PERIODONTITIS

This study tests whether adding an electrolysed saline mouthwash to standard deep-cleaning treatment helps people with advanced gum disease (stage III periodontitis). Sixty adults will be randomly assigned to use either the saline rinse, a standard antiseptic rinse, or a placebo …

This study tests a modified surgical technique (NIPSA) combined with a gum graft and special proteins to treat advanced gum disease and bone loss. About 40 adults with periodontitis will receive the procedure. The goal is to reduce deep gum pockets and improve gum attachment, whi…

This study tests a gentler, non-surgical treatment called MINST against the usual non-surgical care for people with gum disease around dental implants (peri-implantitis). About 106 adults will be treated and followed for 12 months to see which approach better reduces pocket depth…

This study looks at whether adding a diode laser to standard deep cleaning (scaling and root planing) improves gum health in people who have had a kidney transplant and also have gum disease. About 80 adults will be split into two groups: one gets standard cleaning plus laser, th…

This study tests whether a gel made from a patient's own blood can improve gum healing after standard deep cleaning for moderate to severe gum disease (periodontitis). About 14 adults with deep gum pockets will receive the blood gel in half of their mouth and a saltwater rinse in…

This study tests whether adding a special light therapy (antimicrobial photodynamic therapy) to standard deep cleaning improves gum health in people with both obesity and gum disease. Twenty-four participants will receive either standard cleaning alone or cleaning plus light ther…

This study looks at whether taking a probiotic called Prodentis for a long time can help control gum disease (periodontitis) better than taking it for just 3 months after standard treatment. Researchers will measure gum pocket depths and immune markers in blood and saliva. The st…

This study compares three different surgical techniques to repair gum damage caused by periodontitis. Researchers will enroll 60 adults with deep gum pockets and bone loss. The goal is to see which method best reduces pocket depth and improves gum attachment, helping control the …

This study looks at whether using a para-probiotic toothpaste and mouthwash can improve gum health and blood sugar control in adults with type 2 diabetes and gum disease. Forty participants will receive standard gum treatment and then use either the probiotic products or a standa…

This study tests whether a manuka honey mouth rinse can improve gum health in people with severe kidney disease who are on dialysis. Gum disease is very common in these patients and can lead to tooth loss. The trial will compare standard gum treatment plus the honey rinse versus …

This study looks at whether adding low-level laser therapy and hyaluronic acid to standard deep-cleaning (scaling and root planing) can improve gum health in people with periodontitis. About 45 non-smoking adults with untreated gum disease will receive the standard cleaning plus …

This study is testing a new treatment plan called Bioperio® for people with gum disease (periodontitis). The plan includes deep cleaning, brushing instructions, and for severe cases, a special gel to help gums heal. Researchers will check if gum pockets shrink and stay healthy. A…

This study tests whether adding a special laser (FX-405) to standard deep cleaning (scaling and root planing) helps treat gum disease better than cleaning alone. About 70 adults with moderate-to-severe gum disease will receive the laser treatment alongside cleaning. The main goal…

This study tests a new dental cleaning method called guided biofilm therapy (GBT) for people with gum disease (periodontitis). Researchers want to see if GBT works better than standard deep cleaning by checking gum health and certain markers in the fluid around teeth. About 18 ad…

This study tests four different materials used during gum surgery to repair bone damage caused by gum disease. About 30 adults who still have deep gum pockets after initial treatment will be randomly assigned to receive one of the materials. The goal is to see which material work…

This study tests whether a gel containing lovastatin (a cholesterol drug) placed under the gum can improve standard deep-cleaning treatment for periodontitis. About 44 adults, both smokers and non-smokers, will receive the medicated gel on one tooth and a placebo gel on another t…

This study tests a new toothpaste designed to help control periodontitis, a serious gum infection. 28 adults with the condition will brush with the toothpaste for 3 months to see if it improves their gum health. The goal is to support regular dental cleanings, not to cure the dis…

This study compares two ways to treat gum disease without surgery: an ultrasonic tool (Vector®) and special hand instruments (Mini-Five curettes). About 36 adults with moderate to severe gum disease will be randomly assigned to one treatment. Researchers will measure gum pocket d…

This study tests whether adding a special gel (made with polynucleotide and hyaluronic acid) to a standard bone graft procedure helps repair bone damage caused by severe gum disease (periodontitis). About 66 adults with deep gum pockets and bone defects will receive either surger…

This study tests whether adding a special gel made from a patient's own blood (injectable platelet-rich fibrin) to a standard bone graft helps repair deep bone defects caused by gum disease. Sixteen adults with advanced periodontitis will receive either the combination treatment …

This study compares two bone graft materials (bovine bone granules and a sponge-like collagen matrix) used with an enamel protein gel to repair bone defects caused by gum disease. About 40 adults with moderate to severe periodontitis will receive one of the two grafts after stand…

This study compares two ways to treat early gum disease (gingivitis and mild periodontitis). One group uses a smart electric toothbrush with an app, while the other adds professional dental cleaning. The goal is to see if the toothbrush alone works just as well. About 92 adults w…

This study looks at whether eating an anti-inflammatory diet can make standard gum disease treatment work better. One hundred adults with periodontitis will either get the usual deep-cleaning treatment alone or with extra nutrition education. Researchers will check gum health and…

This study aims to see if simpler, less invasive methods like taking mouth photos, answering a questionnaire, or testing saliva can accurately detect gum disease (gingivitis and periodontitis). Researchers will compare these methods to the standard full-mouth dental exam in 2,000…

This study aims to see if an online questionnaire can accurately assess a person's risk for gum disease (periodontitis or gingivitis). About 393 adults in Saudi Arabia will fill out the questionnaire and then get a dental exam to compare results. The goal is to create a simple, r…

This study looks at whether digital tools, such as intraoral scanners and cone-beam CT, can detect dental issues like cavities and gum disease as well as or better than a traditional hands-on exam. About 350 adults who haven't seen a dentist in at least six months will have both …

This study looks at whether taking ibuprofen after a deep dental cleaning can lower inflammation and pain in people with gum disease. Thirty adults with periodontitis will receive ibuprofen or a placebo, and researchers will measure inflammatory markers in the blood and pain leve…

This study tests whether a special gel, made with hyaluronic acid and octenidine, can improve early healing after standard deep cleaning for gum disease. About 26 adults with advanced periodontitis will receive either standard care or standard care plus the gel. Researchers will …

This study looks at whether adding a special light therapy (antimicrobial photodynamic therapy) to standard gum cleaning can better reduce bad breath in people with type 2 diabetes and advanced gum disease. About 32 adults will receive either standard care or standard care plus t…

This study looks at whether adding tongue scraping to standard gum disease treatment can reduce bad breath. About 39 adults with gum disease and bad breath will receive standard gum cleaning and oral hygiene instructions, with half also using a tongue scraper. The goal is to see …

This study checks how often two tiny parasites (Entamoeba gingivalis and Trichomonas tenax) are found in the mouths of 120 adults with or without gum disease. Researchers will collect saliva and plaque samples and look at them under a microscope. The goal is to learn if these par…

This observational study looks at whether a specific immune pathway (JAK1/2) is overactive in people with gum disease (periodontitis) compared to those with healthy gums. Researchers will collect gum tissue from 30 adults to measure pathway activity. The goal is to better underst…

This study looks at two types of gum tissue in people with severe gum disease to see how they affect healing after treatment. Researchers will collect tissue samples during gum surgery and compare smokers to non-smokers. The goal is to understand why some tissues heal better and …

This study aims to discover biological markers that can predict which people with mild gum inflammation will develop serious gum disease. Researchers will analyze saliva, tissue, and bacteria samples from 228 adults aged 18-40 with gingivitis or early-stage periodontitis. The goa…

This study looks at how non-surgical gum cleaning (scaling and root planing) changes certain proteins in the saliva of people with gum disease. It compares 22 smokers to 22 non-smokers to see if smoking affects the body's response to treatment. The goal is to understand how gum d…

This study looks at whether gum disease can increase the risk of a heart attack. Researchers will compare the gum health of 320 people—some who recently had a heart attack and some who haven't—to see if gum disease is more common in heart attack patients. The goal is to understan…

This study aims to find out if a specific bacterium, Treponema parvum, is more common in people with gum disease (periodontitis) compared to those with healthy gums. Researchers will collect plaque samples from 112 participants and use a sensitive test to measure the amount of th…

This study uses a special high-frequency ultrasound to look at the gums of 40 people—some with gingivitis (early gum disease) and some with healthy gums. The goal is to see how inflammation changes the structure and blood flow of gum tissue. Researchers hope this will help them b…

This study is creating and testing a Hindi version of a questionnaire that measures how chronic gum disease (periodontitis) affects a person's quality of life. Researchers will enroll 180 adults with gum disease to check if the translated questionnaire is accurate and reliable. T…

This study looks at five different ways to treat gum disease without surgery. The goal is to see how each method affects inflammation throughout the body and the amount of bacteria that enter the bloodstream during treatment. Researchers will measure blood markers and bacteria le…

This study looks at two proteins, Gas6 and sMerTK, in the fluid around teeth to see if they can help tell the difference between healthy gums, gingivitis, and serious gum disease (periodontitis). Researchers will collect samples from 90 adults—30 with healthy gums, 30 with gingiv…

This study looks at how gum health and smoking influence certain inflammatory proteins (inflammasomes) in saliva. Researchers will compare levels of these proteins in people with healthy gums, those with gum disease, and smokers. The goal is to see if these proteins can help diag…

This study is looking at how common a fungus called Candida albicans is in Syrian adults with gum disease (periodontitis). Researchers will check mouth samples from 100 patients to see if the fungus is linked to more severe gum problems. The goal is to better understand the role …

This study looks at how well non-surgical gum treatment works for adults with advanced periodontitis (stages 3 and 4). Researchers will measure changes in pocket depth using only routine dental records. About 50 people aged 18-65 who smoke fewer than 10 cigarettes a day and are n…

This study looks at a protein called surfactant protein D (SP-D) in the fluid around the gums of people with gum disease (periodontitis). Researchers will measure SP-D levels before and 6 months after a gentle, non-surgical cleaning treatment. The goal is to see if changes in SP-…

This study looks at the link between gum disease and hepatitis B+D, a serious liver infection. Researchers will measure signs of inflammation in saliva and gum fluid from three groups: people with hepatitis B+D taking the drug bulevirtide, those not taking it, and healthy volunte…

This study looks at how the tiny bacteria living in the deep pockets around teeth and dental implants change after different types of gum surgery. Researchers will collect samples from 84 adults with gum disease or implant infection before and after surgery. The goal is to unders…

This study looks at the connection between sleep quality and gum disease (periodontitis) in 48 healthy adults. Researchers will measure participants' sleep patterns, fatigue levels, and certain substances in saliva to see if poor sleep is linked to worse gum health. No treatments…

This study checks how well a Hindi questionnaire (OHIP-P-HIN) captures changes in quality of life for people with gum disease (periodontitis). About 106 adults will fill out the form to help researchers find the smallest meaningful difference in scores. The goal is to improve how…

This observational study looks at whether bacteria in the mouth can influence the stability of plaques in the carotid arteries, which supply blood to the brain. Researchers will collect samples from 200 adults scheduled for carotid surgery to compare the bacteria found in their m…

This study observes 160 adults to understand how their oral hygiene habits and gum health (like gingivitis or periodontitis) relate to their quality of life. Participants will have their gums examined and fill out a questionnaire about how their mouth affects daily living. No tre…

This study aims to understand why some people with gum disease (periodontitis) or infections around dental implants (peri-implantitis) lose bone around their teeth. Researchers will collect samples like saliva and gum fluid from 219 adults with severe gum disease and compare them…

This study looks at whether certain markers in blood and saliva can help predict how well people with gum disease will heal after non-surgical treatment. Researchers will measure these markers in 180 adults (healthy, with gingivitis, or with advanced periodontitis) before and aft…