PERIODONTITIS

This study looked at whether adding platelet-rich fibrin (PRF) or injectable PRF, both made from a person's own blood, to standard deep-cleaning treatment can improve gum health in people with periodontitis. Fifty-six adults received either standard treatment alone or with PRF/i-…

This study tested whether placing a special gel made from the patient's own blood (albumin platelet-rich fibrin) into deep gum pockets after a standard deep cleaning helps gums heal better. 23 adults with advanced gum disease took part. One side of the mouth got the gel plus clea…

This study tested two mouthwashes in 72 adults with gum disease to see which better controls inflammation and prevents the condition from coming back. Participants used either a standard chlorhexidine rinse or a combination rinse with lower chlorhexidine plus cetylpyridinium chlo…

This study tested whether adding antibiotics (amoxicillin and metronidazole) to standard deep-cleaning treatment helps adults with gum disease. 236 participants from dental practices across the U.S. were randomly assigned to get either antibiotics or a placebo along with their cl…

This study tested whether placing a probiotic (Lactobacillus reuteri) directly into deep gum pockets, along with standard deep cleaning, improves gum health in people with type 2 diabetes. Fourteen adults with controlled diabetes and moderate to severe gum disease took part. Each…

This study tested a collagen-based gel called H42 in 38 adults with advanced gum disease (periodontitis). The gel was placed into deep gum pockets after a standard deep cleaning. Researchers measured how much the pocket depth decreased over 12 weeks, along with other signs of gum…

This study tested if a special light device used at home can help manage chronic gum disease (periodontitis). 202 adults with gum disease used the device regularly alongside standard care. The main goal was to see if it reduced bleeding when gums are gently probed, a key sign of …

This study tested whether adding laser therapy to standard gum disease treatment helps people with advanced periodontitis. Twenty adults with severe gum disease received either laser treatment or a placebo alongside regular cleaning. Researchers measured gum health and bacteria l…

This study tested two different lasers (Nd:YAG and diode) for treating stage II gum disease. 33 adults with deep gum pockets received one of the laser treatments or standard cleaning. Both lasers improved gum health, but the Nd:YAG laser was better at reducing certain harmful bac…

This study tested whether a special bone graft material containing zinc, combined with a patient's own blood concentrate (platelet-rich fibrin), can help repair bone damage caused by gum disease. Thirty adults with gum disease bone defects received the treatment, and researchers …

This study tested a new bone substitute material (ALBO-OS) in 20 people with severe gum disease or needing jawbone preservation after tooth extraction. The goal was to see if the material helps heal deep gum pockets and rebuild bone. Results showed reduced pocket depth, improved …

This study tested two antibiotic gels (metronidazole and minocycline) against gum disease in 380 adults with diabetes. Participants received deep cleaning alone or with one or both gels. Researchers measured gum pocket depth, color, and bleeding at 7 and 15 days to see which trea…

This study looked at whether adding ozone gas to standard deep-cleaning treatment helps people with gum disease (periodontitis). 18 healthy adults received standard cleaning on one side of their mouth and standard cleaning plus ozone on the other side. Researchers measured gum po…

This study tested whether adding a light-activated treatment (antimicrobial photodynamic therapy) to standard deep cleaning helps fight severe gum disease. Fifty adults with severe periodontitis received either standard cleaning alone or cleaning plus the light therapy. The goal …

This study looked at whether treating gum disease (periodontitis) could lower prostate-specific antigen (PSA) levels and reduce urinary tract infections in men with chronic prostatitis or recurrent UTIs. Sixty men were split into three groups: one received gum treatment, one got …

This study tested whether taking omega-3 supplements and low-dose aspirin, with or without an antibiotic, could improve standard gum treatment in smokers with advanced periodontitis. 45 smokers participated. The goal was to see if these additions helped reduce gum pocket depth an…

This study tested whether adding chlorhexidine (a common mouthwash ingredient) and zinc to standard deep-cleaning treatment helps people with early-stage gum disease (periodontitis). 44 healthy adults received either the standard cleaning plus the two additives or standard cleani…

This study tested a light-based treatment called FOTOSAN® for severe gum disease (periodontitis). The goal was to see if it helps reduce deep gum pockets and infection better than standard care alone. The study involved 36 adults with severe chronic periodontitis and followed the…

This study tested whether platelet-rich fibrin (PRF), made from a patient's own blood, can help regrow gum and bone tissue damaged by periodontitis. 60 adults with deep gum pockets received either standard surgery or surgery plus PRF. Researchers measured changes in pocket depth …

This study tested whether adding ozone gas to standard deep cleaning improves treatment for severe gum disease. 39 adults received either standard cleaning alone or cleaning plus ozone. The goal was to see if ozone kills more bacteria and improves gum healing. Results may help pe…

This study tested whether adding a gel made from patients' own blood (injectable platelet-rich fibrin, or i-PRF) to standard gum surgery improves healing. 42 adults with deep gum pockets received flap surgery; half also got i-PRF and a cleaning gel on their tooth roots. Over 6 mo…

This study looked at whether treating gum disease (periodontitis) can reduce the severity of rheumatoid arthritis (RA). Researchers enrolled 22 adults with both conditions. They compared standard RA care plus gum treatment to RA care alone. The goal was to see if gum treatment co…

This study looked at whether adding ozone therapy to standard gum surgery (open flap debridement) improves healing in people with advanced gum disease (stage III periodontitis). Twenty-four adults each had one side of their mouth treated with surgery plus ozone and the other side…

This study tested whether a custom oral appliance with a mouth shield (myTAP OA+) could improve gum health in 43 adults who mouth-breathe, snore, and have mild to moderate gum disease. Participants used the device for 12 weeks along with standard gum care. Researchers measured ch…

This study tested whether a hyaluronic acid gel works as well as a standard protein treatment (Emdogain) when used with bone graft material during gum surgery. Seventeen adults with severe gum disease and bone loss around teeth took part. The goal was to see if the hyaluronic aci…

This study looked at whether certain proteins in saliva can help tell if someone has healthy gums, gingivitis, or periodontitis. Researchers measured three proteins (IL-6, IL-8, and LIGHT) in saliva from 60 non-smoking adults. The goal was to see if these proteins could be used a…

This study tested two methods for deep gum cleaning in 36 people with periodontitis: a spray system (Airflow®) and traditional hand scaling. Researchers measured inflammation markers, bleeding, and pocket depth to see which method causes less tissue damage. The goal is to find a …

This study looked at whether a deep cleaning of the gums (called subgingival instrumentation) can help with jaw symptoms like pain, tension, and stiffness in people who grind their teeth and also have gum disease. Sixty adults between 30 and 40 years old took part. The main goal …

This study tested whether low-level laser therapy (LLLT) can reduce pain, speed up tooth movement, and improve gum health during the early phase of braces treatment. 108 adults aged 18-30 received either LLLT on their front teeth or no laser at each visit over 6 months. Researche…

This study tested if using an air-polishing device with erythritol powder is as effective as standard scaling and root planing for maintaining gum health after initial treatment. Twenty adults with periodontitis were randomly assigned to one of two cleaning methods. Researchers m…

This study tested whether adding a diode laser to standard deep-cleaning treatment helps smokers with severe gum disease. Thirty-three smokers were randomly assigned to get either standard cleaning alone or cleaning plus laser. After three months, the laser group had significantl…

This study looked at whether non-surgical gum treatment can improve smell and reduce tongue coating in adults with periodontitis (serious gum disease). 108 non-smoking adults received standard gum treatment, and their smell function and tongue coating were measured before and thr…

This study looked at how comprehensive gum treatment affects chewing and quality of life in people with severe gum disease (stage III periodontitis). Twenty patients received deep cleaning and, if needed, surgery. After treatment, gum health, chewing ability, and quality of life …

This study tested whether a special 5-day plant-based diet that mimics fasting can reduce mouth and body inflammation after deep cleaning for advanced gum disease. Twenty-eight adults with severe periodontitis were randomly assigned to either follow this diet three times or conti…

This study tested whether adding a special laser treatment (photodynamic therapy) to standard gum care and tongue scraping can reduce bad breath in 40 adults with gum disease and self-reported halitosis. Participants received all treatments within 24 hours, and bad breath was mea…

This study looked at how inflammatory bowel disease (IBD) impacts oral health and daily life. Researchers compared 138 adults with IBD to people without IBD, using a questionnaire to measure oral health-related quality of life. The goal was to identify factors like medications or…

This study examined whether knowing dental health terms is linked to gum health in 108 Turkish adults. Participants took a reading test about dental words and had a gum exam. The goal was to see if people with lower health literacy have worse gum disease, highlighting the need fo…

This study looked at 126 people with type 2 diabetes, some with kidney disease (diabetic nephropathy) and some without. Researchers measured three inflammatory markers (NGAL, TNF-α, and IL-10) in both saliva and blood to see how they relate to gum health. The goal was to better u…

This study looked at 69 people with gum disease (periodontitis or gingivitis) to see if non-surgical treatment changes the bone supporting their teeth. Researchers used special X-ray analysis to compare bone structure before and 6 months after treatment. The goal was to better un…

This study looked at how a specific inflammation marker, NLRP3, changes in different stages of gum disease and how it connects to aging-related inflammation. Researchers measured NLRP3 levels in fluid from the gums of 80 people with various stages of periodontitis and healthy ind…

This study looked at 101 adults with gum disease and bad breath to see if dental cleaning could also improve their sense of smell. Participants had their breath and smell ability tested before and one week after a standard deep-cleaning procedure. The goal was to understand if re…

This study looked at whether people with advanced gum disease (stage III or IV periodontitis) grind their teeth more during sleep. Researchers used a muscle monitor to measure jaw activity in 40 adults, comparing those with gum disease to healthy controls. The goal was to better …

This study looked at dental records from 86 people with gum disease to build a computer model that can predict which treatment will work best for each person. The model uses information like pocket depth, bone loss, and patient details to help dentists choose the most effective t…

This study looked at whether non-surgical gum treatment can reduce teeth grinding (bruxism) in people with advanced gum disease. Forty adults with severe gum disease or healthy gums took part. Researchers measured grinding episodes before and three months after treatment using a …

This study looked at certain proteins (GDF-15, Smads, and IL-6) in the saliva and gum fluid of 44 people—22 with gum disease and 22 healthy. The goal was to see if these proteins could help explain how gum disease develops. No treatments were tested; this was purely an observatio…

This study explored whether how addicted a person is to nicotine affects their awareness of having gum disease. Researchers studied 350 adult smokers with gingivitis or periodontitis, using a nicotine dependence questionnaire and dental exams. The goal was to understand if higher…

This study examined whether gum disease and Alzheimer's disease are connected through blood markers. Researchers measured gum health and blood counts in 100 adults over 50 who did not smoke or drink alcohol. The goal was to understand the relationship, not to test a treatment.

This study tested whether 2D and 3D cameras can accurately measure swelling and healing after routine gum surgery. 60 adults with gum disease had their faces and mouths scanned before and after surgery. The goal was to see if these non-invasive imaging tools could replace older, …

This study looked at how diabetes and gum disease affect the cells in your mouth. Researchers collected cells from the gums of 95 adults with diabetes and different stages of gum disease. They checked for changes in the cell's nucleus, like tiny spots or shape shifts, to see if t…

This study looked at dental X-rays from 120 people—half with gum disease (periodontitis) and half healthy—to see if computer analysis could spot differences in jawbone structure. Researchers used special software to measure bone patterns and thickness. The goal was to find out if…

This study looked at 30 people with severe gum disease to see how non-surgical treatment affects inflammatory markers in the fluid around the teeth. Researchers compared smokers and non-smokers before and after treatment. The goal was to find which markers signal disease severity…

This study looked at how low oxygen levels and a specific metabolic pathway (kynurenine) interact during gum inflammation. Researchers measured gum pocket depth, attachment loss, and bleeding in 45 participants, and analyzed their blood and saliva for related molecules. The goal …

This study looked at 120 adults with type 2 diabetes and gum disease to see how well their blood sugar was controlled and how it related to the severity of gum problems and cavities. Researchers grouped participants by their HbA1c levels (a measure of blood sugar control) and com…

This study looked at 163 people who got dental implants between 1999 and 2005 to see how they were doing years later. Researchers checked patient satisfaction, implant survival, bone loss, and signs of infection. They also studied saliva and gum fluid to understand inflammation a…

This study looked at whether a deep dental cleaning (called nonsurgical periodontal therapy) can lower inflammation and improve quality of life in 20 adults who have both rheumatoid arthritis and gum disease. Researchers measured changes in blood markers, bacteria in the mouth, a…

This study looked at 61 adults to see if physical fitness, diet, and body measurements like weight and waist size are linked to gum disease. Researchers reviewed dental records and questionnaires from a previous study. The goal was to understand how lifestyle factors might affect…

This study checked on 126 people who had gum regeneration surgery 2-4 years earlier. Researchers looked at dental records and did a single check-up to see if the surgery kept gum pockets shallow and healthy. The goal was to learn how well these procedures work over time, not to t…

This study looked at how smoking changes immune cells (macrophages) in the gums of people with periodontitis. Researchers compared gum tissue from 80 smokers and non-smokers with healthy gums or gum disease. They measured specific markers to see if smoking shifts the balance of i…

This study followed 471 young people with gum disease (periodontitis) for 10 years to see how the disease progresses and what factors cause it to come back. Researchers also looked at why some patients stop their treatment. The goal is to find early signs and risk factors to impr…

This study looked at whether gum disease (gingivitis or periodontitis) changes how the body's natural clock works in gum tissue. Researchers studied 60 healthy adults with similar sleep patterns. They collected small gum tissue samples and measured clock-related genes and protein…

This study looked at two substances in the fluid around teeth—fractalkine and CX3CR1—that are linked to inflammation. Researchers measured them in 90 adults with healthy gums, gingivitis, or periodontitis before and after a deep cleaning. The goal was to see how these markers cha…