UNRESECTABLE MELANOMA

This study is testing a personalized cell therapy called lifileucel for people with advanced melanoma that has worsened after standard immunotherapy. Doctors take a patient's own tumor-fighting immune cells, grow large numbers of them in a lab, and then infuse them back into the …

This study is testing whether adding specific prebiotic foods to the diet can improve gut bacteria and help people with advanced melanoma respond better to their first-line immunotherapy treatment. Researchers will enroll 75 adults starting immunotherapy and provide them with a s…

This study is testing a new, personalized vaccine designed to teach the body's immune system to recognize and attack a patient's specific cancer. It is being given alongside an existing immunotherapy drug (pembrolizumab) to adults with advanced solid tumors that have spread. The …

This study is testing whether adding an arthritis drug (sarilumab) to three approved melanoma drugs works better and is safer for people with advanced melanoma that cannot be removed by surgery. It will involve about 105 participants with stage III or IV melanoma. The main goals …

This study is testing a new treatment approach for people who have had a kidney transplant and now have advanced skin cancer that cannot be removed by surgery or has spread. The goal is to see if a combination of cancer immunotherapy drugs (nivolumab and ipilimumab) can be given …

This study is testing whether combining two drugs, cabozantinib and nivolumab, can help control advanced melanoma or head and neck cancer that has worsened despite standard immunotherapy. It will enroll about 150 adults whose cancer has progressed on prior treatment. A key goal i…

This study is testing a new, modified drug called IOV-3001 in combination with a personalized cell therapy (lifileucel) for people with advanced melanoma that has spread or cannot be removed by surgery. The main goals are to find a safe dose and see how well the body handles the …

This study is testing a new oral drug, LNS8801, for people with advanced melanoma that has spread and no longer responds to standard immunotherapies. Researchers want to see if LNS8801, taken alone or combined with the drug pembrolizumab, can stop or slow cancer growth better tha…

This study aims to learn if a special scan (PET/CT) and a blood test for tumor DNA can help doctors predict, very early on, which patients with advanced melanoma will respond well to immunotherapy and which might experience side effects. It will enroll 24 patients who are startin…