National Cancer Institute (nci)

This early-phase study aims to find the safest and most effective dose of an experimental drug called teclistamab for adults with plasmablastic lymphoma that has returned or hasn't responded to previous treatments. The drug works by helping the body's immune T-cells recognize and…

This early-stage study is testing a new drug, glofitamab, added to standard chemotherapy for people with previously untreated mantle cell lymphoma, a type of blood cancer. The main goal is to find the safest dose of this combination and understand its side effects. Researchers wi…

This study aims to see if a new two-drug combination (teclistamab and pomalidomide) works better than the current standard three-drug treatment for multiple myeloma that has come back after initial therapy. It will involve about 162 adults whose cancer has relapsed after one or t…

This study is testing if adding a drug called venetoclax to a stem cell transplant helps adults with acute myeloid leukemia (AML) stay in remission longer. About 244 participants will receive either venetoclax or a placebo before and after their transplant. The main goal is to se…

This early-stage trial is testing a new two-drug combination for people with a hard-to-treat form of advanced colorectal cancer that has stopped responding to standard therapies. The study aims to find a safe dose and see if the combination can help control the cancer's growth. I…

This study tests whether adding other drugs to luspatercept helps patients with a lower-risk type of myelodysplastic syndrome (MDS) who have anemia. The goal is to improve red blood cell counts and reduce the need for blood transfusions. About 270 adults who haven't had prior MDS…

This study is testing if adding an inhaled drug called azacytidine to standard pre-surgery treatment can better fight early-stage lung cancer. The inhaled drug is designed to target the lungs directly with fewer side effects. About 60 adults with operable lung cancer will receive…

This study is testing whether an oral medication called TPST-1495 can reduce the number of polyps in the small intestine and colon of people with Familial Adenomatous Polyposis (FAP), an inherited condition that greatly increases colon cancer risk. Thirty-eight adult participants…

This is a first-in-human study to find a safe dose of a new radioactive drug, Sn-117m-DTPA, for patients whose prostate, breast, or non-small cell lung cancer has spread to their bones. The drug is designed to deliver radiation directly to bone tumors while trying to spare the he…

This study is for adults with high-risk multiple myeloma, a blood cancer, that has either returned after initial treatment or stopped responding to it. It compares a new two-drug combination (daratumumab + teclistamab) against two standard three-drug combinations. The main goal i…

This study is for adults aged 60 or older with newly diagnosed acute myeloid leukemia (AML) who are less fit for intensive chemotherapy. It compares two treatment schedules combining the same three oral medications. The goal is to see if taking one of the drugs for 14 days per cy…

This study aims to find out if adding a newer drug called venetoclax to standard chemotherapy works as well as or better than adding an older targeted drug called gemtuzumab ozogamicin for treating a specific type of acute myeloid leukemia (AML). It will enroll 162 younger adults…

This study is testing whether combining two newer cancer drugs can help control aggressive small cell lung cancer and similar neuroendocrine cancers that have returned or stopped responding to standard treatments. The trial will enroll about 120 adults whose cancer has progressed…

This study is testing whether giving an immunotherapy drug called atezolizumab after surgery can prevent early-stage non-small cell lung cancer from returning. It will compare patients who receive the drug for one year against those who receive standard follow-up care with observ…

This study is testing if adding a new drug called olutasidenib to standard treatments helps patients with certain blood cancers. It is for adults newly diagnosed with Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) who have a specific genetic change called an IDH1 …

This study is for adults with a type of blood cancer called acute myeloid leukemia (AML) who have a small amount of leftover cancer after initial treatment. The goal is to test if adding newer drugs to a standard chemotherapy is better at wiping out these hidden cancer cells befo…

This early-stage trial is testing whether a new drug called camonsertib, combined with a precise form of radiation therapy, can help control head and neck cancers that have returned or cannot be surgically removed. The main goals are to find the safest dose of the drug-radiation …

This study is testing if adding a weekly weight-loss injection (tirzepatide) to a hormone-releasing IUD can better treat early-stage uterine cancer or a pre-cancerous condition in women who are overweight or obese. The goal is to see if this combination can eliminate cancer cells…

This early-stage study aims to find a safe dose and understand the side effects of an oral drug combination called ASTX727, given with a white blood cell booster (filgrastim), in children with high-risk acute myeloid leukemia (AML). The treatment is given as 'maintenance therapy'…

This study is testing whether adding a new drug called iberdomide to a standard combination of chemotherapy and immunotherapy is safe and more effective for children and young adults with neuroblastoma that has returned, is not responding, or is getting worse after prior treatmen…

This large, Phase 3 trial is testing if a gentler treatment plan works as well as a stronger one for a specific type of breast cancer. It will enroll nearly 2,000 postmenopausal women and men with high-stage, hormone-sensitive, HER2-negative breast cancer that has a low genetic r…

This is an early-stage trial to see if combining two existing drugs, azacitidine and abatacept, is safe and can shrink tumors in people with T-cell lymphoma that has come back or not responded to prior treatment. The study will involve about 20 adults to find the right dose and s…

This early-stage study is testing a new two-drug combination for glioblastoma, an aggressive brain cancer that has returned after initial treatment. The first drug is a radioactive antibody designed to find and deliver radiation directly to cancer cells. The second drug is an imm…

This study is testing if adding the drug itraconazole to the standard heat treatment (ablation) can better prevent esophageal cancer in people with high-risk Barrett's esophagus. It will involve 64 participants who will receive either itraconazole or a placebo pill alongside thei…

This study is for children and adults (ages 3-65) with a type of blood cancer called B-cell acute lymphoblastic leukemia (ALL). The goal is to see if giving a second, different CAR T-cell treatment (targeting CD22) to people who are already in remission after their first CAR T-ce…

This study is testing a vaccine designed to prevent lung cancer in people at high risk, primarily former and current heavy smokers. The vaccine works by training the body's immune system to recognize and attack cells that could become cancerous. Researchers will enroll 80 partici…

This study aims to understand the quality of care young adults with advanced cancer receive, especially near the end of life. Researchers will survey and interview 70 patients, their caregivers, and clinicians to measure unmet needs in emotional support, communication, and sympto…

This is a survey to find people who might qualify for one of several ongoing cancer genetics research studies. The goal is to better understand why some people and families get certain cancers. Participants fill out a 15-20 minute online questionnaire about their personal and fam…