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Could a saliva test predict gum disease before it starts?

NCT ID NCT07293481

Knowledge-focused Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to find biological markers in saliva, gum fluid, and tissue that can predict which people with mild gum inflammation will develop serious periodontitis. Researchers will use advanced techniques to analyze samples from 228 adults aged 18-40 with gingivitis or early-stage periodontitis. Participants will be followed for 24 months to see if the biomarkers can accurately forecast disease progression.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple test to predict who will develop periodontitis, enabling early treatment and preventing tooth loss.
What could go wrong
This is an early discovery-phase study with no direct treatment. The biomarkers may not prove accurate enough for clinical use, and results may take years to apply.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 228 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult patients seeking care at Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, who are clinically diagnosed with gingivitis or stage I periodontitis. Participants are willing to contribute subgingival microbiome samples, oral fluid specimens, and optionally a small gingival tissue biopsy.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults between 18 and 40 years of age; 2. Diagnosed with varying degrees of periodontal disease, including gingivitis and stage I periodontitis; 3. Voluntarily agree to participate in the study, have signed the informed consent form, and are able to comply with the study protocol. Exclusion Criteria: 1. Pregnant or breastfeeding women; 2. Individuals who have received antibiotic treatment within the past 3 months; 3. Individuals who have received periodontal treatment (including supragingival scaling) within the past 6 months; 4. Individuals with mucosal or salivary gland diseases (e.g., Sjögren's syndrome); 5. Individuals with severe systemic diseases, immune dysfunction, or health conditions that contraindicate surgery; 6. Individuals who are unwilling to cooperate with the study.

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Conditions

The condition(s) this trial relates to.

gingivitis periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Biomarker in early diagnosis Periodontitis SALIVA

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Shanghai 9th people's hospital

    RECRUITING

    Shanghai, Shanghai Municipality, 200120, China

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