Could a light zap cure bad breath in diabetics?
NCT ID NCT07463859
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding antimicrobial photodynamic therapy (aPDT) – a light-based treatment – to standard gum cleaning can reduce bad breath (halitosis) in people with type 2 diabetes and advanced gum disease. Thirty-two participants will receive either standard care or standard care plus aPDT. The main goal is to see if aPDT improves breath odor and gum health over six months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- antimicrobial photodynamic therapy (aPDT) with methylene blue
- What this could lead to
- If it works, this could offer a better way to treat bad breath and gum disease in people with diabetes.
- What could go wrong
- This is a small, early-stage trial with only 32 participants, so results may not apply to everyone. The added benefit of light therapy over standard care may be small or none.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 32 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients diagnosed with type 2 diabetes mellitus according to the 2019 WHO criteria * Stage 3 or 4 periodontitis * No periodontal treatment in the previous 12 months * a minimum of 20 remaining teeth. Exclusion Criteria: * Smokers * Alcohol-dependent individuals * Pregnant or lactating women * Patients with renal disorders * Patients using medications that affect the periodontium
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Bauru School of Dentistry
RECRUITINGBauru, São Paulo, 17012901, Brazil
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