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Saliva test may spot gum disease early

NCT ID NCT06558136

Knowledge-focused Sponsor: Izmir Katip Celebi University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at three proteins in saliva—IL-6, IL-8, and LIGHT—to see if they can tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers measured these proteins in 60 non-smoking, healthy adults (20 with healthy gums, 20 with gingivitis, and 20 with periodontitis). The goal was to find out if these proteins could be used as a simple, non-invasive diagnostic tool for gum disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

60 people

The number who actually took part.

Started

Aug 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult individuals aged 18 to 70 years, including periodontally healthy subjects, patients with gingivitis, and patients with periodontitis, recruited from patients presenting for routine dental examinations at the Department of Periodontology, İzmir Katip Çelebi University

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy participants. * At least twenty permanent teeth present in the oral cavity. * Non-smokers. * No medication for continuous use. * Not pregnant or breastfeeding. Exclusion Criteria: * Any oral or systemic disease. * Regular use of systemic medications. * Pregnancy or lactation. * Received periodontal treatment within the last 6 months. * Use of antibiotics, anti-inflammatory medications, or systemic corticosteroids in the last 6 months. * Smokers.

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Conditions

The condition(s) this trial relates to.

gingivitis periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingivitis Periodontal health Periodontitis

Contacts and locations

Locations

  • Izmir Katip Çelebi University Department of Periodontology

    Izmir, İzmir, 35640, Turkey (Türkiye)

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