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Can special gels and powders regrow gum bone? new trial investigates

NCT ID NCT07292870

Disease control Sponsor: Universitaire Ziekenhuizen KU Leuven Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding different biomaterials (like artificial bone, enamel proteins, or a blood concentrate) to standard gum surgery helps repair bone defects around teeth. Thirty adults with deep gum pockets after initial treatment will receive one of four biomaterial combinations during minimally invasive surgery. Researchers will measure bone and gum healing over 12 months to see which approach works best.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
biomaterials (artificial bone, enamel matrix derivative, hyaluronic acid, L-PRF)
What this could lead to
If successful, this could identify which biomaterial best helps regrow bone around teeth after gum surgery, improving long-term tooth retention.
What could go wrong
This is a small early-stage trial with only 30 people, so results may not apply to everyone. The treatments are surgical and carry risks like infection or incomplete healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures * At least 18 years of age at the time of signing the Informed Consent Form (ICF) * American Society of Anesthesiology (ASA) score I or II * Has already completed the non-surgical periodontal therapy with remaining local pockets of ≥ 6 mm14 * The intra-bony defect should be non-contained (2-wall defect) * Clinical indication for surgical treatment of the intra-bony defect with minimally invasive approach in conjunction with biologicals Exclusion Criteria: * Under the age of 18 years * Any disorder, which in the Investigator's opinion might jeopardise the participant's safety or compliance with the protocol * Any prior or concomitant treatment(s) that might jeopardise the participant's safety or that would compromise the integrity of the Trial * Participation in an interventional Trial with an investigational medicinal product (IMP) or device * Known or suspected current malignancy * History of chemotherapy * History of radiation in the head and neck region * History of other metabolic bone diseases * Current or previous use of intravenous and oral bisphosphonates * Haematological disorders * Pregnancy / lactation * Smoking

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intra-bony pockets Periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UZLeuven, Campus St. Raphaël, Department Oral Health Sciences, Periodontology

    RECRUITING

    Leuven, Vlaams Brabant, 3000, Belgium

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