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Could a Nano-Gel boost gum healing without surgery?

NCT ID NCT07595757

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding nano-hyaluronic acid gel to a non-surgical deep cleaning procedure helps heal gum pockets better than cleaning alone. About 28 adults with moderate to severe gum disease will be randomly assigned to receive either the gel plus cleaning or just cleaning. The main goal is to see if pocket depth decreases more with the gel over 6 months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

28 people

The number who actually took part.

Started

Jul 2025

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Males and females aged ≥ 18 years. 2. Patients with a diagnosis of periodontitis (stage II or III). 3. At least one tooth with ≥5 mm PPD and CAL and evidence of radiographic bone loss. 4. Presenting with at least 1 intrabony defect, with a radiographic intra-bony component ≥3 mm. Exclusion Criteria: 1. Patients with systemic diseases. 2. Pregnant or lactating females. 3. Tobacco smokers (≥ 10 cigarettes per day). 4. Multi-rooted teeth with class II and class III furcation defects. 5. Third molars. 6. Teeth with grade III mobility. 7. Peri-apical pathology and acute abscess. 8. Non-surgical or surgical periodontal treatment in the past 12 months. 9. Prolonged treatment with antibiotics or anti-inflammatory agents within 6 months before periodontal therapy.

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal disease Periodontitis

Contacts and locations

Locations

  • Faculty of Dentistry, Cairo University

    Cairo, Cairo Governorate, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.