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Gum disease may weaken the Body's own dental healing clot

NCT ID NCT07693725

Knowledge-focused Sponsor: Suleyman Demirel University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study investigates whether severe gum disease (periodontitis) changes the quality and quantity of a blood-derived material called leukocyte- and platelet-rich fibrin (L-PRF), which is used to help heal gums and bone after dental procedures. Researchers will compare L-PRF samples from 32 adults—half with healthy gums and half with advanced gum disease—looking at the structure, cell content, and growth factor release. The goal is to understand if the body's systemic inflammation from gum disease affects the healing power of this natural biomaterial.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Leukocyte- and platelet-rich fibrin (L-PRF)
What this could lead to
If gum disease alters L-PRF properties, dentists may need to adjust regenerative treatments for patients with periodontitis.
What could go wrong
This is a small observational study (32 people) that only measures lab differences, not treatment outcomes. Results may not change clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

32 people

The number who actually took part.

Started

Oct 2025

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of systemically healthy, non-smoking adults aged 30-50 years who are referred to the Department of Periodontology, Faculty of Dentistry, Süleyman Demirel University, from the Department of Oral and Maxillofacial Radiology. Participants will be classified as either periodontally healthy or diagnosed with Stage III-IV generalized periodontitis according to the 2017 World Workshop Classification.

Ages

30 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed as periodontally healthy or Stage III-IV generalized periodontitis according to the 2017 World Workshop Classification. * Adults aged 30-50 years. * Systemically healthy individuals. * Non-smokers. * Referred from the Department of Oral and Maxillofacial Radiology to the Department of Periodontology due to periodontal disease. * Willing and able to provide written informed consent and participate in the study. Exclusion Criteria: * Refusal or inability to provide informed consent or participate in the study. * Presence of any systemic disease. * Current smokers. * Pregnancy or breastfeeding. * Individuals with physical or psychological disabilities that may interfere with study participation. * History of substance abuse. * Severe malocclusion. * Current orthodontic treatment, use of orthodontic appliances, or removable prostheses. * Presence of acute dental pain or infection (e.g., dental caries, abscess, or acute odontogenic infection). * History or presence of malignant disease. * Participation in another clinical study at the time of enrollment.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis

Contacts and locations

Locations

  • Suleyman Demirel University, Faculty of Dentistry, Department of Periodontology

    Isparta, Isparta, 32000, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.