Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New combo therapy aims to outsmart relapsed leukemia in kids

NCT ID NCT04546399

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 02, 2026 · Updated 3 times

Summary

This phase 2 trial is testing whether adding nivolumab to blinatumomab helps children and young adults (ages 1 to 30) with relapsed B-cell acute lymphoblastic leukemia (B-ALL), including those with Down syndrome. Blinatumomab helps the immune system find and kill cancer cells, while nivolumab boosts the immune response. The study compares the combination against blinatumomab alone to see if it improves remission rates and extends time without the cancer returning.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
blinatumomab and nivolumab
What this could lead to
If successful, this combination could offer a more effective treatment option for children and young adults with relapsed B-ALL, potentially leading to longer remission without the need for more toxic therapies.
What could go wrong
This is a phase 2 trial, so the combination is still being tested for safety and effectiveness. It may not work better than blinatumomab alone, and there is a risk of side effects like immune system overactivation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 461 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2020

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

1 year to 30 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients must be \>= 1 and \< 31 years at time of enrollment * Patients must have first relapse of CD19+ B-ALL (relapse blasts must express CD19) in one of the following categories: * Isolated bone marrow relapse * Isolated central nervous system (CNS) (excluding known optic nerve/retinal and CNS chloromas) and/or testicular relapse * Combined bone marrow with extramedullary relapse in the CNS (excluding known optic nerve/retinal and CNS chloromas) and/or testes * Patients with Down syndrome (DS) are eligible in the following categories: * Isolated bone marrow relapse * Combined bone marrow with CNS (excluding known optic nerve/retinal and CNS chloromas) and/or testicular relapse * Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1 or 2. Use Karnofsky for patients \> 16 years of age and Lansky for patients =\< 16 years of age * Of note, for patients with developmental delay (e.g., Down syndrome) regardless of age, Lansky scale may be substituted for Karnofsky scale. However, the requirement for ECOG 0-2 remains, regardless of known history of developmental delay * Patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study * Patients with prior blinatumomab or CD19+ chimeric antigen receptor therapy in the upfront setting will be eligible, provided relapsed lymphoblasts retain CD19 expression * Patients must not have had a prior hematopoietic stem cell transplant * A single intrathecal chemotherapy at the time of relapse will be allowed. If \< 7 days have elapsed between this intrathecal therapy (IT) and the start of protocol therapy, then the day 1 intrathecal chemotherapy (i.e. methotrexate, cytarabine, or triple intrathecal) may be omitted * In the 28 days prior to enrollment, up to five days of post-relapse, pre-enrollment therapy (steroids and/or hydroxyurea only) is permissible * Patients with Down syndrome who received pre-enrollment therapy and have a white blood count (WBC) \>= 30,000/ul at the time of enrollment still must receive protocol specified cytoreductive therapy with vincristine and dexamethasone, and no "washout" is required * Patients with Down syndrome who received pre-enrollment therapy and have a WBC \< 30,000/ul at the time of enrollment must be given a 24 hour "washout" before starting immunotherapy * Note: There is no waiting period or "washout" for patients who relapse while receiving upfront therapy * Creatinine clearance or radioisotope glomerular filtration rate (GFR) \>= 70 mL/min/1.73 m\^2 OR a serum creatinine based on age/sex as follows (within 7 calendar days prior to enrollment): * Age: Maximum serum creatinine (mg/dL) * 1 to \< 2 years: 0.6 (male), 0.6 (female) * 2 to \< 6 years: 0.8 (male), 0.8 (female) * 6 to \< 10 years: 1 (male), 1 (female) * 10 to \< 13 years: 1.2 (male), 1.2 (female) * 13 to \< 16 years: 1.5 (male), 1.4 (female) * \>= 16 years: 1.7 (male), 1.4 (female) * The threshold creatinine values in this Table were derived from the Schwartz formula for estimating GFR utilizing child length and stature data published by the Center for Disease Control (CDC) * Shortening fraction of \>= 27% by echocardiogram, or ejection fraction of \>= 50% by echocardiogram, cardiac magnetic resonance imaging (MRI) or radionuclide angiogram * No evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry \> 94% if there is clinical indication for determination * All patients and/or their parents or legal guardians must sign a written informed consent * All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met Exclusion Criteria: * Patients with B-lymphoblastic lymphoma (B-LLy) * Patients with Burkitt leukemia/lymphoma or mature B-cell leukemia * Patients with Philadelphia chromosome positive (Ph+) B-ALL or ABL class Ph-like B-ALL (i.e. rearrangements involving ABL1, ABL2, CSF1R or PDGFRB and predicted to be sensitive to imatinib or dasatinib) * Patients with mixed phenotype acute leukemia (MPAL) * Patients with known Charcot-Marie-Tooth disease * Patients with known MYC translocation associated with mature (Burkitt) B-cell ALL, regardless of blast immunophenotype * Patients with active, uncontrolled infection defined as: * Positive bacterial blood culture within 48 hours of study enrollment * Receiving IV or PO antibiotics for an infection with continued signs or symptoms. Note: Patients may be receiving IV or oral antibiotics to complete a course of therapy for a prior documented infection if cultures have been negative for at least 48 hours and signs or symptoms of active infection have resolved. For patients with clostridium (C.) difficile diarrhea, at least 72 hours of antibacterial therapy must have elapsed and stools must have normalized to baseline. * Fever above 38.2 degrees Celsius (C) within 48 hours of study enrollment with clinical signs of infection. Fever without clinical signs of infection that is attributed to tumor burden is allowed if blood cultures are negative for \> 48 hours * A positive fungal culture within 30 days of study enrollment or active therapy for presumed invasive fungal infection * Active viral or protozoal infection requiring IV treatment * Patients known to have one of the following concomitant genetic syndromes: Bloom syndrome, ataxia-telangiectasia, Fanconi anemia, Kostmann syndrome, Shwachman syndrome or any other known bone marrow failure syndrome are not eligible. * Patients with uncontrolled HIV, hepatitis B, or hepatitis C infection. Of note, patients with known human immunodeficiency virus (HIV) infection on effective anti-retroviral therapy with undetectable viral load for at least the last 6 months prior to enrollment are eligible. Similarly, hepatitis B and hepatitis C positive patients who have been treated and have no viral detectable burden are also eligible * Patients with significant central nervous system pathology that would preclude treatment with blinatumomab, including history of severe neurologic disorder or autoimmune disease with CNS involvement * Note: Patients with a history of seizures that are well controlled on stable doses of anti-epileptic drugs are eligible Patients with a history of cerebrovascular ischemia/hemorrhage with residual deficits are not eligible. Patients with a history of cerebrovascular ischemia/hemorrhage remain eligible provided all neurologic deficits have resolved * Patients with an active known/suspected autoimmune disease are not eligible. However, patients with type I diabetes mellitus, hypothyroidism only requiring hormone replacement, skin disorders (such as vitiligo, psoriasis, or alopecia) not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger are permitted to enroll * Patients with DS patients with known non-hematopoietic, non-CNS/testicular extramedullary disease (i.e., chloromatous disease) are not eligible * Note: Group 3 and 4 patients with known non-hematopoietic, non-CNS/testicular extramedullary disease (i.e., chloromatous disease) are eligible if this is NOT the only site of relapsed disease * Female patients of childbearing potential are not eligible unless a negative pregnancy test result has been obtained within 7 days prior to enrollment. Patients who are sexually active and of reproductive potential are not eligible unless they agree to use an effective contraceptive method for the duration of this study. Men with female partners of childbearing potential should use effective contraception during the duration of their treatment. The effect of blinatumomab on fertility has not been evaluated. Blinatumomab is not recommended for pregnant women or women of childbearing potential (WOCBP) not using contraception. Females of reproductive potential must use effective contraception during treatment and for at least 48 hours after the last dose of blinatumomab. Studies in animal models have shown that nivolumab can adversely impair pregnancy. Thus, nivolumab is expected to cause fetal harm during pregnancy. WOCBP receiving nivolumab must continue contraception for a period of at least 5 months after the last dose of nivolumab. It is unknown whether nivolumab is present in breast milk, thus breastfeeding should be discontinued while a patient is receiving nivolumab * Lactating females are not eligible unless they agree to not breastfeed their infants. It is unknown whether blinatumomab or its metabolites are excreted in human breast milk. Women are not permitted to breastfeed while receiving blinatumomab and for the last 48 hours after the last blinatumomab dose. Due to the potential for serious adverse reactions in the breastfed infant, women are not permitted to breastfeed during treatment and for 5 months after the last nivolumab dose

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Down syndrome are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

B-cell acute lymphoblastic leukemia Burkitt lymphoma Down syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Down syndrome Recurrent B acute lymphoblastic leukemia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    220 sites in 4 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AdventHealth Orlando

    RECRUITING

    Orlando, Florida, 32803, United States

  • Albany Medical Center

    RECRUITING

    Albany, New York, 12208, United States

  • Alberta Children's Hospital

    SUSPENDED

    Calgary, Alberta, T3B 6A8, Canada

  • Alfred I duPont Hospital for Children

    RECRUITING

    Wilmington, Delaware, 19803, United States

  • Alliance for Childhood Diseases/Cure 4 the Kids Foundation

    RECRUITING

    Las Vegas, Nevada, 89135, United States

    Contact Email: •••••@•••••

  • Ann M Wierman MD LTD

    SUSPENDED

    Las Vegas, Nevada, 89128, United States

  • Arkansas Children's Hospital

    RECRUITING

    Little Rock, Arkansas, 72202-3591, United States

  • Arnold Palmer Hospital for Children

    RECRUITING

    Orlando, Florida, 32806, United States

  • BI-LO Charities Children's Cancer Center

    RECRUITING

    Greenville, South Carolina, 29605, United States

  • Banner Children's at Desert

    RECRUITING

    Mesa, Arizona, 85202, United States

  • Banner University Medical Center - Tucson

    RECRUITING

    Tucson, Arizona, 85719, United States

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Beacon Kalamazoo

    SUSPENDED

    Kalamazoo, Michigan, 49048, United States

  • Blank Children's Hospital

    RECRUITING

    Des Moines, Iowa, 50309, United States

  • British Columbia Children's Hospital

    SUSPENDED

    Vancouver, British Columbia, V6H 3V4, Canada

  • Bronson Battle Creek

    SUSPENDED

    Battle Creek, Michigan, 49017, United States

  • Bronson Methodist Hospital

    RECRUITING

    Kalamazoo, Michigan, 49007, United States

  • C S Mott Children's Hospital

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)

    SUSPENDED

    Québec, G1V 4G2, Canada

  • Camden Clark Medical Center

    SUSPENDED

    Parkersburg, West Virginia, 26101, United States

  • Cancer Care Specialists - Reno

    SUSPENDED

    Reno, Nevada, 89511, United States

  • Cancer and Hematology Centers of Western Michigan - Norton Shores

    SUSPENDED

    Norton Shores, Michigan, 49444, United States

  • CancerCare Manitoba

    SUSPENDED

    Winnipeg, Manitoba, R3E 0V9, Canada

  • Cardinal Glennon Children's Medical Center

    RECRUITING

    St Louis, Missouri, 63104, United States

  • Carolinas Medical Center/Levine Cancer Institute

    RECRUITING

    Charlotte, North Carolina, 28203, United States

  • Carson Tahoe Regional Medical Center

    SUSPENDED

    Carson City, Nevada, 89703, United States

  • Cedars-Sinai Medical Center

    RECRUITING

    Los Angeles, California, 90048, United States

    Contact Email: •••••@•••••

  • Centre Hospitalier Universitaire Sainte-Justine

    SUSPENDED

    Montreal, Quebec, H3T 1C5, Canada

  • Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

    SUSPENDED

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital

    RECRUITING

    Atlanta, Georgia, 30329, United States

  • Children's Hospital Colorado

    RECRUITING

    Aurora, Colorado, 80045, United States

  • Children's Hospital Los Angeles

    RECRUITING

    Los Angeles, California, 90027, United States

  • Children's Hospital Medical Center of Akron

    RECRUITING

    Akron, Ohio, 44308, United States

  • Children's Hospital New Orleans

    RECRUITING

    New Orleans, Louisiana, 70118, United States

  • Children's Hospital and Medical Center of Omaha

    RECRUITING

    Omaha, Nebraska, 68114, United States

  • Children's Hospital of Alabama

    RECRUITING

    Birmingham, Alabama, 35233, United States

    Contact Email: •••••@•••••

  • Children's Hospital of Michigan

    SUSPENDED

    Detroit, Michigan, 48201, United States

  • Children's Hospital of Orange County

    RECRUITING

    Orange, California, 92868, United States

    Contact Email: •••••@•••••

  • Children's Hospital of Philadelphia

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact Email: •••••@•••••

  • Children's Hospital of Pittsburgh of UPMC

    RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

  • Children's Hospital of San Antonio

    RECRUITING

    San Antonio, Texas, 78207, United States

  • Children's Hospital of The King's Daughters

    RECRUITING

    Norfolk, Virginia, 23507, United States

    Contact Email: •••••@•••••

  • Children's Hospital of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Children's Hospitals and Clinics of Minnesota - Minneapolis

    RECRUITING

    Minneapolis, Minnesota, 55404, United States

  • Children's Mercy Hospitals and Clinics

    RECRUITING

    Kansas City, Missouri, 64108, United States

    Contact Email: •••••@•••••

  • Children's National Medical Center

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

  • Cincinnati Children's Hospital Medical Center

    RECRUITING

    Cincinnati, Ohio, 45229, United States

    Contact Email: •••••@•••••

  • City of Hope Comprehensive Cancer Center

    ACTIVE_NOT_RECRUITING

    Duarte, California, 91010, United States

  • Cleveland Clinic Foundation

    SUSPENDED

    Cleveland, Ohio, 44195, United States

  • Comprehensive Cancer Centers of Nevada

    SUSPENDED

    Las Vegas, Nevada, 89148, United States

  • Comprehensive Cancer Centers of Nevada - Central Valley

    SUSPENDED

    Las Vegas, Nevada, 89169, United States

  • Comprehensive Cancer Centers of Nevada - Henderson

    SUSPENDED

    Henderson, Nevada, 89052, United States

  • Comprehensive Cancer Centers of Nevada - Northwest

    SUSPENDED

    Las Vegas, Nevada, 89128, United States

  • Comprehensive Cancer Centers of Nevada - Town Center

    SUSPENDED

    Las Vegas, Nevada, 89144, United States

  • Comprehensive Cancer Centers of Nevada-Horizon Ridge

    SUSPENDED

    Henderson, Nevada, 89052, United States

  • Comprehensive Cancer Centers of Nevada-Southeast Henderson

    SUSPENDED

    Henderson, Nevada, 89074, United States

  • Comprehensive Cancer Centers of Nevada-Summerlin

    SUSPENDED

    Las Vegas, Nevada, 89144, United States

  • Connecticut Children's Medical Center

    RECRUITING

    Hartford, Connecticut, 06106, United States

  • Cook Children's Medical Center

    RECRUITING

    Fort Worth, Texas, 76104, United States

    Contact Email: •••••@•••••

  • Corewell Health Beaumont Troy Hospital

    SUSPENDED

    Troy, Michigan, 48085, United States

  • Corewell Health Children's

    RECRUITING

    Royal Oak, Michigan, 48073, United States

  • Corewell Health Dearborn Hospital

    SUSPENDED

    Dearborn, Michigan, 48124, United States

  • Corewell Health Grand Rapids Hospitals - Butterworth Hospital

    SUSPENDED

    Grand Rapids, Michigan, 49503, United States

  • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

    RECRUITING

    Grand Rapids, Michigan, 49503, United States

  • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

    SUSPENDED

    Saint Joseph, Michigan, 49085, United States

  • Corewell Health Lakeland Hospitals - Niles Hospital

    SUSPENDED

    Niles, Michigan, 49120, United States

  • Corewell Health Lakeland Hospitals - Saint Joseph Hospital

    SUSPENDED

    Saint Joseph, Michigan, 49085, United States

  • Corewell Health Reed City Hospital

    SUSPENDED

    Reed City, Michigan, 49677, United States

  • Corewell Health William Beaumont University Hospital

    SUSPENDED

    Royal Oak, Michigan, 48073, United States

  • Covenant Children's Hospital

    RECRUITING

    Lubbock, Texas, 79410, United States

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    RECRUITING

    Lebanon, New Hampshire, 03756, United States

  • Dayton Children's Hospital

    RECRUITING

    Dayton, Ohio, 45404, United States

  • Dell Children's Medical Center of Central Texas

    RECRUITING

    Austin, Texas, 78723, United States

  • Driscoll Children's Hospital

    RECRUITING

    Corpus Christi, Texas, 78411, United States

  • Duke University Medical Center

    RECRUITING

    Durham, North Carolina, 27710, United States

  • East Carolina University

    RECRUITING

    Greenville, North Carolina, 27834, United States

  • East Tennessee Childrens Hospital

    RECRUITING

    Knoxville, Tennessee, 37916, United States

  • Eastern Maine Medical Center

    RECRUITING

    Bangor, Maine, 04401, United States

  • El Paso Children's Hospital

    RECRUITING

    El Paso, Texas, 79905, United States

  • Geisinger Medical Center

    RECRUITING

    Danville, Pennsylvania, 17822, United States

    Contact Email: •••••@•••••

  • Golisano Children's Hospital of Southwest Florida

    RECRUITING

    Fort Myers, Florida, 33908, United States

  • Hackensack University Medical Center

    RECRUITING

    Hackensack, New Jersey, 07601, United States

  • Hope Cancer Care of Nevada

    SUSPENDED

    Las Vegas, Nevada, 89103, United States

  • Hope Cancer Care of Nevada-Pahrump

    SUSPENDED

    Pahrump, Nevada, 89048, United States

  • IWK Health Centre

    SUSPENDED

    Halifax, Nova Scotia, B3K 6R8, Canada

  • Inova Fairfax Hospital

    RECRUITING

    Falls Church, Virginia, 22042, United States

  • Janeway Child Health Centre

    RECRUITING

    St. John's, Newfoundland and Labrador, A1B 3V6, Canada

  • John Hunter Children's Hospital

    SUSPENDED

    Hunter Regional Mail Centre, New South Wales, 2310, Australia

  • Johns Hopkins All Children's Hospital

    RECRUITING

    St. Petersburg, Florida, 33701, United States

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    RECRUITING

    Baltimore, Maryland, 21287, United States

  • Kaiser Permanente Downey Medical Center

    RECRUITING

    Downey, California, 90242, United States

  • Kaiser Permanente Los Angeles Medical Center

    SUSPENDED

    Los Angeles, California, 90027, United States

  • Kaiser Permanente-Anaheim

    RECRUITING

    Anaheim, California, 92806, United States

    Contact Email: •••••@•••••

  • Kaiser Permanente-Bellflower

    SUSPENDED

    Bellflower, California, 90706, United States

  • Kaiser Permanente-Fontana

    RECRUITING

    Fontana, California, 92335, United States

    Contact Email: •••••@•••••

  • Kaiser Permanente-Oakland

    RECRUITING

    Oakland, California, 94611, United States

  • Kaiser Permanente-San Diego Zion

    RECRUITING

    San Diego, California, 92120, United States

    Contact Email: •••••@•••••

  • Kapiolani Medical Center for Women and Children

    RECRUITING

    Honolulu, Hawaii, 96826, United States

  • Kingman Regional Medical Center

    SUSPENDED

    Kingman, Arizona, 86401, United States

  • Las Vegas Cancer Center-Henderson

    SUSPENDED

    Henderson, Nevada, 89052, United States

  • Las Vegas Cancer Center-Medical Center

    SUSPENDED

    Las Vegas, Nevada, 89148-2405, United States

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone

    SUSPENDED

    New York, New York, 10016, United States

  • Legacy Emanuel Children's Hospital

    RECRUITING

    Portland, Oregon, 97227, United States

  • Lehigh Valley Hospital-Cedar Crest

    RECRUITING

    Allentown, Pennsylvania, 18103, United States

  • Loma Linda University Medical Center

    RECRUITING

    Loma Linda, California, 92354, United States

  • Loyola University Medical Center

    RECRUITING

    Maywood, Illinois, 60153, United States

  • Lucile Packard Children's Hospital Stanford University

    RECRUITING

    Palo Alto, California, 94304, United States

  • Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

    ACTIVE_NOT_RECRUITING

    Torrance, California, 90502, United States

  • Lurie Children's Hospital-Chicago

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Madigan Army Medical Center

    RECRUITING

    Tacoma, Washington, 98431, United States

  • Maimonides Medical Center

    RECRUITING

    Brooklyn, New York, 11219, United States

  • Maine Children's Cancer Program

    RECRUITING

    Scarborough, Maine, 04074, United States

    Contact Email: •••••@•••••

  • Mary Bridge Children's Hospital and Health Center

    RECRUITING

    Tacoma, Washington, 98405, United States

    Contact Email: •••••@•••••

  • Mattel Children's Hospital UCLA

    RECRUITING

    Los Angeles, California, 90095, United States

  • Medical City Dallas Hospital

    RECRUITING

    Dallas, Texas, 75230, United States

  • Memorial Health University Medical Center

    RECRUITING

    Savannah, Georgia, 31404, United States

  • Memorial Regional Hospital/Joe DiMaggio Children's Hospital

    RECRUITING

    Hollywood, Florida, 33021, United States

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

  • Mercy Hospital Saint Louis

    RECRUITING

    St Louis, Missouri, 63141, United States

  • Methodist Children's Hospital of South Texas

    RECRUITING

    San Antonio, Texas, 78229, United States

  • Michigan State University

    ACTIVE_NOT_RECRUITING

    East Lansing, Michigan, 48823, United States

  • Miller Children's and Women's Hospital Long Beach

    RECRUITING

    Long Beach, California, 90806, United States

  • Mission Hospital

    RECRUITING

    Asheville, North Carolina, 28801, United States

  • Montefiore Medical Center - Moses Campus

    RECRUITING

    The Bronx, New York, 10467, United States

  • Morristown Medical Center

    RECRUITING

    Morristown, New Jersey, 07960, United States

  • Munson Medical Center

    SUSPENDED

    Traverse City, Michigan, 49684, United States

  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

    RECRUITING

    New York, New York, 10032, United States

    Contact Email: •••••@•••••

  • NYP/Weill Cornell Medical Center

    RECRUITING

    New York, New York, 10065, United States

  • NYU Langone Hospital - Long Island

    RECRUITING

    Mineola, New York, 11501, United States

    Contact Email: •••••@•••••

  • Nationwide Children's Hospital

    RECRUITING

    Columbus, Ohio, 43205, United States

  • Nemours Children's Clinic - Pensacola

    RECRUITING

    Pensacola, Florida, 32504, United States

    Contact Email: •••••@•••••

  • Nemours Children's Clinic-Jacksonville

    RECRUITING

    Jacksonville, Florida, 32207, United States

  • Nemours Children's Hospital

    RECRUITING

    Orlando, Florida, 32827, United States

  • Newark Beth Israel Medical Center

    RECRUITING

    Newark, New Jersey, 07112, United States

  • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

    SUSPENDED

    Yakima, Washington, 98902, United States

  • Norton Children's Hospital

    RECRUITING

    Louisville, Kentucky, 40202, United States

    Contact Email: •••••@•••••

  • OSF Children's Hospital of Illinois

    RECRUITING

    Peoria, Illinois, 61637, United States

    Contact Email: •••••@•••••

  • Ochsner Medical Center Jefferson

    ACTIVE_NOT_RECRUITING

    New Orleans, Louisiana, 70121, United States

  • OptumCare Cancer Care at Charleston

    SUSPENDED

    Las Vegas, Nevada, 89102, United States

  • OptumCare Cancer Care at Fort Apache

    SUSPENDED

    Las Vegas, Nevada, 89183, United States

  • OptumCare Cancer Care at MountainView

    SUSPENDED

    Las Vegas, Nevada, 89128, United States

  • Oregon Health and Science University

    RECRUITING

    Portland, Oregon, 97239, United States

    Contact Email: •••••@•••••

  • Overlake Medical Center

    SUSPENDED

    Bellevue, Washington, 98004, United States

  • PCR Oncology

    SUSPENDED

    Arroyo Grande, California, 93420, United States

  • Penn State Children's Hospital

    RECRUITING

    Hershey, Pennsylvania, 17033, United States

  • Perth Children's Hospital

    SUSPENDED

    Perth, Western Australia, 6009, Australia

  • Phoenix Childrens Hospital

    RECRUITING

    Phoenix, Arizona, 85016, United States

  • Presbyterian Hospital

    RECRUITING

    Albuquerque, New Mexico, 87106, United States

  • Primary Children's Hospital

    RECRUITING

    Salt Lake City, Utah, 84113, United States

  • Prisma Health Cancer Institute - Eastside

    RECRUITING

    Greenville, South Carolina, 29615, United States

  • Prisma Health Richland Hospital

    RECRUITING

    Columbia, South Carolina, 29203, United States

  • ProMedica Flower Hospital

    SUSPENDED

    Sylvania, Ohio, 43560, United States

  • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

    RECRUITING

    Toledo, Ohio, 43606, United States

    Contact Email: •••••@•••••

  • Providence Alaska Medical Center

    SUSPENDED

    Anchorage, Alaska, 99508, United States

  • Providence Sacred Heart Medical Center and Children's Hospital

    RECRUITING

    Spokane, Washington, 99204, United States

  • Queensland Children's Hospital

    SUSPENDED

    South Brisbane, Queensland, 4101, Australia

  • Rady Children's Hospital - San Diego

    RECRUITING

    San Diego, California, 92123, United States

  • Rainbow Babies and Childrens Hospital

    RECRUITING

    Cleveland, Ohio, 44106, United States

  • Renown Regional Medical Center

    RECRUITING

    Reno, Nevada, 89502, United States

  • Rhode Island Hospital

    RECRUITING

    Providence, Rhode Island, 02903, United States

  • Riley Hospital for Children

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

    RECRUITING

    Denver, Colorado, 80218, United States

    Contact Email: •••••@•••••

  • Rutgers Cancer Institute of New Jersey

    RECRUITING

    New Brunswick, New Jersey, 08903, United States

  • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

    RECRUITING

    New Brunswick, New Jersey, 08903, United States

  • Sacred Heart Hospital

    SUSPENDED

    Pensacola, Florida, 32504, United States

  • Saint Christopher's Hospital for Children

    RECRUITING

    Philadelphia, Pennsylvania, 19134, United States

  • Saint Francis Children's Hospital

    RECRUITING

    Tulsa, Oklahoma, 74136, United States

  • Saint Joseph's Hospital/Children's Hospital-Tampa

    RECRUITING

    Tampa, Florida, 33607, United States

  • Saint Joseph's Regional Medical Center

    RECRUITING

    Paterson, New Jersey, 07503, United States

  • Saint Luke's Cancer Institute - Boise

    RECRUITING

    Boise, Idaho, 83712, United States

  • Saint Mary's Medical Center

    RECRUITING

    West Palm Beach, Florida, 33407, United States

  • Saint Mary's Regional Medical Center

    SUSPENDED

    Reno, Nevada, 89503, United States

  • Saint Peter's University Hospital

    RECRUITING

    New Brunswick, New Jersey, 08901, United States

  • Saint Vincent Hospital Cancer Center Green Bay

    RECRUITING

    Green Bay, Wisconsin, 54301, United States

  • Sanford Broadway Medical Center

    RECRUITING

    Fargo, North Dakota, 58122, United States

    Contact Email: •••••@•••••

  • Sanford USD Medical Center - Sioux Falls

    RECRUITING

    Sioux Falls, South Dakota, 57117-5134, United States

    Contact Email: •••••@•••••

  • Seattle Children's Hospital

    RECRUITING

    Seattle, Washington, 98105, United States

  • Sinai Hospital of Baltimore

    RECRUITING

    Baltimore, Maryland, 21215, United States

  • State University of New York Upstate Medical University

    RECRUITING

    Syracuse, New York, 13210, United States

  • Stony Brook University Medical Center

    RECRUITING

    Stony Brook, New York, 11794, United States

  • Summerlin Hospital Medical Center

    RECRUITING

    Las Vegas, Nevada, 89144, United States

    Contact Email: •••••@•••••

  • Sunrise Hospital and Medical Center

    SUSPENDED

    Las Vegas, Nevada, 89109, United States

  • Sutter Medical Center Sacramento

    RECRUITING

    Sacramento, California, 95816, United States

    Contact Email: •••••@•••••

  • Sydney Children's Hospital

    SUSPENDED

    Randwick, New South Wales, 2031, Australia

  • Tampa General Hospital

    RECRUITING

    Tampa, Florida, 33606, United States

  • The Children's Hospital at TriStar Centennial

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • The Children's Hospital at Westmead

    SUSPENDED

    Westmead, New South Wales, 2145, Australia

  • The Montreal Children's Hospital of the MUHC

    SUSPENDED

    Montreal, Quebec, H3H 1P3, Canada

  • The Steven and Alexandra Cohen Children's Medical Center of New York

    RECRUITING

    New Hyde Park, New York, 11040, United States

  • Trinity Health Grand Rapids Hospital

    SUSPENDED

    Grand Rapids, Michigan, 49503, United States

  • Trinity Health Muskegon Hospital

    SUSPENDED

    Muskegon, Michigan, 49444, United States

  • Tufts Children's Hospital

    ACTIVE_NOT_RECRUITING

    Boston, Massachusetts, 02111, United States

  • UCSF Medical Center-Mission Bay

    RECRUITING

    San Francisco, California, 94158, United States

    Contact Email: •••••@•••••

  • UF Health Cancer Institute - Gainesville

    RECRUITING

    Gainesville, Florida, 32610, United States

  • UMC Cancer Center / UMC Health System

    RECRUITING

    Lubbock, Texas, 79415, United States

  • UNC Lineberger Comprehensive Cancer Center

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

    Contact Email: •••••@•••••

  • USA Health Strada Patient Care Center

    RECRUITING

    Mobile, Alabama, 36604, United States

  • UT MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • UT Southwestern/Simmons Cancer Center-Dallas

    RECRUITING

    Dallas, Texas, 75390, United States

    Contact Email: •••••@•••••

  • United Hospital Center

    SUSPENDED

    Bridgeport, West Virginia, 26330, United States

  • University Pediatric Hospital

    RECRUITING

    San Juan, 00926, Puerto Rico

  • University of Alberta Hospital

    SUSPENDED

    Edmonton, Alberta, T6G 2B7, Canada

  • University of California Davis Comprehensive Cancer Center

    RECRUITING

    Sacramento, California, 95817, United States

  • University of Chicago Comprehensive Cancer Center

    RECRUITING

    Chicago, Illinois, 60637, United States

    Contact Email: •••••@•••••

  • University of Illinois

    RECRUITING

    Chicago, Illinois, 60612, United States

  • University of Iowa/Holden Comprehensive Cancer Center

    RECRUITING

    Iowa City, Iowa, 52242, United States

  • University of Kentucky/Markey Cancer Center

    RECRUITING

    Lexington, Kentucky, 40536, United States

  • University of Michigan Health - West

    SUSPENDED

    Wyoming, Michigan, 49519, United States

  • University of Minnesota/Masonic Cancer Center

    RECRUITING

    Minneapolis, Minnesota, 55455, United States

  • University of Mississippi Medical Center

    RECRUITING

    Jackson, Mississippi, 39216, United States

  • University of Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, 68198, United States

  • University of Oklahoma Health Sciences Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

  • University of Rochester

    ACTIVE_NOT_RECRUITING

    Rochester, New York, 14642, United States

  • University of Texas Health Science Center at San Antonio

    RECRUITING

    San Antonio, Texas, 78229, United States

    Contact Email: •••••@•••••

  • University of Vermont and State Agricultural College

    RECRUITING

    Burlington, Vermont, 05405, United States

  • University of Wisconsin Carbone Cancer Center - University Hospital

    RECRUITING

    Madison, Wisconsin, 53792, United States

    Contact Email: •••••@•••••

  • VCU Massey Comprehensive Cancer Center

    RECRUITING

    Richmond, Virginia, 23298, United States

  • Valley Children's Hospital

    RECRUITING

    Madera, California, 93636, United States

    Contact Email: •••••@•••••

  • Valley Medical Center

    SUSPENDED

    Renton, Washington, 98055, United States

  • Vanderbilt University/Ingram Cancer Center

    RECRUITING

    Nashville, Tennessee, 37232, United States

  • WVUH-Berkely Medical Center

    SUSPENDED

    Martinsburg, West Virginia, 25401, United States

  • Wake Forest University Health Sciences

    RECRUITING

    Winston-Salem, North Carolina, 27157, United States

  • Walter Reed National Military Medical Center

    ACTIVE_NOT_RECRUITING

    Bethesda, Maryland, 20889-5600, United States

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact Email: •••••@•••••

  • West Michigan Cancer Center

    SUSPENDED

    Kalamazoo, Michigan, 49007, United States

  • West Virginia University Charleston Division

    RECRUITING

    Charleston, West Virginia, 25304, United States

  • West Virginia University Healthcare

    RECRUITING

    Morgantown, West Virginia, 26506, United States

    Contact Email: •••••@•••••

More trials for these conditions

Other studies related to the condition(s) this trial covers.