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Gum Treatment's hidden effects: saliva proteins may reveal how smokers respond

NCT ID NCT07547202

Knowledge-focused Sponsor: Al-Mustansiriyah University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a standard deep-cleaning procedure for gum disease (scaling and root planing) changes the levels of three specific proteins in saliva. The researchers will compare these changes between smokers and non-smokers with moderate to advanced gum disease. A total of 44 adults will be treated and followed up after six weeks to see if the treatment affects both the proteins and standard measures of gum health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Non-surgical periodontal therapy (scaling and root planing)
What this could lead to
If successful, this study could reveal how gum treatment changes specific saliva markers, potentially leading to better ways to monitor gum disease, especially in smokers.
What could go wrong
This is a small, early-stage study with only 44 participants and no randomization. Results may not apply to all patients, and the saliva markers may not prove useful for routine care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 44 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy. * Diagnosed with Stage II and III periodontitis. * Presence of ≥ 20 teeth (excluding third molars). * Current smoker OR non-smoker Exclusion Criteria: * Presence of systemic diseases affecting the periodontium. * Use of medications affecting inflammation. * Received periodontal therapy in the past 6 months. * Received antibiotic therapy in the last 3 months. * Alcohol use.

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking periodontitis sclerosteosis Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis Smoking ( cigarette)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Al-Sadr Specialized Dental Center

    RECRUITING

    Baghdad, Baghdad Governorate, 10001, Iraq

  • Sadr Specialized Dental Center

    RECRUITING

    Baghdad, Baghdad Governorate, Iraq

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