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New combo aims to wipe out hidden leukemia cells

NCT ID NCT07636564

First seen Jun 11, 2026 · Last updated Jun 19, 2026 · Updated 3 times

Summary

This study tests whether adding a new drug called revumenib to the usual treatment (blinatumomab plus chemotherapy) can better clear leftover leukemia cells in people with a specific genetic type of B-cell acute lymphoblastic leukemia (ALL) or mixed-lineage leukemia. About 90 adults and children with KMT2A-translocation leukemia who still have tiny amounts of disease after initial therapy will be randomly assigned to receive either the standard treatment alone or with revumenib. The goal is to see if the combination is safe and more effective at achieving a deep remission.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acute biphenotypic leukemia acute leukemia of ambiguous lineage B-cell acute lymphoblastic leukemia B-cell childhood acute lymphoblastic leukemia B-lymphoblastic leukemia/lymphoma with t(v;11q23.3) Burkitt lymphoma mixed phenotype acute leukemia with MLL rearranged mixed phenotype acute leukemia with t(v;11q23.3) Precursor T-Cell Lymphoblastic Leukemia-Lymphoma T-cell childhood acute lymphocytic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.