Universitaire Ziekenhuizen Ku Leuven

This study tests whether adding a periodic fasting-mimicking diet and exercise program to standard chemotherapy and immunotherapy can improve outcomes for people with early-stage triple negative breast cancer. About 356 participants will be randomly assigned to receive the lifest…

This study tests whether a program of nutrition, physical activity, and mindfulness can help women with twin pregnancies carry their babies longer, reducing the risk of preterm birth. About 81 women with dichorionic twins will be enrolled before 14 weeks of pregnancy. The goal is…

This study follows 50 people with ventricular tachycardia that hasn't responded to other treatments. They receive a precise, one-time radiation treatment to the heart. Researchers will track heart rhythm episodes and quality of life over 48 months to see how well the treatment wo…

This study tests different biomaterials to repair bone damage around teeth caused by gum disease. 30 adults who still have deep gum pockets after non-surgical treatment will receive a minor surgical procedure. During surgery, the bone defect is cleaned and then filled with one of…

This study compares a new PET/CT tracer, [18F]-AlF-FAPI-74, with the standard tracer [18F]-FDG for diagnosing three inflammatory conditions: fever of unknown origin, IgG4-related disease, and axial spondyloarthritis. Researchers aim to see if the new tracer is as good or better a…

This study tests whether using a CPAP breathing device during radiation therapy for early-stage breast cancer can lower radiation doses to the heart and lungs. About 53 women aged 40-80 with left-sided breast cancer will receive CPAP-assisted radiotherapy. The goal is to see if t…

This study compares a diet app called DOMINO to the standard low FODMAP diet for managing Irritable Bowel Syndrome (IBS) symptoms. About 110 adults with IBS will use either the app or follow the strict diet to see which better reduces belly pain and discomfort. The goal is sympto…

This study tests a new care plan for older adults with a chronic subdural hematoma, a type of brain bleed. The plan includes updated surgery techniques and aftercare to help patients recover faster and avoid repeat procedures. Researchers will compare 150 patients on this plan to…

This study looks at whether adding tongue scraping to standard gum disease treatment can improve bad breath. Researchers will compare breath and gum health in 39 adults with periodontitis and halitosis. The goal is to see if this simple extra step makes a difference in reducing b…

This study explores whether guided breathing exercises can help autistic young adults (ages 16-25) feel less stressed and improve their body's natural stress response, measured by heart rate. Researchers will also ask participants if they found the exercises easy and helpful. The…

This study compares two types of minimally invasive surgery—robotic and laparoscopic—for people with inflammatory bowel disease (IBD) who need colorectal surgery. The goal is to see which method causes fewer complications, less pain, and a quicker recovery. About 110 adults will …

This study follows 30 children with cow's milk allergy who did not become tolerant after a previous treatment. Researchers want to see if these children naturally develop tolerance over time without any new treatment. The study only observes and records reactions to milk, without…

This study tests whether wearing a heart monitor for 14 days (instead of the usual 24 hours) can better detect dangerous heart rhythms in people with mitral valve prolapse, a common valve condition. About 60 adults with MVP will wear a patch monitor at home. The goal is to see ho…

This study looks at how people who had surgery for bone or soft tissue sarcoma in their leg move and feel in daily life. Researchers will measure physical function, quality of life, and activity levels in 60 adults at least one year after surgery. The goal is to learn more about …

This study aims to find out what factors lead to gum recession in adults, whether they have had braces or not. Researchers will measure gum health, tooth alignment, and other mouth features in 50 participants. The goal is to create a simple guide for dentists to predict and preve…

This study looks at how the stomach and intestines digest food in people who have had weight-loss surgery (gastric bypass or sleeve gastrectomy) and in people with obesity who haven't had surgery. Researchers will collect digestive samples and use a small swallowable capsule to m…

This study looks at pain in people with ADPKD, a kidney disease that often causes belly, side, and back pain. Researchers will use simple touch tests and questionnaires to understand the pain better. They will compare results from 150 patients with healthy volunteers to find new …

This study tests how healthy people's feet respond to natural compounds like cinnamon, mustard, and chili. Researchers measure blood flow and pain to understand nerve function better. The goal is to learn more about diabetic peripheral neuropathy, a nerve condition that affects m…

This pilot study looks at how Botox injections affect the muscles, tendons, and nerves in the feet of people who have had a stroke and developed a tight, twisted foot (equinovarus). Researchers will use 3D ultrasound and special movement tests to track these changes over time. Th…

This study tests an immunotherapy drug called dostarlimab in 10 people with stage III colon cancer that is mismatch repair proficient (pMMR/MSS), a type that usually does not respond well to immunotherapy. Participants receive two doses of the drug before their scheduled surgery.…

This study looks at how adults with spinal deformities (like abnormal curves) keep their balance while standing and walking. Researchers will use motion analysis, muscle activity tests, and quality-of-life surveys to better understand these movements. The goal is to improve futur…

This study aims to understand why some people get very sick from COVID-19 while others do not. Researchers will analyze blood samples and genetic information from 100 hospitalized adults with confirmed COVID-19. The goal is to identify immune system patterns and genetic factors t…

This study aims to create reliable methods for measuring balance and trunk strength in adults with spinal deformity. Researchers will compare 30 patients with spinal deformity to healthy volunteers to build a first-of-its-kind database. The goal is to better understand how spinal…

This study collects images and videos of large colon polyps taken during standard colonoscopy. The goal is to use these images to train an artificial intelligence (AI) system to predict whether a polyp has cancer invading deeper layers. About 5,000 adults undergoing colonoscopy w…

This study looks at how the bones in the shoulder joint touch each other in people with shoulder arthritis, both before and after shoulder replacement surgery. The goal is to find out why some shoulder implants loosen over time. Researchers will compare patients with arthritis to…

This study looks at a hip condition called FAI, where bone shape causes pain during movement. Researchers will compare 99 men (21-35 years old) with and without symptoms to see how spine and hip motion differ. The goal is to better understand why some people with the bone shape f…

This study follows 50 adults with hip prosthetic joint infections treated at University Hospitals Leuven. Researchers will collect data on infection clearance, treatment choices, and complications to improve future care and inform patients about success rates. No new treatments a…

This study looks at how muscles change as children with spastic cerebral palsy grow. Researchers will use 3D ultrasound to measure muscle size, length, and quality over time. The goal is to better understand these changes and how they relate to brain injuries and treatments. Abou…

This study aims to understand how different forms of vitamin D work in the body, especially the 'free' form that cells can use directly. Researchers will compare healthy people, pregnant women, and patients with hormone or kidney disorders to see if measuring free vitamin D gives…