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Scientists examine gum tissue to improve periodontal healing predictions

NCT ID NCT07587606

Knowledge-focused Sponsor: University of Roma La Sapienza Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at tissue samples taken from deep gum pockets in people with periodontitis who have already completed initial treatment. Researchers want to describe the tissue features and see if they relate to how well the gums heal. The goal is to better understand healing patterns, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help dentists better predict which deep gum pockets will heal well after standard treatment.
What could go wrong
This is a small, early observational study with only 21 participants. It does not test any new treatment, so it may not lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 21 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Systemically healthy, non-smoking adults with stage III or IV periodontitis and at least one residual periodontal pocket (≥5 mm) requiring surgical treatment after non-surgical therapy.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-75 years * Full Mouth Plaque Score (FMPS) \<15% at re-evaluation * Full Mouth Bleeding Score (FMBS) \<15% at re-evaluation * At least one site with probing depth (PPD) ≥5 mm after non-surgical therapy * Written informed consent * Good compliance throughout periodontal therapy Exclusion Criteria: * Pregnancy or breastfeeding * Use of systemic or local antibiotics in the previous 3 months * Smoking * Use of anti-inflammatory or anticoagulant/antiplatelet drugs * Systemic, cardiovascular, or infectious diseases affecting periodontal health * Dental contraindications to surgery (fractures, untreated endodontic lesions, mobility \> grade 2, or faulty restorations) * Non-compliant patients * History of periodontal therapy in the previous year * Ongoing orthodontic treatment

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sapienza University of Rome, Department of Oral and Maxillofacial Sciences, Section of Periodontology

    Roma, Roma, 00161, Italy

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