Gum disease link to high uric acid under microscope
NCT ID NCT07666126
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether high uric acid levels (hyperuricemia) are linked to more severe gum disease and bone loss. Researchers will measure inflammation and oxidative stress markers in gum fluid and blood from 80 adults. Participants are grouped by gum health and uric acid status. The goal is to better understand the biological connection, not to test a treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could clarify how high uric acid worsens gum disease, pointing toward new ways to prevent or treat periodontitis.
- What could go wrong
- This is an observational study, not a treatment trial. It only measures associations, so it cannot prove cause and effect. Results may not lead to direct clinical changes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Recep Tayyip Erdoğan University Faculty of Dentistry
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Being between 18 and 65 years of age * Being systemically healthy or diagnosed with hyperuricemia * Having at least 20 natural teeth * Being periodontally healthy or diagnosed with periodontitis Exclusion Criteria: * Diabetes, cardiovascular disease, osteoporosis, chronic kidney disease, metabolic syndrome, and obesity are systemic diseases that may affect purine metabolism. * Smoking * Pregnancy or lactation * Having received periodontal treatment within the last 3-6 months * Use of antibiotics, anti-inflammatory drugs, or uric acid-lowering drugs * Presence of systemic diseases that may affect purine metabolism
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Recep Tayyip Erdoğan University
RECRUITINGRize, 53020, Turkey (Türkiye)
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Other studies related to the condition(s) this trial covers.
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- Gum fluid proteins eyed as link between smoking and periodontitis