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Could your mouth bacteria predict a stroke?

NCT ID NCT07296965

Knowledge-focused Sponsor: Semmelweis University Heart and Vascular Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether bacteria in your mouth can influence the buildup of fatty plaques in the neck arteries that supply blood to the brain. Researchers will collect samples from 200 adults having surgery to remove these plaques and compare the bacteria found in the mouth, gut, and plaque itself. The goal is to see if certain bacteria make plaques more likely to rupture and cause a stroke. No treatments are tested—this is purely an observational study to gather knowledge.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Nov 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be recruited from patients undergoing carotid endarterectomy at Semmelweis University, Budapest, Hungary, within the framework of the Semmelweis Carotid Plaque Biobank. Eligible individuals are adults with confirmed internal carotid artery stenosis identified by photon-counting CT angiography. Enrollment is consecutive among surgical candidates who provide informed consent. The study population reflects a tertiary vascular surgery center cohort representing both stable and vulnerable plaque phenotypes, as classified by ultrasound, MR, and CTA imaging.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Confirmed internal carotid artery (ICA) stenosis on preoperative photon-counting computed tomography (CTA) * Adults (≥18 years) undergoing carotid endarterectomy at Semmelweis University. * Eligible for surgery based on standard anesthesiologic evaluation. * Willing and able to provide written informed consent for participation and sample collection. Exclusion Criteria: * Active systemic infection or current antibiotic therapy within 30 days before surgery. * Immunosuppressive therapy or immunodeficiency disorders. * Inability to undergo MRI (e.g., pacemaker, metallic implants, severe claustrophobia). * Pregnancy or lactation. * Malignancy under active treatment. * Prior carotid surgery or stenting on the same side. * Refusal or inability to provide informed consent.

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Conditions

The condition(s) this trial relates to.

atherosclerosis atherosclerotic cardiovascular disease carotid artery disorder carotid stenosis infectious disease periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atherosclerosis cardiovascular disease Atherosclerosis of artery Carotid artery diseases Carotid artery plaque Periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Városmajor Heart and Vascular Center, Semmelweis University

    RECRUITING

    Budapest, Hungary

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