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Gel and bone graft combo aims to regrow Gum-Damaged bone

NCT ID NCT07522684

Disease control Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a gel made from polynucleotide and hyaluronic acid, combined with a bone graft, can help repair bone defects caused by advanced gum disease. 66 adults with severe periodontitis will receive either standard surgery, surgery with bone graft alone, or surgery with both the gel and bone graft. Researchers will measure bone and gum healing over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
polynucleotide and hyaluronic acid gel combined with xenogeneic bone graft
What this could lead to
If successful, this could offer a better way to regenerate bone and tissue around teeth damaged by gum disease, improving tooth stability and reducing the need for extractions.
What could go wrong
This is a small, early-stage trial with only 66 people, so results may not apply to everyone. The gel is new for this use, and its benefits over standard treatments are not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 66 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥ 18 years of age; * diagnosis of periodontitis stage III or IV, grade B or C (Chapple et al., 2018; Papapanou et al., 2018); * full-mouth plaque score (FMPS) and full-mouth bleeding score (FMBS) of ≤ 20%; * presence of a 2- or 3-wall intrabony defect with a depth ≥ 3 mm and probing depth and clinical attachment level ≥ 5 mm in the interproximal region of a single- or multi-rooted tooth; * pulp vitality or satisfactory endodontic treatment in the tooth to be treated; * at least 1 mm of keratinized tissue on the buccal surface of the tooth to be treated. Exclusion Criteria: * presence of furcation involvement associated with the intrabony defect; * presence of systemic conditions that may affect the progression of periodontitis or the response to its treatment; * long-term use of anti-inflammatory or immunosuppressive medications; * use of antimicrobials within the last 6 months; * continuous use of mouthwashes containing antimicrobial agents within the last 6 months; * need for prophylactic antibiotic therapy for routine dental procedures; * current or past tobacco use within the last 5 years; * pregnancy; * breastfeeding.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ribeirão Preto School of Dentistry, University of São Paulo

    RECRUITING

    Ribeirão Preto, São Paulo, 14040904, Brazil

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