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Could a $2 fungus pill stop esophageal cancer before it starts?

NCT ID NCT06732388

First seen Jan 22, 2026 · Last updated May 01, 2026 · Updated 24 times

Summary

This study tests whether adding the antifungal drug itraconazole to standard heat ablation therapy can better prevent esophageal cancer in people with high-risk Barrett's esophagus. About 64 adults with precancerous changes in their esophagus will receive either itraconazole or a placebo alongside their usual endoscopic ablation. The goal is to see if the combination leads to faster and more complete removal of abnormal tissue and lowers the chance of cancer developing.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Baylor University Medical Center

    Dallas, Texas, 75246, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Case Western Reserve University

    Cleveland, Ohio, 44106, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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  • University of Kansas Cancer Center

    Kansas City, Kansas, 66160, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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  • University of Michigan Rogel Cancer Center

    Ann Arbor, Michigan, 48109, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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Conditions

Explore the condition pages connected to this study.