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Could a natural gel boost gum disease treatment?

NCT ID NCT07404072

Disease control Sponsor: Salah Awad Alanazi Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a gel made from ferulic acid, a natural antioxidant, can improve the results of deep cleaning for gum disease. Researchers will compare three groups: cleaning plus the gel, cleaning plus a placebo gel, and cleaning alone. The goal is to see if the gel helps reduce pocket depth and improve gum attachment. The trial involves 80 adults with moderate gum disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ferulic acid gel
What this could lead to
If it works, this could point toward a simple gel that improves gum healing when used with standard deep cleaning.
What could go wrong
This is a small, early-phase trial (Phase 1/2) with only 80 people. Results may not apply to everyone, and the gel might not provide extra benefit over cleaning alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Feb 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients of both sexes 25-55 y. * Patients who are systemically healthy, * Patient exhibiting periodontal pocket depths (PD) ≥5mm, * Presence of clinical attachment loss (CAL) between 3-4mm, * Cooperative individuals capable of adhering to mechanical oral hygiene instructions Exclusion Criteria: * nPatients with sensitivity to the medication used in the study, * Patients with a history of antibiotic use or anti-inflammatory drugs during the previous 3 months prior to the study, * Patients with systemic diseases, * Pregnant and lactating females, * Smokers and tobacco chewers, * Patients are not compliant with oral hygiene procedures.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis

Contacts and locations

Locations

  • Mansura Universtiy

    Al Mansurah, Mansura, 14323, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.