Immunotherapy boost before surgery shows promise for rare urinary tract cancer

NCT ID NCT04628767

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Sep 18, 2026 · Updated 21 times

Summary

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy before surgery helps shrink tumors in people with high-grade upper urinary tract cancer. About 131 adults will be randomly assigned to receive either chemo alone or chemo plus durvalumab before their kidney and ureter removal surgery. The goal is to see if the combination leads to better cancer control and longer survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 131 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2021

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * STEP 1 REGISTRATION AND RANDOMIZATION * Patients must be \>= 18 years of age * Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible * Patient must have a diagnosis of high grade upper tract urothelial carcinoma expected within 14 weeks (98 days) prior to registration/randomization with one of the following: * Biopsy (gold standard, preferred) and either upper urinary tract mass on cross-sectional imaging or tumor directly visualized during upper urinary tract endoscopy * High grade cytology and clinically estimated invasive upper urinary tract mass on cross-sectional imaging (e.g., including presence of tumor-related hydronephrosis) or tumor directly visualized during upper urinary tract endoscopy * NOTE: Universal histologic testing of UTUC with additional studies, such as immunohistochemistry and/or microsatellite instability, is strongly recommended to identify patients with high probability of Lynch-related or other germline mutation related cancers whom clinicians should refer for genetic counseling and germline testing (this is not required for eligibility) * Due to the anatomy of upper urinary tract and lack of muscularis propria, pathologic evidence of cT2 on biopsy is usually not possible * Patients must not have any component of small cell/neuroendocrine carcinoma. Other histologic subtypes (variants) are permitted provided the half or predominant (\>= 50%) subtype is conventional urothelial carcinoma * Leukocytes \>= 3,000/mcL (obtained =\< 14 days prior to registration/randomization) * Platelets \>= 100,000/mcL (obtained =\< 14 days prior to registration/randomization) * Total bilirubin =\< 1.2 mg/dL (or ≤ 2 mg/dL for patients with Gilbert's disease) * Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\]) and alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 2 x institutional ULN (obtained =\< 14 days prior to registration/randomization) * Hemoglobin (Hgb) \>= 9 g/dL (obtained =\< 14 days prior to registration/randomization) * NOTE: Packed red blood transfusion is allowed to achieve this parameter as per treating investigator * Patients must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. All patients of childbearing potential must have a blood test or urine study within 14 days prior to registration to rule out pregnancy. A patient of childbearing potential is defined as any patient, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months) * Patients of childbearing potential and sexually active patients must not expect to conceive or father children, either by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse from the time of registration, while on study treatment and for at least 6 months after the last dose of protocol treatment * Patients must have no evidence of metastatic disease or clinically enlarged regional lymph nodes (\>= 1.5 cm short axis) on imaging required within 28 days prior to registration (Non-regional findings \>=1.5 cm short axis that in the opinion of the investigator are not concerning for involvement based on radiographic characteristics, chronicity, avidity on positron emission tomography (PET) scan or other imaging or other criteria can be eligible based on investigator discretion). * NOTE: Patients with elevated alkaline phosphatase, calcium or suspicious bone pain/tenderness can also undergo baseline bone scan to evaluate for bone metastasis at the discretion of local provider. * Patient must meet below criteria for prior/current malignancy history: * Non-urothelial cancer malignancy history: * Patient must not have another active (or within two years) second malignancy other than resected non-melanoma skin cancers, resected in situ breast, cervical or other in situ carcinoma, and either clinically insignificant per the investigator (e.g. =\< Gleason 3+4) on active surveillance (or watchful waiting) or previously treated prostate cancer with no rising prostate specific antigen (PSA) and no plan to treat * NOTE: Patients with prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial. * Urothelial cancer malignancy history: * Patient may have a history of resectable urothelial cancer as long as patients meet one of the following: * T0, Ta or Tis at any time * T1-4a N0 and no evidence of disease (NED) for more than 2 years from the latest therapy \[e.g., radical surgery, transurethral resection of bladder tumor (TURBT), radiation, chemotherapy (neoadjuvant or adjuvant, or with radiation)\]. Prior systemic immune checkpoint inhibitor is not allowed. * Patient with history of \>= pT4b, N+, and/or M1 UC is not eligible. * NOTE: Patients in whom concomitant or prior bladder/urethra predominant (\>= 50%) urothelial carcinoma have been surgically resected and demonstrated to be only Ta or carcinoma in situ (CIS) (\< cT1 N0) are eligible regardless of time elapsed * Patient must not have any uncontrolled illness including, but not limited to, ongoing or active infection including tuberculosis (clinical evaluation that includes clinical history, physical examination and radiographic findings, and tuberculosis testing in line with local practice), symptomatic congestive heart failure (CHF), myocardial infarction (MI) or unstable angina pectoris, significant uncontrolled cardiac arrhythmia, clinically relevant liver cirrhosis, interstitial lung disease, or psychiatric illness/social situations in the three months prior to registration that would limit compliance with study requirements * Patient must not have received prior radiation therapy to \>= 25% of the bone marrow for other diseases * Patient must not have received prior systemic anthracycline therapy * NOTE: Patients who have received prior intravesical therapy at any time for non-muscle invasive urothelial carcinoma of the bladder are eligible * Patient must not have either history of or active autoimmune disease requiring immunosuppressive therapy within 2 years prior to registration/randomization or any history of inflammatory bowel disease (inflammatory bowel disease \[IBD\], e.g. ulcerative colitis, or Crohn's disease), neuromuscular autoimmune condition, immune-related pneumonitis or interstitial lung disease. Patients with well-controlled hyper/hypothyroidism, celiac controlled by diet alone, diabetes mellitus type I, vitiligo, alopecia, psoriasis, eczema, lichen planus, or similar skin/mucosa condition are eligible * Patient must not be on or have used immunosuppressive medication within 14 days prior to the first dose of durvalumab. The following are exceptions to this criterion and are allowed: * Intranasal, inhaled, intra-auricular, topical steroids, or local steroid injections (e.g. intra-articular injection * Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent at the time of enrollment * Steroids as pre-medications for hypersensitivity reactions (e.g. computed tomography \[CT\] pre-medication) * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months prior to registration/randomization are eligible for this trial * NOTE: These patients must be stable on their anti-retroviral regimen with evidence of at least two undetectable viral loads within the past 6 months on the same regimen; the most recent undetectable viral load must be within the past 12 weeks. They must have a CD4 count of greater than 250 cells/mcL over the past 6 months on this same anti-retroviral regimen and must not have had a CD4 count \< 200 cells/mcL over the past 2 years, unless it was deemed related to the cancer and/or chemotherapy induced bone marrow suppression. They must not be currently receiving prophylactic therapy for an opportunistic infection and must not have had an opportunistic infection within the past 6 months * NOTE: For patients who have received chemotherapy in the past 6 months, a CD4 count \< 250 cells/mcL during chemotherapy is permitted as long as viral loads were undetectable during this same chemotherapy. They must have an undetectable viral load and a CD4 count \>= 250 cells/mcL within 7 days of registration/randomization * For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated * NOTE: Testing for HIV, hepatitis B or hepatitis C is not required unless clinically indicated * Patients with a history of hepatitis C virus (HCV) infection must have been treated and have undetectable viral load. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load * Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better * Patient must not have received live attenuated vaccine within 30 days prior to the first dose of durvalumab, while on protocol treatment and within 30 days after the last dose of durvalumab * Patient must not have had a major surgical procedure within 28 days prior to registration/randomization * NOTE: Cystoscopy/ureteroscopy/TURBT, stent placement or nephrostomy tube is not considered major surgery * Patient must not have history of allogenic organ transplantation * Patient must have a body weight of \> 30 kg * Patient must have life expectancy of \>= 12 weeks * Patient must have creatinine clearance \> 15 ml/min as estimated by Cockcroft-Gault formula or glomerular filtration rate (GFR) \> 15 ml/min/1.73m\^2 within 28 days prior to registration/randomization * NOTE: Patients will be assigned to cisplatin-ineligible and cisplatin-eligible cohorts based on their creatinine clearance, Eastern Cooperative Oncology Group (ECOG) performance status, and grade (if any) of peripheral neuropathy and/or hearing loss in keeping with recommended cisplatin contraindications. Patients who are cisplatin-eligible will be randomized to either Arm A or Arm B and patients who are cisplatin-ineligible will be registered to Arm C * Patients that meet any of the following four criteria will be registered to the cisplatin-ineligible Arm C if they meet other eligibility criteria: * Creatinine clearance \> 15 ml/min and =\< 50 ml/min (estimated by Cockcroft-Gault formula) or GFR \> 15ml/min/1.73m\^2 and ≤ 50 ml/min/1.73 m\^2 * Hearing loss \>= 3 * Neuropathy \>= 2 * ECOG performance status 2 * In addition, the patient must have an absolute neutrophil count (ANC) \>= 1,000/mcL obtained =\< 14 days prior to registration * Patients that meet all of the following four criteria will be randomized to the cisplatin-eligible Arm A or Arm B: * Creatinine clearance \> 50ml/min (estimated by Cockcroft-Gault formula) or GFR \> 50ml/min/1.73m\^2 * ECOG performance status 0-1 * Hearing loss grade 0-2 * Neuropathy 0-1 * In addition, the patient must have an absolute neutrophil count (ANC) \>= 1,500/mcL obtained =\< 14 days prior to randomization * Also, the patient must have left ventricular ejection fraction (LVEF) \>= 50% by (either multigated acquisition scan \[MUGA\] or 2-D echocardiogram) obtained within obtained within 28 days prior to randomization

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Conditions

The condition(s) this trial relates to.

renal pelvis/ureter urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Renal pelvis and ureter urothelial carcinoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

The study's own enquiry address

This study publishes an address for enquiries. See it below .
The places running it

205 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Show contact details

Locations

AMG Crystal Lake - Oncology
RECRUITING

Crystal Lake, Illinois, 60014, United States

Contact Email: •••••@•••••
AMG Libertyville - Oncology
RECRUITING

Libertyville, Illinois, 60048, United States

Contact Email: •••••@•••••
Abbott-Northwestern Hospital
SUSPENDED

Minneapolis, Minnesota, 55407, United States
Advocate Christ Medical Center
RECRUITING

Oak Lawn, Illinois, 60453-2699, United States
Advocate Good Samaritan Hospital
RECRUITING

Downers Grove, Illinois, 60515, United States
Advocate Good Shepherd Hospital
RECRUITING

Barrington, Illinois, 60010, United States
Advocate Illinois Masonic Medical Center
RECRUITING

Chicago, Illinois, 60657, United States
Advocate Lutheran General Hospital
RECRUITING

Park Ridge, Illinois, 60068, United States
Advocate Sherman Hospital
RECRUITING

Elgin, Illinois, 60123, United States
Advocate South Suburban Hospital
RECRUITING

Hazel Crest, Illinois, 60429, United States
Alta Bates Summit Medical Center-Herrick Campus
ACTIVE_NOT_RECRUITING

Berkeley, California, 94704, United States
Armes Family Cancer Center
ACTIVE_NOT_RECRUITING

Findlay, Ohio, 45840, United States
Atrium Medical Center-Middletown Regional Hospital
RECRUITING

Franklin, Ohio, 45005-1066, United States

Contact Email: •••••@•••••
Aurora Bay Area Medical Group-Marinette
RECRUITING

Marinette, Wisconsin, 54143, United States
Aurora BayCare Medical Center
RECRUITING

Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Grafton
RECRUITING

Grafton, Wisconsin, 53024, United States
Aurora Cancer Care-Kenosha South
RECRUITING

Kenosha, Wisconsin, 53142, United States
Aurora Cancer Care-Milwaukee
RECRUITING

Milwaukee, Wisconsin, 53209, United States
Aurora Cancer Care-Milwaukee West
RECRUITING

Wauwatosa, Wisconsin, 53226, United States
Aurora Cancer Care-Racine
RECRUITING

Racine, Wisconsin, 53406, United States
Aurora Cancer Care-Southern Lakes VLCC
RECRUITING

Burlington, Wisconsin, 53105, United States
Aurora Health Care Germantown Health Center
RECRUITING

Germantown, Wisconsin, 53022, United States
Aurora Medical Center in Summit
RECRUITING

Summit, Wisconsin, 53066, United States
Aurora Saint Luke's Medical Center
RECRUITING

Milwaukee, Wisconsin, 53215, United States
Aurora Sinai Medical Center
RECRUITING

Milwaukee, Wisconsin, 53233, United States
Aurora West Allis Medical Center
RECRUITING

West Allis, Wisconsin, 53227, United States
California Pacific Medical Center-Pacific Campus
ACTIVE_NOT_RECRUITING

San Francisco, California, 94115, United States
Cambridge Medical Center
SUSPENDED

Cambridge, Minnesota, 55008, United States
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States
Cancer Care and Hematology-Fort Collins
RECRUITING

Fort Collins, Colorado, 80528, United States
Cancer Center of Western Wisconsin
SUSPENDED

New Richmond, Wisconsin, 54017, United States
Cancer Centers of Southwest Oklahoma Research
RECRUITING

Lawton, Oklahoma, 73505, United States
Cancer Hematology Centers - Flint
RECRUITING

Flint, Michigan, 48503, United States
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact Email: •••••@•••••
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Email: •••••@•••••
Central Care Cancer Center - Bolivar
SUSPENDED

Bolivar, Missouri, 65613, United States
Central Care Cancer Center - Garden City
SUSPENDED

Garden City, Kansas, 67846, United States
Central Care Cancer Center - Great Bend
SUSPENDED

Great Bend, Kansas, 67530, United States
Centralia Oncology Clinic
SUSPENDED

Centralia, Illinois, 62801, United States
Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
City of Hope Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

Duarte, California, 91010, United States
Community Medical Center
RECRUITING

Toms River, New Jersey, 08755, United States
Cooperman Barnabas Medical Center
RECRUITING

Livingston, New Jersey, 07039, United States
CoxHealth South Hospital
SUSPENDED

Springfield, Missouri, 65807, United States
Crossroads Cancer Center
RECRUITING

Effingham, Illinois, 62401, United States
Dayton Physician LLC - Englewood
ACTIVE_NOT_RECRUITING

Dayton, Ohio, 45415, United States
Dayton Physicians LLC-Atrium
ACTIVE_NOT_RECRUITING

Franklin, Ohio, 45005, United States
Dayton Physicians LLC-Miami Valley South
ACTIVE_NOT_RECRUITING

Centerville, Ohio, 45459, United States
Decatur Memorial Hospital
SUSPENDED

Decatur, Illinois, 62526, United States
East Jefferson General Hospital
RECRUITING

Metairie, Louisiana, 70006, United States
Emory Decatur Hospital
RECRUITING

Decatur, Georgia, 30033, United States

Contact Email: •••••@•••••
Emory Saint Joseph's Hospital
RECRUITING

Atlanta, Georgia, 30342, United States
Emory University Hospital Midtown
RECRUITING

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Fairview Clinics and Surgery Center Maple Grove
SUSPENDED

Maple Grove, Minnesota, 55369, United States
Fairview Lakes Medical Center
SUSPENDED

Wyoming, Minnesota, 55092, United States
Fairview Northland Medical Center
SUSPENDED

Princeton, Minnesota, 55371, United States
Fairview Ridges Hospital
SUSPENDED

Burnsville, Minnesota, 55337, United States
Fairview Southdale Hospital
SUSPENDED

Edina, Minnesota, 55435, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Freeman Health System
SUSPENDED

Joplin, Missouri, 64804, United States
Genesee Hematology Oncology PC
SUSPENDED

Flint, Michigan, 48503, United States
Genesys Hurley Cancer Institute
RECRUITING

Flint, Michigan, 48503, United States
Greater Dayton Cancer Center
ACTIVE_NOT_RECRUITING

Kettering, Ohio, 45409, United States
Hackensack University Medical Center
COMPLETED

Hackensack, New Jersey, 07601, United States
Harold Alfond Center for Cancer Care
RECRUITING

Augusta, Maine, 04330, United States
Health Partners Inc
SUSPENDED

Minneapolis, Minnesota, 55454, United States
Heartland Regional Medical Center
SUSPENDED

Saint Joseph, Missouri, 64506, United States
Hematology Oncology Consultants-Clarkston
RECRUITING

Clarkston, Michigan, 48346, United States
Hennepin County Medical Center
SUSPENDED

Minneapolis, Minnesota, 55415, United States
Henry Ford Saint John Hospital - Macomb Medical
RECRUITING

Macomb, Michigan, 48044, United States
Hope Cancer Clinic
SUSPENDED

Livonia, Michigan, 48154, United States
Hurley Medical Center
RECRUITING

Flint, Michigan, 48503, United States
Huron Gastroenterology PC
RECRUITING

Ypsilanti, Michigan, 48106, United States
Illinois CancerCare - Washington
ACTIVE_NOT_RECRUITING

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington
ACTIVE_NOT_RECRUITING

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton
ACTIVE_NOT_RECRUITING

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage
ACTIVE_NOT_RECRUITING

Carthage, Illinois, 62321, United States
Illinois CancerCare-Dixon
ACTIVE_NOT_RECRUITING

Dixon, Illinois, 61021, United States
Illinois CancerCare-Eureka
ACTIVE_NOT_RECRUITING

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg
ACTIVE_NOT_RECRUITING

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic
ACTIVE_NOT_RECRUITING

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb
ACTIVE_NOT_RECRUITING

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic
ACTIVE_NOT_RECRUITING

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin
ACTIVE_NOT_RECRUITING

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria
ACTIVE_NOT_RECRUITING

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru
ACTIVE_NOT_RECRUITING

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton
ACTIVE_NOT_RECRUITING

Princeton, Illinois, 61356, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITING

Baltimore, Maryland, 21287, United States
Kettering Medical Center
ACTIVE_NOT_RECRUITING

Kettering, Ohio, 45429, United States
Kingman Regional Medical Center
RECRUITING

Kingman, Arizona, 86401, United States

Contact Email: •••••@•••••
LSU Healthcare Network / Metairie Multi-Specialty Clinic
RECRUITING

Metairie, Louisiana, 70006, United States
Lakeview Hospital
RECRUITING

Stillwater, Minnesota, 55082, United States
Loyola Center for Health at Burr Ridge
ACTIVE_NOT_RECRUITING

Burr Ridge, Illinois, 60527, United States
Loyola Medicine Homer Glen
ACTIVE_NOT_RECRUITING

Homer Glen, Illinois, 60491, United States
Loyola University Medical Center
ACTIVE_NOT_RECRUITING

Maywood, Illinois, 60153, United States
MU Health Care Goldschmidt Cancer Center
SUSPENDED

Jefferson City, Missouri, 65109, United States
MaineHealth Cancer Care Center of York County
RECRUITING

Sanford, Maine, 04073, United States
MaineHealth Cancer Care and IV Therapy - Sanford
RECRUITING

Sanford, Maine, 04073, United States

Contact Email: •••••@•••••
MaineHealth Cancer Care and IV Therapy - South Portland
RECRUITING

South Portland, Maine, 04106, United States

Contact Email: •••••@•••••
MaineHealth Maine Medical Center - Biddeford
SUSPENDED

Biddeford, Maine, 04005, United States
MaineHealth Maine Medical Center- Scarborough
RECRUITING

Scarborough, Maine, 04074, United States

Contact Email: •••••@•••••
Marjorie Weinberg Cancer Center at Loyola-Gottlieb
ACTIVE_NOT_RECRUITING

Melrose Park, Illinois, 60160, United States
Marshfield Medical Center - Minocqua
RECRUITING

Minocqua, Wisconsin, 54548, United States

Contact Email: •••••@•••••
Marshfield Medical Center - Weston
RECRUITING

Weston, Wisconsin, 54476, United States

Contact Email: •••••@•••••
Marshfield Medical Center-EC Cancer Center
RECRUITING

Eau Claire, Wisconsin, 54701, United States

Contact Email: •••••@•••••
Marshfield Medical Center-Marshfield
RECRUITING

Marshfield, Wisconsin, 54449, United States

Contact Email: •••••@•••••
Marshfield Medical Center-Rice Lake
RECRUITING

Rice Lake, Wisconsin, 54868, United States

Contact Email: •••••@•••••
Marshfield Medical Center-River Region at Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54482, United States

Contact Email: •••••@•••••
Mary Bird Perkins Cancer Center
RECRUITING

Baton Rouge, Louisiana, 70809, United States

Contact Email: •••••@•••••
Mary Bird Perkins Cancer Center - Metairie
RECRUITING

Metairie, Louisiana, 70002, United States
Mary Greeley Medical Center
ACTIVE_NOT_RECRUITING

Ames, Iowa, 50010, United States
Mayo Clinic in Florida
ACTIVE_NOT_RECRUITING

Jacksonville, Florida, 32224-9980, United States
Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
McFarland Clinic - Ames
ACTIVE_NOT_RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Boone
ACTIVE_NOT_RECRUITING

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson
ACTIVE_NOT_RECRUITING

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown
ACTIVE_NOT_RECRUITING

Marshalltown, Iowa, 50158, United States
McFarland Clinic - Trinity Cancer Center
ACTIVE_NOT_RECRUITING

Fort Dodge, Iowa, 50501, United States
MedStar Washington Hospital Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Medical Center of the Rockies
RECRUITING

Loveland, Colorado, 80538, United States
Medical University of South Carolina
ACTIVE_NOT_RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Hospital of Carbondale
SUSPENDED

Carbondale, Illinois, 62902, United States
Memorial Medical Center
ACTIVE_NOT_RECRUITING

Modesto, California, 95355, United States
Mercy Cancer Center - Cape Girardeau
SUSPENDED

Cape Girardeau, Missouri, 63703, United States
Mercy Clinic-Rolla-Cancer and Hematology
SUSPENDED

Rolla, Missouri, 65401, United States
Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Fort Smith
SUSPENDED

Fort Smith, Arkansas, 72903, United States
Mercy Hospital Joplin
SUSPENDED

Joplin, Missouri, 64804, United States
Mercy Hospital Oklahoma City
SUSPENDED

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Saint Louis
RECRUITING

St Louis, Missouri, 63141, United States
Mercy Hospital South
RECRUITING

St Louis, Missouri, 63128, United States
Mercy Hospital Springfield
SUSPENDED

Springfield, Missouri, 65804, United States
Mercy Hospital Washington
SUSPENDED

Washington, Missouri, 63090, United States
Mercy Infusion Center - Chippewa
SUSPENDED

St Louis, Missouri, 63109, United States
Mercy Oncology and Hematology - Clayton-Clarkson
SUSPENDED

Ballwin, Missouri, 63011, United States
Methodist Medical Center of Illinois
SUSPENDED

Peoria, Illinois, 61636, United States
Miami Valley Cancer Care and Infusion
RECRUITING

Greenville, Ohio, 45331, United States
Miami Valley Hospital
RECRUITING

Dayton, Ohio, 45409, United States

Contact Email: •••••@•••••
Miami Valley Hospital North
RECRUITING

Dayton, Ohio, 45415, United States

Contact Email: •••••@•••••
Miami Valley Hospital South
RECRUITING

Centerville, Ohio, 45459, United States

Contact Email: •••••@•••••
Michigan Healthcare Professionals Pontiac
RECRUITING

Pontiac, Michigan, 48341, United States
Minnesota Oncology - Burnsville
SUSPENDED

Burnsville, Minnesota, 55337, United States
Minnesota Oncology Hematology PA-Maplewood
RECRUITING

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury
RECRUITING

Woodbury, Minnesota, 55125, United States
Missouri Baptist Medical Center
RECRUITING

St Louis, Missouri, 63131, United States
Missouri Baptist Sullivan Hospital
RECRUITING

Sullivan, Missouri, 63080, United States
Monticello Cancer Center
SUSPENDED

Monticello, Minnesota, 55362, United States
MyMichigan Medical Center Saginaw
RECRUITING

Saginaw, Michigan, 48601, United States
MyMichigan Medical Center Tawas
RECRUITING

Tawas City, Michigan, 48764, United States
New Ulm Medical Center
SUSPENDED

New Ulm, Minnesota, 56073, United States
Newland Medical Associates-Clarkston
SUSPENDED

Clarkston, Michigan, 48346, United States
Newland Medical Associates-Pontiac
RECRUITING

Pontiac, Michigan, 48341, United States
North Memorial Medical Health Center
SUSPENDED

Robbinsdale, Minnesota, 55422, United States
OSF Saint Anthony's Health Center
SUSPENDED

Alton, Illinois, 62002, United States
Oncology Hematology Associates of Saginaw Valley PC
SUSPENDED

Saginaw, Michigan, 48604, United States
OptumCare Cancer Care at Charleston
RECRUITING

Las Vegas, Nevada, 89102, United States

Contact Email: •••••@•••••
OptumCare Cancer Care at Fort Apache
RECRUITING

Las Vegas, Nevada, 89183, United States

Contact Email: •••••@•••••
Palo Alto Medical Foundation Health Care
ACTIVE_NOT_RECRUITING

Palo Alto, California, 94301, United States
Palo Alto Medical Foundation-Camino Division
ACTIVE_NOT_RECRUITING

Mountain View, California, 94040, United States
Palo Alto Medical Foundation-Fremont
ACTIVE_NOT_RECRUITING

Fremont, California, 94538, United States
Palo Alto Medical Foundation-Santa Cruz
ACTIVE_NOT_RECRUITING

Santa Cruz, California, 95065, United States
Palo Alto Medical Foundation-Sunnyvale
ACTIVE_NOT_RECRUITING

Sunnyvale, California, 94086, United States
Park Nicollet Clinic - Saint Louis Park
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
Parkland Health Center - Farmington
RECRUITING

Farmington, Missouri, 63640, United States
Parkland Memorial Hospital
RECRUITING

Dallas, Texas, 75235, United States

Contact Email: •••••@•••••
Penn State Milton S Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033-0850, United States
Phelps Health Delbert Day Cancer Institute
SUSPENDED

Rolla, Missouri, 65401, United States
Poudre Valley Hospital
RECRUITING

Fort Collins, Colorado, 80524, United States
Premier Blood and Cancer Center
RECRUITING

Dayton, Ohio, 45409, United States
ProHealth D N Greenwald Center
RECRUITING

Mukwonago, Wisconsin, 53149, United States
ProHealth Oconomowoc Memorial Hospital
RECRUITING

Oconomowoc, Wisconsin, 53066, United States
ProHealth Waukesha Memorial Hospital
RECRUITING

Waukesha, Wisconsin, 53188, United States
ProMedica Flower Hospital
RECRUITING

Sylvania, Ohio, 43560, United States

Contact Email: •••••@•••••
Reading Hospital
RECRUITING

West Reading, Pennsylvania, 19611, United States
Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Reid Health
ACTIVE_NOT_RECRUITING

Richmond, Indiana, 47374, United States
Rice Memorial Hospital
SUSPENDED

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center
SUSPENDED

Waconia, Minnesota, 55387, United States
Roswell Park Cancer Institute
ACTIVE_NOT_RECRUITING

Buffalo, New York, 14263, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08903, United States
SIH Cancer Institute
RECRUITING

Carterville, Illinois, 62918, United States

Contact Email: •••••@•••••
SSM Health Good Samaritan
RECRUITING

Mount Vernon, Illinois, 62864, United States
Saint Alphonsus Cancer Care Center-Nampa
RECRUITING

Nampa, Idaho, 83687, United States

Contact Email: •••••@•••••
Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States
Saint Francis Regional Medical Center
SUSPENDED

Shakopee, Minnesota, 55379, United States
Saint John's Hospital - Healtheast
SUSPENDED

Maplewood, Minnesota, 55109, United States
Saint Mary's Oncology/Hematology Associates of West Branch
SUSPENDED

West Branch, Michigan, 48661, United States
Sainte Genevieve County Memorial Hospital
RECRUITING

Sainte Genevieve, Missouri, 63670, United States
Sibley Memorial Hospital
RECRUITING

Washington D.C., District of Columbia, 20016, United States
Southeastern Medical Oncology Center-Clinton
RECRUITING

Clinton, North Carolina, 28328, United States
Southeastern Medical Oncology Center-Goldsboro
RECRUITING

Goldsboro, North Carolina, 27534, United States
Southeastern Medical Oncology Center-Jacksonville
RECRUITING

Jacksonville, North Carolina, 28546, United States
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital
SUSPENDED

Springfield, Illinois, 62781, United States
Springfield Regional Cancer Center
SUSPENDED

Springfield, Ohio, 45504, United States
Stanford Cancer Institute Palo Alto
RECRUITING

Palo Alto, California, 94304, United States

Contact Email: •••••@•••••
Sutter Auburn Faith Hospital
ACTIVE_NOT_RECRUITING

Auburn, California, 95602, United States
Sutter Medical Center Sacramento
ACTIVE_NOT_RECRUITING

Sacramento, California, 95816, United States
Sutter Pacific Medical Foundation
ACTIVE_NOT_RECRUITING

Santa Rosa, California, 95403, United States
Sutter Roseville Medical Center
ACTIVE_NOT_RECRUITING

Roseville, California, 95661, United States
Sutter Solano Medical Center/Cancer Center
ACTIVE_NOT_RECRUITING

Vallejo, California, 94589, United States
ThedaCare Cancer Care - Waupaca
RECRUITING

Waupaca, Wisconsin, 54981, United States

Contact Email: •••••@•••••
ThedaCare Regional Cancer Center
RECRUITING

Appleton, Wisconsin, 54911, United States

Contact Email: •••••@•••••
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Email: •••••@•••••
Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States
Trinity Health Medical Center - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health Medical Center - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
RECRUITING

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States
UC San Diego Medical Center - Hillcrest
RECRUITING

San Diego, California, 92103, United States
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States

Contact Email: •••••@•••••
UCHealth - Cherry Creek
SUSPENDED

Denver, Colorado, 80206, United States
UCHealth Greeley Hospital
RECRUITING

Greeley, Colorado, 80631, United States
UCHealth Highlands Ranch Hospital
RECRUITING

Highlands Ranch, Colorado, 80129, United States
UCHealth Lone Tree Health Center
RECRUITING

Lone Tree, Colorado, 80124, United States
UCHealth University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
UMass Memorial Medical Center - University Campus
RECRUITING

Worcester, Massachusetts, 01655, United States

Contact Email: •••••@•••••
UPMC Cancer Center-Washington
RECRUITING

Washington, Pennsylvania, 15301, United States
UPMC Cancer Centers - Arnold Palmer Pavilion
RECRUITING

Greensburg, Pennsylvania, 15601, United States
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UPMC Hillman Cancer Center - Monroeville
RECRUITING

Monroeville, Pennsylvania, 15146, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center Erie
RECRUITING

Erie, Pennsylvania, 16505, United States

Contact Email: •••••@•••••
UPMC-Passavant Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15237, United States
UPMC-Saint Clair Hospital Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15243, United States
UT Southwestern Clinical Center at Richardson/Plano
RECRUITING

Richardson, Texas, 75080, United States
UT Southwestern Simmons Cancer Center - RedBird
SUSPENDED

Dallas, Texas, 75237, United States
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Email: •••••@•••••
UW Cancer Center at ProHealth Care
RECRUITING

Waukesha, Wisconsin, 53188, United States
United Hospital
SUSPENDED

Saint Paul, Minnesota, 55102, United States
Unity Hospital
ACTIVE_NOT_RECRUITING

Fridley, Minnesota, 55432, United States
University Medical Center New Orleans
RECRUITING

New Orleans, Louisiana, 70112, United States
University of Arkansas for Medical Sciences
ACTIVE_NOT_RECRUITING

Little Rock, Arkansas, 72205, United States
University of Iowa Healthcare Cancer Services Quad Cities
RECRUITING

Bettendorf, Iowa, 52722, United States
University of Iowa/Holden Comprehensive Cancer Center
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kentucky/Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of New Mexico Cancer Center
RECRUITING

Albuquerque, New Mexico, 87106, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania/Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Email: •••••@•••••
University of Washington Medical Center - Montlake
RECRUITING

Seattle, Washington, 98195, United States
Upper Valley Medical Center
RECRUITING

Troy, Ohio, 45373, United States

Contact Email: •••••@•••••
Valley Radiation Oncology
SUSPENDED

Peru, Illinois, 61354, United States
Vince Lombardi Cancer Clinic - Oshkosh
RECRUITING

Oshkosh, Wisconsin, 54904, United States
Vince Lombardi Cancer Clinic-Sheboygan
RECRUITING

Sheboygan, Wisconsin, 53081, United States
Vince Lombardi Cancer Clinic-Two Rivers
RECRUITING

Two Rivers, Wisconsin, 54241, United States
Wake Forest University Health Sciences
ACTIVE_NOT_RECRUITING

Winston-Salem, North Carolina, 27157, United States
West Virginia University Charleston Division
RECRUITING

Charleston, West Virginia, 25304, United States
Western Illinois Cancer Treatment Center
SUSPENDED

Galesburg, Illinois, 61401, United States

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