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New combo therapy shows promise for Hard-to-Treat leukemia

NCT ID NCT03739814

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 19 times

Summary

This phase II trial is testing a combination of two targeted drugs, inotuzumab ozogamicin and blinatumomab, with or without ponatinib, for adults with a type of leukemia called B-ALL. The study includes newly diagnosed older adults and those whose cancer has returned or not responded to treatment. The goal is to see if this approach improves event-free survival and is feasible to complete.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
inotuzumab ozogamicin and blinatumomab (with or without ponatinib)
What this could lead to
If successful, this could offer a more effective, less toxic treatment option for older adults or those with hard-to-treat B-ALL, potentially improving remission rates and survival.
What could go wrong
This is a phase II trial with only 84 participants, so results are preliminary. The combination may cause serious side effects, and not all patients may respond. It is not a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 84 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2019

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * STEP 0: Submission of bone marrow aspirate and peripheral blood for MRD analysis is mandatory prior to registration; the bone marrow sample should be from the first aspiration (i.e. first pull). Aspirate needle should be redirected if needed to get first pull bone marrow aspirate. It should be initiated as soon as possible after pre-registration. The specimens should be sent to the HEME Biobank. * Lumbar Puncture (Spinal Tap) and Intrathecal Methotrexate: * Patients may receive the day 1 of course IA dose of intrathecal (IT) methotrexate during the prior-to-registration lumbar puncture (or the venous line placement) to avoid a second lumbar puncture. If the dose is administered prior to registration, then systemic chemotherapy must begin within 7 days of this IT chemotherapy. * STEP 1: Morphologic diagnosis of precursor B-cell acute lymphoblastic leukemia (ALL) based on World Health Organization (WHO) criteria. Patients with Burkitt lymphoma/leukemia are not eligible. * STEP 1: CD22-positive disease defined as CD22 expression by \>= 20% of lymphoblasts by local hematopathology evaluation. * STEP 1: Philadelphia chromosome/BCR-ABL1-negative or Philadelphia chromosome/BCR-ABL1-positive B-cell ALL by cytogenetics, fluorescence in situ hybridization (FISH), and/or polymerase chain reaction (PCR). * STEP 1: No active central nervous system (CNS) leukemia (i.e. only CNS-1 disease allowed). Active CNS leukemia is defined as morphologic evidence of lymphoblasts in the cerebrospinal fluid (CSF), use of CNS-directed local treatment for active disease within 28 days prior to registration, symptomatic CNS leukemia (i.e. cranial nerve palsies or other significant neurological dysfunction) within the 28 days prior to registration, and/or known asymptomatic parenchymal CNS mass lesions; see below for additional guidance. Prophylactic intrathecal medication alone is not an exclusion. * Categories of CNS Involvement for CNS Evaluation Prior to Registration: * CNS 1: CSF has \< 5 WBC/uL with cytospin negative for blasts; or \>= 10 red blood cell (RBC)/uL with cytospin negative for blasts. * CNS 2: CSF has \< 5 WBC/uL with cytospin positive for blasts; or \>= 10 RBC/uL with cytospin positive for blasts; or \>= 10 RBC/uL, WBC/uL \>= 5 but less than Steinherz/Bleyer algorithm with cytospin positive for blasts (see below). * CNS 3: CSF has \>= 5 WBC/uL with cytospin positive for blasts; or \>= 10 RBC/uL, \>= 5 WBC/uL and positive by Steinherz/Bleyer algorithm (see below); or clinical signs of CNS leukemia (such as facial nerve palsy, brain/eye involvement or hypothalamic syndrome). Steinherz/Bleyer Method of Evaluating Initial Traumatic Lumbar Punctures: * If the patient has leukemia cells in the peripheral blood and the lumbar puncture is traumatic and contains \>= 5 WBC/uL with blasts, the following algorithm should be used to define CNS disease: CSF WBC/CSF RBC \> 2 x (Blood WBC/Blood RBC count) * STEP 1: Patients with known or suspected testicular involvement by leukemia are allowed provided that the patient receives concomitant scrotal/testicular radiotherapy. * Unilateral or bilateral testicular enlargement should be assessed by ultrasound or other imaging technique. Biopsy is recommended if clinical findings are equivocal or suggestive of hydrocele or a non-leukemic mass, but further assessments are per treating physician discretion. * STEP 1: Not pregnant and not nursing. * This study involves agents that have known genotoxic, mutagenic, and teratogenic effects. Therefore, for women of childbearing potential only, a negative pregnancy test done =\< 7 days prior to registration is required. * STEP 1: Eastern Cooperative Oncology Group (ECOG) performance status: 0-2 * STEP 1: No unstable cardiac disease such as myocardial infarction, angina pectoris, uncontrolled heart failure, or uncontrolled cardiac arrhythmia within 6 months of registration. * STEP 1: No impaired cardiac function, defined as left ventricular ejection fraction (LVEF) \< 45% or New York Heart Association (NYHA) stage III or IV congestive heart failure (CHF). * STEP 1: Patients with known human immunodeficiency virus (HIV) infection are eligible if they have been on effective antiretroviral therapy with an undetectable viral load tested within 6 months of registration. * STEP 1: Patients with hepatitis B virus (HBV) are eligible only if they meet all the following: * On HBV-suppressive therapy. * No evidence of active virus. * No evidence of HBV-related liver damage. * STEP 1: Patients with hepatitis C virus (HCV) are eligible only if they meet all the following: * Successfully completed complete-eradication therapy with undetectable viral load. * No evidence of HCV-related liver damage. * STEP 1: No history of clinically relevant neurologic disorder such as epilepsy, seizure, aphasia, stroke, severe brain injury, structural brain abnormality, benign brain tumor, dementia, Parkinson's disease, movement disorder, cerebellar disease, or other significant CNS abnormalities. * STEP 1: No prior additional malignancy (i.e. in addition to ALL) except adequately treated basal- or squamous-cell skin cancer, in situ cervical cancer, stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease-free for \>= 2 years. * STEP 1: No history of clinically significant ventricular arrhythmia, unexplained non-vasovagal syncope, or chronic bradycardic states such as sinoatrial block or higher degree of atrioventricular block unless a permanent pacemaker has been implanted. * STEP 1: No history of chronic liver disease, including cirrhosis. * STEP 1: No history of sinusoidal occlusion syndrome/veno-occlusive disease of the liver. * STEP 1: No uncontrolled infection or recent history (within 4 months prior to registration) of deep tissue infections such as fasciitis or osteomyelitis. * STEP 1: Total bilirubin, serum =\< 1.5 x upper limit of normal (ULN)\* * Except in the event of: 1) Gilbert disease, in which case total bilirubin must be =\< 2 x ULN, or 2) elevated bilirubin believed by investigator to be due to leukemic infiltration, in which case total bilirubin must be =\< 2 x ULN. * STEP 1: Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =\< 2.5 x ULN * STEP 1: Creatinine, serum =\< 1.5 ULN OR creatinine clearance \>= 40 mL/min * STEP 1: QT interval by Fridericia's correction formula (QTcF) =\< 470 msec * COHORT 1: Age \>= 60 years. * COHORT 1: Diagnosis of Philadelphia chromosome/BCR-ABL1-negative B-cell ALL. * COHORT 1: No prior treatment for ALL except a single dose of intrathecal chemotherapy, corticosteroids, hydroxyurea, and/or leukapheresis to reduce peripheral blast count and prevent ALL complications. Allowed therapy may be administered for no more than 14 days and must be completed \>= 24 hours prior to the initiation of protocol therapy. * COHORT 1: No plan for allogeneic or autologous hematopoietic cell transplantation (HCT). * COHORT 2: Age \>= 18 years. * COHORT 2: Diagnosis of Philadelphia chromosome/BCR-ABL1-negative B-cell ALL. * COHORT 2: Relapsed or refractory disease in salvage 1 or 2. * COHORT 2: No isolated extramedullary relapse. * COHORT 2: Prior allogeneic HCT permitted. * COHORT 2: Patients with prior allogeneic HCT must have completed transplantation \>= 4 months prior to registration. * COHORT 2: Patients with prior allogeneic HCT must have no evidence of graft-versus-host disease and must have completed immunosuppressive therapy \>= 30 days prior to registration. * COHORT 2: Prior treatment with inotuzumab ozogamicin, blinatumomab, other CD22-directed therapy, or other CD19-directed therapy is not allowed. * COHORT 2: Prior treatment with rituximab must be completed \>= 7 days prior to registration. * COHORT 2: Prior treatment with other monoclonal antibodies must be completed \>= 6 weeks prior to registration. * COHORT 2: Prior treatment for ALL must be completed \>= 14 days prior to registration with the following exceptions: intrathecal chemotherapy, hydroxyurea, corticosteroids, 6-mercaptopurine, methotrexate, vincristine, and/or leukapheresis to reduce circulating absolute lymphoblast count to =\< 10,000/uL or prevent complications related to ALL are allowed but must be completed \>= 24 hours prior to the initiation of protocol therapy. * COHORT 2: Patients should have resolution of any acute non-hematologic toxicities of prior therapy to National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version (v)5.0 grade =\< 1. * COHORT 2: Peripheral blood absolute lymphoblast count =\< 10,000/uL (treatment allowed as above to reduce blast count to =\< 10,000/uL) * COHORT 3: Age ≥ 75 years OR age ≥ 18 years AND ineligible for hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (HyperCVAD) regimens * COHORT 3: Diagnosis of Philadelphia chromosome/BCR-ABL1-positive B-cell ALL * COHORT 3: No prior treatment for ALL except a single dose of intrathecal chemotherapy, corticosteroids, hydroxyurea, BCR-ABL1-targeted tyrosine kinase inhibitor, and/or leukapheresis to reduce peripheral blast count and prevent ALL complications. Allowed non-protocol therapy may be administered for no more than 14 days and must be completed ≥ 24 hours prior to the initiation of protocol therapy. * COHORT 3: No chronic, strong CYP3A4 inducers

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Conditions

The condition(s) this trial relates to.

B-cell acute lymphoblastic leukemia B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) Burkitt lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

B acute lymphoblastic leukemia, philadelphia chromosome negative Recurrent B acute lymphoblastic leukemia Refractory B acute lymphoblastic leukemia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    263 sites in 2 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Advanced Breast Care Center PLLC

    SUSPENDED

    Warren, Michigan, 48088, United States

  • Alaska Breast Care and Surgery LLC

    SUSPENDED

    Anchorage, Alaska, 99508, United States

  • Alaska Oncology and Hematology LLC

    SUSPENDED

    Anchorage, Alaska, 99508, United States

  • Alaska Women's Cancer Care

    SUSPENDED

    Anchorage, Alaska, 99508, United States

  • Alliance for Childhood Diseases/Cure 4 the Kids Foundation

    SUSPENDED

    Las Vegas, Nevada, 89135, United States

  • Anchorage Associates in Radiation Medicine

    SUSPENDED

    Anchorage, Alaska, 98508, United States

  • Anchorage Oncology Centre

    SUSPENDED

    Anchorage, Alaska, 99508, United States

  • Anchorage Radiation Therapy Center

    SUSPENDED

    Anchorage, Alaska, 99504, United States

  • Ann M Wierman MD LTD

    SUSPENDED

    Las Vegas, Nevada, 89128, United States

  • Bay Area Hospital

    SUSPENDED

    Coos Bay, Oregon, 97420, United States

  • Beebe Health Campus

    SUSPENDED

    Rehoboth Beach, Delaware, 19971, United States

  • Beebe Medical Center

    SUSPENDED

    Lewes, Delaware, 19958, United States

  • Beebe South Coastal Health Campus

    SUSPENDED

    Millville, Delaware, 19967, United States

  • Bhadresh Nayak MD PC-Sterling Heights

    SUSPENDED

    Sterling Heights, Michigan, 48312, United States

  • Cancer Care Center of O'Fallon

    SUSPENDED

    O'Fallon, Illinois, 62269, United States

  • Cancer Care Specialists of Illinois - Decatur

    RECRUITING

    Decatur, Illinois, 62526, United States

  • Cancer Hematology Centers - Flint

    RECRUITING

    Flint, Michigan, 48503, United States

  • Cancer and Blood Specialists-Henderson

    SUSPENDED

    Henderson, Nevada, 89052, United States

  • Caro Cancer Center

    SUSPENDED

    Caro, Michigan, 48723, United States

  • Carson Tahoe Regional Medical Center

    SUSPENDED

    Carson City, Nevada, 89703, United States

  • Central Care Cancer Center - Bolivar

    SUSPENDED

    Bolivar, Missouri, 65613, United States

  • Central Care Cancer Center - Garden City

    SUSPENDED

    Garden City, Kansas, 67846, United States

  • Central Care Cancer Center - Great Bend

    SUSPENDED

    Great Bend, Kansas, 67530, United States

  • Centralia Oncology Clinic

    SUSPENDED

    Centralia, Illinois, 62801, United States

  • Centro Comprensivo de Cancer de UPR

    RECRUITING

    San Juan, 00927, Puerto Rico

  • Chelsea Hospital

    RECRUITING

    Chelsea, Michigan, 48118, United States

  • Christiana Care Health System-Christiana Hospital

    SUSPENDED

    Newark, Delaware, 19718, United States

  • Christiana Care Health System-Concord Health Center

    SUSPENDED

    Chadds Ford, Pennsylvania, 19317, United States

  • Christiana Care Health System-Wilmington Hospital

    SUSPENDED

    Wilmington, Delaware, 19801, United States

  • City of Hope Comprehensive Cancer Center

    RECRUITING

    Duarte, California, 91010, United States

    Contact Email: •••••@•••••

  • Clackamas Radiation Oncology Center

    SUSPENDED

    Clackamas, Oregon, 97015, United States

  • Community Cancer Institute

    ACTIVE_NOT_RECRUITING

    Clovis, California, 93611, United States

  • Comprehensive Cancer Centers of Nevada

    SUSPENDED

    Las Vegas, Nevada, 89148, United States

  • Comprehensive Cancer Centers of Nevada - Central Valley

    SUSPENDED

    Las Vegas, Nevada, 89169, United States

  • Comprehensive Cancer Centers of Nevada - Henderson

    SUSPENDED

    Henderson, Nevada, 89052, United States

  • Comprehensive Cancer Centers of Nevada - Northwest

    SUSPENDED

    Las Vegas, Nevada, 89128, United States

  • Comprehensive Cancer Centers of Nevada - Town Center

    SUSPENDED

    Las Vegas, Nevada, 89144, United States

  • Comprehensive Cancer Centers of Nevada-Horizon Ridge

    SUSPENDED

    Henderson, Nevada, 89052, United States

  • Comprehensive Cancer Centers of Nevada-Southeast Henderson

    SUSPENDED

    Henderson, Nevada, 89074, United States

  • Comprehensive Cancer Centers of Nevada-Summerlin

    SUSPENDED

    Las Vegas, Nevada, 89144, United States

  • Cox Cancer Center Branson

    SUSPENDED

    Branson, Missouri, 65616, United States

  • CoxHealth South Hospital

    SUSPENDED

    Springfield, Missouri, 65807, United States

  • Crossroads Cancer Center

    RECRUITING

    Effingham, Illinois, 62401, United States

  • Decatur Memorial Hospital

    SUSPENDED

    Decatur, Illinois, 62526, United States

  • Delaware Clinical and Laboratory Physicians PA

    SUSPENDED

    Newark, Delaware, 19713, United States

  • Desert West Surgery

    SUSPENDED

    Las Vegas, Nevada, 89102, United States

  • Drexel Town Square Health Center

    RECRUITING

    Oak Creek, Wisconsin, 53154, United States

  • Duke University Medical Center

    ACTIVE_NOT_RECRUITING

    Durham, North Carolina, 27710, United States

  • East Carolina University

    SUSPENDED

    Greenville, North Carolina, 27834, United States

  • Emory Saint Joseph's Hospital

    RECRUITING

    Atlanta, Georgia, 30342, United States

  • Emory University Hospital/Winship Cancer Institute

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Freeman Health System

    SUSPENDED

    Joplin, Missouri, 64804, United States

  • Froedtert Menomonee Falls Hospital

    RECRUITING

    Menomonee Falls, Wisconsin, 53051, United States

  • Froedtert West Bend Hospital/Kraemer Cancer Center

    RECRUITING

    West Bend, Wisconsin, 53095, United States

  • Froedtert and MCW Moorland Reserve Health Center

    RECRUITING

    New Berlin, Wisconsin, 53151, United States

  • Genesee Hematology Oncology PC

    SUSPENDED

    Flint, Michigan, 48503, United States

  • Genesys Hurley Cancer Institute

    RECRUITING

    Flint, Michigan, 48503, United States

  • HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

    SUSPENDED

    Las Vegas, Nevada, 89149, United States

  • HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

    SUSPENDED

    Las Vegas, Nevada, 89109, United States

  • HealthCare Partners Medical Group Oncology/Hematology-San Martin

    SUSPENDED

    Las Vegas, Nevada, 89113, United States

  • HealthCare Partners Medical Group Oncology/Hematology-Tenaya

    SUSPENDED

    Las Vegas, Nevada, 89128, United States

  • Heartland Regional Medical Center

    SUSPENDED

    Saint Joseph, Missouri, 64506, United States

  • Helen F Graham Cancer Center

    RECRUITING

    Newark, Delaware, 19713, United States

  • Hematology Oncology Consultants-Clarkston

    SUSPENDED

    Clarkston, Michigan, 48346, United States

  • Henry Ford Health Saint John Hospital

    RECRUITING

    Detroit, Michigan, 48236, United States

  • Henry Ford Health Warren Hospital

    RECRUITING

    Warren, Michigan, 48093, United States

  • Henry Ford Madison Heights Hospital - Breast

    SUSPENDED

    Warren, Michigan, 48093, United States

  • Henry Ford River District Hospital

    RECRUITING

    East China Township, Michigan, 48054, United States

  • Henry Ford Rochester Hospital

    SUSPENDED

    Rochester Hills, Michigan, 48309, United States

  • Henry Ford Saint John Hospital - Academic

    RECRUITING

    Grosse Pointe Woods, Michigan, 48236, United States

  • Henry Ford Saint John Hospital - Breast

    SUSPENDED

    Grosse Pointe Woods, Michigan, 48236, United States

  • Henry Ford Saint John Hospital - Macomb Medical

    RECRUITING

    Macomb, Michigan, 48044, United States

  • Henry Ford Saint John Hospital - Van Elslander

    RECRUITING

    Grosse Pointe Woods, Michigan, 48236, United States

  • Henry Ford Warren Hospital - Breast Macomb

    SUSPENDED

    Macomb, Michigan, 48044, United States

  • Henry Ford Warren Hospital - GLCMS

    RECRUITING

    Warren, Michigan, 48093, United States

  • Holy Cross Hospital

    SUSPENDED

    Fort Lauderdale, Florida, 33308, United States

  • Hope Cancer Care of Nevada

    SUSPENDED

    Las Vegas, Nevada, 89103, United States

  • Hope Cancer Care of Nevada-Pahrump

    SUSPENDED

    Pahrump, Nevada, 89048, United States

  • Hope Cancer Center

    SUSPENDED

    Pontiac, Michigan, 48341, United States

  • Hope Cancer Clinic

    SUSPENDED

    Livonia, Michigan, 48154, United States

  • Hurley Medical Center

    RECRUITING

    Flint, Michigan, 48503, United States

  • Huron Gastroenterology PC

    RECRUITING

    Ypsilanti, Michigan, 48106, United States

  • Illinois CancerCare - Washington

    SUSPENDED

    Washington, Illinois, 61571, United States

  • Illinois CancerCare-Bloomington

    SUSPENDED

    Bloomington, Illinois, 61704, United States

  • Illinois CancerCare-Canton

    SUSPENDED

    Canton, Illinois, 61520, United States

  • Illinois CancerCare-Carthage

    SUSPENDED

    Carthage, Illinois, 62321, United States

  • Illinois CancerCare-Dixon

    SUSPENDED

    Dixon, Illinois, 61021, United States

  • Illinois CancerCare-Eureka

    SUSPENDED

    Eureka, Illinois, 61530, United States

  • Illinois CancerCare-Galesburg

    SUSPENDED

    Galesburg, Illinois, 61401, United States

  • Illinois CancerCare-Kewanee Clinic

    SUSPENDED

    Kewanee, Illinois, 61443, United States

  • Illinois CancerCare-Macomb

    SUSPENDED

    Macomb, Illinois, 61455, United States

  • Illinois CancerCare-Ottawa Clinic

    SUSPENDED

    Ottawa, Illinois, 61350, United States

  • Illinois CancerCare-Pekin

    SUSPENDED

    Pekin, Illinois, 61554, United States

  • Illinois CancerCare-Peoria

    RECRUITING

    Peoria, Illinois, 61615, United States

  • Illinois CancerCare-Peru

    SUSPENDED

    Peru, Illinois, 61354, United States

  • Illinois CancerCare-Princeton

    SUSPENDED

    Princeton, Illinois, 61356, United States

  • Jupiter Medical Center

    RECRUITING

    Jupiter, Florida, 33458, United States

    Contact Email: •••••@•••••

  • Kadlec Clinic Hematology and Oncology

    SUSPENDED

    Kennewick, Washington, 99336, United States

  • Katmai Oncology Group

    SUSPENDED

    Anchorage, Alaska, 99508, United States

  • Kingman Regional Medical Center

    SUSPENDED

    Kingman, Arizona, 86401, United States

  • Las Vegas Cancer Center-Henderson

    SUSPENDED

    Henderson, Nevada, 89052, United States

  • Las Vegas Cancer Center-Medical Center

    SUSPENDED

    Las Vegas, Nevada, 89148-2405, United States

  • Las Vegas Prostate Cancer Center

    SUSPENDED

    Las Vegas, Nevada, 89113, United States

  • Las Vegas Urology - Cathedral Rock

    SUSPENDED

    Las Vegas, Nevada, 89128, United States

  • Las Vegas Urology - Green Valley

    SUSPENDED

    Henderson, Nevada, 89074, United States

  • Las Vegas Urology - Pebble

    SUSPENDED

    Henderson, Nevada, 89074, United States

  • Las Vegas Urology - Pecos

    SUSPENDED

    Las Vegas, Nevada, 89074, United States

  • Las Vegas Urology - Smoke Ranch

    SUSPENDED

    Las Vegas, Nevada, 89128, United States

  • Las Vegas Urology - Sunset

    SUSPENDED

    Las Vegas, Nevada, 89113, United States

  • Lehigh Valley Hospital - Muhlenberg

    SUSPENDED

    Bethlehem, Pennsylvania, 18017, United States

  • Lehigh Valley Hospital-Cedar Crest

    SUSPENDED

    Allentown, Pennsylvania, 18103, United States

  • Lehigh Valley Hospital-Hazleton

    SUSPENDED

    Hazleton, Pennsylvania, 18201, United States

  • Long Island Jewish Medical Center

    RECRUITING

    New Hyde Park, New York, 11040, United States

  • Loyola Center for Health at Burr Ridge

    SUSPENDED

    Burr Ridge, Illinois, 60527, United States

  • Loyola Medicine Homer Glen

    SUSPENDED

    Homer Glen, Illinois, 60491, United States

  • Loyola University Medical Center

    RECRUITING

    Maywood, Illinois, 60153, United States

  • MU Health Care Goldschmidt Cancer Center

    SUSPENDED

    Jefferson City, Missouri, 65109, United States

  • Macomb Hematology Oncology PC

    SUSPENDED

    Warren, Michigan, 48093, United States

  • Marjorie Weinberg Cancer Center at Loyola-Gottlieb

    SUSPENDED

    Melrose Park, Illinois, 60160, United States

  • Marshfield Medical Center - Minocqua

    RECRUITING

    Minocqua, Wisconsin, 54548, United States

    Contact Email: •••••@•••••

  • Marshfield Medical Center - Weston

    RECRUITING

    Weston, Wisconsin, 54476, United States

    Contact Email: •••••@•••••

  • Marshfield Medical Center-EC Cancer Center

    RECRUITING

    Eau Claire, Wisconsin, 54701, United States

    Contact Email: •••••@•••••

  • Marshfield Medical Center-Marshfield

    RECRUITING

    Marshfield, Wisconsin, 54449, United States

    Contact Email: •••••@•••••

  • Marshfield Medical Center-Rice Lake

    RECRUITING

    Rice Lake, Wisconsin, 54868, United States

    Contact Email: •••••@•••••

  • Marshfield Medical Center-River Region at Stevens Point

    RECRUITING

    Stevens Point, Wisconsin, 54482, United States

    Contact Email: •••••@•••••

  • Mayo Clinic in Rochester

    COMPLETED

    Rochester, Minnesota, 55905, United States

  • MedStar Georgetown University Hospital

    RECRUITING

    Washington D.C., District of Columbia, 20007, United States

  • Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Medical Oncology Hematology Consultants PA

    RECRUITING

    Newark, Delaware, 19713, United States

  • Memorial Hospital of Carbondale

    SUSPENDED

    Carbondale, Illinois, 62902, United States

  • Mercy Cancer Center - Cape Girardeau

    SUSPENDED

    Cape Girardeau, Missouri, 63703, United States

  • Mercy Clinic-Rolla-Cancer and Hematology

    SUSPENDED

    Rolla, Missouri, 65401, United States

  • Mercy Hospital Fort Smith

    SUSPENDED

    Fort Smith, Arkansas, 72903, United States

  • Mercy Hospital Joplin

    SUSPENDED

    Joplin, Missouri, 64804, United States

  • Mercy Hospital Oklahoma City

    SUSPENDED

    Oklahoma City, Oklahoma, 73120, United States

  • Mercy Hospital Saint Louis

    RECRUITING

    St Louis, Missouri, 63141, United States

  • Mercy Hospital South

    RECRUITING

    St Louis, Missouri, 63128, United States

  • Mercy Hospital Springfield

    SUSPENDED

    Springfield, Missouri, 65804, United States

  • Mercy Hospital Washington

    SUSPENDED

    Washington, Missouri, 63090, United States

  • Mercy Infusion Center - Chippewa

    SUSPENDED

    St Louis, Missouri, 63109, United States

  • Mercy Medical Center

    SUSPENDED

    Springfield, Massachusetts, 01104, United States

  • Mercy Oncology and Hematology - Clayton-Clarkson

    SUSPENDED

    Ballwin, Missouri, 63011, United States

  • Methodist Medical Center of Illinois

    SUSPENDED

    Peoria, Illinois, 61636, United States

  • Michigan Healthcare Professionals Pontiac

    SUSPENDED

    Pontiac, Michigan, 48341, United States

  • Missouri Baptist Medical Center

    SUSPENDED

    St Louis, Missouri, 63131, United States

  • Missouri Baptist Sullivan Hospital

    SUSPENDED

    Sullivan, Missouri, 63080, United States

  • MyMichigan Medical Center Saginaw

    RECRUITING

    Saginaw, Michigan, 48601, United States

  • MyMichigan Medical Center Tawas

    RECRUITING

    Tawas City, Michigan, 48764, United States

  • NYP/Weill Cornell Medical Center

    ACTIVE_NOT_RECRUITING

    New York, New York, 10065, United States

  • Nebraska Medicine-Village Pointe

    ACTIVE_NOT_RECRUITING

    Omaha, Nebraska, 68118, United States

  • Newland Medical Associates-Clarkston

    SUSPENDED

    Clarkston, Michigan, 48346, United States

  • Newland Medical Associates-Pontiac

    SUSPENDED

    Pontiac, Michigan, 48341, United States

  • North Shore University Hospital

    RECRUITING

    Manhasset, New York, 11030, United States

  • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

    SUSPENDED

    Yakima, Washington, 98902, United States

  • NorthShore University HealthSystem-Evanston Hospital

    RECRUITING

    Evanston, Illinois, 60201, United States

  • NorthShore University HealthSystem-Glenbrook Hospital

    RECRUITING

    Glenview, Illinois, 60026, United States

  • NorthShore University HealthSystem-Highland Park Hospital

    RECRUITING

    Highland Park, Illinois, 60035, United States

  • Northwell Health/Center for Advanced Medicine

    RECRUITING

    Lake Success, New York, 11042, United States

  • Northwestern Medicine Lake Forest Hospital

    ACTIVE_NOT_RECRUITING

    Lake Forest, Illinois, 60045, United States

  • Northwestern University

    RECRUITING

    Chicago, Illinois, 60611, United States

    Contact Email: •••••@•••••

  • OSF Saint Anthony's Health Center

    SUSPENDED

    Alton, Illinois, 62002, United States

  • OSF Saint Francis Medical Center

    SUSPENDED

    Peoria, Illinois, 61637, United States

  • OSF Saint Francis Radiation Oncology at Pekin

    SUSPENDED

    Pekin, Illinois, 61554, United States

  • OSF Saint Francis Radiation Oncology at Peoria Cancer Center

    SUSPENDED

    Peoria, Illinois, 61615, United States

  • Ochsner Medical Center Jefferson

    ACTIVE_NOT_RECRUITING

    New Orleans, Louisiana, 70121, United States

  • Ohio State University Comprehensive Cancer Center

    RECRUITING

    Columbus, Ohio, 43210, United States

  • Oncology Hematology Associates of Saginaw Valley PC

    SUSPENDED

    Saginaw, Michigan, 48604, United States

  • Oncology Las Vegas - Henderson

    SUSPENDED

    Henderson, Nevada, 89074, United States

  • Oncology Las Vegas - Tenaya

    SUSPENDED

    Las Vegas, Nevada, 89128, United States

  • OptumCare Cancer Care at Charleston

    RECRUITING

    Las Vegas, Nevada, 89102, United States

    Contact Email: •••••@•••••

  • OptumCare Cancer Care at Fort Apache

    RECRUITING

    Las Vegas, Nevada, 89183, United States

    Contact Email: •••••@•••••

  • OptumCare Cancer Care at MountainView

    SUSPENDED

    Las Vegas, Nevada, 89128, United States

  • Oregon Health and Science University

    ACTIVE_NOT_RECRUITING

    Portland, Oregon, 97239, United States

  • Overlake Medical Center

    SUSPENDED

    Bellevue, Washington, 98004, United States

  • PCR Oncology

    SUSPENDED

    Arroyo Grande, California, 93420, United States

  • Pacific Gynecology Specialists

    SUSPENDED

    Seattle, Washington, 98104, United States

  • Parkland Health Center - Farmington

    SUSPENDED

    Farmington, Missouri, 63640, United States

  • PeaceHealth Saint John Medical Center

    SUSPENDED

    Longview, Washington, 98632, United States

  • PeaceHealth Saint Joseph Medical Center

    SUSPENDED

    Bellingham, Washington, 98225, United States

  • PeaceHealth Southwest Medical Center

    SUSPENDED

    Vancouver, Washington, 98664, United States

  • PeaceHealth United General Medical Center

    SUSPENDED

    Sedro-Woolley, Washington, 98284, United States

  • Phelps Health Delbert Day Cancer Institute

    SUSPENDED

    Rolla, Missouri, 65401, United States

  • Pocono Medical Center

    SUSPENDED

    East Stroudsburg, Pennsylvania, 18301, United States

  • Providence Alaska Medical Center

    SUSPENDED

    Anchorage, Alaska, 99508, United States

  • Providence Cancer Institute Clackamas Clinic

    SUSPENDED

    Clackamas, Oregon, 97015, United States

  • Providence Newberg Medical Center

    SUSPENDED

    Newberg, Oregon, 97132, United States

  • Providence Portland Medical Center

    RECRUITING

    Portland, Oregon, 97213, United States

    Contact Email: •••••@•••••

  • Providence Regional Cancer Partnership

    SUSPENDED

    Everett, Washington, 98201, United States

  • Providence Regional Cancer System-Aberdeen

    SUSPENDED

    Aberdeen, Washington, 98520, United States

  • Providence Regional Cancer System-Centralia

    SUSPENDED

    Centralia, Washington, 98531, United States

  • Providence Regional Cancer System-Lacey

    SUSPENDED

    Lacey, Washington, 98503, United States

  • Providence Regional Cancer System-Shelton

    SUSPENDED

    Shelton, Washington, 98584, United States

  • Providence Regional Cancer System-Yelm

    SUSPENDED

    Yelm, Washington, 98597, United States

  • Providence Saint Joseph Medical Center/Disney Family Cancer Center

    SUSPENDED

    Burbank, California, 91505, United States

  • Providence Saint Mary Regional Cancer Center

    SUSPENDED

    Walla Walla, Washington, 99362, United States

  • Providence Saint Vincent Medical Center

    RECRUITING

    Portland, Oregon, 97225, United States

    Contact Email: •••••@•••••

  • Providence Willamette Falls Medical Center

    SUSPENDED

    Oregon City, Oregon, 97045, United States

  • Radiation Oncology Associates

    SUSPENDED

    Reno, Nevada, 89509, United States

  • Radiation Oncology Centers of Nevada Central

    SUSPENDED

    Las Vegas, Nevada, 89106, United States

  • Radiation Oncology Centers of Nevada Southeast

    SUSPENDED

    Las Vegas, Nevada, 89119, United States

  • Renown Regional Medical Center

    SUSPENDED

    Reno, Nevada, 89502, United States

  • Roswell Park Cancer Institute

    ACTIVE_NOT_RECRUITING

    Buffalo, New York, 14263, United States

  • SIH Cancer Institute

    SUSPENDED

    Carterville, Illinois, 62918, United States

  • SSM Health Good Samaritan

    SUSPENDED

    Mount Vernon, Illinois, 62864, United States

  • Saint Alphonsus Cancer Care Center-Nampa

    RECRUITING

    Nampa, Idaho, 83687, United States

    Contact Email: •••••@•••••

  • Saint Charles Health System

    SUSPENDED

    Bend, Oregon, 97701, United States

  • Saint Charles Health System-Redmond

    SUSPENDED

    Redmond, Oregon, 97756, United States

  • Saint Francis Medical Center

    SUSPENDED

    Cape Girardeau, Missouri, 63703, United States

  • Saint Luke's Cancer Institute - Boise

    SUSPENDED

    Boise, Idaho, 83712, United States

  • Saint Luke's Cancer Institute - Fruitland

    SUSPENDED

    Fruitland, Idaho, 83619, United States

  • Saint Luke's Cancer Institute - Meridian

    SUSPENDED

    Meridian, Idaho, 83642, United States

  • Saint Luke's Cancer Institute - Nampa

    SUSPENDED

    Nampa, Idaho, 83687, United States

  • Saint Luke's Cancer Institute - Twin Falls

    SUSPENDED

    Twin Falls, Idaho, 83301, United States

  • Saint Mary's Oncology/Hematology Associates of Marlette

    SUSPENDED

    Marlette, Michigan, 48453, United States

  • Saint Mary's Oncology/Hematology Associates of West Branch

    SUSPENDED

    West Branch, Michigan, 48661, United States

  • Saint Mary's Regional Medical Center

    SUSPENDED

    Reno, Nevada, 89503, United States

  • Saint Patrick Hospital - Community Hospital

    SUSPENDED

    Missoula, Montana, 59802, United States

  • Sainte Genevieve County Memorial Hospital

    SUSPENDED

    Sainte Genevieve, Missouri, 63670, United States

  • San Juan City Hospital

    RECRUITING

    San Juan, 00936, Puerto Rico

  • Siteman Cancer Center at Christian Hospital

    RECRUITING

    St Louis, Missouri, 63136, United States

    Contact Email: •••••@•••••

  • Siteman Cancer Center at Saint Peters Hospital

    RECRUITING

    City of Saint Peters, Missouri, 63376, United States

    Contact Email: •••••@•••••

  • Siteman Cancer Center at West County Hospital

    RECRUITING

    Creve Coeur, Missouri, 63141, United States

    Contact Email: •••••@•••••

  • Siteman Cancer Center-South County

    RECRUITING

    St Louis, Missouri, 63129, United States

    Contact Email: •••••@•••••

  • Southern Illinois University School of Medicine

    SUSPENDED

    Springfield, Illinois, 62702, United States

  • Springfield Clinic

    SUSPENDED

    Springfield, Illinois, 62702, United States

  • Springfield Memorial Hospital

    SUSPENDED

    Springfield, Illinois, 62781, United States

  • Stanford Cancer Institute Palo Alto

    ACTIVE_NOT_RECRUITING

    Palo Alto, California, 94304, United States

  • Stony Brook University Medical Center

    RECRUITING

    Stony Brook, New York, 11794, United States

  • Summerlin Hospital Medical Center

    SUSPENDED

    Las Vegas, Nevada, 89144, United States

  • Sunrise Hospital and Medical Center

    SUSPENDED

    Las Vegas, Nevada, 89109, United States

  • Swedish Cancer Institute-Edmonds

    SUSPENDED

    Edmonds, Washington, 98026, United States

  • Swedish Cancer Institute-Issaquah

    SUSPENDED

    Issaquah, Washington, 98029, United States

  • Swedish Medical Center-Ballard Campus

    SUSPENDED

    Seattle, Washington, 98107, United States

  • Swedish Medical Center-Cherry Hill

    SUSPENDED

    Seattle, Washington, 98122-5711, United States

  • Swedish Medical Center-First Hill

    SUSPENDED

    Seattle, Washington, 98122, United States

  • Thomas Jefferson University Hospital

    ACTIVE_NOT_RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

  • TidalHealth Nanticoke / Allen Cancer Center

    SUSPENDED

    Seaford, Delaware, 19973, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Brighton

    RECRUITING

    Brighton, Michigan, 48114, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Canton

    RECRUITING

    Canton, Michigan, 48188, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    RECRUITING

    Chelsea, Michigan, 48118, United States

  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

    RECRUITING

    Ypsilanti, Michigan, 48197, United States

  • Trinity Health Medical Center - Brighton

    RECRUITING

    Brighton, Michigan, 48114, United States

  • Trinity Health Medical Center - Canton

    RECRUITING

    Canton, Michigan, 48188, United States

  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor

    RECRUITING

    Ann Arbor, Michigan, 48106, United States

  • Trinity Health Saint Joseph Mercy Oakland Hospital

    RECRUITING

    Pontiac, Michigan, 48341, United States

  • Trinity Health Saint Mary Mercy Livonia Hospital

    RECRUITING

    Livonia, Michigan, 48154, United States

  • UC Comprehensive Cancer Center at Silver Cross

    RECRUITING

    New Lenox, Illinois, 60451, United States

    Contact Email: •••••@•••••

  • UC Irvine Health/Chao Family Comprehensive Cancer Center

    RECRUITING

    Orange, California, 92868, United States

    Contact Email: •••••@•••••

  • UC San Diego Moores Cancer Center

    RECRUITING

    La Jolla, California, 92093, United States

    Contact Email: •••••@•••••

  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

    RECRUITING

    Irvine, California, 92612, United States

    Contact Email: •••••@•••••

  • UNC Lineberger Comprehensive Cancer Center

    SUSPENDED

    Chapel Hill, North Carolina, 27599, United States

  • University Cancer Center

    SUSPENDED

    Las Vegas, Nevada, 89169, United States

  • University Medical Center of Southern Nevada

    SUSPENDED

    Las Vegas, Nevada, 89102, United States

  • University Oncology Associates

    ACTIVE_NOT_RECRUITING

    Clovis, California, 93611, United States

  • University of Alabama at Birmingham Cancer Center

    ACTIVE_NOT_RECRUITING

    Birmingham, Alabama, 35233, United States

  • University of Chicago Comprehensive Cancer Center

    RECRUITING

    Chicago, Illinois, 60637, United States

    Contact Email: •••••@•••••

  • University of Chicago Medicine-Orland Park

    RECRUITING

    Orland Park, Illinois, 60462, United States

    Contact Email: •••••@•••••

  • University of Cincinnati Cancer Center-UC Medical Center

    RECRUITING

    Cincinnati, Ohio, 45219, United States

    Contact Email: •••••@•••••

  • University of Cincinnati Cancer Center-West Chester

    RECRUITING

    West Chester, Ohio, 45069, United States

    Contact Email: •••••@•••••

  • University of Illinois

    RECRUITING

    Chicago, Illinois, 60612, United States

  • University of Kansas Cancer Center

    RECRUITING

    Kansas City, Kansas, 66160, United States

  • University of Kansas Hospital-Westwood Cancer Center

    RECRUITING

    Westwood, Kansas, 66205, United States

  • University of Maryland/Greenebaum Cancer Center

    ACTIVE_NOT_RECRUITING

    Baltimore, Maryland, 21201, United States

  • University of Michigan Health - Sparrow Lansing

    SUSPENDED

    Lansing, Michigan, 48912, United States

  • University of Nebraska Medical Center

    ACTIVE_NOT_RECRUITING

    Omaha, Nebraska, 68198, United States

  • University of Oklahoma Health Sciences Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

  • University of Rochester

    RECRUITING

    Rochester, New York, 14642, United States

  • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

    ACTIVE_NOT_RECRUITING

    Madison, Wisconsin, 53718, United States

  • University of Wisconsin Carbone Cancer Center - University Hospital

    ACTIVE_NOT_RECRUITING

    Madison, Wisconsin, 53792, United States

  • Urology Specialists of Nevada - Central

    SUSPENDED

    Las Vegas, Nevada, 89106, United States

  • Urology Specialists of Nevada - Green Valley

    SUSPENDED

    Henderson, Nevada, 89074, United States

  • Urology Specialists of Nevada - Northwest

    SUSPENDED

    Las Vegas, Nevada, 89128, United States

  • Urology Specialists of Nevada - Southwest

    SUSPENDED

    Las Vegas, Nevada, 89113, United States

  • VCU Massey Comprehensive Cancer Center

    RECRUITING

    Richmond, Virginia, 23298, United States

  • Valley Medical Center

    SUSPENDED

    Renton, Washington, 98055, United States

  • Valley Radiation Oncology

    SUSPENDED

    Peru, Illinois, 61354, United States

  • Wake Forest University Health Sciences

    RECRUITING

    Winston-Salem, North Carolina, 27157, United States

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact Email: •••••@•••••

  • West Virginia University Healthcare

    RECRUITING

    Morgantown, West Virginia, 26506, United States

    Contact Email: •••••@•••••

  • Western Illinois Cancer Treatment Center

    SUSPENDED

    Galesburg, Illinois, 61401, United States

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