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Could immunotherapy replace Chemo-Radiation after head and neck cancer surgery?

NCT ID NCT04671667

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 25, 2026 · Updated 11 times

Summary

This phase II trial is testing whether the immunotherapy drug pembrolizumab (Keytruda) alone can work better than the usual combination of chemotherapy and radiation after surgery for head and neck cancer that has come back or is a new primary tumor. About 188 adults aged 18-79 with high-risk features (like positive margins or cancer spread to lymph nodes) will be randomly assigned to receive either pembrolizumab or standard chemo-radiation. The study will compare overall survival, side effects, and disease-free survival to see if a gentler immunotherapy-only approach is effective.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
pembrolizumab (immunotherapy drug)
What this could lead to
If successful, this could offer a less toxic, immunotherapy-only option after surgery for recurrent head and neck cancer, potentially improving survival without the side effects of chemotherapy and radiation.
What could go wrong
This is a mid-stage trial with only 188 participants, so results may not apply to everyone. Pembrolizumab can cause immune-related side effects, and it may not work as well as the standard chemo-radiation approach.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 188 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2021

Expected to finish

Jun 2029

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 79 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient must be between 18 and 79 years of age * Patient must have locoregionally recurrent or second primary HNSCC (oral cavity, oropharynx, larynx, hypopharynx) in a previously radiated field * Patient must have undergone surgery with gross total resection and must be randomized within 8 weeks of surgery * Patients must have high risk disease defined as: * Positive margins and/or extra nodal extension (ENE) * Positive margins are defined as malignancy at or within 1 mm of the margin. High grade dysplasia (i.e. carcinoma in situ) at the margin is also considered positive * ENE may be either gross or microscopic * Patient must have a PD-L1 Combined Positive Score (CPS) \>= 1 in a Clinical Laboratory Improvement Act (CLIA) certified laboratory. Testing can be done locally as long as it is done in a CLIA certified laboratory. This testing must be on the tumor specimen from the resection of the patient's recurrent or second primary HNSCC * Patient must have had prior radiation to the area of recurrent or second primary tumor. This is defined as \> 50% of the presurgical tumor volume having previously received a dose of \> 45 Gy as determined by the treating radiation oncologist * Patient must have completed prior radiation a minimum of 6 months prior to randomization * Patient must not have any evidence of distant disease based on baseline imaging done within 28 days prior to randomization * Patient must not have received anti-PD-1/PD-L1 therapy for recurrent disease. If the patient received anti-PD-1/PD-L1 therapy as part of initial upfront curative intent treatment (either as part of definitive non-surgical therapy or in the adjuvant setting) in the past, the last dosage of anti-PD-1/PD-L1 therapy must have been given greater than one year prior to randomization * Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1 * Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible * Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. All patients of childbearing potential must have a blood test or urine study within 14 days prior to randomization to rule out pregnancy. A urine or serum pregnancy test must be repeated within 72 hours prior to receiving the first dose of pembrolizumab or chemotherapy if the test done for eligibility/randomization is done outside of this 72 hour window. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required. A patient of childbearing potential is someone, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months) * Patient must not expect to conceive or father children by using by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse while on study treatment, and continue for 120 days after the last dose of study treatment * Absolute neutrophil count (ANC) \>= 1,500/mcL (obtained =\< 28 days prior to protocol randomization) * Platelets \>= 100,000/mcL (obtained =\< 28 days prior to protocol randomization) * Total bilirubin =\< 1.5 x institutional upper limit of normal (ULN) (obtained =\< 28 days prior to protocol randomization) * Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase \[SGPT\]) =\< 3.0 x institutional ULN (obtained =\< 28 days prior to protocol randomization) * Creatinine clearance \> 30 ml/min using the Cockcroft-Gault formula (obtained =\< 28 days prior to protocol randomization) * Patient must not have a current active infection that requires systemic treatment at time of randomization * Patient must not have a history of non-infectious pneumonitis requiring steroids within 3 years prior to randomization * Patient must not have a history of solid organ transplant or stem cell transplant * Patient must not be on immunosuppressive medication within 7 days prior to randomization, EXCEPT for the following: a) intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection); b) systemic corticosteroids at physiologic doses =\< 10 mg/day of prednisone or equivalent; c) steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication) * Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional classification. Patients with New York Heart Association class III or IV heart failure are not eligible * Patient must not have received a live vaccine within 30 days prior to the first dose of study drug. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., FluMist \[registered trademark\]) are live attenuated vaccines and are not allowed * Patient must not have severe hypersensitivity (\>= grade 3) to pembrolizumab and/or any of its excipients * Patient must not have an active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed * Patient must not have a known psychiatric or substance abuse disorder that would interfere with the participant's ability to cooperate with the requirements of the study * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial as long as they have not been HIV-infected with a history of Kaposi sarcoma and/or multicentric Castleman disease * Patient must not have a known history of hepatitis B (defined as hepatitis B surface antigen \[HBsAg\] reactive) or known active hepatitis C virus (defined as HCV ribonucleic acid \[RNA\] \[qualitative\] is detected) infection * NOTE: No testing for hepatitis B and hepatitis C is required unless mandated by a local health authority

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Conditions

The condition(s) this trial relates to.

head and neck squamous cell carcinoma hypopharynx squamous cell carcinoma laryngeal squamous cell carcinoma oral cavity squamous cell carcinoma oropharynx squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Recurrent head and neck squamous cell carcinoma Recurrent hypopharyngeal squamous cell carcinoma Recurrent laryngeal squamous cell carcinoma Recurrent oral cavity squamous cell carcinoma Recurrent oropharyngeal squamous cell carcinoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    145 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Annie Penn Memorial Hospital

    RECRUITING

    Reidsville, North Carolina, 27320, United States

  • Aspirus Cancer Care - Stevens Point

    RECRUITING

    Stevens Point, Wisconsin, 54481, United States

  • Aspirus Cancer Care - Wisconsin Rapids

    RECRUITING

    Wisconsin Rapids, Wisconsin, 54494, United States

  • Aspirus Cancer Care-Antigo-Volm Cancer Center

    RECRUITING

    Antigo, Wisconsin, 54409, United States

  • Aspirus Cancer Care-Rhinelander-James Beck Cancer Center

    RECRUITING

    Rhinelander, Wisconsin, 54501, United States

  • Aspirus Cancer Care-Wausau

    RECRUITING

    Wausau, Wisconsin, 54401, United States

  • Atrium Medical Center-Middletown Regional Hospital

    RECRUITING

    Franklin, Ohio, 45005-1066, United States

    Contact Email: •••••@•••••

  • Avera Cancer Institute

    RECRUITING

    Sioux Falls, South Dakota, 57105, United States

    Contact Email: •••••@•••••

  • Avera Cancer Institute at Yankton

    RECRUITING

    Yankton, South Dakota, 57078, United States

    Contact Email: •••••@•••••

  • Benefis Sletten Cancer Institute

    RECRUITING

    Great Falls, Montana, 59405, United States

    Contact Email: •••••@•••••

  • Broadlawns Medical Center

    RECRUITING

    Des Moines, Iowa, 50314, United States

  • California Protons Cancer Therapy Center

    ACTIVE_NOT_RECRUITING

    San Diego, California, 92121, United States

  • Cancer Care Specialists of Illinois - Decatur

    SUSPENDED

    Decatur, Illinois, 62526, United States

  • Cancer Centers of Southwest Oklahoma Research

    RECRUITING

    Lawton, Oklahoma, 73505, United States

  • Carle Cancer Center

    RECRUITING

    Urbana, Illinois, 61801, United States

    Contact Email: •••••@•••••

  • Carle Physician Group-Effingham

    RECRUITING

    Effingham, Illinois, 62401, United States

    Contact Email: •••••@•••••

  • Carle Physician Group-Mattoon/Charleston

    RECRUITING

    Mattoon, Illinois, 61938, United States

    Contact Email: •••••@•••••

  • Carle at The Riverfront

    RECRUITING

    Danville, Illinois, 61832, United States

    Contact Email: •••••@•••••

  • Central Maryland Radiation Oncology in Howard County

    RECRUITING

    Columbia, Maryland, 21044, United States

  • Clackamas Radiation Oncology Center

    SUSPENDED

    Clackamas, Oregon, 97015, United States

  • Cleveland Clinic Foundation

    RECRUITING

    Cleveland, Ohio, 44195, United States

    Contact Email: •••••@•••••

  • Community Medical Center

    RECRUITING

    Missoula, Montana, 59804, United States

    Contact Email: •••••@•••••

  • Cone Health Cancer Center

    RECRUITING

    Greensboro, North Carolina, 27403, United States

  • Crossroads Cancer Center

    RECRUITING

    Effingham, Illinois, 62401, United States

  • Dayton Physician LLC - Englewood

    ACTIVE_NOT_RECRUITING

    Dayton, Ohio, 45415, United States

  • Dayton Physicians LLC-Atrium

    ACTIVE_NOT_RECRUITING

    Franklin, Ohio, 45005, United States

  • Dayton Physicians LLC-Miami Valley South

    ACTIVE_NOT_RECRUITING

    Centerville, Ohio, 45459, United States

  • Decatur Memorial Hospital

    RECRUITING

    Decatur, Illinois, 62526, United States

  • Drexel Town Square Health Center

    RECRUITING

    Oak Creek, Wisconsin, 53154, United States

  • Emory Proton Therapy Center

    RECRUITING

    Atlanta, Georgia, 30308, United States

  • Emory University Hospital Midtown

    RECRUITING

    Atlanta, Georgia, 30308, United States

  • Emory University Hospital/Winship Cancer Institute

    SUSPENDED

    Atlanta, Georgia, 30322, United States

  • Fox Chase Cancer Center

    RECRUITING

    Philadelphia, Pennsylvania, 19111, United States

  • Froedtert Menomonee Falls Hospital

    RECRUITING

    Menomonee Falls, Wisconsin, 53051, United States

  • Froedtert West Bend Hospital/Kraemer Cancer Center

    RECRUITING

    West Bend, Wisconsin, 53095, United States

  • Geisinger Medical Center

    RECRUITING

    Danville, Pennsylvania, 17822, United States

    Contact Email: •••••@•••••

  • Geisinger Medical Oncology-Lewisburg

    RECRUITING

    Lewisburg, Pennsylvania, 17837, United States

    Contact Email: •••••@•••••

  • Geisinger Wyoming Valley/Henry Cancer Center

    RECRUITING

    Wilkes-Barre, Pennsylvania, 18711, United States

    Contact Email: •••••@•••••

  • Greater Dayton Cancer Center

    ACTIVE_NOT_RECRUITING

    Kettering, Ohio, 45409, United States

  • HSHS Sacred Heart Hospital

    ACTIVE_NOT_RECRUITING

    Eau Claire, Wisconsin, 54701, United States

  • HSHS Saint Elizabeth's Hospital

    RECRUITING

    O'Fallon, Illinois, 62269, United States

  • Heartland Oncology and Hematology LLP

    RECRUITING

    Council Bluffs, Iowa, 51503, United States

  • Huntsman Cancer Institute/University of Utah

    ACTIVE_NOT_RECRUITING

    Salt Lake City, Utah, 84112, United States

  • IRMC Cancer Center

    RECRUITING

    Indiana, Pennsylvania, 15701, United States

  • Indu and Raj Soin Medical Center

    ACTIVE_NOT_RECRUITING

    Beavercreek, Ohio, 45431, United States

  • Iowa Lutheran Hospital

    SUSPENDED

    Des Moines, Iowa, 50316, United States

  • Iowa Methodist Medical Center

    RECRUITING

    Des Moines, Iowa, 50309, United States

  • Jefferson Torresdale Hospital

    RECRUITING

    Philadelphia, Pennsylvania, 19114, United States

    Contact Email: •••••@•••••

  • John H Stroger Jr Hospital of Cook County

    RECRUITING

    Chicago, Illinois, 60612, United States

  • Kaiser Permanente Los Angeles Medical Center

    RECRUITING

    Los Angeles, California, 90027, United States

    Contact Email: •••••@•••••

  • Kaiser Permanente-Anaheim

    RECRUITING

    Anaheim, California, 92806, United States

    Contact Email: •••••@•••••

  • Kaiser Permanente-Bellflower

    RECRUITING

    Bellflower, California, 90706, United States

    Contact Email: •••••@•••••

  • Kaiser Permanente-Ontario

    RECRUITING

    Ontario, California, 91761, United States

    Contact Email: •••••@•••••

  • Kettering Medical Center

    ACTIVE_NOT_RECRUITING

    Kettering, Ohio, 45429, United States

  • Logan Health Medical Center

    RECRUITING

    Kalispell, Montana, 59901, United States

    Contact Email: •••••@•••••

  • Loyola University Medical Center

    RECRUITING

    Maywood, Illinois, 60153, United States

  • Maryland Proton Treatment Center

    SUSPENDED

    Baltimore, Maryland, 21201, United States

  • MedStar Washington Hospital Center

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

  • Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Medical University of South Carolina

    RECRUITING

    Charleston, South Carolina, 29425, United States

  • Memorial Health University Medical Center

    SUSPENDED

    Savannah, Georgia, 31404, United States

  • Memorial Sloan Kettering Basking Ridge

    RECRUITING

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Bergen

    RECRUITING

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack

    RECRUITING

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth

    RECRUITING

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau

    RECRUITING

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Westchester

    RECRUITING

    Harrison, New York, 10604, United States

  • Mercy Hospital Saint Louis

    RECRUITING

    St Louis, Missouri, 63141, United States

  • Mercy Hospital South

    RECRUITING

    St Louis, Missouri, 63128, United States

  • Mercy Hospital Springfield

    SUSPENDED

    Springfield, Missouri, 65804, United States

  • Methodist Jennie Edmundson Hospital

    RECRUITING

    Council Bluffs, Iowa, 51503, United States

  • Methodist West Hospital

    SUSPENDED

    West Des Moines, Iowa, 50266-7700, United States

  • Miami Valley Cancer Care and Infusion

    RECRUITING

    Greenville, Ohio, 45331, United States

  • Miami Valley Hospital North

    RECRUITING

    Dayton, Ohio, 45415, United States

    Contact Email: •••••@•••••

  • Miami Valley Hospital South

    RECRUITING

    Centerville, Ohio, 45459, United States

    Contact Email: •••••@•••••

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612, United States

    Contact Email: •••••@•••••

  • Moffitt Cancer Center - McKinley Campus

    RECRUITING

    Tampa, Florida, 33612, United States

    Contact Email: •••••@•••••

  • Moffitt Cancer Center at Wesley Chapel

    RECRUITING

    Wesley Chapel, Florida, 33544, United States

    Contact Email: •••••@•••••

  • Moffitt Cancer Center-International Plaza

    RECRUITING

    Tampa, Florida, 33607, United States

    Contact Email: •••••@•••••

  • Montefiore Medical Center - Moses Campus

    RECRUITING

    The Bronx, New York, 10467, United States

  • Montefiore Medical Center-Einstein Campus

    RECRUITING

    The Bronx, New York, 10461, United States

  • Mount Sinai Chelsea

    RECRUITING

    New York, New York, 10011, United States

  • Mount Sinai Hospital

    RECRUITING

    New York, New York, 10029, United States

  • Mount Sinai Union Square

    RECRUITING

    New York, New York, 10003, United States

  • Nebraska Cancer Specialists/Oncology Hematology West PC - MECC

    SUSPENDED

    Omaha, Nebraska, 68114, United States

  • Nebraska Methodist Hospital

    RECRUITING

    Omaha, Nebraska, 68114, United States

  • Northwestern Medicine Cancer Center Delnor

    RECRUITING

    Geneva, Illinois, 60134, United States

  • Northwestern Medicine Cancer Center Kishwaukee

    RECRUITING

    DeKalb, Illinois, 60115, United States

  • Northwestern Medicine Cancer Center Warrenville

    RECRUITING

    Warrenville, Illinois, 60555, United States

  • Northwestern Medicine Lake Forest Hospital

    ACTIVE_NOT_RECRUITING

    Lake Forest, Illinois, 60045, United States

  • Northwestern University

    RECRUITING

    Chicago, Illinois, 60611, United States

    Contact Email: •••••@•••••

  • Oncology Associates PC

    SUSPENDED

    Omaha, Nebraska, 68114, United States

  • Premier Blood and Cancer Center

    RECRUITING

    Dayton, Ohio, 45409, United States

  • Providence Cancer Institute Clackamas Clinic

    SUSPENDED

    Clackamas, Oregon, 97015, United States

  • Providence Newberg Medical Center

    RECRUITING

    Newberg, Oregon, 97132, United States

    Contact Email: •••••@•••••

  • Providence Portland Medical Center

    RECRUITING

    Portland, Oregon, 97213, United States

    Contact Email: •••••@•••••

  • Providence Saint Vincent Medical Center

    RECRUITING

    Portland, Oregon, 97225, United States

    Contact Email: •••••@•••••

  • Randolph Hospital

    SUSPENDED

    Asheboro, North Carolina, 27203, United States

  • Reid Health

    ACTIVE_NOT_RECRUITING

    Richmond, Indiana, 47374, United States

  • Saint Francis Medical Center

    SUSPENDED

    Cape Girardeau, Missouri, 63703, United States

  • Saint Vincent Hospital Cancer Center Green Bay

    RECRUITING

    Green Bay, Wisconsin, 54301, United States

  • Saint Vincent Hospital Cancer Center at Saint Mary's

    RECRUITING

    Green Bay, Wisconsin, 54303, United States

  • Saint Vincent Hospital Cancer Center at Sturgeon Bay

    RECRUITING

    Sturgeon Bay, Wisconsin, 54235-1495, United States

  • Sanford Bismarck Medical Center

    RECRUITING

    Bismarck, North Dakota, 58501, United States

    Contact Email: •••••@•••••

  • Sanford Joe Lueken Cancer Center

    RECRUITING

    Bemidji, Minnesota, 56601, United States

    Contact Email: •••••@•••••

  • Sanford Roger Maris Cancer Center

    RECRUITING

    Fargo, North Dakota, 58122, United States

    Contact Email: •••••@•••••

  • Sanford USD Medical Center - Sioux Falls

    RECRUITING

    Sioux Falls, South Dakota, 57117-5134, United States

    Contact Email: •••••@•••••

  • Siteman Cancer Center at Christian Hospital

    ACTIVE_NOT_RECRUITING

    St Louis, Missouri, 63136, United States

  • Siteman Cancer Center at Saint Peters Hospital

    ACTIVE_NOT_RECRUITING

    City of Saint Peters, Missouri, 63376, United States

  • Siteman Cancer Center at West County Hospital

    ACTIVE_NOT_RECRUITING

    Creve Coeur, Missouri, 63141, United States

  • Siteman Cancer Center-South County

    ACTIVE_NOT_RECRUITING

    St Louis, Missouri, 63129, United States

  • Smilow Cancer Center/Yale-New Haven Hospital

    RECRUITING

    New Haven, Connecticut, 06510, United States

    Contact Email: •••••@•••••

  • Smilow Cancer Hospital Care Center - Waterford

    RECRUITING

    Waterford, Connecticut, 06385, United States

    Contact Email: •••••@•••••

  • Smilow Cancer Hospital Care Center-Trumbull

    RECRUITING

    Trumbull, Connecticut, 06611, United States

    Contact Email: •••••@•••••

  • Southern Illinois University School of Medicine

    RECRUITING

    Springfield, Illinois, 62702, United States

  • Springfield Clinic

    RECRUITING

    Springfield, Illinois, 62702, United States

  • Springfield Memorial Hospital

    RECRUITING

    Springfield, Illinois, 62781, United States

  • Stony Brook University Medical Center

    RECRUITING

    Stony Brook, New York, 11794, United States

  • Sutter Cancer Centers Radiation Oncology Services-Roseville

    ACTIVE_NOT_RECRUITING

    Roseville, California, 95661, United States

  • Sutter Roseville Medical Center

    ACTIVE_NOT_RECRUITING

    Roseville, California, 95661, United States

  • Temple University Hospital

    ACTIVE_NOT_RECRUITING

    Philadelphia, Pennsylvania, 19140, United States

  • The Carle Foundation Hospital

    SUSPENDED

    Urbana, Illinois, 61801, United States

  • The James Graham Brown Cancer Center at University of Louisville

    RECRUITING

    Louisville, Kentucky, 40202, United States

  • ThedaCare Regional Cancer Center

    RECRUITING

    Appleton, Wisconsin, 54911, United States

    Contact Email: •••••@•••••

  • Thomas Jefferson University Hospital

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

    Contact Email: •••••@•••••

  • Tufts Medical Center

    RECRUITING

    Boston, Massachusetts, 02111, United States

  • UC Irvine Health/Chao Family Comprehensive Cancer Center

    RECRUITING

    Orange, California, 92868, United States

    Contact Email: •••••@•••••

  • UC San Diego Moores Cancer Center

    ACTIVE_NOT_RECRUITING

    La Jolla, California, 92093, United States

  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

    RECRUITING

    Irvine, California, 92612, United States

    Contact Email: •••••@•••••

  • UF Health Cancer Institute - Gainesville

    ACTIVE_NOT_RECRUITING

    Gainesville, Florida, 32610, United States

  • UI Health Care Mission Cancer and Blood - Ankeny Clinic

    RECRUITING

    Ankeny, Iowa, 50023, United States

  • UI Health Care Mission Cancer and Blood - Des Moines Clinic

    RECRUITING

    Des Moines, Iowa, 50309, United States

  • UI Health Care Mission Cancer and Blood - Laurel Clinic

    RECRUITING

    Des Moines, Iowa, 50314, United States

  • UI Health Care Mission Cancer and Blood - Waukee Clinic

    RECRUITING

    Waukee, Iowa, 50263, United States

  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic

    RECRUITING

    Clive, Iowa, 50325, United States

  • UM Baltimore Washington Medical Center/Tate Cancer Center

    RECRUITING

    Glen Burnie, Maryland, 21061, United States

  • UM Sylvester Comprehensive Cancer Center at Coral Gables

    RECRUITING

    Coral Gables, Florida, 33146, United States

  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach

    RECRUITING

    Deerfield Beach, Florida, 33442, United States

  • UM Sylvester Comprehensive Cancer Center at Plantation

    RECRUITING

    Plantation, Florida, 33324, United States

  • UNC Lineberger Comprehensive Cancer Center

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

    Contact Email: •••••@•••••

  • UPMC Altoona

    RECRUITING

    Altoona, Pennsylvania, 16601, United States

  • UPMC Cancer Center at UPMC Horizon

    RECRUITING

    Farrell, Pennsylvania, 16121, United States

  • UPMC Hillman Cancer Center

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • UPMC Hillman Cancer Center - New Castle

    RECRUITING

    New Castle, Pennsylvania, 16105, United States

  • UPMC Hillman Cancer Center Erie

    RECRUITING

    Erie, Pennsylvania, 16505, United States

    Contact Email: •••••@•••••

  • UPMC Memorial

    RECRUITING

    York, Pennsylvania, 17408, United States

  • UPMC-Passavant Hospital

    RECRUITING

    Pittsburgh, Pennsylvania, 15237, United States

  • UPMC-Saint Margaret

    RECRUITING

    Pittsburgh, Pennsylvania, 15215, United States

  • UPMC-Shadyside Hospital

    ACTIVE_NOT_RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • University of Alabama at Birmingham Cancer Center

    ACTIVE_NOT_RECRUITING

    Birmingham, Alabama, 35233, United States

  • University of Arkansas for Medical Sciences

    RECRUITING

    Little Rock, Arkansas, 72205, United States

  • University of Illinois

    RECRUITING

    Chicago, Illinois, 60612, United States

  • University of Kansas Cancer Center

    ACTIVE_NOT_RECRUITING

    Kansas City, Kansas, 66160, United States

  • University of Kansas Cancer Center - Lee's Summit

    ACTIVE_NOT_RECRUITING

    Lee's Summit, Missouri, 64064, United States

  • University of Kansas Cancer Center - North

    ACTIVE_NOT_RECRUITING

    Kansas City, Missouri, 64154, United States

  • University of Kansas Cancer Center at North Kansas City Hospital

    ACTIVE_NOT_RECRUITING

    North Kansas City, Missouri, 64116, United States

  • University of Kansas Cancer Center-Overland Park

    ACTIVE_NOT_RECRUITING

    Overland Park, Kansas, 66210, United States

  • University of Kansas Hospital-Indian Creek Campus

    ACTIVE_NOT_RECRUITING

    Overland Park, Kansas, 66211, United States

  • University of Kansas Hospital-Westwood Cancer Center

    ACTIVE_NOT_RECRUITING

    Westwood, Kansas, 66205, United States

  • University of Kentucky/Markey Cancer Center

    RECRUITING

    Lexington, Kentucky, 40536, United States

  • University of Maryland/Greenebaum Cancer Center

    RECRUITING

    Baltimore, Maryland, 21201, United States

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    RECRUITING

    Miami, Florida, 33136, United States

  • University of Michigan Rogel Cancer Center

    SUSPENDED

    Ann Arbor, Michigan, 48109, United States

  • University of Mississippi Medical Center

    SUSPENDED

    Jackson, Mississippi, 39216, United States

  • University of New Mexico Cancer Center

    ACTIVE_NOT_RECRUITING

    Albuquerque, New Mexico, 87106, United States

  • University of Oklahoma Health Sciences Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

  • University of Rochester

    RECRUITING

    Rochester, New York, 14642, United States

  • UofL Health Medical Center Northeast

    RECRUITING

    Louisville, Kentucky, 40245, United States

    Contact Email: •••••@•••••

  • Upper Valley Medical Center

    RECRUITING

    Troy, Ohio, 45373, United States

    Contact Email: •••••@•••••

  • VCU Massey Cancer Center at Stony Point

    RECRUITING

    Richmond, Virginia, 23235, United States

  • VCU Massey Comprehensive Cancer Center

    RECRUITING

    Richmond, Virginia, 23298, United States

  • Vanderbilt University/Ingram Cancer Center

    RECRUITING

    Nashville, Tennessee, 37232, United States

  • Washington University School of Medicine

    ACTIVE_NOT_RECRUITING

    St Louis, Missouri, 63110, United States

  • Wayne State University/Karmanos Cancer Institute

    ACTIVE_NOT_RECRUITING

    Detroit, Michigan, 48201, United States

  • Weisberg Cancer Treatment Center

    ACTIVE_NOT_RECRUITING

    Farmington Hills, Michigan, 48334, United States

  • Wilmot Cancer Institute at Webster

    RECRUITING

    Webster, New York, 14580, United States

    Contact Email: •••••@•••••

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06520, United States

    Contact Email: •••••@•••••

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