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Biomarker-Guided combo aims to outsmart tough cancers

NCT ID NCT05136196

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 18, 2026 · Updated 27 times

Summary

This phase II trial is testing whether the combination of cabozantinib (a targeted therapy) and nivolumab (an immunotherapy) can shrink or stabilize advanced melanoma and head and neck cancers that have stopped responding to prior immunotherapy. Researchers are also checking if two tumor biomarkers can quickly sort patients into groups that respond differently. About 150 participants will receive the drug combo and undergo biopsies and scans to track results and side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cabozantinib and nivolumab
What this could lead to
If successful, this could show that combining these drugs helps shrink or stabilize advanced cancers, and that using tumor biomarkers can quickly identify who might benefit most.
What could go wrong
This is a mid-stage trial with only 150 participants, so results may not apply to everyone. The combination can cause significant side effects, and it's unclear if it will work better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2022

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * STEP 1 - SPECIMEN SUBMISSION * Participants must have histologically confirmed melanoma that is stage III or IV, unresectable, recurrent, or metastatic non-uveal melanoma OR Participants must have histologically confirmed squamous cell carcinoma of the head and neck (HNSCC) that is either locally recurrent and non-amendable to curative therapy (e.g., radiation, surgery) or metastatic. The primary tumor location must be the oropharynx, oral cavity, hypopharynx, or larynx. Primary tumor site of nasopharynx (any histology) or unknown primary tumor are not eligible * Note: For participants with primary oropharyngeal cancer, human papillomavirus (HPV) or p16 status must be known prior to step 1 registration * Participants must have disease presentation consistent with measurable disease. Note: Current disease measurements will not be required until step 2 registration * Participants must have had documented progression during or within 12 weeks after the last dose of PD-1 checkpoint inhibition-based therapy. Participants must have been receiving checkpoint inhibition for a minimum of 6 weeks. Participants who recur during adjuvant anti-PD1 treatment or within 12 weeks of completion of adjuvant anti-PD1 treatment are eligible if they have measurable disease and are considered unresectable * Participants with known human immunodeficiency virus (HIV)-infection must be receiving anti-retroviral therapy and have an undetectable viral load test within 6 months prior to step 1 registration * Participants with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load within 28 days prior to step 1 registration * Participants with a history of hepatitis C virus (HCV) infection must have no detectable viral load within 28 days prior to step 1 registration * Participants must not have an active infection requiring systemic therapy (except HBV, HCV or HIV as mentioned above) * Participants must not have experienced myocardial infarction or thromboembolic event requiring anticoagulation within 90 days prior to step 1 registration, unless clinically stable with ongoing medical management * Participants must have recovered to baseline or =\< grade 1 Common Terminology Criteria for Adverse Events (CTCAE) version (v) 5 toxicities related to any prior treatments, unless adverse events are deemed clinically nonsignificant by the treating investigator or stable on supportive therapy * Participants must not have received more than one prior primary radiotherapy regimen, curative or adjuvant, to the mucosal surfaces of the head and neck, with the additional following criteria: * If the primary radiation is combined with chemotherapy, a minimum of 16 weeks will be required to have elapsed between the end of radiotherapy and step 1 registration. If the radiation is given alone, a minimum of 8 weeks will be required to have elapsed between the end of radiotherapy and step 1 registration * Additional palliative radiotherapy regimens are permitted but cannot have been administered to previously treated tissue (i.e., overlapping fields are excluded) with the exception of central nervous system (CNS) radiation and must be completed at least 4 weeks prior to step 1 registration * Treatment areas should be healed with no sequelae from radiation therapy (RT) that would predispose to fistula formation * Participants must not have received prior treatment with anti-VEGF therapies for any reason * Participants must be \>= 18 years of age * Participants must have a Zubrod Performance Status 0 or 1 * Participants must have adequate cardiac function. Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification and must be class 2B or better to be eligible for this trial * Participants must not have any known significant organ disfunction that, in the opinion of the treating investigator, may impact suitability for receiving combination nivolumab/cabozantinib treatment * Participants must be able to take oral medication without breaking, opening, crushing, dissolving or chewing capsules * Participants must not have malabsorption syndrome * Participants must not have active autoimmune disease requiring systemic steroids (equivalent of \> 10mg of prednisone) or other immune suppression. Exceptions: * Type 1 diabetes mellitus * Endocrinopathy only requiring hormone replacement * Skin disorders (e.g., vitiligo, psoriasis, or alopecia) not requiring systemic treatment * Conditions not expected to recur in the absence of an external trigger * Participants must not have received an organ allograft * Participants must not have a history of hemoptysis (defined as \>= 1/2 tsp of bright red blood per day) or tumor bleeding within 90 days prior to step 1 registration * Participants must not have any of the following criteria due to the possibility of increased risk for tumor bleeding with cabozantinib therapy: * Prior carotid bleeding * Tumors that invade major vessels (e.g., the carotid) as shown unequivocally by imaging studies * Central (e.g., within 2 cm from the hilum) lung metastases that are cavitary as shown unequivocally by imaging studies * Any prior history of bleeding related to the current head and neck cancer * History of gross hemoptysis (bright red blood of 1/2 teaspoon or more per episode of coughing) within 3 months * Participants must not require concomitant anticoagulation with coumarin agents (e.g., warfarin), direct thrombin inhibitors (e.g., dabigatran), direct factor Xa inhibitor betrixaban, or platelet inhibitors (e.g., clopidogrel) * Participants must not require anticoagulants except for the following: * Prophylactic use of low-dose aspirin for cardio-protection (per local applicable guidelines) and low-dose low molecular weight heparins (LMWH). * Therapeutic doses of LMWH or anticoagulation with direct factor Xa inhibitors, rivaroxaban, edoxaban, or apixaban in participants without known brain metastases who are on a stable dose of the anticoagulant for at least 1 week prior to step 1 registration without clinically significant hemorrhagic complications from the anticoagulation regimen or the tumor * Participants must not have evidence of preexisting uncontrolled hypertension 28 days prior to step 1 registration as documented by baseline blood pressure reading with systolic blood pressure \> 150 mmHg and/or diastolic blood pressure \> 90 mmHg. Participants on antihypertensive therapies with controlled blood pressure are eligible * Participants must not have a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) has the potential to interfere with the safety or efficacy assessment of the investigational regimen * Participants must not be pregnant or nursing due to the known safety profiles of the drugs in this study. Individuals who are of reproductive potential must have agreed to use an effective contraceptive method with details provided as a part of the consent process. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential". In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion and vasectomy with testing showing no sperm in the semen * Have an adequate archival tissue specimen verified by the local pathologist and documented on the Pathology Review Form from a procedure obtained after the development of resistance to anti-PD-1/L1 therapy. Archival tissue must consist of tumor block or at least 1 hematoxylin and eosin (H\&E)-stained 4-5 micron slide and 20 freshly cut serially sectioned and numbered 4-5 micron unstained, uncharged slides OR Be willing to undergo research biopsy AND have tumor accessible for biopsy based on the following criteria: * Mediastinal, laparoscopic, gastrointestinal, or bronchial endoscopic biopsies can be obtained incidentally to a clinically necessary procedure and NOT for the sole purpose of the clinical trial * Acceptable biopsy procedures are: * Percutaneous biopsy with local anesthetic and/or sedation with an expected risk of severe complications \< 2% * Direct transoral biopsy (with or without local anesthetic and/or sedation) with an expected risk of severe complications \< 2% * Excisional cutaneous biopsy with local anesthetic and/or sedation with an expected risk of severe complications \< 2% * Biopsy with removal of additional tumor tissue during a medically necessary mediastinoscopy, laparoscopy, gastrointestinal endoscopy, bronchoscopy or craniotomy. No open surgical, laparoscopic or endoscopic procedure should be performed solely to obtain a biopsy for this protocol * Removal of additional tumor tissue during a medically necessary surgical procedure * Participants must submit whole blood for germline genomic analysis * Participants must have been offered the opportunity to participate in specimen banking * Note: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system * Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines * Participants with impaired decision-making capacity are eligible as long as their neurological or psychological condition does not preclude their safe participation in the study (e.g., tracking pill consumption and reporting adverse events to the investigator) * STEP 2 TREATMENT REGISTRATION * Note: No tests or exams are required to be repeated for step 2 registration (Treatment). However, participants who are known to have a change in eligibility status after step 1 registration are not eligible for step 2 registration * Participants must continue to meet eligibility for step 1 registration prior to step 2 registration * Participants must have had their tumor tissue submitted via the Southwest Oncology Group (SWOG) Specimen Tracking System prior to step 2 registration * Participants registered during stage II of the protocol must have received assignment to an open cohort from the SWOG Statistics and Data Management Center based on their biomarker screening profile (not applicable for patients registered during stage I of the protocol) * Participants must have measurable disease. All measurable disease must be assessed within 28 days prior to step 2 registration. All non-measurable disease must be assessed within 42 days prior to step 2 registration. Note: All disease must be assessed and documented on the Baseline Tumor Assessment Form (Response Evaluation Criteria in Solid Tumors \[RECIST\] 1.1) * For melanoma participants, CT chest, abdomen and pelvis must be obtained. For HNSCC participants, CT neck and chest must be obtained. Further imaging (i.e., MR brain, CT abdomen/pelvis or extremities, bone scan) will be performed as deemed appropriate by the treating physician * Participants with treated brain metastases must have no evidence of progression on the follow-up brain imaging after central nervous system (CNS)-directed therapy * Participants must not have experienced any significant health changes that, in the opinion of the treating investigator, may impact continued suitability for receiving combination nivolumab/cabozantinib treatment * Participants with treated brain metastases must have discontinued steroid treatment at least 14 days prior to step 2 registration * Participants must not have received investigational agents or monoclonal antibodies (except Food and Drug Administration \[FDA\] approved supportive care antibodies, such as denosumab) within 28 days prior to step 2 registration * Participants must not have received surgery, chemotherapy, radiation therapy, biologic agents, or steroids within 14 days prior to step 2 registration * Participants must not have received administration of a live, attenuated vaccine within 30 days prior to step 2 registration. Note: Participants may have received a messenger ribonucleic acid (mRNA) or viral vector-based coronavirus disease 2019 (COVID-19) vaccine within 30 days prior to step 2 registration * Participants must not have received administration of any strong CYP3A4 inducers, such as but not limited to rifampin, carbamazepine, enzalutamide, mitotane, phenytoin and St. John's wort, within 14 days prior to step 2 registration * Participants must not have received administration of any strong CYP3A4 inhibitors, such as but not limited to clarithromycin, itraconazole, ketoconazole, grapefruit juice, indinavir, nelfinavir, ritonavir, nefazodone, saquinavir, and telithromycin, within 5 times the half-life of the CYP3A inhibitor prior to step 2 registration * Participants must have a history and physical examination performed within 28 days prior to step 2 registration * Leukocytes \>= 3,000/uL (within 28 days prior to step 2 registration) * Absolute neutrophil count \>= 1,500/uL (within 28 days prior to step 2 registration) * Platelets \>= 100,000/uL (within 28 days prior to step 2 registration) * Total bilirubin =\< 1.5 x institutional upper limit of normal (ULN) or =\< 3 x ULN for participants with Gilbert's disease (within 28 days prior to step 2 registration) * Aspartate aminotransferase (AST) =\< 3 x institutional ULN (within 28 days prior to step 2 registration) * Alanine aminotransferase (ALT) =\< 3 x institutional ULN (within 28 days prior to step 2 registration) * Urinalysis: For baseline value (no required value for eligibility) * Measured (OR calculated) creatinine clearance \>= 30 mL/min using the following Cockcroft-Gault Formula. This specimen must have been drawn and processed within 28 days prior to step 2 registration

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Conditions

The condition(s) this trial relates to.

carcinoma cutaneous melanoma head and neck squamous cell carcinoma hypopharyngeal carcinoma hypopharynx cancer hypopharynx squamous cell carcinoma laryngeal carcinoma laryngeal neoplasm laryngeal squamous cell carcinoma larynx cancer lip and oral cavity carcinoma lip and oral cavity squamous cell carcinoma melanoma metastatic melanoma metastatic squamous cell carcinoma Mouth Neoplasms oral cavity squamous cell carcinoma oropharyngeal carcinoma oropharynx cancer oropharynx squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Clinical stage III cutaneous melanoma ajcc V8 Clinical stage III HPV-mediated (P16-positive) oropharyngeal carcinoma ajcc V8 Clinical stage IV cutaneous melanoma ajcc V8 Clinical stage IV HPV-mediated (P16-positive) oropharyngeal carcinoma ajcc V8 Locally recurrent head and neck squamous cell carcinoma Locally recurrent hypopharyngeal squamous cell carcinoma Locally recurrent laryngeal squamous cell carcinoma Locally recurrent oral cavity squamous cell carcinoma Locally recurrent oropharyngeal squamous cell carcinoma Metastatic head and neck squamous cell carcinoma Metastatic hypopharyngeal squamous cell carcinoma Metastatic laryngeal squamous cell carcinoma Metastatic melanoma Metastatic oral cavity squamous cell carcinoma Metastatic oropharyngeal squamous cell carcinoma Recurrent melanoma Stage III hypopharyngeal carcinoma ajcc V8 Stage III laryngeal cancer ajcc V8 Stage III lip and oral cavity cancer ajcc V8 Stage III oropharyngeal (P16-negative) carcinoma ajcc V8 Stage IV hypopharyngeal carcinoma ajcc V8 Stage IV laryngeal cancer ajcc V8 Stage IV lip and oral cavity cancer ajcc V8 Stage IV oropharyngeal (P16-negative) carcinoma ajcc V8 Unresectable melanoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    219 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Abbott-Northwestern Hospital

    RECRUITING

    Minneapolis, Minnesota, 55407, United States

  • Asplundh Cancer Pavilion

    ACTIVE_NOT_RECRUITING

    Willow Grove, Pennsylvania, 19090, United States

  • Atrium Medical Center-Middletown Regional Hospital

    RECRUITING

    Franklin, Ohio, 45005-1066, United States

    Contact Email: •••••@•••••

  • Baystate Medical Center

    RECRUITING

    Springfield, Massachusetts, 01199, United States

  • Beacon Kalamazoo Cancer Center

    SUSPENDED

    Kalamazoo, Michigan, 49009, United States

  • Benefis Sletten Cancer Institute

    RECRUITING

    Great Falls, Montana, 59405, United States

    Contact Email: •••••@•••••

  • Billings Clinic Cancer Center

    RECRUITING

    Billings, Montana, 59101, United States

    Contact Email: •••••@•••••

  • Bozeman Health Deaconess Hospital

    RECRUITING

    Bozeman, Montana, 59715, United States

    Contact Email: •••••@•••••

  • Bronson Battle Creek

    RECRUITING

    Battle Creek, Michigan, 49017, United States

  • Bronson Methodist Hospital

    RECRUITING

    Kalamazoo, Michigan, 49007, United States

  • Cancer Care Center of O'Fallon

    RECRUITING

    O'Fallon, Illinois, 62269, United States

  • Cancer Care Specialists of Illinois - Decatur

    RECRUITING

    Decatur, Illinois, 62526, United States

  • Cancer Care and Hematology-Fort Collins

    RECRUITING

    Fort Collins, Colorado, 80528, United States

  • Cancer Center of Western Wisconsin

    RECRUITING

    New Richmond, Wisconsin, 54017, United States

  • Cancer Hematology Centers - Flint

    RECRUITING

    Flint, Michigan, 48503, United States

  • Cancer and Hematology Centers of Western Michigan - Norton Shores

    SUSPENDED

    Norton Shores, Michigan, 49444, United States

  • Carle BroMenn Medical Center

    RECRUITING

    Normal, Illinois, 61761, United States

    Contact Email: •••••@•••••

  • Carle Cancer Center

    RECRUITING

    Urbana, Illinois, 61801, United States

    Contact Email: •••••@•••••

  • Carle Cancer Institute Normal

    RECRUITING

    Normal, Illinois, 61761, United States

    Contact Email: •••••@•••••

  • Carle Physician Group-Effingham

    RECRUITING

    Effingham, Illinois, 62401, United States

    Contact Email: •••••@•••••

  • Carle Physician Group-Mattoon/Charleston

    RECRUITING

    Mattoon, Illinois, 61938, United States

    Contact Email: •••••@•••••

  • Carle at The Riverfront

    RECRUITING

    Danville, Illinois, 61832, United States

    Contact Email: •••••@•••••

  • Cedars-Sinai Medical Center

    RECRUITING

    Los Angeles, California, 90048, United States

    Contact Email: •••••@•••••

  • Centra Alan B Pearson Regional Cancer Center

    RECRUITING

    Lynchburg, Virginia, 24501, United States

  • Centralia Oncology Clinic

    RECRUITING

    Centralia, Illinois, 62801, United States

  • Chelsea Hospital

    RECRUITING

    Chelsea, Michigan, 48118, United States

  • Clackamas Radiation Oncology Center

    SUSPENDED

    Clackamas, Oregon, 97015, United States

  • Community Hospital of Anaconda

    RECRUITING

    Anaconda, Montana, 59711, United States

    Contact Email: •••••@•••••

  • Community Medical Center

    RECRUITING

    Missoula, Montana, 59804, United States

    Contact Email: •••••@•••••

  • Corewell Health Grand Rapids Hospitals - Butterworth Hospital

    RECRUITING

    Grand Rapids, Michigan, 49503, United States

  • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

    RECRUITING

    Saint Joseph, Michigan, 49085, United States

  • Corewell Health Lakeland Hospitals - Niles Hospital

    RECRUITING

    Niles, Michigan, 49120, United States

  • Corewell Health Reed City Hospital

    RECRUITING

    Reed City, Michigan, 49677, United States

  • Crossroads Cancer Center

    RECRUITING

    Effingham, Illinois, 62401, United States

  • Dartmouth Cancer Center - North

    RECRUITING

    Saint Johnsbury, Vermont, 05819, United States

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    RECRUITING

    Lebanon, New Hampshire, 03756, United States

  • Decatur Memorial Hospital

    RECRUITING

    Decatur, Illinois, 62526, United States

  • Duluth Clinic Ashland

    RECRUITING

    Ashland, Wisconsin, 54806, United States

    Contact Email: •••••@•••••

  • Essentia Health - Deer River Clinic

    RECRUITING

    Deer River, Minnesota, 56636, United States

    Contact Email: •••••@•••••

  • Essentia Health - Fosston

    RECRUITING

    Fosston, Minnesota, 56542, United States

    Contact Email: •••••@•••••

  • Essentia Health - Jamestown Clinic

    RECRUITING

    Jamestown, North Dakota, 58401, United States

    Contact Email: •••••@•••••

  • Essentia Health - Park Rapids

    RECRUITING

    Park Rapids, Minnesota, 56470, United States

    Contact Email: •••••@•••••

  • Essentia Health Cancer Center

    RECRUITING

    Duluth, Minnesota, 55805, United States

    Contact Email: •••••@•••••

  • Essentia Health Cancer Center-South University Clinic

    RECRUITING

    Fargo, North Dakota, 58103, United States

    Contact Email: •••••@•••••

  • Essentia Health Hibbing Clinic

    RECRUITING

    Hibbing, Minnesota, 55746, United States

  • Essentia Health Saint Joseph's Medical Center

    RECRUITING

    Brainerd, Minnesota, 56401, United States

    Contact Email: •••••@•••••

  • Essentia Health Saint Mary's - Detroit Lakes Clinic

    RECRUITING

    Detroit Lakes, Minnesota, 56501, United States

    Contact Email: •••••@•••••

  • Essentia Health Saint Mary's Hospital - Superior

    RECRUITING

    Superior, Wisconsin, 54880, United States

  • Essentia Health Sandstone

    RECRUITING

    Sandstone, Minnesota, 55072, United States

    Contact Email: •••••@•••••

  • Essentia Health Virginia Clinic

    RECRUITING

    Virginia, Minnesota, 55792, United States

    Contact Email: •••••@•••••

  • Fairview Southdale Hospital

    RECRUITING

    Edina, Minnesota, 55435, United States

  • Genesee Hematology Oncology PC

    SUSPENDED

    Flint, Michigan, 48503, United States

  • Genesys Hurley Cancer Institute

    RECRUITING

    Flint, Michigan, 48503, United States

  • Gundersen Lutheran Medical Center

    RECRUITING

    La Crosse, Wisconsin, 54601, United States

    Contact Email: •••••@•••••

  • Hawaii Cancer Care - Westridge

    SUSPENDED

    ‘Aiea, Hawaii, 96701, United States

  • Hawaii Cancer Care Inc - Waterfront Plaza

    ACTIVE_NOT_RECRUITING

    Honolulu, Hawaii, 96813, United States

  • Helen F Graham Cancer Center

    RECRUITING

    Newark, Delaware, 19713, United States

  • Huntsman Cancer Institute/University of Utah

    RECRUITING

    Salt Lake City, Utah, 84112, United States

    Contact Email: •••••@•••••

  • Hurley Medical Center

    RECRUITING

    Flint, Michigan, 48503, United States

  • Huron Gastroenterology PC

    RECRUITING

    Ypsilanti, Michigan, 48106, United States

  • Illinois CancerCare - Washington

    RECRUITING

    Washington, Illinois, 61571, United States

  • Illinois CancerCare-Bloomington

    RECRUITING

    Bloomington, Illinois, 61704, United States

  • Illinois CancerCare-Canton

    RECRUITING

    Canton, Illinois, 61520, United States

  • Illinois CancerCare-Carthage

    RECRUITING

    Carthage, Illinois, 62321, United States

  • Illinois CancerCare-Dixon

    RECRUITING

    Dixon, Illinois, 61021, United States

  • Illinois CancerCare-Eureka

    RECRUITING

    Eureka, Illinois, 61530, United States

  • Illinois CancerCare-Galesburg

    RECRUITING

    Galesburg, Illinois, 61401, United States

  • Illinois CancerCare-Kewanee Clinic

    RECRUITING

    Kewanee, Illinois, 61443, United States

  • Illinois CancerCare-Macomb

    RECRUITING

    Macomb, Illinois, 61455, United States

  • Illinois CancerCare-Ottawa Clinic

    RECRUITING

    Ottawa, Illinois, 61350, United States

  • Illinois CancerCare-Pekin

    RECRUITING

    Pekin, Illinois, 61554, United States

  • Illinois CancerCare-Peoria

    RECRUITING

    Peoria, Illinois, 61615, United States

  • Illinois CancerCare-Peru

    RECRUITING

    Peru, Illinois, 61354, United States

  • Illinois CancerCare-Princeton

    RECRUITING

    Princeton, Illinois, 61356, United States

  • Inova Alexandria Hospital

    RECRUITING

    Alexandria, Virginia, 22304, United States

  • Inova Fair Oaks Hospital

    RECRUITING

    Fairfax, Virginia, 22033, United States

  • Inova Fairfax Hospital

    RECRUITING

    Falls Church, Virginia, 22042, United States

  • Inova Schar Cancer Institute

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • Jefferson Torresdale Hospital

    ACTIVE_NOT_RECRUITING

    Philadelphia, Pennsylvania, 19114, United States

  • Kootenai Clinic Cancer Services - Post Falls

    RECRUITING

    Post Falls, Idaho, 83854, United States

    Contact Email: •••••@•••••

  • Kootenai Clinic Cancer Services - Sandpoint

    RECRUITING

    Sandpoint, Idaho, 83864, United States

    Contact Email: •••••@•••••

  • Kootenai Health - Coeur d'Alene

    RECRUITING

    Coeur d'Alene, Idaho, 83814, United States

    Contact Email: •••••@•••••

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone

    RECRUITING

    New York, New York, 10016, United States

    Contact Email: •••••@•••••

  • Logan Health Medical Center

    RECRUITING

    Kalispell, Montana, 59901, United States

    Contact Email: •••••@•••••

  • Los Angeles General Medical Center

    RECRUITING

    Los Angeles, California, 90033, United States

    Contact Email: •••••@•••••

  • Loyola University Medical Center

    RECRUITING

    Maywood, Illinois, 60153, United States

  • Marshfield Medical Center - Minocqua

    RECRUITING

    Minocqua, Wisconsin, 54548, United States

    Contact Email: •••••@•••••

  • Marshfield Medical Center - Weston

    RECRUITING

    Weston, Wisconsin, 54476, United States

    Contact Email: •••••@•••••

  • Marshfield Medical Center-EC Cancer Center

    RECRUITING

    Eau Claire, Wisconsin, 54701, United States

    Contact Email: •••••@•••••

  • Marshfield Medical Center-Marshfield

    RECRUITING

    Marshfield, Wisconsin, 54449, United States

    Contact Email: •••••@•••••

  • Marshfield Medical Center-Rice Lake

    RECRUITING

    Rice Lake, Wisconsin, 54868, United States

    Contact Email: •••••@•••••

  • Marshfield Medical Center-River Region at Stevens Point

    RECRUITING

    Stevens Point, Wisconsin, 54482, United States

    Contact Email: •••••@•••••

  • Mary Greeley Medical Center

    RECRUITING

    Ames, Iowa, 50010, United States

  • Mayo Clinic Hospital in Arizona

    RECRUITING

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic in Florida

    RECRUITING

    Jacksonville, Florida, 32224-9980, United States

  • Mayo Clinic in Rochester

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • McFarland Clinic - Ames

    RECRUITING

    Ames, Iowa, 50010, United States

  • McFarland Clinic - Boone

    SUSPENDED

    Boone, Iowa, 50036, United States

  • McFarland Clinic - Jefferson

    SUSPENDED

    Jefferson, Iowa, 50129, United States

  • McFarland Clinic - Marshalltown

    RECRUITING

    Marshalltown, Iowa, 50158, United States

  • McFarland Clinic - Trinity Cancer Center

    RECRUITING

    Fort Dodge, Iowa, 50501, United States

  • Medical Center of the Rockies

    RECRUITING

    Loveland, Colorado, 80538, United States

  • Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Medical Oncology Hematology Consultants PA

    RECRUITING

    Newark, Delaware, 19713, United States

  • Memorial Hospital East

    RECRUITING

    Shiloh, Illinois, 62269, United States

  • Memorial Hospital North

    RECRUITING

    Colorado Springs, Colorado, 80920, United States

  • Mercy Cancer Center-West Lakes

    RECRUITING

    Clive, Iowa, 50325, United States

  • Mercy Hospital

    RECRUITING

    Cedar Rapids, Iowa, 52403, United States

  • Mercy Hospital

    RECRUITING

    Coon Rapids, Minnesota, 55433, United States

  • Mercy Hospital South

    RECRUITING

    St Louis, Missouri, 63128, United States

  • Mercy Medical Center - Des Moines

    RECRUITING

    Des Moines, Iowa, 50314, United States

  • Miami Valley Cancer Care and Infusion

    RECRUITING

    Greenville, Ohio, 45331, United States

  • Miami Valley Hospital North

    RECRUITING

    Dayton, Ohio, 45415, United States

    Contact Email: •••••@•••••

  • Miami Valley Hospital South

    RECRUITING

    Centerville, Ohio, 45459, United States

    Contact Email: •••••@•••••

  • Minnesota Oncology - Burnsville

    RECRUITING

    Burnsville, Minnesota, 55337, United States

  • Minnesota Oncology Hematology PA-Woodbury

    RECRUITING

    Woodbury, Minnesota, 55125, United States

  • Munson Medical Center

    RECRUITING

    Traverse City, Michigan, 49684, United States

  • NYU Langone Hospital - Long Island

    RECRUITING

    Mineola, New York, 11501, United States

    Contact Email: •••••@•••••

  • Nebraska Medicine-Bellevue

    RECRUITING

    Bellevue, Nebraska, 68123, United States

  • Nebraska Medicine-Village Pointe

    RECRUITING

    Omaha, Nebraska, 68118, United States

  • Northwell Health/Center for Advanced Medicine

    ACTIVE_NOT_RECRUITING

    Lake Success, New York, 11042, United States

  • Northwestern Medicine Cancer Center Delnor

    RECRUITING

    Geneva, Illinois, 60134, United States

  • Northwestern Medicine Cancer Center Kishwaukee

    RECRUITING

    DeKalb, Illinois, 60115, United States

  • Northwestern Medicine Cancer Center Warrenville

    RECRUITING

    Warrenville, Illinois, 60555, United States

  • Northwestern Medicine Glenview Outpatient Center

    RECRUITING

    Glenview, Illinois, 60026, United States

  • Northwestern Medicine Grayslake Outpatient Center

    RECRUITING

    Grayslake, Illinois, 60030, United States

  • Northwestern Medicine Lake Forest Hospital

    RECRUITING

    Lake Forest, Illinois, 60045, United States

    Contact Email: •••••@•••••

  • Northwestern Medicine Orland Park

    RECRUITING

    Orland Park, Illinois, 60462, United States

  • Northwestern University

    RECRUITING

    Chicago, Illinois, 60611, United States

    Contact Email: •••••@•••••

  • OSF Saint Francis Hospital and Medical Group

    RECRUITING

    Escanaba, Michigan, 49829, United States

  • Oncology Associates at Mercy Medical Center

    RECRUITING

    Cedar Rapids, Iowa, 52403, United States

  • Park Nicollet Clinic - Saint Louis Park

    RECRUITING

    Saint Louis Park, Minnesota, 55416, United States

  • Poudre Valley Hospital

    RECRUITING

    Fort Collins, Colorado, 80524, United States

  • Premier Blood and Cancer Center

    RECRUITING

    Dayton, Ohio, 45409, United States

  • ProHealth D N Greenwald Center

    RECRUITING

    Mukwonago, Wisconsin, 53149, United States

  • ProHealth Oconomowoc Memorial Hospital

    RECRUITING

    Oconomowoc, Wisconsin, 53066, United States

  • ProHealth Waukesha Memorial Hospital

    RECRUITING

    Waukesha, Wisconsin, 53188, United States

  • Providence Newberg Medical Center

    SUSPENDED

    Newberg, Oregon, 97132, United States

  • Providence Portland Medical Center

    RECRUITING

    Portland, Oregon, 97213, United States

    Contact Email: •••••@•••••

  • Providence Saint Vincent Medical Center

    RECRUITING

    Portland, Oregon, 97225, United States

    Contact Email: •••••@•••••

  • Providence Willamette Falls Medical Center

    SUSPENDED

    Oregon City, Oregon, 97045, United States

  • Queen's Cancer Cenrer - POB I

    SUSPENDED

    Honolulu, Hawaii, 96813, United States

  • Queen's Cancer Center - Kuakini

    SUSPENDED

    Honolulu, Hawaii, 96817, United States

  • Queen's Medical Center

    SUSPENDED

    Honolulu, Hawaii, 96813, United States

  • Rapid City Regional Hospital

    RECRUITING

    Rapid City, South Dakota, 57701, United States

    Contact Email: •••••@•••••

  • Regions Hospital

    RECRUITING

    Saint Paul, Minnesota, 55101, United States

  • Ridgeview Medical Center

    RECRUITING

    Waconia, Minnesota, 55387, United States

  • Rocky Mountain Regional VA Medical Center

    ACTIVE_NOT_RECRUITING

    Aurora, Colorado, 80045, United States

  • Rush-Copley Healthcare Center

    RECRUITING

    Yorkville, Illinois, 60560, United States

    Contact Email: •••••@•••••

  • Rush-Copley Medical Center

    RECRUITING

    Aurora, Illinois, 60504, United States

  • Saint Alphonsus Cancer Care Center-Boise

    RECRUITING

    Boise, Idaho, 83706, United States

  • Saint Alphonsus Cancer Care Center-Caldwell

    RECRUITING

    Caldwell, Idaho, 83605, United States

  • Saint Alphonsus Cancer Care Center-Nampa

    RECRUITING

    Nampa, Idaho, 83687, United States

    Contact Email: •••••@•••••

  • Saint Alphonsus Cancer Care Center-Ontario

    RECRUITING

    Ontario, Oregon, 97914, United States

    Contact Email: •••••@•••••

  • Saint Charles Health System

    RECRUITING

    Bend, Oregon, 97701, United States

  • Saint Francis Medical Center

    RECRUITING

    Cape Girardeau, Missouri, 63703, United States

  • Saint John's Hospital - Healtheast

    RECRUITING

    Maplewood, Minnesota, 55109, United States

  • Saint Luke's Cancer Institute - Boise

    RECRUITING

    Boise, Idaho, 83712, United States

  • Saint Luke's Cancer Institute - Fruitland

    RECRUITING

    Fruitland, Idaho, 83619, United States

  • Saint Luke's Cancer Institute - Meridian

    RECRUITING

    Meridian, Idaho, 83642, United States

  • Saint Luke's Cancer Institute - Nampa

    RECRUITING

    Nampa, Idaho, 83687, United States

  • Saint Luke's Cancer Institute - Twin Falls

    RECRUITING

    Twin Falls, Idaho, 83301, United States

  • Saint Vincent Hospital Cancer Center Green Bay

    RECRUITING

    Green Bay, Wisconsin, 54301, United States

  • Saint Vincent Hospital Cancer Center at Oconto Falls

    RECRUITING

    Oconto Falls, Wisconsin, 54154, United States

  • Saint Vincent Hospital Cancer Center at Saint Mary's

    RECRUITING

    Green Bay, Wisconsin, 54303, United States

  • Saint Vincent Hospital Cancer Center at Sheboygan

    RECRUITING

    Sheboygan, Wisconsin, 53081, United States

  • Saint Vincent Hospital Cancer Center at Sturgeon Bay

    RECRUITING

    Sturgeon Bay, Wisconsin, 54235-1495, United States

  • Sanford Bismarck Medical Center

    RECRUITING

    Bismarck, North Dakota, 58501, United States

    Contact Email: •••••@•••••

  • Sanford Broadway Medical Center

    RECRUITING

    Fargo, North Dakota, 58122, United States

    Contact Email: •••••@•••••

  • Sanford Cancer Center Oncology Clinic

    RECRUITING

    Sioux Falls, South Dakota, 57104, United States

    Contact Email: •••••@•••••

  • Sanford Joe Lueken Cancer Center

    RECRUITING

    Bemidji, Minnesota, 56601, United States

    Contact Email: •••••@•••••

  • Sanford Roger Maris Cancer Center

    RECRUITING

    Fargo, North Dakota, 58122, United States

    Contact Email: •••••@•••••

  • Sanford USD Medical Center - Sioux Falls

    RECRUITING

    Sioux Falls, South Dakota, 57117-5134, United States

    Contact Email: •••••@•••••

  • Siteman Cancer Center at Christian Hospital

    RECRUITING

    St Louis, Missouri, 63136, United States

    Contact Email: •••••@•••••

  • Siteman Cancer Center at Saint Peters Hospital

    RECRUITING

    City of Saint Peters, Missouri, 63376, United States

    Contact Email: •••••@•••••

  • Siteman Cancer Center at West County Hospital

    RECRUITING

    Creve Coeur, Missouri, 63141, United States

    Contact Email: •••••@•••••

  • Siteman Cancer Center-South County

    RECRUITING

    St Louis, Missouri, 63129, United States

    Contact Email: •••••@•••••

  • Southeastern Medical Oncology Center-Clinton

    RECRUITING

    Clinton, North Carolina, 28328, United States

  • Southeastern Medical Oncology Center-Goldsboro

    RECRUITING

    Goldsboro, North Carolina, 27534, United States

  • Southeastern Medical Oncology Center-Jacksonville

    RECRUITING

    Jacksonville, North Carolina, 28546, United States

  • Southern Illinois University School of Medicine

    RECRUITING

    Springfield, Illinois, 62702, United States

  • Springfield Clinic

    RECRUITING

    Springfield, Illinois, 62702, United States

  • Springfield Memorial Hospital

    RECRUITING

    Springfield, Illinois, 62781, United States

  • The Angeles Clinic and Research Institute - West Los Angeles Office

    RECRUITING

    Los Angeles, California, 90025, United States

  • Thomas Jefferson University Hospital

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

    Contact Email: •••••@•••••

  • Tower Cancer Research Foundation

    RECRUITING

    Beverly Hills, California, 90211, United States

    Contact Email: •••••@•••••

  • Trinity Health Grand Rapids Hospital

    SUSPENDED

    Grand Rapids, Michigan, 49503, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Brighton

    RECRUITING

    Brighton, Michigan, 48114, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Canton

    RECRUITING

    Canton, Michigan, 48188, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    RECRUITING

    Chelsea, Michigan, 48118, United States

  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

    RECRUITING

    Ypsilanti, Michigan, 48197, United States

  • Trinity Health Medical Center - Brighton

    RECRUITING

    Brighton, Michigan, 48114, United States

  • Trinity Health Medical Center - Canton

    RECRUITING

    Canton, Michigan, 48188, United States

  • Trinity Health Muskegon Hospital

    SUSPENDED

    Muskegon, Michigan, 49444, United States

  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor

    RECRUITING

    Ann Arbor, Michigan, 48106, United States

  • Trinity Health Saint Joseph Mercy Oakland Hospital

    RECRUITING

    Pontiac, Michigan, 48341, United States

  • Trinity Health Saint Mary Mercy Livonia Hospital

    RECRUITING

    Livonia, Michigan, 48154, United States

  • Tufts Medical Center

    ACTIVE_NOT_RECRUITING

    Boston, Massachusetts, 02111, United States

  • Tufts Medical Center Cancer Center Stoneham

    ACTIVE_NOT_RECRUITING

    Stoneham, Massachusetts, 02180, United States

  • UC Irvine Health/Chao Family Comprehensive Cancer Center

    RECRUITING

    Orange, California, 92868, United States

    Contact Email: •••••@•••••

  • UCHealth Greeley Hospital

    RECRUITING

    Greeley, Colorado, 80631, United States

  • UCHealth Memorial Hospital Central

    RECRUITING

    Colorado Springs, Colorado, 80909, United States

  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

    RECRUITING

    Irvine, California, 92612, United States

    Contact Email: •••••@•••••

  • UI Health Care Mission Cancer and Blood - Ankeny Clinic

    RECRUITING

    Ankeny, Iowa, 50023, United States

  • UI Health Care Mission Cancer and Blood - Des Moines Clinic

    RECRUITING

    Des Moines, Iowa, 50309, United States

  • UI Health Care Mission Cancer and Blood - Laurel Clinic

    RECRUITING

    Des Moines, Iowa, 50314, United States

  • UI Health Care Mission Cancer and Blood - Waukee Clinic

    RECRUITING

    Waukee, Iowa, 50263, United States

  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic

    RECRUITING

    Clive, Iowa, 50325, United States

  • USC / Norris Comprehensive Cancer Center

    RECRUITING

    Los Angeles, California, 90033, United States

  • UW Cancer Center at ProHealth Care

    RECRUITING

    Waukesha, Wisconsin, 53188, United States

  • United Hospital

    RECRUITING

    Saint Paul, Minnesota, 55102, United States

  • Unity Hospital

    ACTIVE_NOT_RECRUITING

    Fridley, Minnesota, 55432, United States

  • University of Arkansas for Medical Sciences

    RECRUITING

    Little Rock, Arkansas, 72205, United States

  • University of Illinois

    RECRUITING

    Chicago, Illinois, 60612, United States

  • University of Michigan Health - Sparrow Lansing

    RECRUITING

    Lansing, Michigan, 48912, United States

  • University of Michigan Health - West

    RECRUITING

    Wyoming, Michigan, 49519, United States

  • University of Michigan Rogel Cancer Center

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

    Contact Email: •••••@•••••

  • University of Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, 68198, United States

  • University of New Mexico Cancer Center

    RECRUITING

    Albuquerque, New Mexico, 87106, United States

  • University of Oklahoma Health Sciences Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

  • Upper Valley Medical Center

    RECRUITING

    Troy, Ohio, 45373, United States

    Contact Email: •••••@•••••

  • VCU Health Tappahannock Hospital

    RECRUITING

    Tappahannock, Virginia, 22560, United States

  • VCU Massey Cancer Center at Stony Point

    RECRUITING

    Richmond, Virginia, 23235, United States

  • VCU Massey Comprehensive Cancer Center

    RECRUITING

    Richmond, Virginia, 23298, United States

  • Virginia Cancer Institute

    RECRUITING

    Richmond, Virginia, 23229, United States

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact Email: •••••@•••••

  • Wayne State University/Karmanos Cancer Institute

    ACTIVE_NOT_RECRUITING

    Detroit, Michigan, 48201, United States

  • Weisberg Cancer Treatment Center

    ACTIVE_NOT_RECRUITING

    Farmington Hills, Michigan, 48334, United States

  • West Michigan Cancer Center

    RECRUITING

    Kalamazoo, Michigan, 49007, United States

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