Honey rinse could tame gum disease in dialysis patients

NCT ID NCT06726876

Disease control Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a manuka honey mouthwash can improve gum health in people with kidney failure who are on dialysis and also have gum disease. About 150 adults will rinse with a diluted honey solution three times daily. Researchers will measure gum attachment, bleeding, plaque, and a marker of inflammation. The goal is to find a simple, natural way to manage gum problems in this high-risk group.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Manuka honey oral rinse
What this could lead to: If it works, this could offer a simple, natural mouthwash to help control gum disease and reduce inflammation in people on kidney dialysis.
What could go wrong: This is a single study with 150 participants, so results may not apply to everyone. Honey rinse is generally safe, but it may not be more effective than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2024

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Both genders, aged above 18 years. * All patients must be clinically diagnosed of ESRD undergoing hemodialysis. * All patients must have a periodontal disease. * Patients must be able to make reliable decision or communications. Exclusion Criteria: * Smoking, Alcohol. * Patient with history of any serious illness as malignancy, who undergo kidney transplant. * Patients with any autoimmune disease. * Vulnerable groups such as pregnant females, prisoners, mentally and physically handicapped individuals. * Known hypersensitivity or severe adverse effects to the treatment drugs or to any ingredient of their preparation.

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Conditions

The condition(s) this trial relates to.

end stage renal failure periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hemodialysis Periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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Honey rinse could tame gum disease in dialysis patients

What the study statuses mean