National Cancer Institute (nci)

This study is testing whether a bone marrow or blood stem cell transplant from a healthy donor can cure people with severe primary immune deficiencies. The goal is to replace the patient's faulty immune system with a healthy one from a donor. Researchers are enrolling 354 patient…

This study is testing whether a stem cell transplant can cure people with serious inherited immune system disorders. Doctors will give patients healthy stem cells from a donor to try to rebuild their immune system. The goal is to see if this procedure can successfully replace the…

This is an early-stage study to check the safety and immune response of a new vaccine called RG1-VLP. It aims to protect against additional types of human papillomavirus (HPV) that can cause cancer but aren't targeted by current vaccines like Gardasil-9. The trial will enroll 18 …

This early-stage trial is testing the safety and best dose of a new drug, ZEN003694, when given with the standard chemotherapy capecitabine. It is for adults with advanced solid tumors (like colorectal cancer) that have spread or cannot be removed by surgery and have worsened on …

This study is testing whether a pill called olaparib can help control advanced bladder and other urinary cancers that have specific genetic problems in their DNA repair system. It is for patients whose cancer has spread or worsened despite prior treatments like chemotherapy or im…

This study is testing whether starting a two-drug treatment early, before patients show symptoms, leads to better survival for people with high-risk chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). It will compare early treatment to the current standard of …

This study is testing an oral drug called pacritinib for adults with moderate to severe chronic graft-versus-host disease (cGVHD) that has not improved after at least two prior treatments. cGVHD is a serious immune reaction that can occur after a stem cell transplant. The goal is…

This study is testing a new treatment approach for young people (up to age 21) newly diagnosed with nasopharyngeal carcinoma (NPC), a type of head and neck cancer. It combines standard chemotherapy drugs with an immunotherapy drug called nivolumab, followed by radiation and more …

This early-stage trial is testing the safety and best dose of an experimental drug called triapine when given with radiation therapy. It's for adults whose glioblastoma or astrocytoma brain tumors have returned after previous treatment. The main goal is to find out if the combina…

This study is testing whether adding an immunotherapy drug (PDS01ADC) to a standard prostate cancer pill (enzalutamide) works better than the pill alone for men whose prostate cancer has returned after initial treatment. The goal is to see if the combination keeps prostate-specif…

This study is testing whether the immunotherapy drug nivolumab can slow or stop the growth of certain cancers linked to the Epstein-Barr virus (EBV). It is for people aged 12 and older with EBV-positive lymphomas or related disorders who have few or no standard treatment options …

This trial is testing an experimental cell therapy for people with metastatic melanoma that has spread. Doctors take a patient's own immune cells from a tumor, grow them in large numbers in a lab, and then infuse them back into the patient. The study is also testing whether addin…

This trial is testing if a simple blood test can help doctors decide which patients need extra treatment after surgery for aggressive bladder cancer. The test looks for tiny pieces of cancer DNA in the blood. Patients with a positive test will receive immunotherapy drugs to try t…

This study is testing whether a radioactive drug called lutetium Lu 177 dotatate can shrink tumors in men with a specific, aggressive form of advanced prostate cancer that has spread. The drug is designed to seek out and deliver radiation directly to cancer cells that have certai…

This study aims to improve a treatment for cancer that has spread to the lining of the abdomen. The treatment involves surgery to remove tumors, followed by a heated chemotherapy wash inside the abdomen. Researchers will test different chemotherapy drugs on tumor samples in the l…

This study is testing if giving an extra infusion of a donor's immune cells one week after a blood cancer transplant can help prevent the cancer from coming back. It involves adults with high-risk blood cancers who receive a transplant from a relative. The main goal is to find th…

This study is testing whether two drugs that help the immune system fight cancer can help people with advanced Kaposi sarcoma (KS), a type of skin cancer. Up to 80 adults whose KS has been treated before will receive injections of PDS01ADC alone or combined with M7824, given thro…

This study is testing whether a radioactive drug called Lu-177-DOTATATE can safely help control rare adrenal and nerve-related tumors that cannot be removed by surgery. Adults with these specific tumors that show up on a special PET scan will receive four doses of the drug over s…

This study is for adults with advanced neuroendocrine tumors in the digestive system that have spread and cannot be removed by surgery, and have worsened after a previous course of a targeted radiation therapy. It aims to see if getting a second course of that same radiation trea…

This study is testing a drug called tivozanib for people with advanced bile duct cancer (cholangiocarcinoma) that cannot be removed by surgery and has continued to grow after initial chemotherapy. The main goals are to find a safe dose and see if the drug can shrink or stop the g…

This study is testing a new drug, rhIL-15, combined with three standard cancer drugs, for children and young adults whose neuroblastoma has come back or hasn't responded to other treatments. The main goal is to find the safest and most effective dose of this new combination. Part…

This study is testing if giving radiation therapy before surgery is safe for people with a rare adrenal gland cancer that has come back. Up to 32 adults whose cancer can be surgically removed will receive a few weeks of radiation, followed by surgery about a month later. The main…

This study is testing the safety of the immunotherapy drug nivolumab in people who have both advanced cancer and an autoimmune disease like lupus, rheumatoid arthritis, or Crohn's disease. It will enroll 300 adults to see how well they tolerate the treatment and to find the right…

This study is testing whether a supplement called Urolithin A can help reduce cellular stress in prostate cancer tumors. It involves 90 men who are already scheduled to have their prostate surgically removed. Participants will take either the supplement or a placebo for 3 to 6 we…

This study is testing whether the drug talazoparib can help control advanced cancers in patients whose tumors have specific genetic mutations that affect DNA repair. The trial is for adults with various advanced solid tumors (like breast, ovarian, prostate, pancreatic, or gastric…

This study is testing if using a lower dose of a chemotherapy drug (cyclophosphamide) after a bone marrow transplant can reduce side effects while still effectively preventing a dangerous complication where donor cells attack the patient's body. It is for adults aged 18-85 with b…

This study is testing whether a stem cell transplant from a donor can successfully treat VEXAS syndrome, a rare and serious condition that causes severe inflammation and blood problems. Adults with severe VEXAS who haven't responded to standard treatments will receive donor stem …

This study is testing if adding an immunotherapy drug called cemiplimab to standard chemotherapy before surgery works better than chemotherapy alone for a type of head and neck cancer. It aims to see if the combination can better shrink tumors, improve survival, and potentially h…

This study is testing an oral medication called pacritinib for people aged 12 and older with myelodysplastic syndromes (MDS) or related blood disorders. The goal is to find a safe and effective dose for teenagers and to see if the drug can help control the disease in adults who h…

This study is for people with weakened immune systems who have advanced skin cancer that has returned or spread. It compares a new combination of drugs given as an injection (amivantamab with hyaluronidase) against a standard drug given by IV infusion (cetuximab). The goal is to …

This study is testing a new approach to dosing a cancer immunotherapy drug called atezolizumab. Researchers want to see if they can use blood tests to personalize the timing and amount of the drug, aiming to use lower doses less often while still keeping it effective. The goal is…

This study is testing whether adding an immunotherapy drug (cemiplimab) to a targeted cancer drug (cabozantinib) works better for controlling advanced adrenal cancer than the targeted drug alone. It will involve about 48 adolescents and adults whose cancer has spread, returned, o…

This early-stage study is testing a new, personalized treatment for people with hard-to-treat blood cancers like leukemia and myelodysplastic syndrome. Researchers take a patient's own immune cells (T cells), modify them in a lab to better target their specific cancer, and then i…

This study aims to find the safest schedule for giving radiation treatment to people whose glioblastoma brain tumors have returned after previous radiation. Researchers will test three different treatment lengths (1, 2, or 3 weeks) in 28 adults with recurrent grade 4 brain tumors…

This study is testing whether a stem cell transplant from a donor can treat GATA2 deficiency, a genetic condition that causes serious infections and blood cancers. Participants (ages 6-70) will receive chemotherapy and then donor stem cells to try to rebuild their immune system. …

This early-stage study is testing the safety and best dose of a new two-drug combination for people with advanced bladder cancer that has spread and no longer responds to standard immunotherapy. The trial combines an experimental pill (CA-4948) with an existing immunotherapy drug…

This study is testing whether giving a new combination of immune-boosting drugs before surgery can help the body fight head and neck cancer more effectively. It will enroll 40 adults with a specific type of head and neck cancer who are scheduled for tumor-removal surgery. The goa…

This early-stage study is testing a new combination of three drugs (iadademstat, venetoclax, and azacitidine) for adults with newly diagnosed acute myeloid leukemia (AML) who have not yet received treatment. The main goals are to find the safest and most effective dose and to und…

This early-stage trial is testing the safety and best dose of a new oral drug called ASTX727 when given alongside standard chemotherapy (paclitaxel) and immunotherapy (pembrolizumab) for metastatic triple-negative breast cancer. The study aims to see if adding ASTX727 can help sh…

This large study is testing whether adding an immunotherapy drug called durvalumab to standard chemotherapy is better at preventing cancer from returning than chemotherapy alone. It is for adults with a specific high-risk type of breast cancer (HR-positive, HER2-negative, stage I…

This study is testing a two-drug combination (glofitamab and obinutuzumab) for adults with mantle cell lymphoma, a type of blood cancer, that has come back or stopped responding to a previous advanced treatment called CAR T-cell therapy. The main goal is to see if this new approa…

This early-stage study is testing whether a patient's own immune cells can be genetically modified to fight certain T-cell lymphomas that have returned or not responded to standard treatments. Doctors will collect white blood cells from participants, alter them in a lab to target…

This study is testing whether a daily pill called enasidenib can help control advanced cancers in the nasal cavity or skull base that have returned or spread. It is for adults whose cancers have a specific genetic change (IDH2 mutation) and have worsened after prior treatments. T…

This study is testing a two-step treatment for a type of blood cancer called B-cell acute lymphoblastic leukemia (ALL). It is for older adults who are newly diagnosed or for adults whose cancer has come back or hasn't responded to other treatments. The treatment first uses a targ…

This study is for people with advanced bladder cancer that has spread and has stopped responding to a common type of immunotherapy. It aims to see if a new combination of two drugs (pembrolizumab and sacituzumab govitecan) works better and helps people live longer than the curren…

This study is testing whether two existing cancer drugs, nilotinib and paclitaxel, can help shrink or stop the growth of rare, advanced cancers. It is for adults whose cancer has continued to grow despite standard treatments. Participants will take the drugs in repeating cycles a…

This study is testing a new type of personalized cell therapy for adults with advanced cancers that have a specific marker called CD70. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer, and then infuse them back int…

This large study is testing whether adding a newer drug called cabozantinib to standard chemotherapy works better for treating newly diagnosed osteosarcoma, a type of bone cancer. It will involve over 1,100 children and young adults under 40. The goal is to see if the combination…

This early-stage study is testing whether two new immunotherapy drugs, M7824 and PDS01ADC, can help the body's immune system fight advanced bladder, kidney, and related cancers that have spread. Researchers want to see if adding a precise, high-dose radiation treatment (SBRT) mak…

This study is testing whether adding a new drug called sapanisertib to an existing drug, cabozantinib, works better than cabozantinib alone for people with advanced liver cancer that has a specific genetic change (β-catenin mutation). The first part of the trial will find the saf…

This early-stage study is testing a new type of personalized cell therapy for people with advanced solid tumors, including mesothelioma, that have come back or spread after standard treatments. Doctors collect a patient's own immune cells, genetically modify them in a lab to bett…

This study is testing a new, highly focused radiation treatment for men with early-stage prostate cancer that is confined to one spot in the prostate. The goal is to see if delivering a high dose of radiation directly to the tumor in just two sessions can effectively control the …

This study is testing a drug called abemaciclib for people with Neurofibromatosis type 1 (NF1) who have nerve tumors called atypical neurofibromas. The main goals are to find a safe dose of the drug and to see if it can shrink these tumors, which can sometimes turn into cancer. P…

This early-stage study is testing whether adding a new oral drug called ipatasertib to the standard treatment of chemotherapy plus radiation is safe and more effective for people with locally advanced head and neck cancer. The main goal is to find the safest and most effective do…

This study is testing the safety and effectiveness of a combination of five targeted drugs (called ViPOR) for adults whose B-cell lymphoma has come back or not improved after prior treatment. The goal is to see if this drug mix can control the cancer. Participants will receive th…

This early-stage study is testing whether adding the drug pomalidomide to standard chemotherapy (with or without rituximab) is safe and tolerable for adults with HIV and aggressive B-cell lymphomas. The main goal is to find the highest dose that doesn't cause severe side effects.…

This study is for people with cervical cancer that has spread to nearby tissues or lymph nodes. It compares two treatment plans that combine chemotherapy, radiation, and an immunotherapy drug called pembrolizumab. One plan adds extra chemotherapy and immunotherapy at the start. T…

This is a first-in-human study to find a safe dose and understand the side effects of an experimental drug called TAK-243. It is for adults with acute myeloid leukemia or myelodysplastic syndromes that have returned or not responded to prior treatments. The drug is given by IV an…

This early-stage study is testing the safety and best dose of a new two-drug combination for multiple myeloma that has come back or stopped responding to other treatments. The trial combines an oral pill (iberdomide) that targets cancer cell proteins with an injected immunotherap…

This early-phase study is testing the safety of a new personalized treatment for advanced cancers, primarily liver cancer. Doctors take a patient's own immune cells, modify them in a lab to better target cancer, and infuse them back. The main goal is to see if this approach is sa…

This study is for older adults or those too frail for intensive chemotherapy who have a newly diagnosed, specific type of acute myeloid leukemia (AML) with an FLT3 mutation. It aims to see if adding a third drug, gilteritinib, to the standard two-drug treatment (azacitidine and v…

This study is testing a new combination of drugs designed to prevent a dangerous complication called graft-versus-host disease (GVHD) after a bone marrow transplant. The goal is to see if this approach is safe and effective for people living with HIV who have blood cancers that c…

This early-stage study is testing a new type of personalized cell therapy for children and young adults whose rhabdomyosarcoma (a muscle cancer) has come back or hasn't responded to standard treatments. Doctors take a patient's own immune cells, modify them in a lab to better tar…

This study is testing whether combining two existing cancer drugs—pembrolizumab and aldesleukin—works better than either alone for adults with advanced melanoma or kidney cancer that has stopped responding to standard treatments. The goal is to see if this combination can shrink …

This early-phase study aims to find a safe and tolerable dose of a new drug combination for people with advanced breast cancer and other solid tumors that have a protein called HER2. The trial will test pidnarulex, which aims to stop tumor cell growth, together with an existing t…

This early-stage study is testing the safety and best dose of a two-drug combination for people with B-cell lymphomas that have come back or stopped responding to other treatments. The treatment pairs an immunotherapy drug (nivolumab) with a pill (ASTX727) that may help the immun…

This early-stage study is testing a new oral drug, SNDX-5613, when given alongside standard chemotherapy for adults newly diagnosed with specific genetic types of acute myeloid leukemia (AML). The main goals are to find the safest and most effective dose of the new combination an…

This study is testing whether a combination of two oral drugs, ZEN-3694 and talazoparib, can shrink or stop the growth of advanced solid tumors that have specific genetic features. It aims to enroll 88 adults whose cancer has progressed despite prior treatments. A key goal is to …

This study is for adults whose nasopharyngeal cancer (a type of head and neck cancer linked to the Epstein-Barr virus) has returned or spread. After initial chemotherapy and immunotherapy, patients who are stable are randomly assigned to continue with standard immunotherapy alone…

This early-stage study aims to find a safe dose for a new combination treatment for pancreatic cancer that has grown locally but cannot be removed by surgery. The treatment combines a targeted drug (olaparib), an immunotherapy drug (durvalumab), and radiation therapy. The main go…

This study is testing a new drug called PT-112 for people with advanced thymoma or thymic carcinoma, rare cancers that have returned or worsened after standard chemotherapy. The main goal is to see if the drug can shrink tumors. Participants will receive PT-112 by IV infusion in …

This study is testing a new combination of two drugs, sasanlimab and palbociclib, for people with advanced kidney cancer. The goal is to find a safe and effective dose and to see if the treatment can shrink tumors. It is for adults with specific types of kidney cancer who have li…

This study is testing a new combination of four immunotherapy drugs for people with metastatic colorectal cancer that has spread and stopped responding to standard treatments. The goal is to see if this multi-drug approach can help the body's immune system fight the cancer more e…

This early-stage trial is testing a new drug called pidnarulex (CX-5461) in adults with aggressive, hard-to-treat B-cell lymphomas that have a specific genetic feature called MYC aberration. The main goals are to find the safest and most effective dose and to see if the drug can …

This study is testing if adding a new drug, enasidenib, to a standard treatment works better for controlling a high-risk type of myelodysplastic syndrome (MDS), a bone marrow disorder. It will involve about 54 adults with a specific genetic change (IDH2 mutation) who have not had…

This study is testing whether a lab-made protein called CYT107 can shrink Kaposi sarcoma tumors in people living with HIV. Participants receive weekly injections for four weeks to see if boosting their immune system helps fight the cancer. The goal is to see if this approach can …

This early-stage trial is testing the safety and best dose of combining two targeted cancer drugs for people with advanced pancreatic neuroendocrine tumors (PNETs). One drug blocks signals that help tumors grow, while the other delivers radiation directly to cancer cells. Researc…

This large, late-stage trial is comparing three different drug combinations for treating advanced or recurrent endometrial (uterine) cancer that has specific genetic features. It aims to see if adding a drug called bevacizumab to standard chemotherapy and immunotherapy helps pati…

This study is testing an oral drug called pacritinib for two rare, severe inflammatory diseases caused by the Kaposi sarcoma herpesvirus (KSHV) in people living with HIV. Up to 75 adults with either KSHV-associated multicentric Castleman disease (MCD) or KSHV inflammatory cytokin…

This study is testing if adding an experimental pill called M3814 to a short, intense course of radiation therapy is safe and more effective than radiation alone for people with locally advanced pancreatic cancer. The goal is to better control the cancer and stop it from growing …

This study is comparing two different drug combination strategies for people newly diagnosed with a rare, slow-growing blood cancer called Waldenström's macroglobulinemia. About 92 participants will be randomly assigned to receive either a combination of ibrutinib and rituximab (…

This study is testing whether a pill called erdafitinib can help control a specific type of recurrent brain tumor (glioma) that has a particular genetic change. It is for adults whose tumors have grown back or worsened after initial treatment. The drug aims to block a faulty prot…

This study is testing a new, focused treatment for prostate cancer that uses heat from an ultrasound device to destroy tumors. The procedure is guided by MRI imaging to precisely target the cancer. The goal is to control the disease while potentially avoiding the common side effe…

This study is testing whether a newer drug called mosunetuzumab is better than the standard drug rituximab at keeping a rare, slow-growing lymphoma from getting worse. About 70 adults with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) will be randomly assigned to receiv…

This study is testing a new treatment approach for people who have had a kidney transplant and now have advanced skin cancer that cannot be removed by surgery or has spread. The goal is to see if a combination of cancer immunotherapy drugs (nivolumab and ipilimumab) can be given …

This study is testing if adding the drug nivolumab to a standard immunotherapy (blinatumomab) works better for controlling B-cell acute lymphoblastic leukemia (B-ALL) that has come back after initial treatment. It is for children and young adults aged 1 to 31 who have had their f…

This study is testing whether adding a personalized vaccine to standard immunotherapy and chemotherapy helps control advanced triple-negative breast cancer that has spread. It will compare two groups of about 70 patients total: one gets the vaccine plus standard drugs, the other …

This study is testing if adding an immunotherapy drug called atezolizumab to standard chemotherapy works better for controlling a rare and aggressive type of cancer that starts outside the lungs. It will involve about 189 adults whose cancer has spread and cannot be removed by su…

This study is testing a new targeted radiation drug for adults whose gastrointestinal neuroendocrine tumors (GI NET) or adrenal tumors (pheochromocytoma/paragangliomas) have spread and cannot be removed by surgery, and have already been treated with a similar type of radiation th…

This trial is a large screening program that matches patients with advanced solid tumors to one of many smaller treatment studies. It uses genetic testing on a patient's tumor to find specific mutations. Patients are then assigned to a drug combination designed to target those mu…

This study is testing a new approach for adults with aggressive blood cancers that are hard to cure. It combines two powerful treatments—a bone marrow transplant from a partially matched donor and genetically modified immune cells (CAR-T cells)—given at the same time. The goal is…

This study is testing if adding an immunotherapy drug called durvalumab to standard chemotherapy before surgery helps people with a high-risk type of liver cancer called cholangiocarcinoma. The goal is to shrink the tumor before the operation, potentially making surgery more succ…

This early-stage study aims to find a safe dose of two drugs, pomalidomide and nivolumab, for adults whose cancers are caused by viruses. It is for people with cancers like Kaposi sarcoma, certain lymphomas, and HPV-linked cancers that have not responded to standard treatments. T…

This early-phase study is testing whether adding two inhaled antibiotics to a standard immunotherapy drug (pembrolizumab) is safe and feasible for people with advanced non-small cell lung cancer. The idea is that bacteria in the lungs might help tumors grow, and treating these ba…

This study is testing if adding a drug called dinutuximab to the first stage of treatment helps children with newly diagnosed high-risk neuroblastoma. Dinutuximab is an immunotherapy that helps the body's own immune system find and kill cancer cells. The trial will compare the cu…

This study is testing if a daily pill called osimertinib can help control advanced non-small cell lung cancer that has a specific genetic change called an EGFR exon 20 insertion. It is for adults whose cancer has worsened after at least one prior treatment. The main goal is to se…

This study is testing whether combining two drugs, cabozantinib and nivolumab, can help control advanced melanoma or head and neck cancer that has worsened despite standard immunotherapy. It will enroll about 150 adults whose cancer has progressed on prior treatment. A key goal i…

This study is testing a personalized cell therapy for adults with advanced B-cell leukemias that have not responded to standard drugs. Doctors take a patient's own immune cells, modify them in a lab to target a protein (CD19) found on their cancer cells, and then infuse them back…

This study is testing a new treatment approach for people with advanced soft tissue sarcomas, including leiomyosarcoma and dedifferentiated liposarcoma. It aims to find the safest dose and best schedule for combining the drug abemaciclib with chemotherapy (gemcitabine). The main …

This study is testing whether a pill called venetoclax can help control hairy cell leukemia that has come back after previous treatments. About 20 adults whose cancer has relapsed will take the daily pill for up to 19 months. Researchers want to see if the treatment shrinks the c…

This early-stage study aims to find the safest dose of two oral drugs—ZEN003694 and abemaciclib—when given together to patients with advanced cancers that have spread or cannot be removed by surgery. The trial will enroll about 45 adults and teens (12+) with specific cancers, inc…

This study is testing a new two-drug combination (tovorafenib + rituximab) for hairy cell leukemia that has come back or hasn't responded to prior treatment. It will also compare this new combo to the current standard treatment (cladribine + rituximab) for patients who haven't st…

This study is testing whether adding a new drug called iadademstat to an existing treatment (ASTX727) works better for controlling advanced blood cancers. It will involve about 62 adults with specific aggressive forms of myeloproliferative neoplasms (MPNs) that have progressed. T…

This early-stage study is testing a new combination of two drugs, DS-8201a and olaparib, for people with advanced cancers that have a protein called HER2. The main goal is to find the safest and most effective dose. Researchers will also check if the treatment helps shrink or con…

This study is for patients who have had surgery for high-risk head and neck cancer. It aims to find the best combination of radiation and drugs to prevent the cancer from coming back. Researchers are comparing the standard treatment (radiation with cisplatin) to two newer approac…

This study is for people with advanced HER2-positive cancers that have come back or spread. It aims to see if taking two targeted drugs together works better than taking one alone to slow or stop cancer growth. About 70 participants will be randomly assigned to one of the two tre…

This study is testing if adding an experimental vaccine (PRGN-2009) to standard chemotherapy can effectively treat newly diagnosed HPV-linked throat cancer. The goal is to see if this combination can control the cancer so well that patients can avoid radiation therapy, which ofte…

This study is testing if adding a new immune-boosting drug (CDX-1140) to an existing immunotherapy (cemiplimab) works better before surgery for advanced head and neck cancer. The goal is to shrink the tumor more effectively, which could lead to less extensive surgery. About 44 pa…

This study is for people with advanced stomach or esophageal cancer that has worsened after initial treatment. It tests if adding an immunotherapy drug called nivolumab to the standard two-drug chemotherapy helps control the cancer better and helps patients live longer. About 224…

This study is testing whether adding a new immune-stimulating drug called PDS01ADC to a specialized liver cancer treatment can better control advanced cancers that have spread to the liver. The treatment involves surgically placing a pump that delivers chemotherapy directly to th…

This study is for children and young adults (ages 2-21) with a specific type of slow-growing brain tumor called low-grade glioma. It compares a newer oral drug, selumetinib, to the current standard intravenous chemotherapy (carboplatin and vincristine). The main goal is to see if…

This study is testing whether a combination of radiation therapy and an immunotherapy drug (pembrolizumab) can help patients with muscle-invasive bladder cancer avoid having their bladder surgically removed. It is for patients whose tumors have shrunk significantly after initial …

This study is testing an oral drug called mirdametinib for adults with chronic lymphocytic leukemia (CLL) or a related lymphoma that has returned or stopped responding to standard treatments. The drug aims to block a specific signal that tells cancer cells to grow, potentially sl…

This study is for people whose endometrial (uterine) cancer has returned after treatment. It compares two different immunotherapy approaches to see which is better at controlling the cancer. One group gets a single immunotherapy drug (nivolumab), while the other gets a combinatio…

This study is testing whether adding two newer drugs, blinatumomab and venetoclax, to standard chemotherapy works better for babies under one year old with a rare and aggressive type of blood cancer called acute lymphoblastic leukemia (ALL). The main goal is to see if these combi…

This study is for people with early-stage non-small cell lung cancer who have had surgery and whose initial treatment completely removed the cancer. It compares two approaches: one group receives a year of immunotherapy (durvalumab) to try to prevent the cancer from returning, wh…

This study is testing a new four-drug combination for adults with advanced bile duct cancer that has worsened after initial treatment. The goal is to see if adding a new immunotherapy drug (CDX-1140) to standard chemotherapy and another immunotherapy (Keytruda) can better control…

This study is testing whether a new targeted radiation treatment is better than a standard pill at controlling advanced lung neuroendocrine tumors (also called carcinoid tumors). The new treatment, called lutetium Lu 177 dotatate, is an IV drug that seeks out and delivers radiati…

This study is testing the safety and effectiveness of a new two-drug combination for people with advanced solid tumors, including pancreatic cancer, that have spread or stopped responding to standard treatments. The trial aims to find the best dose and see if the drugs can help c…

This early-stage study is testing the safety and best dose of a new two-drug combination for people with advanced solid tumors that have a specific marker called HER2. The treatment pairs an existing targeted cancer drug with a new pill that aims to block cancer cells' ability to…

This study is testing whether adding an immunotherapy drug called durvalumab to standard chemotherapy is safe and can help the immune system better fight cancer. It is for adults with advanced solid tumors that have spread or cannot be removed by surgery. Researchers will monitor…

This study is testing two personalized treatment plans for anal cancer in people living with HIV. For patients with low-risk cancer, researchers are testing a reduced dose of chemotherapy and radiation to see if it's effective with fewer side effects. For patients with high-risk …

This study is testing an experimental drug called daratumumab for people with rare, aggressive types of lymphoma that have come back or haven't responded to standard treatments. The drug is given as a simple injection under the skin. Researchers want to see if it can help control…

This early-stage study is testing a new combination of six different targeted drugs for adults whose B-cell lymphoma has come back or hasn't responded to previous treatment. The main goal is to find the safest dose of this combination and see if it can help control the cancer. Re…

This study is testing an oral drug called zotiraciclib for people whose aggressive brain tumors (gliomas) have come back after prior treatment. It is specifically for patients whose tumors have certain genetic changes (IDH1 or IDH2 mutations). The main goals are to find a safe do…

This study is for people whose head and neck cancer has come back after initial treatment. After surgery, it compares a newer immunotherapy drug (pembrolizumab) to the standard combination of chemotherapy and radiation. The main goal is to see if the immunotherapy helps patients …

This large, late-stage trial is testing whether adding an immunotherapy drug (pembrolizumab) to standard chemotherapy (doxorubicin) works better than chemotherapy alone for people with advanced or inoperable sarcomas. The goal is to see if the combination helps patients live long…

This early-stage trial is testing a new drug called CBX-12 in patients with advanced solid tumors that have spread to other parts of the body. The drug works by damaging cancer cell DNA to kill tumors. Researchers will study how the drug affects cancer cells, measure tumor respon…

This study is testing whether two existing cancer drugs, sacituzumab govitecan and atezolizumab, can help control rare and aggressive cancers of the bladder, urinary tract, kidney, and penis. The trial will enroll 60 adults to receive one or both drugs, given through an IV, to se…

This study is for people with advanced nasopharyngeal cancer (a type of throat cancer) that has spread or returned after standard treatments. It will test if adding a pill called cabozantinib to two immunotherapy drugs (nivolumab and ipilimumab) works better than the two immunoth…

This study is testing a new oral drug, ZEN003694, in combination with standard chemotherapy for people with advanced NUT carcinoma, a rare and aggressive cancer. The main goals are to find a safe dose of the combination and see if it helps shrink tumors or slow the cancer's growt…

This study is testing whether a combination of two drugs, already approved for some common bladder cancers, can help control rare types of urinary tract and testicular cancers. It will involve about 68 adults whose cancer has spread and who have few other treatment options. The g…

This study is for people with extensive-stage small cell lung cancer that has spread. It tests if adding a targeted course of radiation therapy to ongoing immunotherapy (atezolizumab) can keep the cancer from growing or spreading for a longer time compared to continuing immunothe…

This study is for people with a specific type of advanced lung cancer that has spread and has an EGFR gene change. It compares a standard drug (osimertinib) alone against that same drug combined with a second drug (bevacizumab). The goal is to see if the two-drug combination can …

This is the first-ever study in people of an experimental drug called metarrestin. The main goals are to find a safe dose and see if it can shrink tumors. It is for adults and teenagers (12+) with advanced solid tumors that have spread and have not been cured by standard treatmen…

This study is testing whether adding an experimental drug called TRC102 to standard treatment helps people with stage III non-squamous non-small cell lung cancer live longer without their cancer getting worse. About 42 participants will receive either the standard treatment (chem…

This study is for women whose ovarian or endometrial cancer has returned or persisted despite prior treatment and has a specific genetic change (a RAS pathway mutation). It aims to see if taking two targeted drugs (selumetinib and olaparib) together works better than taking just …

This study tests whether a patient's own immune cells, removed from their tumor and multiplied in a lab, can shrink tumors when given back alongside the drug pembrolizumab. It's for adults with advanced digestive tract, breast, ovarian, or other cancers that have spread and stopp…

This early-phase study is testing the safety and best dose of two oral drugs, abemaciclib and olaparib, given together for ovarian cancer that has returned and is resistant to standard platinum-based chemotherapy. The goal is to see if combining these drugs, which work in differe…

This study is testing whether combining a bone-targeting radiation drug with one or two other medications works better for advanced prostate cancer that has spread to bones and stopped responding to standard hormone therapy. It will compare three approaches: the radiation drug al…

This study is testing a personalized cell therapy for adults with advanced non-small cell lung cancer that has stopped responding to standard treatments. Doctors remove a patient's tumor, grow special immune cells from it in a lab, and then infuse a large number of these 'tumor-f…

This study is for people with high-grade cancer in their upper urinary tract (kidney or ureter). It compares two approaches before surgery: standard chemotherapy alone versus chemotherapy plus an immunotherapy drug called durvalumab. The goal is to see if adding durvalumab helps …

This large, late-stage trial is testing if adding an immunotherapy drug (pembrolizumab) to standard chemotherapy helps patients live longer without their cancer returning. It is for people with stage II or III non-small cell lung cancer who have already had their tumor surgically…

This early-stage trial is testing the safety of a new three-drug combination for people with advanced triple-negative breast cancer. It combines a new experimental pill (ZEN003694) with an immunotherapy drug (pembrolizumab) and a standard chemotherapy (nab-paclitaxel). The main g…

This study is testing whether combining two drugs can help people with aggressive cancers that have stopped responding to standard treatments. It focuses on small cell lung cancer and other cancers with specific genetic weaknesses that have become resistant to previous drugs. The…

This study is testing whether adding an experimental immunotherapy drug called PDS01ADC to standard chemotherapy (docetaxel) is safe and can help men whose prostate cancer has spread. It is for men with two types of advanced prostate cancer: one that still responds to hormone the…

This study is testing the safety and early effects of a new treatment called anti-CD22 CAR T-cell therapy for adults with hairy cell leukemia that has come back or not responded to other standard treatments. Doctors will collect a patient's own immune cells, modify them in a lab …

This is the first-ever study in people for a new drug called ADCT-701, designed for adults with rare and hard-to-treat cancers like neuroendocrine tumors and malignant peripheral nerve sheath tumors. The main goal is to find the safest and most effective dose by giving the drug t…

This study is testing if adding the drug olaparib after surgery and chemotherapy can help prevent pancreatic cancer from returning. It is for patients whose cancer has been surgically removed and who have specific genetic mutations (BRCA1, BRCA2, or PALB2). Participants will take…

This early-stage trial is testing whether adding a new oral drug called CA-4948 to standard chemotherapy is safe and tolerable for people with advanced pancreatic cancer that has spread or cannot be removed by surgery. The main goal is to find the highest dose that patients can h…

This study is testing whether combining two drugs, Lutathera and Olaparib, can shrink rare neuroendocrine tumors in the digestive system or pancreas that cannot be removed by surgery. About 56 adults will receive Lutathera through an IV every 8 weeks and take Olaparib pills twice…

This large study compares two antibody treatments for people with early-stage follicular lymphoma, a slow-growing blood cancer. Researchers want to see if a newer drug called mosunetuzumab keeps the cancer under control longer than the standard treatment rituximab. The trial will…

This is an early safety study testing a drug called novobiocin in people with advanced solid tumors that have specific mutations affecting DNA repair. The main goal is to find the safest dose and understand the side effects. Researchers hope the drug will block a cancer cell's ba…

This study is testing a stem cell transplant to try to cure or control a rare and aggressive type of blood cancer called peripheral T-cell lymphoma. It is for patients aged 12 and older whose cancer has not responded to standard treatments. Researchers are also testing different …

This large, late-stage trial is comparing a new immunotherapy approach to standard chemotherapy for children and adults with early-stage Hodgkin lymphoma. The goal is to see if the immunotherapy combination (brentuximab vedotin and nivolumab) can help patients live longer without…

This early-stage study is testing the safety and best dose of a new two-drug combination for people with advanced cancers that have a specific marker called HER2. The trial focuses on stomach and gastroesophageal junction cancers that have spread or cannot be removed by surgery, …

This study is testing a combination of three drugs—cabozantinib, nivolumab, and ipilimumab—for patients with rare types of bladder, kidney, penile, and other urinary tract cancers that have spread. The goal is to see if this three-drug approach can shrink tumors and control the d…

This study is for people with extensive-stage small cell lung cancer that has spread. It tests whether adding a new oral drug called iadademstat to standard immunotherapy maintenance treatment can help control the cancer and prevent it from growing for a longer period. The first …

This study aims to find the lowest effective dose of a drug called cyclophosphamide, given after a stem cell transplant, to prevent a serious complication called graft-versus-host disease (GVHD). The goal is to reduce the drug's own side effects while still protecting patients. I…

This is an early-stage study testing a new oral drug called pidnarulex in patients with advanced solid tumors that have spread. The main goals are to see how safe the drug is, find the right dose, and understand how it affects cancer cells. Researchers will also check if the drug…

This early-stage trial is testing whether combining two cancer drugs—abemaciclib and 5-fluorouracil—is safe and tolerable for people with advanced colorectal cancer that has spread and stopped responding to standard treatments. Researchers will enroll 39 adults to find the best d…

This study is testing if adding a second drug (panitumumab) to a targeted cancer pill (sotorasib) works better than the pill alone for patients with advanced solid tumors that have a specific KRAS G12C mutation. It is for people whose cancer has spread and who have already tried …

This is a first-in-human study to find a safe dose of a new drug called cirtuvivint for patients with advanced forms of blood cancer. The trial will test cirtuvivint by itself in patients whose cancer has returned or resisted treatment, and also test it combined with an existing …

This early-stage study is testing a new combination of two oral drugs, M1774 and ZEN-3694, for women with recurrent ovarian or endometrial cancer. The main goals are to find the safest and most effective dose and to see how well the drugs work together to stop cancer cell growth.…

This international Phase 3 trial is testing whether adding an immunotherapy drug called blinatumomab to standard chemotherapy and targeted drugs works better for young people (under 25) with specific, hard-to-treat types of B-cell acute lymphoblastic leukemia. The goal is to impr…

This study is testing whether a daily supplement made from broccoli seeds and sprouts can help the bodies of heavy smokers break down and remove cancer-causing chemicals from tobacco. Researchers will enroll 135 current smokers and randomly give them either the broccoli extract o…

This study is testing a new, experimental CAR-T cell therapy designed to fight two targets (CD19 and CD22) on cancer cells at once. It is for children and young adults (ages 3-39) whose B-cell leukemia or lymphoma has come back or hasn't responded to standard treatments. Doctors …

This study is testing if adding a pill called acalabrutinib to standard chemotherapy can help more people with an aggressive type of blood cancer called diffuse large B-cell lymphoma (DLBCL). It is for adults who have not yet started any treatment for their lymphoma. Researchers …

This study is testing whether a new combination of two immunotherapy drugs (relatlimab and nivolumab) works better and is safer than the standard chemotherapy (lomustine) for glioblastoma that has returned after initial treatment. The trial will involve about 184 adults whose bra…

This study is testing if adding an immunotherapy drug (atezolizumab) to standard chemotherapy works better for controlling peritoneal mesothelioma, a rare cancer in the abdomen's lining. It will involve about 66 newly diagnosed patients who will be randomly assigned to receive ei…

This trial is testing a new type of gene therapy for people with advanced pancreatic, colon, and other cancers that have a specific genetic change called KRAS G12V. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer c…

This study is testing whether a series of advanced blood and bone marrow tests can help doctors better monitor children and young adults with a type of leukemia (B-ALL) who have recently received CAR-T cell therapy. The goal is to see if these tests can identify who is at high ri…

This study is for older adults (or younger adults unfit for standard chemo) newly diagnosed with a specific type of acute myeloid leukemia (AML) caused by a change in the IDH2 gene. It compares two oral drug combinations to see if adding a third drug, enasidenib, helps more patie…

This study is testing an oral medication called tovorafenib (DAY101) in children and young adults with Langerhans cell histiocytosis (LCH) that has come back or hasn't responded to previous treatments. LCH is a rare disorder where too many immune cells build up and can damage bon…

This early-stage trial is testing a new oral drug called Aza-TdC in adults with advanced solid tumors that have worsened after standard treatments. The main goal is to find a safe dose and see how well the body handles the drug. Researchers hope the medication can turn back on ce…

This study is testing a new combination of drugs for a rare and aggressive brain cancer called primary central nervous system lymphoma. The main goal is to find the safest and most effective dose of a targeted drug called ibrutinib when given with a specific chemotherapy regimen.…

This study is testing if a combination of two drugs, atezolizumab and selinexor, can shrink tumors in patients with advanced alveolar soft part sarcoma, a rare and difficult-to-treat cancer. The trial is for patients whose cancer has continued to grow despite prior immunotherapy.…

This early-stage study is testing a new combination of two drugs, peposertib and liposomal doxorubicin, for people with advanced soft tissue sarcomas that have spread or cannot be removed by surgery. The main goal is to find the safest and most effective dose of this drug pair. R…

This large, late-stage trial is testing if adding an immunotherapy drug (cemiplimab) before and after surgery works better than surgery alone for people with advanced, operable skin cancer. The goal is to see if this approach helps the body's immune system fight the cancer, reduc…

This study is testing whether combining two targeted cancer drugs is safe and effective for people with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. The trial is for patients whose cancer has continued to grow despite previous treatment…

This study is testing a four-part treatment for advanced endometrial cancer that has come back or worsened after prior therapy. It combines a personalized vaccine made from a patient's own blood cells with three drugs designed to help the immune system attack the cancer. The goal…

This study is testing five different drug combinations to see which works best for adults under 60 with high-risk acute myeloid leukemia (AML), a fast-growing blood cancer that's hard to treat. Participants are randomly assigned to receive either the standard chemotherapy or one …

This trial is for people with mucosal melanoma, a rare and aggressive cancer, that has been surgically removed. It tests whether adding a pill called cabozantinib to an immunotherapy drug (nivolumab) is better at preventing the cancer from returning than the immunotherapy alone. …

This study is testing if a combination of two oral drugs, encorafenib and binimetinib, works better than a previous single drug for adults with hairy cell leukemia that has a specific genetic change (BRAF V600 mutation) and has come back or stopped responding to standard treatmen…

This study is testing a personalized cell therapy for people with metastatic cancer that has not responded to standard treatments. Doctors take a patient's own white blood cells, genetically modify them in a lab to better recognize and attack their specific cancer, and then infus…

This early-stage trial is testing the safety and best dose of a new four-drug combination for primary central nervous system (CNS) lymphoma, a rare cancer of the brain or spinal cord. The study combines standard chemotherapy drugs with two newer agents—one that helps the immune s…

This study is testing a combination of five medications (called ViPOR) for people with aggressive types of B-cell lymphoma that have returned after treatment or did not respond to prior therapy. The goal is to see if this drug combination can effectively control the cancer and le…

This study is for people whose head and neck cancer has come back or never fully went away after initial treatment. It tests whether adding a short course of chemotherapy or chemotherapy plus an immunotherapy drug before a second surgery is better than surgery alone. The goal is …

This early-stage study is testing whether a drug called imatinib, already used for some cancers, can help people with a specific inherited gene change (RUNX1 mutation). People with this mutation often bruise or bleed easily and have a higher lifetime risk of blood cancers. The ma…

This study is for younger adults (18-59) newly diagnosed with a specific intermediate-risk type of acute myeloid leukemia (AML), a blood and bone marrow cancer. It compares three different drug combinations to see if adding a newer drug called venetoclax to standard chemotherapy …

This study is testing whether adjusting the dose of a cancer drug (belinostat) based on a patient's specific genetics can make treatment safer and more effective. It is for adults with aggressive neuroendocrine cancers. Participants receive a combination of three drugs, with the …

This study is for people with advanced head and neck cancer that has returned or spread and has stopped responding to standard platinum-based chemotherapy. It aims to see if combining two immunotherapy drugs (pembrolizumab and cetuximab) helps patients live longer than using pemb…

This early-stage trial is testing a new combination of two oral drugs, peposertib and tuvusertib, in adults with advanced solid tumors that have spread and stopped responding to standard treatments. The main goals are to find the safest and most effective dose of the drug pair an…

This early-stage study is testing a drug called TURALIO in children and young adults (ages 3-35) whose cancers have returned or not responded to standard treatments. The main goals are to find the highest safe dose of the drug and understand its side effects. Participants will ta…

This early-stage trial is testing a two-part personalized treatment for adults with advanced solid cancers that have spread and contain specific KRAS gene mutations. Doctors take a patient's own immune cells, genetically modify them in a lab to recognize and attack cancer cells w…

This study is testing if a drug called abemaciclib, currently used for breast cancer, can safely treat Kaposi Sarcoma (KS), a skin cancer often linked to HIV. Researchers want to find the right dose and see if it can shrink KS lesions. The trial is open to adults with KS, whether…

This study is for adults 70 and older with advanced non-small cell lung cancer. It compares two treatment approaches: immunotherapy alone versus immunotherapy combined with chemotherapy. The main goal is to see if the combination helps patients live longer and better control thei…

This is an early safety study for a new drug called TAK-243 in adults with advanced solid tumors or lymphoma. The main goal is to find the safest dose and understand the side effects. Researchers will give the drug to about 95 patients and closely monitor how their bodies handle …

This study is testing if adding newer, faster-to-administer targeted drugs to standard chemotherapy works better for people with a specific type of advanced uterine cancer (HER2-positive). It will involve 360 participants who have not had prior chemotherapy. The main goal is to s…

This study is testing whether two existing cancer drugs, lurbinectedin and avelumab, can help control a rare and aggressive type of bladder cancer called small cell carcinoma. It is for adults whose cancer has returned and spread after their first treatment. The goal is to see if…

This early-phase study is testing the safety and best dose of a three-drug combination (venetoclax, ixazomib, and dexamethasone) for adults with light chain amyloidosis that has returned or stopped responding to prior treatments. The study is specifically for patients who have a …

This study is testing a new drug called PLX038 for adults with aggressive brain or spinal cord tumors that have returned or progressed. It focuses on tumors with specific genetic changes (MYC or MYCN) that drive cancer growth. The goal is to find a safe dose and see if the drug c…

This early-stage trial is testing the safety and best dose of a new oral drug, CA-4948, when added to a standard chemotherapy regimen for people with advanced colorectal cancer that has spread. The main goal is to see if the combination is safe and tolerable for patients. Researc…

This early-stage study is testing whether adding an experimental drug called ZEN003694 to two existing cancer drugs (cetuximab and encorafenib) is safe and effective for people with advanced colorectal cancer that has stopped responding to previous treatments. The trial will enro…

This early-stage study is testing a new combination of two drugs, pelcitoclax and cobimetinib, for women with ovarian or endometrial cancer that has returned after prior treatment. The main goals are to find the safest and most effective dose and to check for side effects. Resear…

This study is for people with a specific type of high-grade bladder cancer that has not spread into the muscle wall. It compares two different treatment combinations, both given with radiation therapy. One group gets a standard chemotherapy drug, while the other gets an immunothe…

This study is testing whether a computer algorithm called ENLIGHT can find better treatment options for people with aggressive, metastatic breast cancer that has stopped responding to standard therapies. Researchers will analyze a tumor sample from each participant using the algo…

This study is testing a combination of three drugs—bevacizumab, erlotinib, and atezolizumab—to see if they can control or shrink advanced kidney cancers linked to a hereditary condition (HLRCC) or a specific type called papillary renal cell cancer. The trial aims to enroll 65 pat…

This study is testing whether adding a new oral drug called selinexor to standard radiation therapy is safe and effective for children and young adults with newly diagnosed, aggressive brain tumors (DIPG or high-grade glioma). The first part of the trial aims to find the safest d…

This study is testing if taking a daily pill called iberdomide can help patients with multiple myeloma live longer without their cancer getting worse after they receive a powerful one-time treatment called CAR-T cell therapy. Currently, doctors just monitor patients after CAR-T t…

This early-stage trial is testing a new drug that delivers radiation directly to cancer cells in people with advanced tumors that have spread and cannot be removed by surgery. The treatment targets a specific protein found on several cancer types, including some lung, kidney, hea…

This study is testing whether adding a new immune-boosting drug called M9241 to standard radiation and hormone therapy can help the body's own defenses fight prostate cancer better. It will involve about 65 men with high- or intermediate-risk prostate cancer that hasn't spread. T…

This study aims to see if matching patients to one of three targeted cancer drugs works better for treating advanced solid tumors. It will enroll 500 adults whose cancer has spread and who have specific proteins (Trop-2, nectin-4, or HER2) in their tumor. Patients will first be s…

This early-phase trial is testing a new combination of two drugs, temozolomide and M1774, for people with advanced cancers that have spread. The main goals are to find the safest and most effective dose and to see if the combination can shrink or stabilize tumors, especially in a…

This study is testing two new blood tests designed to screen for 11 different cancers at the same time. It will enroll 24,000 healthy adults aged 45-75 to see how well these tests work for early detection and to understand how people and their doctors respond to the results. The …

This study is testing if a new type of imaging scan can better detect multiple myeloma, a blood cancer, compared to the scan currently used. Researchers want to see if this new scan can find returning disease earlier, which could help doctors start treatment sooner. About 60 adul…

This study is testing a new imaging substance called [18F]FAPI-74 to see if it can detect certain cancers better than current standard scans. It will involve 320 adults with one of 10 specific cancer types who are scheduled for treatment. Participants will receive both the new tr…

This study is testing whether people can collect their own vaginal samples at home for HPV testing, which could make cervical cancer screening easier and more accessible. Researchers will compare the accuracy of these self-collected samples to samples collected by a doctor during…

This study is testing a new radioactive tracer called [68Ga]Ga-PentixaFor to see if it can make PET scans better at identifying adrenal tumors that are overproducing hormones. Researchers will give the tracer to 80 adults with conditions like hyperaldosteronism or Cushing's syndr…

This study is testing two medications, acolbifene and a low dose of tamoxifen, to see if they can help prevent breast cancer in premenopausal women who are at high risk for developing it. About 80 participants will take one of the pills daily for six months. Researchers will chec…

This study is testing if a drug called obeticholic acid can prevent Barrett's esophagus from turning into cancer. It will involve 30 adults with Barrett's esophagus who will take either the drug or a placebo pill daily for six months. The main goal is to see if the drug reduces c…

This study is testing a personalized approach to using the drug tamoxifen to prevent breast cancer in premenopausal women at higher-than-average risk. Researchers want to see if starting with a low dose and increasing it only for women who don't show a good initial response on th…

This early-stage study is testing a drug called ONC201 (dordaviprone) to see if it is safe and can help prevent colorectal cancer. It is for adults who have a high risk of developing colon cancer due to a condition called Familial Adenomatous Polyposis (FAP) or a history of many …

This study is testing whether a low dose of the drug tamoxifen, taken with or without high-dose omega-3 fish oil supplements, can help prevent breast cancer in women at high risk. It is for overweight or obese postmenopausal women who have specific risk factors, like a family his…

This study is looking at whether a special week-long camping experience can improve the quality of life and self-esteem of children with cancer. Researchers will observe and interview kids aged 7-17 who are in treatment or recently finished, as well as young adult counselors, bef…

This study is testing whether a home-use electrical stimulation device can help reduce urinary incontinence in men who have been treated for prostate cancer. Participants will use the device at home for 20 minutes a day, five days a week, for six weeks. The main goal is to see if…

This study is testing if a type of therapy called Acceptance and Commitment Therapy (ACT) can help parents and guardians better manage the stress of caring for a child with a rare genetic condition known as a RASopathy. The 8-week program is done completely from home using a smar…

This study aims to understand why some breast cancer patients develop nerve damage (peripheral neuropathy) from the chemotherapy drug paclitaxel, while others do not. Researchers will analyze the DNA of about 575 patients who previously received this treatment to look for genetic…

This study aims to understand the long-term health of people who have received a stem cell transplant from a relative. Researchers will follow 2000 transplant recipients and their donors for years, collecting health data and samples to learn about late complications like new canc…

This study aims to learn more about where HIV hides in the body when it is controlled by daily medication. Researchers will compare two groups of adults with HIV: one group stays on their medication, while another takes a short, monitored break. The team will use special body sca…

This study aims to find better methods for early cancer detection in people who carry an inherited BAP1 gene mutation, which nearly guarantees they will develop cancer. Researchers will follow 800 participants age 30+ using advanced imaging scans, blood tests, and minor surgical …

This study aims to better understand chordoma, a rare type of bone cancer, by tracking 300 children and adults over time. Researchers will monitor how the disease progresses, how it responds to treatments, and how it affects patients' quality of life. The goal is to gather inform…

This study aims to better understand gastrointestinal stromal tumors (GIST) by following patients for up to 10 years and collecting tumor tissue during any needed surgeries. Researchers will monitor 400 participants, including children as young as 6, to study the tumors in the la…

This study aims to learn more about Li-Fraumeni syndrome (LFS), a rare genetic condition that greatly increases a person's risk of developing many types of cancer. Researchers will follow up to 5,000 individuals and families with LFS over many years, collecting health information…

This study aims to understand why some prostate cancers become resistant to standard treatments by collecting blood samples from patients. Researchers will analyze genetic material from the blood to look for differences linked to more aggressive disease. The goal is to gather kno…

This study aims to collect samples from healthy people to create a comparison database for research on myelodysplastic syndromes (MDS), a type of blood disorder that can develop into cancer. Researchers need healthy samples to better understand how these diseases develop and to h…

This study aims to understand how inherited changes in a gene called DDX41 increase a person's risk of developing blood cancers like myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Researchers will follow over 500 participants, including people with these gene ch…

This study aims to understand how inherited gene mutations, particularly in the BAP1 gene, lead to cancers like mesothelioma. Researchers will follow 1,000 participants, including mesothelioma patients and their family members who carry these mutations, for many years. The goal i…

This study aims to collect blood, urine, saliva, and tissue samples from people with bladder/urinary tract cancer and healthy volunteers. Researchers will compare these samples to understand what genetic and cellular changes cause this cancer to develop. The goal is to identify n…

This study aims to better understand how pancreatic tumors develop and grow in people with von Hippel-Lindau (VHL) disease, a rare genetic condition. Researchers will follow 740 participants aged 12 and older over many years, using regular scans and tests to track tumor changes. …

This study aims to collect tumor and normal tissue samples from patients who are already scheduled for surgery or a biopsy for a solid tumor. The goal is to use these samples in research to discover new targets for future cancer therapies. No experimental treatments are given as …

This study aims to understand why some breast cancer patients develop heart problems after certain treatments while others do not. Researchers will analyze stored DNA samples from 162 patients who previously received chemotherapy. By comparing the genes of patients who developed …

This study collects blood and other samples from cancer patients and healthy volunteers to help researchers better understand cancer biology and the immune system. Participants provide samples for analysis, but this is not a treatment study. The goal is to gather information that…

This study aims to understand why some breast cancer patients develop severe high blood pressure as a side effect of the drug bevacizumab. Researchers will analyze the DNA of 354 patients who either did or did not develop this side effect during a previous clinical trial. The goa…

This study aims to collect and link research data from cancer patients who participate in multiple treatment trials at the National Cancer Institute. By connecting information from blood tests, biopsies, and treatment responses across different studies, researchers hope to unders…

This study collects immune cells from healthy volunteers to help researchers develop new cancer treatments. Participants undergo a 4-6 hour blood filtering process to donate white blood cells. These donated cells are used in the lab to help grow cancer patients' own immune cells,…

This study aims to collect blood, urine, and tissue samples from adults with certain blood cancers and from healthy volunteers. The goal is to study these samples in a lab to better understand diseases like hairy cell leukemia and to help develop future treatments. No treatment i…

This study aims to collect detailed medical and imaging data from 10,000 men with or at risk for prostate cancer. Researchers will analyze this information over at least five years to understand how different scan results relate to a patient's disease and outcomes. The goal is to…

This study aims to understand why people with inherited bone marrow failure syndromes have a higher risk of developing cancer. Researchers will follow 4,000 participants, including patients with these rare genetic conditions and their family members, to track cancer rates and ide…

This study aims to find out if measuring certain proteins in the blood and urine of patients with a serious brain tumor (glioblastoma) can help predict if the cancer will come back within a year after radiation treatment. Researchers will collect samples from about 200 adults bef…

This study aims to collect blood, urine, saliva, and tissue samples from men with prostate cancer to understand the genetic and cellular changes that cause the disease. Researchers will analyze these samples to learn how prostate cancer develops and progresses, which could lead t…

This study aims to understand the genetic causes of a rare, inherited condition called Hereditary Leiomyomatosis Renal Cell Cancer (HLRCC). Researchers are recruiting families affected by HLRCC to learn which gene changes cause the disease and how it leads to kidney tumors, skin …

This study aims to understand how follicular lymphoma, a type of blood cancer, naturally changes and progresses over time. Researchers will closely monitor 200 adults who have been diagnosed but have not yet started any treatment. By collecting blood, tissue, and scan data regula…

This study aims to better understand why some prostate cancers return after radiation treatment. Researchers will use detailed MRI scans and biopsies to closely examine the prostate before and after radiation therapy. The goal is to improve the detection of cancer recurrence and …

This study aims to collect special blood stem cells from adults with specific, rare immune system diseases. The cells are taken to a laboratory to test if scientists can fix their genetic defects. No treatment or therapy is given to participants as part of this study; it is purel…

This study aims to create better questionnaires to understand how visible tumors affect the appearance and daily life of people with Neurofibromatosis Type 1 (NF1). Researchers are asking 110 patients and caregivers to review and discuss draft questionnaires in focus groups. The …

This study aims to collect blood, tumor tissue, and stool samples from people diagnosed with gastrointestinal cancers. Researchers will use these samples to study how the patient's immune system responds to the cancer and how gut bacteria might influence the disease. No treatment…

This study is testing a modified surgical tool to see if it can provide better information about bladder cancer tumors. Researchers will use the tool on bladders that have already been surgically removed from patients for medical reasons. The goal is to see if this new method of …

This study aims to understand why some people and families develop rare or multiple cancers. Researchers will observe 500 participants, including those with unusual cancers or a strong family history, to learn how genes and environmental factors work together. The study involves …

This study aims to understand how medullary thyroid cancer and the related MEN2 genetic syndrome develop and change over time in children and adults. Researchers will observe 259 participants who have the condition, tracking their health through regular check-ups, scans, and bloo…

This study aims to learn more about olfactory neuroblastoma, a rare cancer that starts in the upper nasal cavity and can affect the sense of smell. Researchers will track the health of 525 children and adults with this condition over many years, collecting medical information, sa…

This study aims to create and test better questionnaires for people with neurofibromatosis 1 (NF1) who have painful plexiform tumors. Researchers are working with patients and parents to improve how pain and its impact on daily life are measured. The goal is to develop reliable t…

This study aims to learn more about myelodysplastic syndromes (MDS), a group of rare blood disorders, by observing how the disease naturally progresses over a very long time. Researchers will enroll about 1,100 people, including those with MDS and healthy donors, to collect blood…

This study aims to understand how stem cell transplants affect how patients process medications. Researchers will collect DNA samples from adults with blood cancers before and after transplant to determine the best source for genetic testing. The goal is to improve medication dos…

This study collects blood, tissue, and other samples from adults with cancer or pre-cancerous conditions. The goal is to understand how cancer works and why treatments affect people differently. Researchers will bank these samples for future lab studies to help develop better imm…

This study aims to understand how and why people with Fanconi anemia develop certain cancers, particularly in the mouth, throat, and genital areas. Researchers will regularly screen 200 participants aged 8 and older over 10 years to track early warning signs and disease progressi…

This study aims to learn more about chronic graft-versus-host disease (cGVHD), a serious and complex condition that can occur after a stem cell transplant. Researchers will observe about 650 patients, including some who have had transplants but do not have cGVHD, to identify mark…

This study aims to learn more about rare cancers by collecting health information and biological samples from people who have them or are at risk. Researchers will follow 10,000 participants over time to understand how these rare tumors develop and behave. The goal is to use this…

This study aims to collect blood, tissue, and fluid samples from adults with lymphoma, multiple myeloma, or related blood cancers. The goal is to help researchers better understand the biology of these diseases in the lab. This is a sample collection study only and does not provi…

This study aims to learn how to better predict which benign nerve tumors in people with Neurofibromatosis type 1 (NF1) might become cancerous. Researchers will observe 225 participants, aged 3 and up, for 10 years, using scans and check-ups to track their tumors. Participants wil…

This study aims to understand the course of rare cancers in the urinary system (like bladder, kidney, and prostate cancers) by tracking patients over time. Researchers will collect medical information, blood, urine, and sometimes tumor samples from about 1,100 adults with these c…

This study aims to collect tissue samples from adults with various lung and thymic cancers to better understand these diseases. Researchers will analyze blood, tumor, and other samples from up to 2000 participants to learn how these cancers develop and respond to treatment. The g…

This study aims to understand how specific gene mutations affect the course of prostate cancer over a person's lifetime. Researchers will follow 2,000 men who have prostate cancer and certain gene changes to see how their disease progresses and responds to treatments. The goal is…

This study aims to learn more about which men with specific inherited genetic changes are most likely to develop prostate cancer. Researchers will follow 500 men, aged 30-75, who have these genetic changes but do not have prostate cancer. Participants will have regular health che…

This study is a large screening program designed to help match adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) to the most appropriate treatment study within the national MyeloMATCH network. It involves testing a patient's bone marrow and blood for spec…

This long-term study aims to understand what causes cancer by tracking 200,000 healthy adults aged 30-70. Participants will regularly complete health surveys, donate blood and saliva samples, and share their electronic health records over many years. Researchers will analyze this…

This study aims to create and test a new questionnaire specifically for children and teens living with chronic graft-versus-host disease (cGVHD), a serious and often painful side effect of stem cell transplants. Researchers will work with 420 children (ages 5-17) and their parent…

This study aims to understand why people react differently to cancer drugs. Researchers will collect blood or cheek swab samples from about 1,100 cancer patients already enrolled in treatment trials at the National Cancer Institute. By analyzing genes, they hope to learn which ge…

This study collects tissue and fluid samples from adults and children with cancer. The goal is to gather these samples for research to help scientists better understand cancer and develop new tests and models for future treatments. Samples are collected during procedures patients…

This study aims to learn more about inherited kidney and urinary tract cancers by observing families who have them. Researchers will collect health information and genetic samples from up to 5,000 participants over time. The goal is to understand how these diseases develop, how t…

This study aims to collect tissue, blood, and urine samples from people with cancers of the chest (like lung, esophageal, or pleural cancers) to better understand the genetic changes in these diseases. Researchers will analyze these samples to learn how cancers develop and potent…

This study aims to understand a rare illness called KSHV Inflammatory Cytokine Syndrome (KICS), which is caused by a virus. Researchers will observe up to 140 adults who have the virus and related symptoms to learn how the disease develops and affects people over time. The goal i…

This study collects blood, urine, and tissue samples from people with or suspected of having cancers of the kidney, bladder, prostate, and other urinary system cancers. The samples are stored in a tissue bank and used for research to understand the genetic causes of these cancers…

This study aims to learn about a rare genetic condition called DICER1 syndrome, which increases the risk for several rare cancers, especially in children. Researchers are enrolling 1,500 people who have these cancers or are close relatives, to collect family histories, medical re…

This study aims to understand how Kaposi sarcoma (KS), a cancer often linked to HIV, behaves over many years. Researchers will observe 150 adults with KS, tracking their health through regular exams, scans, and tissue samples for up to 10 years. The goal is to learn why the disea…

This study is testing a new technology called SmartMatch that analyzes small pieces of surgically removed brain tumor tissue to see how they react to different drugs. Researchers want to see if this analysis can be completed and a report provided to doctors within 21 days of surg…

This study is a long-term health check-up for people who previously received experimental cancer vaccines in other research trials. It aims to monitor their health for up to 15 years to ensure the vaccines are safe in the long run. Participants will have annual check-ups or phone…

This study is collecting blood, bone marrow, and tissue samples from people with HIV or certain virus-related cancers. The goal is to help researchers better understand how these diseases work, which could lead to future treatments. Participants will provide samples but will not …

This study is testing whether advanced MRI scans can improve how doctors monitor men with low-risk prostate cancer who are on 'active surveillance' (watchful waiting). Researchers want to see if these scans can accurately track the cancer over time and possibly reduce the need fo…

This study aims to learn about the anxiety people with Fanconi anemia feel during their required cancer screenings. Researchers will observe 20 adults during their regular screening visits, taking notes on their body language, conversations, and environment. The goal is to better…

This study aims to collect blood, urine, and tumor samples from up to 1,000 patients with mesothelioma and other related cancers. The purpose is to build a tissue bank for future research to better understand these diseases. Participants will be followed over time to track their …

This study is exploring whether structured conversations about future care preferences are helpful and acceptable for young adults (ages 18-39) undergoing stem cell transplants and their caregivers. Participants will have three guided discussions over several weeks to talk about …

This study aims to understand the genetic makeup of cancers that occur in people with viral infections, HIV, or immune system disorders like Castleman disease. Researchers will collect and analyze tissue samples from adult participants to look for genetic changes that might expla…

This study aims to understand how prostate cancer that returns after initial treatment changes over time. Researchers will use a new type of PET scan on up to 350 men to track the cancer's progression for up to five years. The goal is to gather knowledge about the disease's behav…

This study is collecting tissue and blood samples from cancer patients over time to create a research resource called a biobank. Researchers will analyze these samples to understand how cancer changes during treatment and why some treatments stop working. The goal is to help scie…

This study screens adults with various cancers to see if they qualify for experimental treatments being tested by the National Cancer Institute's Surgery Branch. Participants undergo tests and evaluations to determine their eligibility for specific treatment trials. The study als…

This study aims to better understand Birt-Hogg-Dubé (BHD) syndrome, a rare inherited condition. Researchers want to learn how the gene that causes BHD increases a person's risk for developing kidney tumors, lung cysts, and skin growths. The study is enrolling about 950 people wit…

This study aims to learn more about rare neuroendocrine cancers by observing people who have them over their lifetime. Researchers will collect blood, saliva, and tumor samples from up to 300 participants to understand how these cancers progress and what treatments work best. The…

This study aims to collect cancer tissue samples shortly after death to help researchers understand how cancers spread and become resistant to treatments. Adults with advanced lung, ovarian, bladder, or certain other cancers who are receiving end-of-life hospice care can particip…

This study aims to understand if CAR T-cell therapy, a powerful treatment for aggressive blood cancers, affects how children and young adults think, learn, and remember. Researchers will follow 60 participants aged 5-35 for up to 3 years, giving them regular thinking and memory t…

This study aims to understand why some families are at high risk for melanoma, a serious skin cancer. Researchers will observe 3,000 people with a personal or family history of melanoma or unusual moles. Participants will provide health information, blood or cheek cell samples, a…

This study aims to learn more about a rare and serious disease called KSHV-associated Multicentric Castleman's Disease (MCD). Researchers will observe 195 adult patients over several years to understand how the disease progresses, how patients respond to current treatments, and w…

This study aims to collect and store blood, tumor, and tissue samples from children and adults with cancer to create a large research repository. The goal is to help scientists better understand cancer biology by studying these samples in the lab. Participants provide samples onl…

This study aims to learn more about a group of rare genetic conditions called RASopathies. Researchers will follow 500 people with these conditions and their family members over many years to understand their health challenges, especially their risk of developing cancer. The goal…

This study is testing a new device to see if it can objectively measure pain and other sensory problems in people with neurofibromatosis type 1 (NF1). Researchers will use a camera to record changes in the pupil of the eye while a small, non-painful electrical signal is applied t…

This study aims to collect and analyze tissue samples from people undergoing surgery for endocrine tumors (like thyroid, adrenal, or pancreatic tumors). Researchers will study the genetic and molecular makeup of these tumors to learn how to better tell benign from cancerous growt…

This study aims to understand the long-term health effects and disease progression in people who have received radiation therapy for cancer. Researchers will collect follow-up health data from 700 adult participants who previously had radiation treatment. The goal is to learn abo…