New triple drug combo aims to slash cholesterol after heart attacks
NCT ID NCT07440381
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving a triple combination of cholesterol-lowering drugs (a high-intensity statin, ezetimibe, and bempedoic acid) right after a heart attack works better than usual care. About 600 adults hospitalized for a heart attack will be randomly assigned to the triple therapy or standard treatment. The main goal is to see if the triple therapy lowers LDL cholesterol more at 8 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
bempedoic acid (a cholesterol-lowering drug) combined with a high-intensity statin and ezetimibe
What this could lead to
If it works, this could show that starting a triple cholesterol-lowering pill early after a heart attack is better than usual care at quickly reducing bad cholesterol.
What could go wrong
This is a phase 3 trial, but it has not started recruiting yet. The benefit may be modest, and bempedoic acid can cause side effects like muscle pain or gout. Results may not apply to all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Aor San Carlo - Ospedale San Carlo - Ssd Terapia Intensiva Cardiologica
Potenza, Italy
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Aorn San Giuseppe Moscati - U.O. Cardiologia/Utic 'D. Rotiroti'
Avellino, Italy
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Aou Careggi - Interventistica Cardiologica Strutturale
Florence, Italy
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Aou Policlinico P. Giaccone - U.O.C. Cardiologia
Palermo, Italy
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Arcispedale Sant'Anna - U.O. Cardiologia
Ferrara, Italy
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Arnas P.O. Civico E Benfratelli - Uoc Utic
Palermo, Italy
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Asst Ospedale Metropolitano Niguarda - Cardiologia 1 - Emodinamica
Milan, Italy
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Azienda Ospedaliera Cannizzaro - Uoc Cardiologia
Catania, Italy
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Azienda Ospedaliera S. Anna E S. Sebastiano - U.O. Cardiologia D'Emergenza Con Utic
Caserta, Italy
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FONDAZIONE IRCCS POLICLINICO SAN MATTEO - UOC Cardiologia
Pavia, Italy
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Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico - Uoc Malattie Cardiovascolari
Milan, Italy
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Irccs Ospedale Galeazzi - Sant'Ambrogio - Cardiologia Universitaria Ed Imaging Cardiaco
Milan, Italy
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Nuovo Ospedale Di Vimercate - S.C. Cardiologia E Utic
Vimercate, Italy
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OSPEDALE CA' FONCELLO - UOC Cardiologia
Treviso, Italy
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OSPEDALE CIVILE FORNAROLI - UO Cardiologia
Magenta, Italy
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OSPEDALE DEGLI INFERMI - SC Cardiologia
Rivoli, Italy
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OSPEDALE PIO XI - UOC di Cardiologia
Desio, Italy
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OSPEDALE SANTA CHIARA - Divisione di Cardiologia
Trento, Italy
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Ospedale Del Tigullio Polo Lavagna - Sc Cardiologia E Utic
Lavagna, Italy
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Ospedale Della Murgia - Fabio Perinei - S.C. Cardiologia-Utic
Altamura, Italy
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Ospedale Giovanni Paolo Ii - U.O.C. Cardiologia-Utic
Ragusa, Italy
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Ospedale Miulli - U.O.C. CARDIOLOGIA - UTIC
Acquaviva delle Fonti, Italy
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Ospedale Policlinico - Uoc Di Cardiologia
Modena, Italy
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Ospedale San Camillo - Uoc Cardiologia
Roma, Italy
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Ospedale San Donato - U.O.C Cardiologia
Arezzo, Italy
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Ospedale San Jacopo - Soc Cardiologia
Pistoia, Italy
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Ospedale San Paolo - Cardiologia-Utic
Bari, Italy
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Ospedale Santo Spirito - Cardiologia Con Utic
Pescara, Italy
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Ospedale Santo Spirito - SC Cardiologia
Casale Monferrato, Italy
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P.O. Levante - Ospedale San Paolo - S.C. Cardiologia Levante
Savona, Italy
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P.O. San Filippo Neri - Asl Roma 1 - Cardiologia Clinica E Riabilitativa
Roma, Italy
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PRESIDIO OSPEDALIERO - UO Cardiologia
Sanremo, Italy
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Po Santa Maria Nuova - Ausl Re Irccs - Soc Cardiologia Ospedaliera
Reggio Emilia, Italy
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Policlinico Riuniti - S.C. Di Cardiologia Universitaria-Utic
Foggia, Italy
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Presidio Ospedaliero "Santa Maria Del Prato" - U.O.C. Di Cardiologia-Utic
Feltre, Italy
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