whether the anti-inflammatory drug anakinra can help children with acute myocarditis (heart inflammation) recover heart function faster. About 110 children in intensive care will receive either anakinra or a placebo for 7 days, alongside standard care. Th…

This study tests whether a herbal medicine called Danhong injection can help protect the heart in people with sepsis, a life-threatening infection. Researchers will give 140 patients either the injection or a placebo for 7 days and check heart function and survival rates. The goa…

This study tests whether dapagliflozin, a drug typically used for diabetes, can lower inflammation in the heart arteries of people who recently had a heart attack but do not have diabetes or heart failure. About 110 participants will receive either the drug plus standard care or …

This study tests if a special balloon pump placed in a heart vein (coronary sinus) can reduce heart muscle damage when used alongside standard angioplasty in people having a major heart attack (STEMI). About 177 adults aged 18-80 with moderate heart pumping weakness will be rando…

This early-phase trial will test whether injecting lab-grown heart muscle cells (made from stem cells) into the heart can safely help people with severe heart failure. Fourteen participants with weak hearts will receive the cells via a catheter. The main goal is to check for side…

This study tests whether giving a powerful cholesterol-lowering drug (recaticimab) early after a heart attack can safely reduce future heart problems. About 2,442 adults who recently had a heart attack will receive the drug or standard care. The goal is to see if this approach lo…

This study tests whether using a smartwatch combined with artificial intelligence can improve recovery for people who have had a heart attack. 200 adults aged 18-75 who recently had a heart attack and a stent placed will wear a smartwatch that tracks health data. The AI analyzes …

This study tests a smartphone-based rehab program for young and middle-aged people (18-60) who had a heart attack. The program uses an app to guide exercise, diet, medication, and stress management, with support from a team of heart doctors, nurses, nutritionists, and psychologis…

This study tests whether adding a PCSK9 inhibitor (a strong cholesterol-lowering drug) to standard statin therapy can stabilize fatty plaques in the arteries of people who recently had a heart attack. About 212 participants will receive either the drug combination or standard car…

This study tests whether an educational smartphone app can help people who have had a heart attack or other acute coronary event achieve their LDL cholesterol targets. About 240 patients across 24 hospitals will be randomly assigned to use the app or receive usual care. The main …

This study tests whether starting the drug tafolecimab (a PCSK9 inhibitor) just before emergency angioplasty can lower the chance of major heart problems over the next year in people having a heart attack. About 1,160 adults will either get the drug plus standard care or standard…

This study tests whether adding visits with a nurse, dietitian, and pharmacist to standard care helps more heart attack patients reach their LDL (bad) cholesterol goals. About 230 adults who had a recent heart attack will be randomly assigned to usual follow-up or extra team-base…

This study tests whether a short course of the antibiotic rifaximin can improve how well the blood thinner ticagrelor works in people who have had a heart attack. The idea is that unhealthy gut bacteria may interfere with the drug, and clearing them out could help prevent future …

This study tests whether adding the blood thinner rivaroxaban to standard aspirin and clopidogrel can improve sluggish blood flow in heart attack patients who just had a stent placed. About 60 adults will receive either the triple therapy or standard dual therapy for one month. R…

This study will test whether adding a special breathing exercise (inspiratory muscle training) to standard cardiac rehab helps heart patients recover better. About 80 adults who have been hospitalized for a heart condition will take part. The main goal is to see if the training i…

This study tests if gently cooling the body (to 33-34°C) during emergency heart procedures can limit heart damage in people having a severe heart attack complicated by shock. All 44 participants will receive standard care with a heart-lung machine, and half will also be cooled fo…

This study tests whether digital health tools can help people recover safely at home after a heart attack. Researchers will compare two types of follow-up care: education alone versus education plus extra support like symptom tracking and virtual appointments. The goal is to redu…

This large study will test whether adding Shexiang Baoxin Pill (Muskardia) to standard treatment helps people who have had a heart attack. About 9,588 participants will receive either standard care alone or standard care plus the pill for 12 months. The goal is to see if the pill…

This study looks at whether a 12-week cardiac rehabilitation program—including supervised exercise, education, and lifestyle advice—can improve heart function and quality of life in people who have had a heart attack treated with stenting. One hundred participants will be randoml…

This trial tests whether a special ultrasound technique can detect heart muscle ischemia (reduced blood flow) in people with suspected acute coronary syndrome. The approach uses microbubbles that stick to activated immune cells and blood vessel linings, potentially revealing infl…

This early-phase study tests whether a special ultrasound with a targeted contrast agent (Sonazoid) can quickly diagnose heart inflammation caused by immune checkpoint inhibitor cancer drugs. About 30 adults who recently received these drugs and show signs of heart inflammation w…

This trial compares two blood-test strategies for diagnosing heart attacks in people with chest pain: the standard approach of testing at arrival and again 3 hours later, versus an accelerated approach testing at arrival and again after just 1 hour. The goal is to see whether the…

This trial tests whether a smartphone app called Antshrike, paired with a smartwatch, can predict heart attacks or strokes within 3-4 days in people at high risk. Participants aged 40 to 79 with existing heart disease or elevated risk will wear the smartwatch for 18 months while …

This trial tests whether a 4-electrode tablet-based ECG (DigitalCardio) can record heart activity as quickly and clearly as the standard 10-electrode ECG. About 50 cardiology patients will undergo both methods in random order. Researchers will measure recording time and compare t…

This study explores whether the electrical signal measured by a pacemaker or defibrillator during implantation can help identify cardiac amyloidosis — a condition where abnormal proteins build up in the heart. Researchers will enroll 242 adults aged 65 and older who already need …

This study tests whether a simple, 1-minute electrocardiogram (ECG) analyzed by artificial intelligence can accurately detect significant blockages in the heart's arteries. Researchers will compare the AI's predictions against standard imaging tests in 400 adults. If successful, …

This study looks at whether a simple blood test done in the ambulance can safely rule out a heart attack in people with chest pain. Many patients are taken to the hospital even though they are not having a heart attack. The test uses a portable device to measure a heart protein c…

This study is testing a new digital stethoscope that listens for subtle changes in heart sounds to detect coronary artery disease and valve problems earlier. Researchers will record heart sounds from 500 adults who are already scheduled for heart scans or echocardiograms. The goa…

This study aims to create a risk prediction model for acute myocardial infarction (heart attack) using artificial intelligence and wearable devices. Researchers will enroll 3,000 high-risk patients in the Beijing area and collect data from ECGs and other sources. The goal is to e…

This early study tests a new radioactive tracer called 64Cu-GRIP B that targets a protein released by immune cells during heart inflammation. Researchers will scan 10 people with acute myocarditis to see if the tracer can clearly highlight inflamed areas of the heart. If it works…

This study will develop and test an artificial intelligence (AI) model to predict the risk of a heart attack within 6 months in people who have already had one. Researchers will combine different types of patient data to create a more accurate risk score. The goal is to identify …

This study aims to see if a simple breath test can help doctors quickly tell which patients with chest pain are at high risk for a heart attack or other serious condition. Researchers will collect breath samples from 6,000 adults coming to the emergency room with chest pain and a…

This study compares two ways to diagnose bleeding problems during surgery: a quick bedside test (viscoelastic test) and standard lab tests. The goal is to see which method gives faster results, helping doctors treat bleeding sooner. About 210 adults having high-risk surgeries (li…

This study is testing a new tool called UFR, which uses ultrasound images to measure blockages in heart arteries during a heart attack. Currently, the most accurate method requires patients to return 30 days later for a second invasive procedure. The study will enroll 200 heart a…

This study tests whether an artificial intelligence (AI) tool can help emergency room doctors interpret heart CT scans more accurately. About 530 adults with chest pain and intermediate risk of a heart attack will be randomly assigned to have their scans read with or without AI a…

This study looks at whether two blood markers – mean platelet volume (MPV) and the systemic inflammatory response index (SIRI) – can help diagnose and predict outcomes in people with acute coronary syndrome (heart attack or unstable angina). Researchers will measure these markers…

This trial tests whether a structured oral hydration plan—drinking at least 1,500 mL of fluid within 12 hours around the procedure—can reduce the risk of contrast-induced acute kidney injury (CI-AKI) in patients with ST-elevation myocardial infarction (STEMI) undergoing primary P…

This trial tests whether offering a seasonal flu vaccine to heart patients while they are still in the hospital, along with active counseling, increases vaccination rates compared to counseling alone. The study enrolls adults hospitalized for acute coronary syndrome or heart fail…

This study tests whether adding cilostazol, a drug that improves blood flow, to standard aspirin or clopidogrel therapy can prevent another stroke or heart attack in people who have recently had a stroke or mini-stroke. About 2,000 participants will take either cilostazol or a pl…

This study tests a 13-week remote stress recovery program for people who had a heart attack before age 55 and still feel distressed. The program includes online sessions with a therapist, a workbook, and videos. The goal is to see if a larger trial is possible by checking how man…

This study looks at whether 12 virtual health coaching sessions over 16 weeks can help people with heart disease (like heart failure or a heart attack) improve their health, reduce stress, and lower the chance of going back to the hospital. About 70 adults will take part, and the…

This study tests if combining arm and leg cycling exercise is better than leg cycling alone for improving fitness and quality of life in people who have had a heart attack. Forty medically stable adults aged 40-70 will exercise three times a week for six weeks. Researchers will m…

This early study tests whether a special gel, injected into the heart during a procedure to open blocked arteries, can safely reduce injury in people having their first major heart attack. Twenty participants will be randomly assigned to get the gel plus standard care or standard…

This study tests whether a combination of a motivational phone call for patients and reminders for their doctors can increase attendance at cardiac rehabilitation after a type 2 heart attack. Researchers will compare 60 adults who receive this extra support to those who get usual…

This study will compare two types of aerobic exercise—interval training and continuous training—in 48 people with stable coronary artery disease. Participants will exercise twice a week for 8 weeks as part of a cardiac rehab program. Researchers will measure heart efficiency, exe…

This phase 2 trial tests whether a traditional Chinese herbal paste called Chaigui Longmu Ejiao Paste can reduce weekly angina attacks in people with ischemic heart disease. Sixty adults aged 18-75 who have stable angina and are on standard heart medications will take the paste o…

This study looks at whether listening to music can help lower anxiety and improve sleep in people who have had a heart attack and are spending their first night in a special heart unit. About 64 adults will take part. They will listen to music and then use eye masks and earplugs …

This phase 3 trial will compare methoxyflurane (Penthrox®), a painkiller gas patients inhale themselves, against standard morphine injections for chest pain during a heart attack. About 700 adults with a specific type of heart attack (STEMI) will be enrolled in pre-hospital setti…

This study tests a new care program for older adults in Thailand who have had a heart attack. The program combines in-person education, motivational counseling, and a mobile app to help them adopt healthy habits and track their recovery. Researchers will measure if this approach …

This study looks at two simple methods to help local anesthesia work better for children aged 6-12 with a condition called Molar-Incisor Hypomineralization (MIH), which makes teeth sensitive and hard to numb. Researchers will apply either silver diamine fluoride or a cold pack to…

This study tests whether a short virtual reality (VR) session before a first-time cardiac catheterization can lower patient anxiety and improve satisfaction. About 120 adults in Oman will be randomly assigned to either the VR experience or standard education. Researchers will mea…

This study tests whether a home-based cardiac rehabilitation program can improve quality of life and health behaviors in heart patients living in low-resource settings in Pakistan. The program includes diet advice, exercise suggestions, medication reminders, and counseling, deliv…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study will examine 108 adults aged 30-65 to see if a gene called Klotho, certain mouth bacteria, and viruses are linked to gum disease and acute coronary syndrome (a type of heart attack). Researchers will measure gum health and collect samples to look for these markers. The…

This study investigates whether insulin resistance, measured by the TyG index, is linked to the no-reflow phenomenon—where blood flow fails to restore properly—after primary PCI (stenting) for heart attacks in people with type 2 diabetes. Researchers will also examine how insulin…

This study follows 600 older adults (age 60+) who have had a heart attack to see if aging-related markers in their blood and body can predict future heart problems or death. Researchers collect medical data, blood samples, and heart scans over at least two years. The goal is to b…

This study investigates whether measuring blood flow in the heart's smallest blood vessels (microcirculation) can help predict serious health events within a year after a person is hospitalized for acute myocarditis. Researchers will use a special technique during a standard hear…

This study follows 25,000 people referred to a specialized heart clinic with symptoms like chest pain or shortness of breath. Researchers will track which heart conditions are actually diagnosed and how patients are evaluated. The goal is to improve diagnostic accuracy and unders…

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study will follow 400 people who had a heart attack and have moderately reduced heart function (ejection fraction 35-50%). Participants will get a small implantable heart monitor to track their heart rhythm for up to 5 years. The goal is to identify markers that could predic…

This study aims to see if wearable foot-pods (like Stryd) and breathing frequency monitors can accurately measure exercise intensity in people who have had a heart attack in the past 6 months. 24 participants will perform walking tests on flat ground and a treadmill while their o…

This study looks at whether Guanxinning tablets can help repair tiny blood vessels in the heart after a heart attack. About 70 people who have had a severe heart attack will take the tablets or a placebo for 6 months. The main goal is to see if the tablets reduce bleeding in the …

This study investigates whether a condition called clonal hematopoiesis of indeterminate potential (CHIP), which is an age-related change in blood cells, is linked to more severe heart damage in people who have had a major heart attack (STEMI). Researchers will test blood samples…

This early-stage study will use advanced PET scans to look at how the brain and body work together in people with and without heart disease. Researchers want to see if blood flow and energy use in different organs change during physical or mental stress. The goal is to better und…

This study will follow up to 840 people with heart disease or COPD who join a group rehab program. Researchers want to see how many patients take part, how often they attend, and how their test results and quality of life change. The goal is to find out what helps patients improv…

This study tests whether using a CT scan to plan a heart stent procedure (PCI) makes it faster, safer, and more effective than the usual approach. About 200 adults with coronary artery disease will either get CT-guided planning or standard care. Researchers will compare procedure…

This study will check if a routine blood measure called mean platelet volume (MPV) can predict acute coronary syndrome (heart attack or unstable angina) in people with metabolic dysfunction-associated steatotic liver disease (MASLD). Researchers will compare MPV levels between 60…

This study will enroll 144 adults with acute coronary syndrome (heart attack or unstable angina) to see how inflammatory markers (hs-CRP and neutrophil-to-lymphocyte ratio) and cardiac troponin levels relate to heart function measured by echocardiography. Researchers hope to impr…

This study will look at health records of 10,000 patients in Qatar who were hospitalized for heart problems and have diabetes or prediabetes. Researchers will use artificial intelligence to find patterns that predict future heart attacks, strokes, or death. The goal is to create …

This study aims to improve how MRI scans measure blood flow in the heart muscle. Researchers will compare a new, fully quantitative method with the standard semi-quantitative approach in 35 people with possible heart disease. The goal is to develop a more accurate tool for diagno…

This study will create a digital twin of the heart for 1,000 people who have had a heart attack. The goal is to see if this computer model can better predict who is at risk for sudden cardiac death compared to the current standard method. Participants will undergo a cardiac CT sc…

This study will follow 1,800 people who had a stent placed in their heart arteries using a special camera (OCT). Researchers want to see if new measurements from routine angiograms can better predict future heart problems like heart attacks or chest pain. The goal is to improve h…

This study looks back at medical records of 1500 adults hospitalized for acute myocarditis (heart muscle inflammation). The goal is to find out how often dangerous heart rhythms occur and what factors predict them. No new treatments are tested—researchers will use existing data t…

This study will follow 6000 people with heart disease or recent heart attacks for years. Researchers will collect blood, urine, and stool samples, plus medical data, to build a huge database. They hope artificial intelligence can find new ways to predict, diagnose, and treat hear…

This study will enroll 1,000 patients in China who have a heart attack complicated by cardiogenic shock, a life-threatening condition. Researchers will test a new team-based care system and create a risk model tailored to Chinese patients. The goal is to reduce deaths and improve…

This observational study will enroll 20,000 Korean adults who have had a heart attack (acute myocardial infarction). Researchers will collect detailed data from hospitals nationwide to understand what factors affect long-term outcomes. The goal is to create better risk prediction…

This study tests whether sending an electronic letter to people with heart disease and high cholesterol encourages them to get their cholesterol checked. Researchers will compare those who receive the letter to those who don't, using national health records to track results. The …

This study develops and tests an AI system that reads de-identified patient admission notes to classify four types of coronary syndromes, including heart attacks and angina. The tool is designed to protect patient privacy while helping doctors diagnose more accurately and quickly…

This study tests whether a short educational video, shown alongside standard information, can help first-time heart attack patients better understand their upcoming heart catheterization and feel less anxious. About 140 participants will be randomly assigned to receive either sta…

This study looks at a protein called GARP and related inflammatory markers in the blood of 600 adults with either acute (sudden) or chronic (long-term) coronary syndrome. Participants will have blood drawn during a routine heart catheterization. The goal is to understand how GARP…

This study is testing a new algorithm that helps paramedics decide if a patient with chest pain is having a heart attack. About 304 patients will get a quick blood test in the ambulance, and researchers will track their outcomes for 90 days. The goal is to fine-tune the algorithm…

This study uses a large Korean health database to see if developing insomnia after a heart attack (treated with stents or bypass surgery) is linked to worse long-term outcomes like death, another heart attack, or stroke. Researchers will compare patients who take insomnia medicat…

This study will follow 1,500 people with lupus or other autoimmune diseases to see if advanced heart scans can predict heart attacks, strokes, or other heart problems. Participants will have one of three types of heart imaging. The goal is to learn if these scans can help doctors…

This study will follow 1200 people who have had a heart attack or unstable angina and also have sleep apnea. Researchers will collect blood, urine, and stool samples to understand how sleep apnea affects metabolism and heart risk. The goal is to build an AI-based tool to better p…

This study aims to see if artificial intelligence can predict serious heart rhythm problems, like atrial fibrillation, after high-risk surgeries. Researchers will record ECGs from 300 adults before surgery and analyze over 200 heart cycle parameters to find the best prediction me…

This study tests a patient decision aid designed to help heart attack survivors with high bleeding risk choose the best blood-thinner plan. The tool explains risks and options so patients can share their preferences with doctors. The trial will enroll 26 participants to see if th…

This study will collect data from 5,000 adults with acute myocarditis (heart muscle inflammation) across France. Researchers will analyze heart MRI scans to see if certain patterns can predict who is at risk for serious complications like death, heart failure, or dangerous heart …

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study looks at how well hospitals follow guidelines for blood thinner use after heart stent placement. It will enroll 3,500 patients with acute coronary syndrome who are at high risk for bleeding. Researchers will track their treatment and outcomes for 12 months to see if a …

This study will use data from over 10,000 people to create a risk prediction model for coronary artery disease. Researchers will combine heart imaging scans (like CT angiograms) with blood markers (like cholesterol) to better identify who is at high risk for heart attacks or othe…

This study will track 320 people in Hong Kong who have a heart attack complicated by cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will collect data on standard treatments, including the use of a heart pump called Impella, to…

This study looks at whether heart attack patients get to the hospital just as fast when a non-doctor team (like firefighters or paramedics) does the ECG compared to a doctor-staffed team. Researchers will review records of 350 adults who called emergency services in France betwee…

This study will follow 500 people with dual-chamber pacemakers to see how the pacemaker's programming affects the development of permanent atrial fibrillation (AF), a common heart rhythm problem. Researchers will track AF episodes, quality of life, hospitalizations, and deaths ov…

This observational study will enroll 135 adults who had a severe type of heart attack (STEMI) and were treated with angioplasty. Researchers will use a special ultrasound technique to measure left atrium strain within 48 hours of admission. The goal is to see if this measurement …

This study will develop an artificial intelligence model that combines heart MRI scans and patient data to predict long-term risks after a heart attack. Researchers will enroll 800 patients who have had a severe type of heart attack (STEMI) and undergone emergency artery-opening …

This study will develop a new AI-powered model to predict major heart problems after a heart attack. Researchers will analyze data from over 1,500 patients who had a heart attack and received a stent. The goal is to create a more accurate tool than current methods to identify pat…

This trial tests whether using a risk score and a rapid blood test in the ambulance can help decide where to take patients with chest pain. About 1,048 adults at intermediate or high risk for a heart attack will be randomly assigned to either this new triage method or usual care.…

This study tests whether using very low radiation doses combined with special software can produce clear images of the heart's arteries. About 50 adults scheduled for a standard heart angiogram will have extra images taken with the new low-radiation method. The goal is to see if …

This study looks at whether a score called CALLY, calculated from routine blood tests, can help predict short-term problems like heart failure or death in people having emergency treatment for a heart attack. Researchers will follow 140 patients for 30 days after their procedure.…

This study will check if measuring CO2 gap, lactate, and oxygen in the blood can help predict serious problems after heart bypass surgery. About 130 adults having planned bypass surgery will be followed for 7 days after their operation. The goal is to see if these simple tests ca…

This study tests new MRI and CT imaging methods to better identify scar tissue in the heart that causes a dangerous fast heartbeat called ventricular tachycardia (VT). About 15 adults with VT and heart disease will get these scans. The goal is to see if the scans can clearly show…

This study will follow 645 older adults (65+) who come to the hospital with a heart attack. Researchers want to see if frailty—a state of reduced strength and energy—affects how doctors treat them and whether they have serious problems like death or another heart event within 30 …

This study will follow 500 people having a major heart attack (STEMI) to see how the time from symptom onset to balloon treatment affects electrical signals on their ECG and their risk of complications. Researchers will track heart rhythm problems and major events like death or a…

This study will follow 100 children aged 1 to 18 with myocarditis (inflammation of the heart muscle) to see how different types of the disease progress. Researchers will track symptoms, treatments, and outcomes over one year. The goal is to better understand which children recove…

This study looks at whether the bacteria in your gut can affect how your heart heals after a heart attack procedure called PCI. Researchers will measure a substance called TMAO, made by gut bacteria, in 144 patients. The goal is to see if TMAO levels are linked to changes in hear…

This study aims to create a risk prediction tool for ischemic stroke in people who have had a heart attack but do not have atrial fibrillation. Researchers will analyze the medical records of 4,000 past patients to see if common hospital data can accurately predict stroke risk du…

This study will enroll 850 adults over 65 who have had a heart attack (acute coronary syndrome). Researchers want to see if adding frailty measurements to standard risk scores improves the prediction of serious bleeding during the hospital stay and up to 6 months later. The goal …

This study will enroll 1,000 people with diabetes who are having an emergency procedure to open a blocked artery after a severe heart attack (STEMI). Researchers want to see if certain blood markers of inflammation and clotting can predict complications like heart failure, abnorm…

This study will follow 400 people receiving a stem cell transplant to see how often they develop heart problems like heart attacks, irregular heartbeat, or heart failure. Researchers will use heart scans, blood tests, and other tools to find early warning signs. The goal is to be…

This study looks at 100 adults with frequent extra heartbeats (PVCs) to see if hidden heart inflammation (myocarditis) is the cause. Participants will get advanced heart scans and lab tests. The goal is to better understand the link and see if anti-inflammatory therapy helps thos…