PERIODONTITIS

This study looks at whether treating gum disease (periodontitis) can improve heart failure in 80 adults. Participants with heart failure and gum disease get deep dental cleaning, while a control group waits 6 months for treatment. Researchers check blood and saliva for heart fail…

This study tests whether a gel made from ferulic acid (an antioxidant found in plants) can improve the results of standard deep cleaning for gum disease (periodontitis). About 80 adults with moderate gum disease will receive either the gel plus cleaning or cleaning alone. The goa…

This study tests whether adding nano-hyaluronic acid gel to a standard non-surgical gum cleaning procedure helps heal deep gum pockets better than the cleaning alone. About 28 adults with moderate to severe gum disease will be randomly assigned to receive either the gel plus clea…

This study looks at whether adding hyaluronic acid gel or a special platelet-rich fibrin (Alb-PRF) to standard deep-cleaning treatment helps people with advanced gum disease (stage III periodontitis). 51 non-smoking adults aged 30-60 will be randomly assigned to one of three grou…

This study looks at two ways to treat advanced gum disease that has reached the area where the roots of back teeth split. About 59 adults with severe periodontitis will receive either non-surgical cleaning or a surgical procedure. The goal is to see which approach helps the tooth…

This study tests whether a graft made from a patient's own extracted tooth works as well as a standard bone graft to repair bone damage from gum disease. Sixty adults with chronic periodontitis will receive one of the two materials, both combined with a healing gel. The goal is t…

This study compares two types of minimally invasive gum surgery for people with advanced periodontitis (gum disease) that has caused bone loss. Fifty adults will be randomly assigned to receive either a single-flap or double-flap surgical technique. Researchers will measure gum p…

This study looks at whether adding omega-3 fatty acids and low-dose aspirin to standard deep-cleaning gum treatment helps people with severe periodontitis. About 120 adults will be split into three groups: standard cleaning alone, cleaning plus omega-3, or cleaning plus omega-3 a…

This study looks at whether treating severe gum disease can help slow down Alzheimer's disease. The idea is that gum disease causes body-wide inflammation, which may worsen Alzheimer's. Researchers will give 26 people with both conditions either immediate or delayed gum treatment…

This study looks at whether adding a splint (a device that holds loose teeth together) to a gentle gum cleaning treatment helps people with advanced gum disease and loose front teeth. About 50 adults with stage III or IV periodontitis and at least one loose front tooth will be tr…

This study tested whether adding a gel made from a patient's own blood (injectable Platelet-Rich Fibrin, or i-PRF) to standard deep cleaning improves gum disease treatment. Thirteen adults with moderate gum disease received standard cleaning on one side of their mouth and cleanin…

This study tests if a blackberry mouthwash works as well as a standard medicated mouthwash (chlorhexidine) for treating gum disease. About 48 adults with gum disease will get standard deep cleaning and then use one of the mouthwashes or just the cleaning alone. Researchers will c…

This study looks at whether using a diode laser along with standard deep cleaning helps people with gum disease (periodontitis). Forty adults with at least three deep gum pockets will receive either standard cleaning alone or cleaning plus laser. Researchers will measure pocket d…

This study tests a new numbing method called intraseptal anesthesia for gum surgery. It involves a small injection of a common dental anesthetic. The goal is to see if it works as well as or better than standard numbing. The study includes 60 adults with gum disease who need surg…

This study looks at 50 people with gum disease (25 smokers, 25 non-smokers) to see if smoking lowers a protein called histatin-1 in saliva, which may explain slower healing. Participants get standard non-surgical gum treatment, and their saliva and gum health are checked before, …

This study compares 148 adults (over 30) with and without gum disease to measure levels of two bacteria, E. saphenum and P. gingivalis, in dental plaque. Researchers will collect biofilm samples and use advanced lab tests to see if these bacteria are more common in diseased gums.…

This study examines two specific genes (Cofilin-2 and Lactoferrin) in people with gum disease, some of whom also have coronary heart disease. Researchers want to see if non-surgical gum treatment changes these gene-related proteins and if they are linked to heart health. The goal…

This study follows 200 adults with high blood pressure and gum disease to see how gum health affects blood pressure and cholesterol levels over 6 to 12 months. Researchers aim to understand if treating gum disease could help manage hypertension better. Participants must be 18 or …

This study looks at whether the Parkinson's medication Levodopa-Benserazide affects gum health and inflammation. Researchers will compare gum measurements and saliva samples from 136 people, including those with and without Parkinson's and with or without gum disease. The goal is…

This study examines how nicotine buildup in gum tissue influences the success of non-surgical periodontitis treatment. Researchers will compare results between smokers and non-smokers with periodontitis. The goal is to understand whether nicotine makes treatment less effective, w…

This study looks back at patient records to see how effective scaling and root planing (a deep cleaning) is for gum pockets that are 5 to 8 millimeters deep. Researchers will analyze data from 110 patients treated by dental students over two years. The goal is to confirm earlier …

This study watches 30 adults with gum disease after they have gum surgery. Researchers check how deep the gum pockets are and whether teeth survive over many years. The goal is to see which surgery type works better and how long the benefits last.

This study looks at how smoking changes the body's inflammatory response in people with gum disease. Researchers compared smokers and non-smokers with healthy gums, gingivitis, or periodontitis. They measured specific proteins and genes in gum tissue to understand the link betwee…

This study looks at gum tissue samples from 21 adults who still have deep pockets after initial gum disease treatment. Researchers want to describe the tissue features and see if they relate to how well the gums heal. The goal is to better understand why some pockets don't close …