Heart study seeks clues to hidden cause of chest pain in women

NCT ID NCT03537586

Ongoing Knowledge-focused Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at why some women with chest pain or signs of heart disease have normal-looking large arteries but still have problems with tiny blood vessels in the heart. Researchers will measure platelet activity and inflammation during a heart catheterization to see if these factors are linked to microvascular dysfunction. The goal is to find better ways to diagnose and understand this condition, which affects up to 40% of women with stable heart disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help identify non-invasive ways to diagnose coronary microvascular dysfunction and point toward new treatment targets.
What could go wrong: This is an observational study, not a treatment trial, so it will not directly benefit participants. The findings may not apply to men or other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary microvascular disorder Microvascular Angina myocardial ischemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY MICROVASCULAR DISEASE ISCHEMIC HEART DISEASE MYOCARDIAL ISCHEMIA

Contacts and locations

Locations

New York University School of Medicine

New York, New York, 10016, United States

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