Your own tooth could fix your gum disease bone loss
NCT ID NCT06991998
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether using a patient's own extracted tooth as a bone graft works as well as a traditional bone graft to repair bone damage from severe gum disease. Sixty adults with chronic periodontitis will receive one of the two graft types, both combined with a healing gel. The goal is to see if the tooth graft is a less painful and equally effective option.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2024
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients diagnosed with chronic periodontitis * Both male and female participants * Patients with less than 25% plaque score (FMPS: Full Mouth Plaque Score) and bleeding index (FMBS: Full Mouth Bleeding Score) after non-surgical periodontal therapy * Good patient compliance (maintains good oral hygiene and is willing to participate in 12-month follow-up) * Patients who understand the nature of the study after receiving written information and provide signed informed consent * Patients older than 18 years * Non-self-contained intraosseous defects (wide (radiological angle \> 37°) and/or one- or two-wall defects) in the maxilla or mandible with a baseline probing depth of ≥ 6 mm * The defect has an intraosseous component of ≥ 3 mm * The patient has at least one tooth that needs extraction for any reason Exclusion Criteria: * Patients with systemic conditions such as: Alcoholism Drug addiction Known HIV, HBV, or HCV infection Patients undergoing chemotherapy or radiation therapy Current or past head and neck radiation therapy Untreated insulin-dependent diabetes mellitus Clinically significant osteoporosis or other systemic conditions affecting bone metabolism Clinically significant cardiovascular conditions such as decompensated heart failure, hemodynamically significant heart valve insufficiency, or myocardial infarction within the last 3 months Clinically significant coagulation disorders * Previous or current systemic corticosteroid therapy (within 2 months of inclusion): more than 5 mg of prednisolone per day * Previous or current bisphosphonate therapy lasting at least 30 days within the past 12 months * Long-term antibiotic or anti-inflammatory therapy within the past 4 months * Pregnant or breastfeeding women * Smoking (\>5 cigarettes/day) * Furcation involvement * Wisdom teeth
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Semmelweis University, Department of Periodontology
Budapest, Budapest, 1088, Hungary
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can pulling a loose tooth and putting it back save it?
- Gum fluid proteins eyed as link between smoking and periodontitis
- Gum fluid holds clues to Behçet's disease puzzle
- Magnifying the fight against gum disease: loupe vs microscope
- Can teaching people with diabetes to care for their gums also help their blood sugar?