New bone graft shows promise for treating gum disease in small trial

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria in case of regenerative periodontal treatment: * Informed consent has been signed * Age 18 years and above * Stable dose of current regular medication (specify type if needed) for at least 4 weeks before trial entry * Acceptable laboratory analysis * No systemic diseases which could influence the outcome of the therapy, or interfere in any way with treatment outcomes, such as they are: an acute or chronic infection (e.g., osteomyelitis) at the site of implantation, uncontrolled metabolic diseases such as diabetes, osteomalacia, disorders of the thyroid gland, or heavy disturbances in the liver or kidney * Good compliance with individual plaque control following initial periodontal therapy * Teeth to be involved should be vital (intact or with fillings but without the presence of caries lesion) with score 0 mobility * The selected 2- or 3-wall intrabony defect depth, which ranges from 3-5 mm, as detected in diagnostic Panoramic Radiograph and clinical examination * Selected pocket depth (PD) ≥ 5 mm and clinical attachment level (CAL) ≥ 3 mm at the site of the endosseous defect * Angle radiographic bone defect ≤55 and ≥15 * The availability of program monitoring and maintenance of oral hygiene * No history of periodontal therapy in the previous 6 months * No history of antibiotics' intake or other medications affecting the periodontium in the previous 3 months * Minimum number of teeth is 16 (50% of all teeth/mouth) to achieve a desirable treatment effect * To preserve the dimensions of the bone of the alveolar ridge, in the indication of alveolus preservation, immediately after previous tooth extraction, in the case of planned installation of implants based on titanium alloys, it is necessary to preserve the alveolus for at least two months before implant installation Exclusion Criteria in case of regenerative periodontal treatment: * Pregnancy and lactation 6 months before the study and during the study * Significant renal or hepatic impairment * Scheduled elective surgery or other procedures requiring general anesthesia or local (oral) surgery during the trial * Subject with a life expectancy of less than 6 months * Periodontal treatment for the previous year * Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial * Participation in another research trial involving an investigational product of a similar type in the past 12 weeks Eligibility criteria if ARP was indicated: Inclusion criteria: age ≥18 years; good general health; non-smokers or light smokers (up to 10 cigarettes per day); no active periodontal disease; presence of single or multiple hopeless teeth; tooth/teeth to be extracted having at least one neighboring tooth and at least two socket walls with 3 mm of alveolar bone height; more than two residual teeth after extraction to be used as references during image superimposition. Exclusion criteria: pregnancy or lactation; presence of systemic conditions and medications that alter bone metabolism (i.e. uncontrolled diabetes mellitus, renal or hepatic impairment, immunodeficiency, severe autoimmune diseases, malignancy, radiotherapy or chemotherapy in the past 5 years, intake of corticosteroids, bisphosphonates or other anti-resorptive drugs); active periodontal disease; heavy smoking (more than 10 cigarettes per day).