Ischemic disease

This trial tests whether a chelation therapy infusion—a cocktail that removes toxic metals from the blood—can reduce the risk of heart attacks, strokes, and leg amputations in people with diabetes and critical limb ischemia (severe blockage in leg arteries). Half of the 50 partic…

This trial tests whether a home-based tele-rehabilitation program is as effective as traditional center-based cardiac rehabilitation for people who have recently had a heart attack (acute coronary syndrome). Participants will either complete 20 sessions at a rehab center or 20 se…

This early study tests a new stent system designed to treat blockages at artery branch points in the heart. It involves 13 people with heart disease who need a procedure to open these blockages. The main goal is to see if the stent can be safely placed and work as intended.

This study is following 300 people with peripheral artery disease who received the MicroStent, a small mesh tube placed in leg arteries to improve blood flow. Researchers are tracking how well the arteries stay open over time and whether patients avoid major complications like am…

This study tests a new device called the MOTIV Sirolimus-Eluting Bioresorbable Vascular Scaffold for people with severe leg artery disease (critical limb ischemia). The scaffold slowly releases medicine to keep the artery open and then dissolves over time. Researchers compare it …

This early study tests a special scaffold that dissolves over time in 10 people with severe leg artery disease (critical limb-threatening ischemia). The scaffold is placed in arteries below the knee to help keep them open after balloon treatment. Researchers check safety and how …

This study planned to test whether giving a child their own stored umbilical cord blood is safe for treating perinatal arterial ischemic stroke. It was designed for children aged 6 weeks to 6 years with MRI-confirmed stroke. The trial was withdrawn before enrolling any participan…

This trial studies nearly 1,000 people with severe aortic stenosis and blocked coronary arteries who need both a valve replacement (TAVI) and artery stenting (PCI). Researchers want to see if doing the stenting before or after the valve replacement leads to fewer deaths, heart at…

This large Phase 3 study tests whether milvexian, an experimental oral blood thinner, can prevent another stroke in people who recently had a mild stroke or a high-risk mini-stroke (TIA). Over 12,500 participants are randomly assigned to receive either milvexian or a placebo, alo…

This study tests whether using a special camera (OCT) inside the heart's arteries during a heart attack procedure leads to better outcomes than the standard X-ray method. About 3000 people having a heart attack will be randomly assigned to one of the two approaches. The goal is t…

This study looks at 3,500 unconscious patients who survived a cardiac arrest to find the best combination of sedation, fever control, and blood pressure management in the ICU. Each patient gets one of two levels for each factor (e.g., deep vs. light sedation, tight vs. loose feve…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study compares two strategies for placing stents in people with multiple blocked heart arteries. One group gets standard guidance using a pressure wire (FFR), while the other also uses an imaging catheter (OCT) to spot unstable plaques. The goal is to see if the combined app…

This study tests whether a combination of high-dose statins, blood pressure medications (ACE inhibitors or ARBs), and low-dose aspirin can reduce the risk of death, heart attack, stroke, or hospitalization in women who have chest pain or shortness of breath but no major blockages…

This study was designed to test a new surgical technique called transverse tibial bone transport in people with chronic limb-threatening ischemia (CLTI) who have no standard treatment options left. The procedure involves slowly moving a small piece of shinbone to stimulate new bl…

This study tests whether a drug-coated balloon is as safe and effective as a drug-eluting stent for people with large coronary artery disease. About 1,400 participants from multiple countries will be randomly assigned to one of the two treatments. The goal is to see which approac…

This Phase 3 study tests a weekly injection called retatrutide in about 1,946 people with severe obesity (BMI ≥35) and established heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over 113 weeks compared to a placebo. Parti…

This study tests a new device called the Acolyte Catheter System in people with completely blocked heart arteries (chronic total occlusions) who still have symptoms despite medication. The goal is to see if the catheter can safely help doctors guide wires through the blockage to …

This study tests whether a weekly injection of CagriSema (a combination of two drugs) can reduce the risk of heart attacks, strokes, and other heart-related events in people with established cardiovascular disease. About 7,100 participants will receive either CagriSema or a place…

This study tests whether using a special imaging tool called OCT during stent placement leads to fewer heart problems over two years compared to standard methods. About 1,200 adults with blocked heart arteries that need complex stenting are taking part. The goal is to see if OCT …

This study tests whether briefly inflating a blood-pressure cuff on the arm before non-cardiac surgery can reduce heart damage in high-risk patients. Over 1,200 participants will receive either the cuff procedure or no intervention. The goal is to see if this simple, low-cost tec…

This study tests whether two biofeedback devices—a balance platform (Huber) and a smart treadmill (C-Mill)—can improve balance and reduce fall risk in 120 older adults (65+) with chronic cerebral ischemia. Participants will do 8 sessions of training, and researchers will compare …

This phase 3 trial tests whether a monthly injection of pelacarsen can reduce major heart problems like heart attacks and strokes in people with high levels of Lp(a), a genetic risk factor. Over 8,000 participants with existing heart disease are being followed for several years. …

This study tests a smartphone app called MED-AD that sends reminders and tracks medication use for people with heart disease, high blood pressure, or high cholesterol. About 1,000 adults in Oman will be randomly assigned to use the app, receive daily text reminders, or get usual …

This study tests a newer drug-coated stent (Resolute Onyx) against an older one (Resolute Integrity) in 550 people with blocked heart arteries in China. The goal is to see if the new stent works better at keeping arteries open after angioplasty. Participants receive one of the tw…

This study tests a structured nutrition plan for 300 ICU patients who had abdominal surgery and cannot eat normally. The plan includes IV nutrition, oral supplements, and a device to measure calorie needs. Researchers will track infections, ICU stay length, and muscle loss to see…

This study tests a special stent coated with a drug called zotarolimus to treat people with blocked heart arteries. The stent is placed during a procedure to open the artery and slowly releases medication to prevent re-blockage. About 591 participants in China are being followed …

This study looks at whether genetic testing can help doctors pick the right antiplatelet medicine for people who have had a stroke or mini-stroke. About 350 patients will be randomly assigned to either standard care or a genetic test that checks if a common drug, clopidogrel, is …

This study tests whether a very low blood pressure target (below 120 mmHg) can prevent major heart problems in people who have had a stroke or mini-stroke. About 4,300 participants are randomly assigned to either intensive or standard blood pressure control and followed for about…

This study compares taking two blood thinners for just 1 month versus the standard 12 months after getting a heart stent. It involves over 3,700 patients with acute coronary syndrome. The goal is to see if the shorter regimen reduces bleeding risks without increasing heart proble…

This study tests a new device called the MicroStent, a small mesh tube placed in leg arteries below the knee to keep them open. It involves 177 adults with severe peripheral artery disease who have pain at rest or non-healing sores. Half get the stent plus standard balloon treatm…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This study compares two approaches—short-term anticoagulation (stronger blood thinners) versus antiplatelet therapy (milder blood thinners)—to prevent clots on a device placed in the heart's left atrial appendage. The trial involves 510 adults who have had this procedure. The goa…

This study follows about 200 people with chronic limb-threatening ischemia (CLTI) who receive the Esprit BTK System, a dissolvable scaffold coated with a drug to keep leg arteries open. The goal is to see how safe and effective it is in routine medical practice. Researchers will …

This early study tests a new freezing treatment for people who recently had a heart attack or unstable chest pain. The treatment uses a special balloon to freeze high-risk plaque in the heart's arteries that could rupture and cause another heart attack. The goal is to stabilize t…

This study tests whether giving stroke patients extra tests—like checking for hidden heart problems, artery stiffness, and leg circulation—can lower their chance of having another stroke or heart attack. About 600 people in Stockholm will get this expanded check-up and a personal…

This study follows 25 people aged 2 to 65 with cerebral palsy or brain damage from lack of oxygen who have already received a new gene therapy given as a nose spray. The therapy delivers 15 genes meant to repair the brain, reduce inflammation, and improve movement and thinking. R…

This study tests whether an implantable heart monitor with remote follow-up can help doctors decide when to prescribe blood thinners to patients who have had a heart attack and developed new atrial fibrillation. The goal is to reduce bleeding complications compared to the standar…

This trial tests whether a procedure called catheter ablation works better than anti-arrhythmic drugs for people with structural heart disease who have had a dangerous fast heart rhythm (ventricular tachycardia). About 162 participants will be randomly assigned to either ablation…

This study looks at whether people with stable ischemic heart disease (but with normal heart pumping function and no ongoing chest pain or arrhythmias) can safely stop taking beta-blockers. About 59 participants will either continue or stop their beta-blocker and be followed for …

This study is tracking 251 patients with symptomatic coronary heart disease who received the EucaLimus stent, a sirolimus-coated device designed to keep arteries open. The goal is to see how well the stent works and how safe it is over the long term in real-world use. Researchers…

This study tests whether using the Impella heart pump during a high-risk stenting procedure helps people with weak hearts and blocked arteries. About 1,250 participants will be randomly assigned to get either Impella-supported stenting or standard care. The goal is to see if the …

This study compares two types of stents (small mesh tubes) used to open blocked heart arteries in people with severe three-vessel coronary artery disease. About 1,550 participants will receive either the SUPRAFLEX Cruz or SYNERGY stent. The goal is to see which stent is safer and…

This study tests a program that combines a mobile health app, community health workers, and text message reminders to help people lower their risk of heart disease. About 968 adults in Argentina who are at high risk will take part. The goal is to see if this approach can improve …

This study tests a device called the Boomerang Catheter in 120 people with chronic limb-threatening ischemia (CLTI), a severe condition where blocked leg arteries can lead to amputation. The catheter creates a connection between a vein and an artery to reroute blood around the bl…

This study is tracking 400 people with coronary artery disease who received the ihtDEStiny drug-eluting stent during a routine procedure to open blocked heart arteries. Researchers are monitoring how well the stent works over time, including rates of heart attacks, repeat procedu…

This early-stage trial tests whether metformin, a common diabetes drug, is safe and feasible for infants who suffered brain injury from lack of oxygen at birth. Thirty infants under 6 months old will receive metformin for 6 weeks, with close monitoring of kidney and liver functio…

This study tests whether a newer type of blood thinner (DOA) works better than the standard one (VKA) for dissolving dangerous blood clots inside the heart. About 340 adults with such clots will be randomly assigned to one of the two treatments. The goal is to see which drug redu…

This study looks at how well the GENOSS stent works in real-world patients who have had a heart attack or unstable chest pain (acute coronary syndrome). Researchers are tracking heart-related events like death, heart attacks, and the need for repeat procedures. The study involves…

This study tests whether a temporary heart pump can help high-risk patients during coronary stenting. The pump supports the heart's main chamber during the procedure, aiming to prevent heart failure or death. About 300 patients with severe coronary disease and weak heart muscle w…

This study is tracking 282 patients with coronary artery disease who received a paclitaxel-coated balloon catheter (Support C DCB) during routine care. Researchers are monitoring for heart-related events like cardiac death, heart attack, or the need for repeat procedures over the…

This study tests whether using a CPAP machine to treat sleep apnea shortly after an ischemic stroke can reduce the risk of another stroke, heart attack, or death within 6 months. It also looks at whether CPAP improves overall recovery and brain function. Over 3,000 participants a…

This study looks at whether a telehealth system can help people in rural areas get better heart care. It connects local emergency services and clinics with heart experts at a major medical center. About 215 adults with heart symptoms will take part. The goal is to see if this app…

This study looks at whether giving steroids early to children who had a stroke from a condition called focal cerebral arteriopathy (FCA) can help reduce damage to the brain's arteries. About 80 children aged 1 to 18 will be randomly assigned to get steroids right away or only if …

This study tests whether a blood test can help doctors safely lower the dose of strong blood thinners (P2Y12 inhibitors) in people who recently had a heart attack or stent. The goal is to reduce bleeding complications without raising the risk of another heart attack or stroke. Ab…

This study compares two methods of prescribing high-intensity interval training (HIIT) for people in cardiac rehabilitation. Thirty adults with heart conditions will follow a 12-week exercise program to see which prescription approach improves fitness, heart function, and oxygen …

This study tests a new health management program for people with coronary heart disease who also have frailty (weakness, low energy). The program uses a mobile app to guide exercise and healthy habits, with support from a cardiac rehab center. Researchers will enroll 200 particip…

This study tests whether giving patients capsules containing gut bacteria (called Probacine) before and after heart surgery can reduce gut injury and organ failure. Researchers will enroll 500 adults undergoing cardiovascular surgery. The goal is to see if changing the gut microb…

This trial tests whether injecting a patient's own bone marrow stem cells into the heart can improve exercise ability and reduce chest pain in people with severe, untreatable angina. About 343 participants will either receive the stem cell treatment or a sham procedure. The goal …

This study looked at whether using a person's genetic information to choose their blood thinner medication after getting a heart stent can reduce the risk of heart attacks, strokes, and death. About 4,000 people with heart disease were given either clopidogrel or ticagrelor based…

This trial tests a special device called the Esprit BTK, which is a tiny mesh tube coated with a drug that helps keep leg arteries open. It is for people with critical limb ischemia, a serious condition where blocked arteries cause pain and wounds. About 261 participants will rec…

This study tests a simple idea: telling heart attack survivors that they will have an important fitness test might encourage them to attend cardiac rehab. The trial includes 200 people who had an acute coronary syndrome. The goal is to see if this nudge increases the number of pa…

This study compares a special balloon coated with sirolimus (a drug that prevents re-blockage) to a standard balloon for opening blocked arteries below the knee in people with peripheral artery disease. About 230 participants will be randomly assigned to one of the two treatments…

This study tests whether giving melatonin to full-term newborns with hypoxic-ischemic encephalopathy (HIE) — a type of brain injury from lack of oxygen at birth — can improve survival and reduce brain damage. Half of the 110 babies will receive a single dose of melatonin through …

This study tests whether using a patient's gender, weight, and kidney function to calculate the starting dose of the blood thinner heparin gets patients to the right level faster than the standard flat rate. About 145 adults with blood clots, atrial fibrillation, or mechanical he…

This study looks at a new, less invasive way to remove plaque from leg arteries in people with severe blockages that threaten the limb. About 60 participants will get the procedure, called atherectomy, to see if it can restore blood flow without needing more surgery. The goal is …

This study is checking how well a device called the GORE® CARDIOFORM Septal Occluder works and how safe it is for people who have had a stroke caused by a hole in the heart (PFO). Researchers will follow 300 patients in Japan for 12 months after the device is implanted. The goal …

This early-stage trial tests whether a stimulant drug (methylphenidate, also known as Ritalin) given through an IV can safely help people with severe brain injuries regain consciousness. Ten adults in a coma or minimally conscious state will receive increasing doses to check for …

This study was designed to test whether a supplement called chondroitin sulfate is safe for newborns with necrotizing enterocolitis (NEC), a severe gut infection. The plan was to give the supplement to very low birth weight babies for two days and compare their outcomes to those …

This study tested a stem cell treatment (HB-adMSCs) in one 84-year-old man who had a stroke. The cells were taken from his own fat tissue and given through an IV every 28 days for 6 doses. The goal was to see if it was safe and could help him recover. The study is no longer avail…

This study was designed to test the safety of a gene therapy called VM202 in people with chronic refractory myocardial ischemia—severe chest pain that doesn't improve with standard treatments. The therapy would be injected directly into the heart via a catheter. However, the tria…

This study aimed to test a gene therapy called VM202RY in people who recently had a heart attack. The treatment was injected directly into the heart muscle to help it heal and improve pumping strength. However, the trial was withdrawn before enrolling any participants, so no data…

This early-phase trial is testing whether heart muscle cells grown from stem cells can be safely injected into the hearts of 10 people with severe heart failure caused by blocked arteries. The main goal is to check for side effects over 26 weeks, while also measuring whether the …

This program allows individual patients with vascular disease or end-stage kidney disease on dialysis to request an experimental lab-grown blood vessel (ATEV) if they have no other treatment options and cannot join a clinical study. The vessel is designed to replace or bypass dam…

This study tests a program called BAT-CS that combines smoking cessation counseling with mood management for people who have had a heart attack (acute coronary syndrome). The goal is to help them quit smoking and reduce depression symptoms, which could lower their risk of dying f…

This study looks at whether SGLT-2 inhibitors, a type of diabetes medication, can prevent kidney damage from contrast dye used during heart procedures like angioplasty. Researchers will follow 3,600 adults with acute coronary syndrome who are undergoing invasive treatment. The go…

This study compares two wound treatments for people with diabetes who have severe foot wounds after leg artery surgery. One group gets standard vacuum therapy, the other gets the same therapy plus a silver nanoparticle spray applied to the wound. The goal is to see which approach…

This study looks at whether using a drug-coated balloon (DCB) on vulnerable plaques in heart arteries can prevent future heart problems. 140 people with acute coronary syndrome and non-threatening plaques were randomly assigned to get either standard medication alone or medicatio…

This study tests whether a video-based telehealth program, including an iPad and remote blood pressure monitoring, can help stroke survivors better control their blood pressure after leaving the hospital. The program also aims to reduce racial disparities in post-stroke care. Abo…

This study compares two blood thinners (ticagrelor plus aspirin) against aspirin alone after coronary artery bypass grafting (CABG) in people who recently had a heart attack or unstable angina. Over 2,200 participants are being followed for 12 months to see if the dual therapy re…

This study tests whether ivabradine, a drug that slows heart rate, can prevent heart injury after noncardiac surgery. About 2,100 high-risk patients aged 45 and older will receive either ivabradine or a placebo before and after surgery. The goal is to see if the drug reduces hear…

This study tests a device called Infrasensor that may help doctors quickly identify people with severe heart artery blockages. About 350 adults with chest pain will use the device for 5 minutes, and results will be compared to standard heart catheterization. If accurate, it could…

This study looks at better ways to find hidden atrial fibrillation (an irregular heartbeat) in people who have had a stroke. About 337 participants will use either a wearable patch for 72 hours or a handheld device three times a day to monitor their heart rhythm. The goal is to s…

This study is testing a new finger-prick blood test that measures troponin levels in about 10 minutes, compared to the usual 2-hour lab test. Researchers hope it will help diagnose heart attacks faster and reassure patients who are not having one, allowing them to be discharged s…

This large UK study (EVAREST) aims to improve how doctors interpret stress echocardiograms for diagnosing coronary artery disease. Researchers will collect blood samples and analyze echocardiogram images from up to 23,000 patients to find new biomarkers that make diagnosis more a…

This study tests whether a water-resistant, wireless ECG patch worn for 7 days can detect more cases of hidden atrial fibrillation (a heart rhythm problem that raises stroke risk) than the usual 24-hour Holter monitor. Researchers will enroll 320 adults who recently had a stroke …

This study tests a new PET heart scan that uses 100 times less radiation than current methods. Researchers will scan 200 adults with known or suspected heart artery disease to see if the ultra-low dose still produces clear images. The goal is to make heart imaging safer while kee…

This study is testing whether a special heart scan (dynamic SPECT) can accurately detect remaining blockages in heart arteries after a heart attack, compared to the current standard invasive procedure (FFR). Sixty adults with multiple blocked arteries will receive both tests one …

This study enrolls 800 patients having heart attacks to test an artificial intelligence model that reads standard 12-lead ECGs. The AI aims to detect which artery is blocked and how severely blood flow is reduced, at the moment of a heart catheterization. If accurate, this could …

This study is testing whether a device called magnetocardiography (MCG) can quickly and accurately tell if chest pain is caused by a heart attack. Researchers at Mayo Clinic will use the MCG scanner on 1,000 emergency room patients with chest pain and compare its accuracy to stan…

This study tests whether personalized risk models can safely reduce the number of diagnostic tests for people with new chest pain. Researchers will enroll 2,000 adults aged 30-75 and compare the model-based approach to standard care. They will also test a new laser method to meas…

This study explores whether a simple, non-invasive leg movement test can measure blood vessel health in older adults. Researchers will use ultrasound to track blood flow changes after a passive leg movement, comparing young healthy people and older patients undergoing heart tests…

This study is testing a new way to diagnose blocked heart arteries using an ultrasound-based method called Ultrasonic Flow Ratio (UFR). It involves 112 people with suspected heart disease. The goal is to see if UFR can accurately identify significant blockages compared to the cur…

This study was designed to see if measuring blood flow resistance in tiny leg vessels could predict whether a limb could be saved after artery-opening procedures in people with critical limb ischemia. It planned to enroll patients with severe leg artery disease and use a special …

This study looks at whether using a special camera called optical coherence tomography (OCT) during heart artery procedures helps doctors make better decisions and get better results. About 3,200 people with various heart conditions will be included. The goal is to see if OCT gui…

This study compares how well AI and radiologists diagnose brain diseases using CT and MRI scans. Over 30,000 patients will be included, and the AI has been trained on more than 100,000 previous scans. The goal is to see if AI can match human experts and whether combining AI with …

This study tests a new way to classify heart attacks based on whether a coronary artery is fully blocked (occlusion) or not, instead of the traditional ST-elevation vs non-ST-elevation method. Researchers will compare outcomes in 6,000 patients to see if the new approach leads to…

This pilot study tests a personalized lifestyle program for young adults (18-65) who have had a stroke or high-risk mini-stroke. The program includes intensive counseling on diet, exercise, and smoking, plus a wearable device to track health. Researchers want to see if this appro…

This study looks at whether clopidogrel, a blood thinner, can prevent new silent brain infarctions (small, unnoticed strokes) in people who recently had a stroke or mini-stroke. Researchers will track 134 participants over 24 months using MRI scans and cognitive tests. The goal i…

This phase 3 trial tests whether adding regular, personalized exercise to standard medical care can prevent new strokes in 1300 people with symptomatic intracranial arterial stenosis (narrowed arteries in the brain). Participants are randomly assigned to either standard care or s…

This large study tested whether taking daily vitamin D3 and omega-3 (fish oil) supplements can lower the risk of developing cancer, heart disease, or stroke. Over 25,000 healthy older adults (men 50+, women 55+) took the supplements or placebos for about 5 years. The goal is to s…

This study looks at whether aquatic therapy in a warm pool can help children ages 3-9 with conditions like cerebral palsy improve their swimming safety, arm function, and ability to do daily tasks. Children attend sessions twice a week for ten weeks. Researchers will measure chan…

This study tests a nurse-led education program designed to help women in cardiac rehab address sexual concerns after a heart event. Sixty-six women will be randomly assigned to either the program or usual care. The goal is to see if the program improves sexual function, mood, and…

This study looks at whether tai chi exercises and wearable fitness trackers can help people who have survived a heart attack (acute coronary syndrome) become more physically active. About 70 adults who are currently inactive will take part. The goal is to see if this approach is …

This trial compares three common heart-rate-lowering drugs—metoprolol, atenolol, and ivabradine—to see which one reduces heart rate fastest before a cardiac CT scan. About 350 adults aged 30–80 with a heart rate over 65 beats per minute will receive one of the drugs or a placebo.…

This study looks at whether measuring lactate in stool can help doctors predict how well critically ill patients with low blood flow will respond to treatment. About 40 adults in the ICU will provide a stool sample within 24 hours of admission. Researchers will check if high stoo…

This study looks at how caffeine is processed in newborns with hypoxic-ischemic encephalopathy (HIE), a brain injury caused by lack of oxygen, who are receiving cooling therapy. Researchers will test different doses of caffeine in 16 babies to find the safest and most effective a…

This study looks at 90 people who recently had a heart attack and have other artery narrowings that may or may not be dangerous. Researchers will use two types of scans—optical coherence tomography (OCT) and magnetic resonance angiography (MRA)—to see if they can tell which narro…

This study tests a new way to find unstable plaques in the heart arteries of people who come to the emergency room with chest pain but are not having a heart attack. Researchers use a simple calcium scan to group patients by risk, then follow up with special PET scans to see if p…

This study tracks 120 adults with heart disease and at least two other long-term illnesses to see how often dangerous drug interactions happen. Researchers check medications, including over-the-counter and herbal products, and follow participants for a year. The goal is to unders…

This study looks at how blood flow in the feet changes during a 12-week heart and blood vessel rehab program for people with narrowed arteries. Researchers will track 80 adults with conditions like peripheral artery disease or coronary artery disease. The goal is to better unders…

This study was designed to see if a device called AirGlove, which applies heat, could improve blood flow in the legs of people with peripheral arterial disease (PAD). It planned to include healthy volunteers and people with PAD who experience leg pain when walking. However, the s…

This study reviewed medical records of 1000 people who received a special balloon treatment (drug-coated balloon angioplasty) for blocked heart arteries between 2009 and 2015. Researchers tracked major heart problems like death, heart attacks, or need for repeat procedures for up…

This study looks at women who have had a heart attack or unstable angina but do not have major blockages in their heart arteries. Doctors will use special imaging techniques, like IVUS and MRI, to find hidden causes such as cholesterol plaque in artery walls or problems with tiny…

This study uses advanced CT scans to look for fat and scar tissue inside the heart. Researchers want to see if these findings can help predict who is at risk for dangerous heart rhythms. About 110 adults with heart disease who already have a defibrillator or need one will get a C…

This study looks at whether adding a stress CT scan that checks blood flow to the heart muscle helps doctors decide the best treatment for people with known or suspected heart disease. About 2000 adults will be followed to see if this extra test reduces the need for more tests an…

This study looks at whether having a rehabilitation doctor see stroke patients early in their hospital stay can shorten how long they stay and reduce the chance of coming back. Researchers are tracking 3,000 stroke patients to see if this coordinated care approach improves recove…

This study follows 500 people with peripheral artery disease (PAD) who undergo a procedure to open blocked leg arteries. Researchers check blood and heart ultrasound before and after the procedure to find hidden heart injury. The goal is to see if certain markers can predict futu…

This study tracks over 1,700 heart patients who had hip or knee replacement surgery. Researchers want to see how often bleeding or blood clots happen in the months after surgery. The goal is to find better ways to prevent these complications.

This study is creating a statewide collection of blood samples and medical information from people with various brain blood vessel diseases, such as stroke and dementia. The goal is to build a resource that scientists can use in future research to better understand and potentiall…

This study looks at whether giving a personalized dose of a radioactive tracer (rubidium-82) based on a patient's weight can improve the quality of PET heart scans. Researchers will enroll 48 adults with known or suspected heart disease and divide them into four weight groups. Th…

This study follows nearly 20,000 patients who had major non-cardiac surgery to see how often heart injury occurs and what happens a year later. Researchers are looking at death rates and major heart complications. The goal is to better understand who is at risk and how to improve…

This study looks at whether a computer model can predict heart injury after major orthopedic surgery in patients 65 and older. Researchers will combine blood tests, frailty scores, and other health data to build a machine learning tool. The goal is to help doctors spot high-risk …

This international registry is collecting information from 2000 people who have had spontaneous coronary artery dissection (SCAD), a rare cause of heart attacks. Researchers will track participants' health over time to better understand the condition and develop best practices fo…

This study looks at whether MRI or CT should be the first scan for people with suspected acute ischemic stroke. Researchers will track how often doctors follow the assigned scan type and compare outcomes. The goal is to see if a larger study comparing these imaging methods is pos…

This study is a large international registry that will collect data from up to 130,000 people who have had a heart attack or unstable chest pain. Researchers will track treatments, outcomes, and safety to understand what works best in real-world care. No new drugs or devices are …

This study tests a small sensor placed in reconstructed tissue after flap surgery. The sensor measures CO2 and temperature continuously for up to 10 days to detect early signs of poor blood flow. If it works, doctors could be alerted sooner and take action to save the tissue. Abo…

This study tests a small sensor placed in the muscle of a replanted arm or leg after traumatic amputation. The sensor continuously measures carbon dioxide and temperature to detect blocked blood flow early. If a problem is found, doctors can quickly operate to restore blood flow.…

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study looks at whether a specific type of heart stent (zotarolimus-eluting) can be expanded more than usual to treat tricky blockages. Researchers will use a special camera (OCT) to check the stent's size and safety in 30 adults with coronary artery disease. The goal is to s…

This study looks at 40 people who recently had a heart attack and had one blockage treated. Researchers will use special pressure wires and optical imaging to examine other blockages that were not treated. The goal is to see how many of these leftover blockages are actually dange…

This study looks at whether a computer-guided breathing machine (ventilator) protocol can help patients with serious brain injuries. The goal is to use low air volumes to protect the lungs while keeping carbon dioxide levels normal to protect the brain. About 728 adults on ventil…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study observes how doctors use a special imaging technique called OCT during heart stent procedures in routine care. Researchers will track 2,000 patients with heart artery blockages to see if using the MLD-MAX algorithm helps achieve better stent placement. The goal is to u…

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …

This study planned to compare virtual clinic visits (using video calls on tablets) with in-person visits for people with vascular diseases. Doctors would classify patients as low, moderate, or high risk for treatment after each visit type. The goal was to see if virtual visits co…

This study looks at whether a sticker-like sensor on the skin can accurately measure carbon dioxide levels in newborns with brain injury who are receiving cooling treatment. About 53 babies will take part. If it works, it could replace frequent blood draws and make monitoring eas…

This study looks at whether artificial intelligence can improve predictions of serious heart events in people with chest pain. Researchers will analyze stress echocardiogram results and routine medical data from about 2,281 adults. No extra visits or tests are needed for particip…

This study looks at over 3,400 newborns who are not vigorous at birth (between 35 and 42 weeks). Doctors want to see if milking the umbilical cord (pushing blood into the baby) before clamping it leads to fewer cases of brain injury or death compared to clamping the cord right aw…

This study is creating a database of medical information and biological samples (blood, urine, and cheek swabs) from 1,000 newborns with hypoxic-ischemic encephalopathy (HIE), a type of brain injury caused by lack of oxygen. The goal is to measure biomarkers in the blood that cou…

This study is a registry that follows over 1,000 people with suspected ischemic heart disease. Doctors use special tests during heart catheterization to measure blood flow and pressure in the heart's small vessels. The goal is to see if these measurements can predict future heart…

This study tracks how doctors in Spain use injectable blood thinners (cangrelor or GPIs) during heart procedures like stent placement. It includes 717 patients and will look at short-term outcomes like death, heart attack, stroke, and bleeding within 48 hours. The goal is to unde…

This study follows about 300 children who had seizures shortly after birth to see if their genes influence whether they develop epilepsy later in childhood. Researchers will combine genetic information with brain scans and EEG results to create a risk score. No new treatments are…

This study looks at whether a quick, point-of-care blood test for heart damage can give results faster than standard lab tests for people with chest pain in the emergency room. Researchers will compare the time it takes to get test results and how long patients stay in the ER. Th…

This study will use advanced heart scans (coronary CT angiography) on 4,000 people with rheumatoid arthritis aged 50-75. The goal is to better understand why people with this condition have higher risks of heart attacks, strokes, and lung problems. Researchers will track particip…

This study looks at whether a coaching program called BA-HD is practical and well-liked by adults who had a heart attack in the last 2 to 12 months and feel depressed. Sixty participants from three states will either get the coaching or usual care. The goal is to prepare for a la…

This study follows over 5,000 people with stable heart disease who were previously treated with either an invasive strategy (like stents or bypass surgery) plus medication, or medication alone. Researchers want to see which approach leads to better survival over 10 years. The goa…

This study tracks how much of a drug called everolimus enters the blood after placing a special coated device (Esprit BTK) in leg arteries of people with severe blocked leg circulation (critical limb ischemia). About 7 participants will have blood samples taken over 60 days. The …

This study looks at how being in a hospital intensive care unit (ICU) after heart surgery affects your body's natural sleep-wake cycle. Researchers will track sleep patterns and thinking ability in 15 adults to see if disrupted rhythms slow down recovery. The goal is to understan…

This study looks at whether routine screening for heart disease is a good use of healthcare money for people with type 2 diabetes who are at very high risk but have no known heart problems. Researchers will analyze data from 90,000 patients in French health databases to compare c…

This study uses MRI scans to see how the brain's blood vessels react when people breathe in extra carbon dioxide. Researchers want to compare healthy adults and those with brain blood vessel diseases. The goal is to learn more about brain blood flow and oxygen use, which could he…

This study looks at people with rare adrenal tumors (pheochromocytomas and paragangliomas) that do not produce excess hormones. Researchers want to see if these 'silent' tumors still cause heart problems, blood pressure changes, or metabolic issues like diabetes and high choleste…

This study looks at two methods for setting the pressure of a tourniquet (a tight band that stops blood flow) during surgery for a broken wrist. The goal is to see which method gives surgeons a clearer view, causes less pain, and leads to fewer complications. About 140 adults hav…

This study is testing whether a device that gently stimulates a nerve in the ear is safe and tolerable for healthy children. Ten children will receive a single 30-minute session while their heart rate, oxygen levels, and brain waves are monitored. The goal is to learn how the sti…

This study looks at whether adding regular ultrasound scans to standard check-ups helps people who had keyhole surgery for blocked leg arteries. About 70 adults with chronic limb threatening ischaemia will be split into two groups: one gets usual clinic visits, the other gets ext…

This study aimed to see if using a special pad along with a standard closure device could help patients get out of bed sooner after a heart catheterization. It was planned for adults having the procedure through the groin. However, the study was withdrawn before any participants …

This study is collecting information from 500 people who had a first heart attack and received a cardiac MRI. The goal is to see if MRI images of the heart can help predict who will have future heart problems like heart failure or need a heart transplant. Researchers are looking …

This study involves 500 people who have chest pain or other signs of heart trouble, but whose main heart arteries are not blocked. Researchers use special tools during a heart catheterization to measure tiny blood vessel function and look for hidden causes like microvascular dise…

This study looks back at over 2,400 people diagnosed with acute mesenteric ischemia (a sudden blockage of blood flow to the intestine) in a region of Sweden between 2000 and 2023. Researchers want to understand how often it occurs, how treatments and survival have changed over ti…

This study looks at why some women with chest pain or signs of heart disease have normal-looking large arteries but still have problems with tiny blood vessels in the heart. Researchers will measure platelet activity and inflammation during a heart catheterization to see if these…

This study looks at three ways to treat severely hardened heart arteries before placing a stent: using sound waves (lithotripsy), a high-pressure balloon, or a tiny rotating device (orbital atherectomy). The goal is to see how each method affects the small blood vessels in the he…

This study looks at whether modern medicines (like statins and newer blood thinners) can keep the one-year stroke rate below 5% in people with narrowed neck arteries who have already had a minor stroke or warning signs. About 114 participants are being followed to see how well th…

This study is collecting information from 458 people with critical limb-threatening ischemia, a severe form of peripheral artery disease that can lead to amputation. The goal is to learn how different treatments affect patients' daily lives and health outcomes. Researchers hope t…

This study follows 347 heart surgery patients to understand why some develop swallowing problems (dysphagia). Researchers will use special camera tests to watch how patients swallow and look for risk factors. The goal is to create simple tools that doctors can use at the bedside …

This study is following 10,000 adults who are having a heart MRI for medical reasons. Researchers want to see if the MRI results can help predict who will have heart problems in the future, like heart attacks or heart failure. The goal is to better understand how MRI scans can gu…

This study looks back at over 5,500 people with known or suspected heart disease who had a stress heart MRI. Researchers want to see if the MRI results can predict who is at higher risk of dying over many years. The goal is to help doctors better understand test results and guide…

This study follows 1,400 women who had a stroke with no known cause. Researchers use a small implantable heart monitor to check for hidden atrial fibrillation, an irregular heartbeat that can cause strokes. The goal is to see if detecting this condition and using blood thinners c…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. The study was withdrawn before enrolling …

This study looks back at medical records of 1,000 people who had a special test during a heart catheterization to measure blood flow in their heart arteries. Researchers want to see if the test results can predict future heart attacks, the need for another procedure, or death fro…

This study compares specially trained nurses to interventional cardiologists in performing radial catheterization for elective coronary angiography. Over 1,600 participants will be randomly assigned to have the procedure done by a nurse or a cardiologist. The goal is to see if nu…

This study aimed to create a 12-month profile of patients admitted for vascular surgery at University Hospital Limerick in Ireland. The goal was to understand patient characteristics like frailty and other health conditions to improve hospital services and reduce length of stay. …

This study was designed to see if helping heart patients with social problems like food, housing, and mental health could keep them out of the hospital. The researchers planned to screen patients and connect them to community resources. However, the study was withdrawn before enr…